Prevalence and Clinical Profile of Pancreatic Cancer–Associated Diabetes Mellitus
Open accessAbstract
Background & aims Information on the clinical profile of pancreatic cancer (PaC) associated diabetes (DM) is limited. We compared the prevalence and clinical characteristics of DM in subjects with and without PaC.Methods We prospectively recruited 512 newly diagnosed PaC cases and 933 controls of similar age, who completed demographic and clinical questionnaires and had fasting blood glucose (FBG) levels measured at recruitment and after pancreaticoduodenectomy (n = 105). Subjects with a FBG level >126 mg/dL or who were on antidiabetic treatment were classified as having DM.Results DM was more prevalent (47% vs 7%; P < .001) and predominantly of new onset (<2-year duration) (74% vs 53%; P = .002) among cases compared with controls. Among PaC cases, those with DM (n = 243) were older (68 +/- 10 vs 64 +/- 12 years; P < .001), reported higher usual adult body mass index (30 +/- 6 vs 27 +/- 5 kg/m(2); P < .001), and had a greater frequency of family history of DM (47% vs 31%; P < .001) compared with those without DM (n = 269). After pancreaticoduodenectomy, while DM resolved in 17 of 30 patients (57%) with new-onset DM, its prevalence was unchanged in patients with long-standing DM (n = 11) (P = .009).Conclusions PaC is a powerful diabetogenic state; DM associated with PaC is often new-onset, resolves following cancer resection, and appears to be associated with conventional risk factors for DM. New-onset DM in patients with PaC is likely induced by the tumor.
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Around 80% of patients with pancreatic ductal adenocarcinoma have abnormal fasting glucose or glucose intolerance.
“When diagnosed with pancreatic ductal adenocarcinoma, around 80% of patients have abnormal fasting glucose or glucose intolerance.49,50”
From Early detection of pancreatic cancer (2020) · cites this paper as [50]
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- Authors
- Pannala, R., Leirness, J. B., Bamlet, W. R., Basu, A., Petersen, G. M., & Chari, S. T.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Chari, Suresh T.
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 134
- Issue
- 4
- Pages
- 981-987
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC2323514
- OpenAlex
- W1998608669
- Cited by
- 621
- References
- 40
- Citations by year
- 2026: 25 · 2025: 45 · 2024: 32 · 2023: 50 · 2022: 40 · 2021: 59 · 2020: 47 · 2019: 42 · 2018: 39 · 2017: 36 · 2016: 20 · 2015: 29 · 2014: 35 · 2013: 26 · 2012: 38
- FWCI
- 10.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P50 CA 10270, P50CA102701, R01CA100685)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- pancreatic cancer, diabetes mellitus, new-onset diabetes, pancreaticoduodenectomy, fasting blood glucose, body mass index, family history of diabetes, diabetes risk factors, cancer-associated diabetes
- MeSH terms
- Aged, Blood Glucose, Diabetes Mellitus, Female, Humans, Male, Neoplasm Staging, Pancreatic Neoplasms, Prospective Studies, Surveys and Questionnaires, Risk Factors, United States, Prevalence, Pancreaticoduodenectomy, Disease Progression
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