A prodrug of green tea polyphenol (–)-epigallocatechin-3-gallate (Pro-EGCG) serves as a novel angiogenesis inhibitor in endometrial cancer
Abstract
Anti-angiogenesis effect of a prodrug of green tea polyphenol (-)-epigallocatechin-3-gallate (Pro-EGCG) in malignant tumors is not well studied. Here, we investigated how the treatment with Pro-EGCG inhibited tumor angiogenesis in endometrial cancer. Tumor xenografts of human endometrial cancer were established and subjected to microarray analysis after Pro-EGCG treatment. First, we showed Pro-EGCG inhibited tumor angiogenesis in xenograft models through down-regulation of vascular endothelial growth factor A (VEGFA) and hypoxia inducible factor 1 alpha (HIF1α) in tumor cells and chemokine (C-X-C motif) ligand 12 (CXCL12) in host stroma by immunohistochemical staining. Next, we investigated how HIF1α/VEGFA was down-regulated and how the reduction of CXCL12 inhibited tumor angiogenesis. We found that VEGFA secretion from endometrial cancer cells was decreased by Pro-EGCG treatment through inhibiting PI3K/AKT/mTOR/HIF1α pathway. Furthermore, the down-regulation of CXCL12 in stromal cells by Pro-EGCG treatment restricted migration and differentiation of macrophages thereby inhibited infiltration of VEGFA-expressing tumor-associated macrophages (TAMs). Taken together, we demonstrated that treatment with Pro-EGCG not only decreases cancer cell-secreted VEGFA but also inhibits TAM-secreted VEGFA in endometrial cancer. These findings demonstrate that Pro-EGCG is a novel angiogenesis inhibitor for endometrial cancer.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
EGCG inhibits the initiation, promotion, and progression of different types of tumors in vitro and in vivo.
“Numerous studies, both in vitro using various cancer cell lines and in vivo in animal models, have consistently demonstrated the ability of EGCG to inhibit the initiation, promotion, and progression of different types of tumors.141–145”
From Drug repurposing for cancer therapy (2024) · cites this paper as [144]
Cites
Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D. M., Forman, D., & Bray, F. (2015) · International Journal of Cancer · doi:10.1002/ijc.29210 · Cited by 28,766 · see citing works
Tumor-Associated Macrophages: From Mechanisms to Therapy
Noy, R., & Pollard, J. W. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.010 · Cited by 4,089 · see citing works
Targeting hypoxia in cancer therapy
Wilson, W. R., & Hay, M. P. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3064 · Cited by 3,172 · see citing works
Hypoxia in cancer: significance and impact on clinical outcome
Vaupel, P., & Mayer, A. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9055-1 · Cited by 2,240 · see citing works
HIF-1α pathway: role, regulation and intervention for cancer therapy
Masoud, G. N., & Li, W. (2015) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2015.05.007 · Cited by 1,871 · see citing works
Holmgren, L., O’Reilly, M. S., & Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0295-149 · Cited by 1,870 · see citing works
Singh, B. N., Shankar, S., & Srivastava, R. K. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.07.093 · Cited by 1,603 · see citing works
PI3K/AKT/mTOR Pathway in Angiogenesis
Karar, J., & Maity, A. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00051 · Cited by 1,468 · see citing works
Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
Solinas, G., Germano, G., Mantovani, A., & Allavena, P. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0609385 · Cited by 1,418 · see citing works
Genin, M., Clement, F., Fattaccioli, A., Raes, M., & Michiels, C. (2015) · BMC Cancer · doi:10.1186/s12885-015-1546-9 · Cited by 1,090 · see citing works
The origin and function of tumor-associated macrophages
Mantovani, A., Bottazzi, B., Colotta, F., Sozzani, S., & Ruco, L. P. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90008-u · Cited by 1,088 · see citing works
Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells
Liu, Y., Cox, S. R., Morita, T., & Kourembanas, S. (1995) · Circulation Research · doi:10.1161/01.res.77.3.638 · Cited by 1,044 · see citing works
Tumor angiogenesis: past, present and the near future
Kerbel, R. S. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.505 · Cited by 973 · see citing works
Claesson, L., & Welsh, M. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12019 · Cited by 875 · see citing works
Tumor-associated macrophages: from basic research to clinical application
Yang, L., & Zhang, Y. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-017-0430-2 · Cited by 847 · see citing works
Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway
Polivka, J., & Janku, F. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.12.004 · Cited by 765 · see citing works
Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions
Vasudev, N. S., & Reynolds, A. R. (2014) · Angiogenesis · doi:10.1007/s10456-014-9420-y · Cited by 735 · see citing works
Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis
Riabov, V., Gudima, A., Wang, N., Mickley, A., Orekhov, A. N., & Kzhyshkowska, J. G. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00075 · Cited by 631 · see citing works
Tumor-associated macrophages: Effectors of angiogenesis and tumor progression
Coffelt, S. B., Hughes, R., & Lewis, C. E. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.02.004 · Cited by 350 · see citing works
Antiangiogenic therapy of transgenic mice impairs de novo tumor growth.
Parangi, S., OʼReilly, M., Christofori, G., Holmgren, L., Grosfeld, J. A., Folkman, J., & Hanahan, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.5.2002 · Cited by 343 · see citing works
Landis‐Piwowar, K. R., Huo, C., Chen, D., Milacic, V., Shi, G., Chan, T. H., & Dou, Q. P. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4699 · Cited by 236 · see citing works
Self-citationGreen tea and its anti-angiogenesis effects
Rashidi, B., Malekzadeh, M., Goodarzi, M., Masoudifar, A., & Mirzaei, H. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.01.161 · Cited by 197 · see citing works
Angiogenic factors as potential drug target: Efficacy and limitations of anti-angiogenic therapy
Gacche, R. N., & Meshram, R. J. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.05.002 · Cited by 195 · see citing works
Clinical and Biological Significance of Vascular Endothelial Growth Factor in Endometrial Cancer
Kamat, A. A., Merritt, W. M., Coffey, D., Lin, Y. G., Patel, P. R., Broaddus, R. R., Nugent, E. K., Han, L. Y., Landen, C. N., Spannuth, W. A., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1017 · Cited by 192 · see citing works
Gu, J., Makey, K. L., Tucker, K. B., Chinchar, E., Mao, X., Pei, I., Thomas, E. Y., & Miele, L. (2013) · Vascular Cell · doi:10.1186/2045-824x-5-9 · Cited by 189 · see citing works
Wang, S., Hong, J., Hsueh, C., & Chiang, C. (2011) · Laboratory Investigation · doi:10.1038/labinvest.2011.128 · Cited by 172 · see citing works
Tumour-associated macrophages and cancer
Cook, J. A., & Hagemann, T. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.05.017 · Cited by 165 · see citing works
Targeting Tumor-Infiltrating Macrophages to Combat Cancer
Panni, R. Z., Linehan, D. C., & DeNardo, D. G. (2013) · Immunotherapy · doi:10.2217/imt.13.102 · Cited by 152 · see citing works
Lam, W. H., Kazi, A., Kuhn, D. J., Chow, L. M. C., Chan, A. S. C., Dou, Q. P., & Chan, T. H. (2004) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.08.002 · Cited by 148 · see citing works
Self-citationMolecular Mechanisms of Tumor Angiogenesis and Tumor Progression
Cavallaro, U., & Christofori, G. (2000) · Journal of Neuro-Oncology · doi:10.1023/a:1006414621286 · Cited by 135 · see citing works
Wang, C. C., Xu, H., Man, G. C. W., Zhang, T., Chu, K. O., Chu, C. Y., Cheng, J. T. Y., Li, G., He, Y., Qin, L., et al. (2012) · Angiogenesis · doi:10.1007/s10456-012-9299-4 · Cited by 125 · see citing works
Self-citationThe role of tumor-associated macrophages in tumor vascularization
Guo, C., Buranych, A., Sarkar, D., Fisher, P. B., & Wang, X. (2013) · Vascular Cell · doi:10.1186/2045-824x-5-20 · Cited by 115 · see citing works
Hirai, M., Nakagawara, A., 大崎, 達., Hayashi, Y., Hirono, M., & Yoshihara, T. (2001) · Gynecologic Oncology · doi:10.1006/gyno.2000.6056 · Cited by 109 · see citing works
Xu, H., Becker, C. M., Lui, W. T., Chu, C. Y., Davis, T. N., Kung, A. L., Birsner, A. E., D’Amato, R. J., Man, G. C. W., & Wang, C. C. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.07.008 · Cited by 107 · see citing works
Self-citationAntiangiogenic Therapies: Going beyond Their Limits
Moserle, L., Jiménez-Valerio, G., & Casanovas, O. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0199 · Cited by 102 · see citing works
Wang, Z., Huang, Y., & Zhang, J. (2014) · Cellular & Molecular Biology Letters · doi:10.2478/s11658-014-0191-7 · Cited by 80 · see citing works
Lee, S.-C., Chan, W.-K., Lee, T.-W., Lam, W. H., Wang, X., Chan, T. H., & Wong, Y.-C. (2008) · Nutrition and Cancer · doi:10.1080/01635580801947674 · Cited by 76 · see citing works
Self-citationMacrophage infiltration and angiogenesis in endometrial cancer.
Hashimoto, I., Kodama, J., Seki, N., Hongo, A., Miyagi, Y., Yoshinouchi, M., & Kudo, T. (2000) · PubMed · Cited by 45 · see citing works
Targeting angiogenesis in endometrial cancer - new agents for tailored treatments
Papa, A., Zaccarelli, E., Caruso, D., Vici, P., Panici, P. B., & Tomao, F. (2015) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2016.1116517 · Cited by 40 · see citing works
Hypoxia‐Inducible Factor‐1 as a Therapeutic Target in Endometrial Cancer Management
Seeber, L. M. S., Zweemer, R. P., Verheijen, R. H. M., & van Diest, P. J. (2010) · Obstetrics and Gynecology International · doi:10.1155/2010/580971 · Cited by 27 · see citing works
Emerging strategies for targeting PI3K in gynecologic cancer
Bregar, A. J., & Growdon, W. B. (2015) · Gynecologic Oncology · doi:10.1016/j.ygyno.2015.09.083 · Cited by 25 · see citing works
Zsíros, E., & Odunsi, K. O. (2014) · Gynecologic Oncology · doi:10.1016/j.ygyno.2014.10.012 · Cited by 16 · see citing works
Wang, C. C., Man, G. C. W., Chu, C. Y., Borchert, A., Ugun‐Klusek, A., Billett, E. E., Kühn, H., & Ufer, C. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.522094 · Cited by 14 · see citing works
Self-citationBiological markers with potential clinical value in endometrial cancer — review of the literature
Taoussi, N., Alghamdi, A. J., Futyma, K., & Rechberger, T. (2017) · Ginekologia Polska · doi:10.5603/gp.a2017.0062 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine
Luo, H., Vong, C. T., Chen, H., Gao, Y., Lyu, P., Qiu, L., Zhao, M., Liu, Q., Cheng, Z., Zou, J., et al. (2019) · Chinese Medicine · doi:10.1186/s13020-019-0270-9 · Cited by 569 · see citing works
Drug repurposing for cancer therapy
Xia, Y., Sun, M., Huang, H., & Jin, W.-L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01808-1 · Cited by 443 · see citing works
Almatroodi, S. A., Almatroudi, A., Khan, A. A., Alhumaydhi, F. A., Alsahli, M. A., & Rahmani, A. H. (2020) · Molecules · doi:10.3390/molecules25143146 · Cited by 366 · see citing works
Bioavailability of Tea Catechins and Its Improvement
Cai, Z., Li, X.-M., Liang, J.-P., Xiang, L., Wang, K., Shi, Y., Yang, R., Shi, M., Ye, J., Lu, J., et al. (2018) · Molecules · doi:10.3390/molecules23092346 · Cited by 333 · see citing works
Han, K., Nam, J., Xu, J., Sun, X., Huang, X., Animasahun, O., Achreja, A., Jeon, J. H., Pursley, B., Kamada, N., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00749-2 · Cited by 287 · see citing works
Tumor-associated macrophages: role in cancer development and therapeutic implications
Salmaninejad, A., Valilou, S. F., Soltani, A., Ahmadi, S., Abarghan, Y. J., Rosengren, R. J., & Sahebkar, A. (2019) · Cellular Oncology · doi:10.1007/s13402-019-00453-z · Cited by 244 · see citing works
Epigallocatechin 3-gallate: From green tea to cancer therapeutics
Alam, M., Ali, S., Ashraf, G. M., Bilgrami, A. L., Yadav, D. K., & Hassan, M. I. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.132135 · Cited by 239 · see citing works
Molecular mechanisms of action of epigallocatechin gallate in cancer: Recent trends and advancement
Aggarwal, V., Tuli, H. S., Tania, M., Srivastava, S., Ritzer, E. E., Pandey, A., Aggarwal, D., Barwal, T. S., Jain, A., Kaur, G., et al. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.05.011 · Cited by 224 · see citing works
A review on anti-cancer effect of green tea catechins
Cheng, Z., Zhang, Z., Han, Y., Wang, J., Wang, Y., Chen, X., Shao, Y., Cheng, Y., Zhou, W., Lu, X., et al. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104172 · Cited by 195 · see citing works
Self-citationRole of chemokines in the crosstalk between tumor and tumor-associated macrophages
Qin, R., Ren, W., Ya, G., Wang, B., He, J., Ren, S., Jiang, L., & Zhao, S. (2022) · Clinical and Experimental Medicine · doi:10.1007/s10238-022-00888-z · Cited by 167 · see citing works
Molecular mechanisms underlying health benefits of tea compounds
Shang, A., Li, J., Zhou, D.-D., Gan, R., & Li, H. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.06.006 · Cited by 147 · see citing works
Targeting PI3K/Akt/mTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach
Zughaibi, T. A., Suhail, M., Tarique, M., & Tabrez, S. S. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212455 · Cited by 137 · see citing works
Chen, G., He, L., Zhang, P., Zhang, J., Mei, X., Wang, D., Zhang, Y., Ren, X., & Chen, Z. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.110686 · Cited by 129 · see citing works
Effects and mechanisms of tea for the prevention and management of cancers: An updated review
Xu, X., Zhao, C., Cao, S., Tang, G., Gan, R., & Li, H. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1588223 · Cited by 128 · see citing works
Zhang, J., Wu, Y., Li, Y., Li, S., Liu, J., Yang, X., Xia, G., & Wang, G. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155600 · Cited by 120 · see citing works
Talib, W. H., Awajan, D., Alqudah, A. M., Alsawwaf, R., Althunibat, R., AlRoos, M. A., Safadi, A. A., Asab, S. A., Hadi, R. W., & Kury, L. T. A. (2024) · Molecules · doi:10.3390/molecules29061373 · Cited by 111 · see citing works
Targeting PI3K/Akt/mTOR signaling pathway by polyphenols: Implication for cancer therapy
Mirza‐Aghazadeh‐Attari, M., Ekrami, E., Mousavi‐Aghdas, S. A., Mihanfar, A., Hallaj, S., Yousefi, B., Safa, A., & Majidinia, M. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117481 · Cited by 110 · see citing works
Yuan, M., Zhang, G., Bai, W., Han, X., Li, C., & Bian, S. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1429869 · Cited by 97 · see citing works
Menon, D. R., Li, Y., Yamauchi, T., Osborne, D. G., Vaddi, P. K., Wempe, M. F., Zhai, Z., & Fujita, M. (2021) · Pharmaceuticals · doi:10.3390/ph14111081 · Cited by 96 · see citing works
Sheng, J., Shi, W., Guo, H., Long, W., Wang, Y., Qi, J., Liu, J., & Xu, Y. (2019) · Molecules · doi:10.3390/molecules24162899 · Cited by 95 · see citing works
Zhang, F., Zhang, Y., Sun, Y., Ma, R., Thakur, K., Zhang, J., & Wei, Z. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b07103 · Cited by 89 · see citing works
Protective Effects of Epigallocatechin Gallate (EGCG) on Endometrial, Breast, and Ovarian Cancers
Huang, Y.-J., Wang, K.-L., Chen, H.-Y., Chiang, Y., & Hsia, S. (2020) · Biomolecules · doi:10.3390/biom10111481 · Cited by 74 · see citing works
Bina, F., Soleymani, S., Toliat, T., Hajimahmoodi, M., Tabarrai, M., Abdollahi, M. R., & Rahimi, R. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.11.008 · Cited by 74 · see citing works
Liao, Z.-H., Zhu, H., Chen, Y., Chen, R.-L., Fu, L.-X., Li, L., Zhou, H., Zhou, J., & Liang, G. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112852 · Cited by 71 · see citing works
Wu, D., Liu, Z., Li, J., Zhang, Q., Zhong, P., Teng, T., Chen, M., Xie, Z., Ji, A., & Li, Y. (2019) · Cancer Cell International · doi:10.1186/s12935-019-0762-9 · Cited by 70 · see citing works
Panji, M., Behmard, V., Zare, Z., Malekpour, M., Nejadbiglari, H., Yavari, S., Dizaj, T. N., Safaeian, A., Maleki, N., Abbasi, M., et al. (2021) · Gene · doi:10.1016/j.gene.2021.145774 · Cited by 66 · see citing works
Molecular mechanisms and applications of tea polyphenols: A narrative review
Chen, Y., Cheng, S., Dai, J., Wang, L., Xu, Y., Peng, X., Xie, X., & Peng, C. Y. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13910 · Cited by 66 · see citing works
Flavonoids with Anti-Angiogenesis Function in Cancer
Wei, Q., & Zhang, Y. (2024) · Molecules · doi:10.3390/molecules29071570 · Cited by 62 · see citing works
Xu, J., Tu, Y., Wang, Y., Xu, X., Sun, X., Xie, L., Zhao, Q., Guo, Y., Gu, Y., Du, J., et al. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109606 · Cited by 61 · see citing works
Phytochemicals in Gynecological Cancer Prevention
Woźniak, M., Krajewski, R. G., Makuch, S., & Agrawal, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031219 · Cited by 61 · see citing works
Li, D., Cao, D., Sun, Y., Cui, Y., Zhang, Y., Jiang, J., & Cao, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1331641 · Cited by 61 · see citing works
Oh, J., Muthu, M., Pushparaj, S. S. C., & Gopal, J. (2023) · Molecules · doi:10.3390/molecules28052151 · Cited by 59 · see citing works
Zhang, L., Liu, Y., & Wang, Y. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.125294 · Cited by 59 · see citing works
Zhang, N., Wang, Y., Liu, H., & Shen, W. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112113 · Cited by 58 · see citing works
Recent insights on tea metabolites, their biosynthesis and chemo-preventing effects: A review
Samynathan, R., Thiruvengadam, M., Nile, S. H., Shariati, M. A., Ребезов, М. Б., Mishra, R. K., Venkidasamy, B., Periyasamy, S., Chung, I., Pateiro, M., et al. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1984871 · Cited by 56 · see citing works
Perspectives on the recent developments with green tea polyphenols in drug discovery.
Li, F., Wang, Y., Li, D., Chen, Y., Qiao, X., Fardous, R., Lewandowski, A., Liu, J., Chan, T. H., & Dou, Q. P. (2018) · PubMed · doi:10.1080/17460441.2018.1465923 · Cited by 56 · see citing works
Self-citationWei, R., Wirkus, J., Yang, Z., Machuca, J., Esparza, Y., & Mackenzie, G. G. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108546 · Cited by 56 · see citing works
Liu, K., Sun, Q., Liu, Q., Li, H., Zhang, W., & Sun, C. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113618 · Cited by 54 · see citing works
Du, J., Wang, Y., Tu, Y., Guo, Y., Sun, X., Xu, X., Liu, X., Wang, L., Qin, X., Zhu, M., et al. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108065 · Cited by 54 · see citing works
Zhuang, Y., Quan, W., Wang, X., Cheng, Y., & Ye, J. (2024) · Foods · doi:10.3390/foods13081232 · Cited by 53 · see citing works
Zubair, H., Khan, M. A., Anand, S., Srivastava, S. K., Singh, S., & Singh, A. P. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.05.009 · Cited by 53 · see citing works
Angiogenesis, a key point in the association of gut microbiota and its metabolites with disease
Wang, Y., Bai, M., Peng, Q., Li, L., Tian, F., Guo, Y., & Jing, C. (2024) · European journal of medical research · doi:10.1186/s40001-024-02224-5 · Cited by 49 · see citing works
Advanced Nanovehicles-Enabled Delivery Systems of Epigallocatechin Gallate for Cancer Therapy
Li, K., Teng, C., & Min, Q. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.573297 · Cited by 49 · see citing works
A Comprehensive Review on Beneficial Effects of Catechins on Secondary Mitochondrial Diseases
Chen, B., Zhang, W., Lin, C., & Zhang, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911569 · Cited by 51 · see citing works
Tian, X., Liu, Y., Wang, Z., & Wu, S. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.03.016 · Cited by 46 · see citing works
Implications of flavonoids as potential modulators of cancer neovascularity
Líšková, A., Koklesová, L., Samec, M., Varghese, E., Abotaleb, M., Samuel, S. M., Šmejkal, K., Biringer, K., Petráš, M., Blahútová, D., et al. (2020) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-020-03383-8 · Cited by 45 · see citing works
Islam, M. A., Medha, M. M., Nahar, A. U., Fahad, M. A. A., Siraj, M. A., & Seidel, V. (2023) · Nutrition and Cancer · doi:10.1080/01635581.2023.2183546 · Cited by 44 · see citing works
Pirola, L., Ciesielski, O., & Balcerczyk, A. (2018) · Cancers · doi:10.3390/cancers10080268 · Cited by 42 · see citing works
Piwowarczyk, L., Kucińska, M., Tomczak, S., Młynarczyk, D. T., Piskorz, J., Gośliński, T. A., Murias, M., & Jelińska, A. (2022) · Nanomaterials · doi:10.3390/nano12081274 · Cited by 39 · see citing works
Natural Compounds and Derivatives as Ser/Thr Protein Kinase Modulators and Inhibitors
Guerra, B., & Issinger, O. (2019) · Pharmaceuticals · doi:10.3390/ph12010004 · Cited by 38 · see citing works
Man, G. C. W., Wang, J., Song, Y., Wong, J. H., Zhao, Y. F., Lau, T., Leung, K. T., Chan, T. H., Wang, H., Kwong, J., et al. (2020) · BMC Cancer · doi:10.1186/s12885-020-07455-3 · Cited by 38 · see citing works
Self-citationBerger, A. A., Dao, F., & Levine, D. A. (2020) · Gynecologic Oncology · doi:10.1016/j.ygyno.2020.12.016 · Cited by 38 · see citing works
New therapeutic approaches for endometriosis besides hormonal therapy
Chen, F.-Y., Wang, X., Tang, R.-Y., Guo, Z., Deng, Y.-Z.-J., & Yu, Q. (2019) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000569 · Cited by 35 · see citing works
Green Tea Epigallocatechin-3-Gallate Regulates Autophagy in Male and Female Reproductive Cancer
Hung, S. W., Li, Y., Chen, X., Chu, K. O., Zhao, Y., Liu, Y., Guo, X. W., Man, G. C. W., & Wang, C. C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.906746 · Cited by 33 · see citing works
Self-citationGreen Tea Catechins as Therapeutic Antioxidants for Glaucoma Treatment
Ng, T. K., Chu, K. O., Wang, C. C., & Pang, C. P. (2023) · Antioxidants · doi:10.3390/antiox12071320 · Cited by 35 · see citing works
Self-citationCombination gut microbiota modulation and chemotherapy for orthotopic colorectal cancer therapy
Chen, Z., Li, J.-L., Pan, P., Bao, P., Zeng, X., & Zhang, X. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101329 · Cited by 31 · see citing works
Wang, C., Li, Y., Chen, H., Huang, K., Liu, X., Qiu, M., Liu, Y., Yang, Y., & Yang, J. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.247130 · Cited by 31 · see citing works
Self-citationWłodarczyk, M., Ciebiera, M., Nowicka, G., Łoziński, T., Ali, M. K., & Al-Hendy, A. A. (2024) · Nutrients · doi:10.3390/nu16040559 · Cited by 31 · see citing works
Fakhri, S., Moradi, S. Z., Faraji, F., Kooshki, L., Webber, K. J., & Bishayee, A. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10136-9 · Cited by 30 · see citing works
Chakrabarty, S., Nag, D., Ganguli, A., Das, A. K., Dastidar, D. G., & Chakrabarti, G. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27886 · Cited by 30 · see citing works
The effects and mechanisms of epigallocatechin-3-gallate on reversing multidrug resistance in cancer
Zhang, W., Zhang, W., Sun, L., Xiang, L., Lai, X., Li, Q., & Sun, S. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.09.017 · Cited by 27 · see citing works
Green Tea in Reproductive Cancers: Could Treatment Be as Simple?
Parish, M. A., Massoud, G., Hazimeh, D., Segars, J. H., & Islam, M. S. (2023) · Cancers · doi:10.3390/cancers15030862 · Cited by 27 · see citing works
Cui, Y., Wang, Y., & Liu, G. (2021) · Pharmaceutical Biology · doi:10.1080/13880209.2021.1972124 · Cited by 25 · see citing works
Circulating Tumour Cells (CTCs) in NSCLC: From Prognosis to Therapy Design
Kejík, Z., Kaplánek, R., Dytrych, P., Masařík, M., Veselá, K., Abramenko, N., Hoskovec, D., Vašáková, M., Králová, J., Pavel Martasek, E., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111879 · Cited by 23 · see citing works
Wei, X., Luo, D., Yan, Y., Yu, H., Sun, L., Wang, C., Song, F., Ge, H., Qian, H., Li, X., et al. (2018) · Experimental Eye Research · doi:10.1016/j.exer.2018.12.020 · Cited by 22 · see citing works
Self-citationAnticancer Molecular Mechanisms of Epigallocatechin Gallate: An Updated Review on Clinical Trials
Noman, A. M., Sultan, M. T., Mazhar, A., Baig, I., Javaid, J., Hussain, M., Imran, M., Alsagaby, S. A., Abdulmonem, W. A., Mujtaba, A., et al. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70735 · Cited by 21 · see citing works
Fan, X., Xiao, X., Mao, X., Chen, D., Yu, B., Wang, J., & Yan, H. (2020) · IUBMB Life · doi:10.1002/iub.2445 · Cited by 20 · see citing works
Self-citationMulti-Anticancer Activities of Phytoestrogens in Human Osteosarcoma
Cimmino, A., Fasciglione, G. F., Gioia, M., Marini, S., & Ciaccio, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713344 · Cited by 20 · see citing works
Research Progress in Regulation of Ferroptosis by Epigallocatechin-3- gallate in Tumor Cells
Li, Y., Zhang, L., & dong, R. (2022) · Letters in Drug Design & Discovery · doi:10.2174/1570180819666220819150351 · Cited by 19 · see citing works
Deng, P., Hu, C., Xiong, Z., Li, Y., Jiang, J., Yang, H., Tang, Y., Cao, L., & Lu, R. (2019) · Cancer Management and Research · doi:10.2147/cmar.s187750 · Cited by 18 · see citing works
Therapeutic effects of green tea on endometriosis
Chen, X., Man, G. C. W., Hung, S. W., Zhang, T., Fung, L. W. Y., Cheung, C. W., Chung, J. P. W., Li, T. C., & Wang, C. C. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1986465 · Cited by 18 · see citing works
Self-citationThe Exploration of Chemokines Importance in the Pathogenesis and Development of Endometrial Cancer
Dobroch, J., Bojczuk, K., Kołakowski, A., Baczewska, M., & Knapp, P. (2022) · Molecules · doi:10.3390/molecules27072041 · Cited by 18 · see citing works
Ma, J., Yao, Q., Chen, X., Lv, C., Zang, J., & Zhao, G. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c03427 · Cited by 17 · see citing works
Epigallocatechin-3-gallate and cancer: focus on the role of microRNAs
Wang, C., Bai, M., Sun, Z., Yao, N., Zhang, A., Guo, S., & Asemi, Z. (2023) · Cancer Cell International · doi:10.1186/s12935-023-03081-8 · Cited by 17 · see citing works
Self-citationUnraveling cancer progression pathways and phytochemical therapeutic strategies for its management
Sharma, V., Chaudhary, A. A., Bawari, S., Gupta, S. K., Mishra, R., Khan, S.-U.-D., Ali, M. A. M., Shahid, M., Srivastava, S., Verma, D., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1414790 · Cited by 15 · see citing works
Lin, J., Weng, X., Xie, X., Lian, N.-Z., Qiu, S., Wang, J.-B., Lü, J., Chen, Q., Cao, L., Lin, M., et al. (2019) · Cancer Cell International · doi:10.1186/s12935-019-0997-5 · Cited by 15 · see citing works
Self-citationEndothelial Cells (ECs) Metabolism: A Valuable Piece to Disentangle Cancer Biology
Lopes‐Coelho, F., Martins, F., & Serpa, J. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-34025-4_8 · Cited by 14 · see citing works
Flavonoids in cancer therapy: current and future trends
Gürler, S. B., Kiraz, Y., & Baran, Y. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819541-3.00021-9 · Cited by 14 · see citing works
Role of Epigallocatechin Gallate in Selected Malignant Neoplasms in Women
Markowska, A., Antoszczak, M., Markowska, J., & Huczyński, A. (2025) · Nutrients · doi:10.3390/nu17020212 · Cited by 11 · see citing works
Andrade, E. D. S., Santos, R. A., Guillermo, L. V. C., Miyoshi, N., & da Costa, D. C. F. (2024) · Molecules · doi:10.3390/molecules29194575 · Cited by 11 · see citing works
Mohammad, S. I., Vasudevan, A., Mohammed, S. N., Uthirapathy, S., Rekha, M. M., Kundlas, M., Prasad, G. V. S., Kumari, M., Mustafa, Y. F., & Hussein, Z. A. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04235-3 · Cited by 9 · see citing works
MiR-20a-5p targets RBM24 and alleviates hypertensive intracerebral hemorrhage
Xu, L., Mo, C., Lu, M., Wang, P., & Liu, Y. (2023) · Cellular and Molecular Biology · doi:10.14715/cmb/2023.69.13.21 · Cited by 8 · see citing works
The key role of natural products in the fight against endometrial Cancer
Chen, W., Zhou, W., & Liu, S. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114344 · Cited by 8 · see citing works
Zheng, F., Chen, K., Zhong, J., Tang, S., Xu, S., Lü, W., Wu, Y., & Xia, D. (2023) · Nutrients · doi:10.3390/nu15020403 · Cited by 8 · see citing works
Wu, M., Ming, J., Xue, M., Li, Q., Cheng, B., Huang, M., Xu, L., & Zhang, Y. (2020) · PubMed Central · doi:10.12122/j.issn.1673-4254.2020.09.02 · Cited by 8 · see citing works
He, C., Zhou, J., Wang, D., Wang, R., Wu, M., & Dong, T. (2022) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2022.23.6.2119 · Cited by 7 · see citing works
Application of nano/microencapsulated ingredients in milk and dairy products
Rashidinejad, A., & Singh, H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815726-8.00002-7 · Cited by 7 · see citing works
Chemoprophylactic Effects of Epigallocatechin Gallate in Female Reproductive Cancers - A Review
Xiao, S., Jia, H., Guo, Y., Ding, X., & Zheng, A. (2025) · Journal of Dietary Supplements · doi:10.1080/19390211.2025.2518409 · Cited by 7 · see citing works
RNA-seq profiling of white and brown adipocyte differentiation treated with epigallocatechin gallate
Zhang, P., Wu, W., Du, C., Ji, X., Wang, Y., Han, Q., Xu, H., Li, C., & Xu, Y. (2022) · Scientific Data · doi:10.1038/s41597-022-01149-0 · Cited by 6 · see citing works
Research Advances of Traditional Chinese Medicine in Cancer Immunotherapy
Li, J., Wang, S., Wang, N., & Wang, Z. (2020) · Chinese Medicine and Culture · doi:10.4103/cmac.cmac_42_20 · Cited by 5 · see citing works
Phytochemical baicalin potentially inhibits Bcl-2 and VEGF: an in silico approach
Sharma, V., Gupta, A., Singh, M., Singh, A. K., Chaudhary, A. A., Ahmed, Z. H., Khan, S.-U.-D., Rustagi, S., Kumar, S., & Kumar, U. (2025) · Frontiers in Bioinformatics · doi:10.3389/fbinf.2025.1545353 · Cited by 5 · see citing works
Şanlıer, N. T., Türkoğlu, İ., Saçıntı, K. G., & Sanlier, N. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1746959 · Cited by 4 · see citing works
Khosravi, A., Saghebjoo, M., & Vahabzadeh, Z. (2020) · Middle East Journal of Rehabilitation and Health Studies · doi:10.5812/mejrh.99183 · Cited by 4 · see citing works
Al‐Hetty, H. R. A. K., Ahmed, A. T., Saleem, H. M., Abdulhadi, H. L., Muhammed, T. M., & Ali, L. H. (2024) · PharmaNutrition · doi:10.1016/j.phanu.2024.100392 · Cited by 4 · see citing works
Chemopreventive and Therapeutic Potential of Natural Agents and Their Combinations for Breast Cancer
Shrivastava, N., Iqbal, B., Ali, J., & Baboota, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821277-6.00009-x · Cited by 4 · see citing works
Anti-cancer Potential of Phytoflavonoidal Drugs against Gynecological Cancer
Sangwan, K., & Goyal, P. K. (2024) · Current Cancer Therapy Reviews · doi:10.2174/0115733947289878240126111236 · Cited by 4 · see citing works
Targeting Tumor-Associated Macrophages by Plant Compounds
Grigore, A. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.92298 · Cited by 4 · see citing works
Hao, S.-J., Ge, P., Su, W.-T., Wang, Y.-X., El-Aty, A. M. A., & Tan, M.-Q. (2024) · Foods · doi:10.3390/foods13091363 · Cited by 2 · see citing works
Barbieri, A., Aliberti, S. M., Barretta, M. L., Picone, C., Luciano, A., Barbieri, M., Scognamillo, G., Santonastaso, C., Alfieri, T., Sarnicola, F., et al. (2023) · Preprints.org · doi:10.20944/preprints202311.1309.v1 · Cited by 2 · see citing works
Chu, K. O., Man, G. C. W., Hung, S. W., Chan, T. H., Lee, T. W.-Y., Chan, K. P., Pang, C. P., & Wang, C. C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1025053 · Cited by 1 · see citing works
Self-citation
- Authors
- Wang, J., Man, G. C. W., Chan, T. H., Kwong, J., & Wang, C. C.
- Affiliations
- Chinese University of Hong Kong (HK)
- Hong Kong Polytechnic University (HK)
- Corresponding author
- Wang, Chi Chiu
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 412
- Pages
- 10-20
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W2761665465
- Cited by
- 127
- References
- 44
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 16 · 2023: 11 · 2022: 12 · 2021: 18 · 2020: 29 · 2019: 13 · 2018: 11
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Letters (publishedVersion)
- PubMed (publishedVersion)
- PolyU Institutional Research Archive (Hong Kong Polytechnic University) (submittedVersion)
- Funders
- University of Hong Kong
- Chinese University of Hong Kong
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- epigallocatechin gallate, green tea polyphenols, prodrugs, endometrial cancer, tumor angiogenesis, anti-angiogenic therapy, VEGF-A, HIF-1α, PI3K/AKT/mTOR pathway, CXCL12, tumor-associated macrophages, macrophage infiltration, tumor stroma, xenograft models
- MeSH terms
- Phosphoinositide-3 Kinase Inhibitors, Animals, Catechin, Cell Movement, Female, Humans, Macrophages, Prodrugs, Tea, Endometrial Neoplasms, Angiogenesis Inhibitors, Vascular Endothelial Growth Factor A, Mice, Chemokine CXCL12
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review