CoChat
Sign Up
Cited by 168

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Targeted delivery and apoptosis induction of trans-resveratrol-ferulic acid loaded chitosan coated folic acid conjugate solid lipid nanoparticles in colon cancer cells

Senthil Kumar, Chinnaiyan, Thangam, Ramar, Mary, Soloman Agnes, Kannan, Perumal Ramesh, Arun, Gopinath, Madhan, Balaraman·2020·Carbohydrate Polymers
DOI 10.1016/j.carbpol.2019.115682
Open this paper in CoChat — free account

Abstract

The present study is aimed to study and to evaluate the colon cancer targeting efficacy of chitosan-coated-trans-resveratrol (RSV) and ferulic acid (FER) loaded SLNs (solid lipid nanoparticles) that conjugated with folic acid (FA) (C-RSV-FER-FA-SLNs) in suitable models (in vitro). The FA conjugation is performed using co-encapsulation method of stearic acid. Similarly, the prepared SLNs are exhibited better stability even under acidic conditions to exhibit their potentials to use as drug delivery system. Further, the optimized formulations (SLNs) are tested for physiochemical characterizations, which include FTIR, XRD, 1 HNMR, particle size, zeta potential, and drug release. In vitro anti-cancer studies using HT-29 cells including, fluorescence staining, flow cytometry, and western blot analysis revealed that the C-RSV-FER-FA-SLNs effectively involved and increased cytotoxicity in cancer cells that leads to induction of apoptosis as compared to free RSV-FER. Thus, it is reported that, the good stability under acidic conditions of this C-RSV-FER-FA-SLNs may serve as a promising candidate for novel nanodrug formulations in cancer therapy.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.carbpol.2019.115682

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 3 references

Research works printed but not linked: 61

  1. Almeida, 2007, Solid lipid nanoparticles as a drug delivery system for peptides and proteins, Advanced Drug Delivery Reviews, 59, 478, 10.1016/j.addr.2007.04.007 · DOI
  2. Anselmi, 2006, Analytical characterization of a ferulic acid/γ-cyclodextrin inclusion complex, Journal of Pharmaceutical and Biomedical Analysis, 40, 875, 10.1016/j.jpba.2005.08.019 · DOI
  3. Badawy, 2011, A biopolymer chitosan and its derivatives as promising antimicrobial agents against plant pathogens and their applications in crop protection, International Journal of Carbohydrate Chemistry, 2011, 10.1155/2011/460381 · DOI
  4. Bae, 2011, Targeted drug delivery to tumors: Myths, reality and possibility, Journal of Controlled Release, 153, 198, 10.1016/j.jconrel.2011.06.001 · DOI
  5. Banerjee, 2017, Strategies for targeted drug delivery in treatment of colon cancer: Current trends and future perspectives, Drug Discovery Today, 22, 1224, 10.1016/j.drudis.2017.05.006 · DOI · Paper page
  6. Basavaraj, 2014, Improved oral delivery of resveratrol using proliposomal formulation: Investigation of various factors contributing to prolonged absorption of unmetabolized resveratrol, Expert Opinion on Drug Delivery, 11, 493, 10.1517/17425247.2014.878701 · DOI
  7. Birnbaum, 2000, Optimization of preparation techniques for poly (lactic acid-co-glycolic acid) nanoparticles, Journal of Nanoparticle Research, 2, 173, 10.1023/A:1010038908767 · DOI
  8. Bondi, 2009, Ferulic acid-loaded lipid nanostructures as drug delivery systems for Alzheimer’s disease: Preparation, characterization and cytotoxicity studies, Current Nanoscience, 5, 26, 10.2174/157341309787314656 · DOI
  9. Brannon-Peppas, 2012, Nanoparticle and targeted systems for cancer therapy, Advanced Drug Delivery Reviews, 64, 206, 10.1016/j.addr.2012.09.033 · DOI
  10. Delmas, 2003, Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells, The Journal of Biological Chemistry, 278, 41482, 10.1074/jbc.M304896200 · DOI
  11. Dhule, 2012, Curcumin-loaded γ-cyclodextrin liposomal nanoparticles as delivery vehicles for osteosarcoma, Nanomedicine Nanotechnology Biology and Medicine, 8, 440, 10.1016/j.nano.2011.07.011 · DOI
  12. Dolatabadi, 2015, Solid lipid nanoparticles as efficient drug and gene delivery systems: Recent breakthroughs, Advanced Pharmaceutical Bulletin, 5, 151, 10.15171/apb.2015.022 · DOI
  13. Doss, 2018, Ferulic acid, a dietary polyphenol suppresses osteoclast differentiation and bone erosion via the inhibition of RANKL dependent NF-κB signalling pathway, Life Sciences, 207, 284, 10.1016/j.lfs.2018.06.013 · DOI
  14. Fan, 2005, Caspase family proteases and apoptosis, Acta Biochimica et Biophysica Sinica, 37, 719, 10.1111/j.1745-7270.2005.00108.x · DOI
  15. Fonte, 2012, Chitosan-coated solid lipid nanoparticles for insulin delivery, 295, 10.1016/B978-0-12-391860-4.00015-X · DOI
  16. Fonte, 2011, Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin, Drug Delivery and Translational Research, 1, 299, 10.1007/s13346-011-0023-5 · DOI
  17. Fulda, 2010, Resveratrol and derivatives for the prevention and treatment of cancer, Drug Discovery Today, 15, 757, 10.1016/j.drudis.2010.07.005 · DOI
  18. Gao, 1998, Molecular structure of two crystal forms of cyclic triadenylic acid at 1Å resolution, Journal of Biomolecular Structure & Dynamics, 16, 69, 10.1080/07391102.1998.10508228 · DOI
  19. George, 2006, Polyionic hydrocolloids for the intestinal delivery of protein drugs: Alginate and chitosan—A review, Journal of Controlled Release, 114, 1, 10.1016/j.jconrel.2006.04.017 · DOI · Paper page
  20. Hao, 2015, Preparation and optimization of resveratrol nanosuspensions by antisolvent precipitation using Box-Behnken design, AAPS PharmSciTech, 16, 118, 10.1208/s12249-014-0211-y · DOI
  21. Hu, 2017, Food macromolecule based nanodelivery systems for enhancing the bioavailability of polyphenols, Journal of Food and Drug Analysis, 25, 3, 10.1016/j.jfda.2016.11.004 · DOI
  22. Hu, 2012, Nanoparticle-based combination therapy toward overcoming drug resistance in cancer, Biochemical Pharmacology, 83, 1104, 10.1016/j.bcp.2012.01.008 · DOI
  23. Hudson, 2000, Characterization of potentially chemopreventive phenols in extracts of brown rice that inhibit the growth of human breast and colon cancer cells, Cancer Epidemiology and Prevention Biomarkers, 9, 1163
  24. Hwang, 2012, CDK2 differentially controls normal cell senescence and cancer cell proliferation upon exposure to reactive oxygen species, Biochemical and Biophysical Research Communications, 425, 94, 10.1016/j.bbrc.2012.07.059 · DOI
  25. Janicke, 2011, The antiproliferative effect of dietary fiber phenolic compounds ferulic acid and p-coumaric acid on the cell cycle of Caco-2 cells, Nutrition and Cancer, 63, 611, 10.1080/01635581.2011.538486 · DOI
  26. Kolishetti, 2010, Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy, Proceedings of the National Academy of Sciences, 107, 17939, 10.1073/pnas.1011368107 · DOI
  27. Kumar, 2016, Ultrafast synthesis of stabilized gold nanoparticles using aqueous fruit extract of Limonia acidissima L. And conjugated epirubicin: Targeted drug delivery for treatment of breast cancer, RSC Advances, 6, 26874, 10.1039/C6RA01482H · DOI
  28. Kumar, 2015, Hyaluronic acid co-functionalized gold nanoparticle complex for the targeted delivery of metformin in the treatment of liver cancer (HepG2 cells), Carbohydrate Polymers, 128, 63, 10.1016/j.carbpol.2015.04.010 · DOI
  29. Lee, 2008, The role of Ca2+ in baicalein-induced apoptosis in human breast MDA-MB-231 cancer cells through mitochondria-and caspase-3-dependent pathway, Anticancer Research, 28, 1701
  30. Li, 2017, Preparation of chitosan-ferulic acid conjugate: Structure characterization and in the application of pharmaceuticals, International Journal of Biological Macromolecules, 105, 1539, 10.1016/j.ijbiomac.2017.04.103 · DOI
  31. Lu, 2016, Nanoparticle-based oral delivery systems for colon targeting: Principles and design strategies, Science Bulletin, 61, 670, 10.1007/s11434-016-1056-4 · DOI
  32. Lu, 2012, Folate-mediated delivery of macromolecular anticancer therapeutic agents, Advanced Drug Delivery Reviews, 64, 342, 10.1016/j.addr.2012.09.020 · DOI
  33. Lu, 2009, Complexation of resveratrol with cyclodextrins: Solubility and antioxidant activity, Food Chemistry, 113, 17, 10.1016/j.foodchem.2008.04.042 · DOI
  34. Luo, 2015, Solid lipid nanoparticles for oral drug delivery: Chitosan coating improves stability, controlled delivery, mucoadhesion and cellular uptake, Carbohydrate Polymers, 122, 221, 10.1016/j.carbpol.2014.12.084 · DOI
  35. Majumdar, 2009, Curcumin synergizes with resveratrol to inhibit colon cancer, Nutrition and Cancer, 61, 544, 10.1080/01635580902752262 · DOI
  36. Mori, 1999, Chemopreventive effects of ferulic acid on oral and rice germ on large bowel carcinogenesis, Anticancer Research, 19, 3775
  37. Mosmann, 1983, Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays, Journal of Immunological Methods, 65, 55, 10.1016/0022-1759(83)90303-4 · DOI · Paper page
  38. Elzoghby, 2016, Natural polymeric nanoparticles for brain-targeting: Implications on drug and gene delivery, Current Pharmaceutical Design, 22, 3305, 10.2174/1381612822666160204120829 · DOI
  39. Patel, 2010, Chitosan mediated targeted drug delivery system: A review, Journal of Pharmacy & Pharmaceutical Sciences, 13, 536, 10.18433/J3JC7C · DOI
  40. Pillai, 2015, Curcumin entrapped folic acid conjugated PLGA–PEG nanoparticles exhibit enhanced anticancer activity by site specific delivery, RSC Advances, 5, 25518, 10.1039/C5RA00018A · DOI
  41. Poovi, 2010, In vitro characterization and invivo toxicity study of repaglinide loaded poly (methyl methacrylate) nanoparticles, International Journal of Pharmaceutics, 396, 194, 10.1016/j.ijpharm.2010.06.023 · DOI
  42. Poste, 1983, Site–specific (targeted) drug delivery in cancer therapy, Bio/Technology, 1, 869, 10.1038/nbt1283-869 · DOI
  43. Rompicharla, 2017, Formulation optimization, characterization, and evaluation of in vitro cytotoxic potential of curcumin loaded solid lipid nanoparticles for improved anticancer activity, Chemistry and Physics of Lipids, 208, 10, 10.1016/j.chemphyslip.2017.08.009 · DOI
  44. Rosa, 2016, Anticancer properties of phenolic acids in colon cancer–a review, Journal of Nutrition & Food Sciences, 6
  45. Rossin, 2005, 64Cu-labeled folate-conjugated shell cross-linked nanoparticles for tumor imaging and radiotherapy: Synthesis, radiolabeling, and biologic evaluation, Journal of Nuclear Medicine, 46, 1210
  46. Ruktanonchai, 2009, Physicochemical characteristics, cytotoxicity, and antioxidant activity of three lipid nanoparticulate formulations of alpha-lipoic acid, AAPS PharmSciTech, 10, 227, 10.1208/s12249-009-9193-6 · DOI
  47. San Hipólito-Luengo, 2017, Dual effects of resveratrol on cell deathand proliferation of colon cancer cells, Nutrition and Cancer, 69, 1019, 10.1080/01635581.2017.1359309 · DOI
  48. Shukla, 2013, Chitosan-based nanomaterials: A state-of-the-art review, International Journal of Biological Macromolecules, 59, 46, 10.1016/j.ijbiomac.2013.04.043 · DOI
  49. Sturm, 1999, Analysis of the p53/BAX pathway in colorectal cancer: Low BAX is a negative prognostic factor in patients with resected liver metastases, Journal of Clinical Oncology, 17, 10.1200/JCO.1999.17.5.1364 · DOI
  50. Sudimack, 2000, Targeted drug delivery via the folate receptor, Advanced Drug Delivery Reviews, 41, 147, 10.1016/S0169-409X(99)00062-9 · DOI
  51. Summerlin, 2015, Resveratrol nanoformulations: Challenges and opportunities, International Journal of Pharmaceutics, 479, 282, 10.1016/j.ijpharm.2015.01.003 · DOI
  52. Sundarraj, 2014, Ligand-conjugated mesoporous silica nanorattles based on enzyme targeted prodrug delivery system for effective lung cancer therapy, Toxicology and Applied Pharmacology, 275, 232, 10.1016/j.taap.2014.01.012 · DOI
  53. Thangam, 2014, Activation of intrinsic apoptotic signaling pathway in cancer cells by Cymbopogon citratus polysaccharide fractions, Carbohydrate Polymers, 107, 138, 10.1016/j.carbpol.2014.02.039 · DOI
  54. Thangam, 2014, Induction of ROS-dependent mitochondria-mediated intrinsic apoptosis in MDA-MB-231 cells by glycoprotein from Codium decorticatum, Journal of Agricultural and Food Chemistry, 62, 3410, 10.1021/jf405329e · DOI
  55. Thangam, 2013, C-Phycocyanin from Oscillatoria tenuis exhibited an antioxidant and in vitro antiproliferative activity through induction of apoptosis and G0/G1 cell cycle arrest, Food Chemistry, 140, 262, 10.1016/j.foodchem.2013.02.060 · DOI
  56. Vashisth, 2015, Biomedical applications of ferulic acid encapsulated electrospun nanofibers, Biotechnology Reports, 8, 36, 10.1016/j.btre.2015.08.008 · DOI
  57. Vijayakumar, 2016, Intravenous administration of trans-resveratrol-loaded TPGS-coated solid lipid nanoparticles for prolonged systemic circulation, passive brain targeting and improved in vitro cytotoxicity against C6 glioma cell lines, RSC Advances, 6, 50336, 10.1039/C6RA10777J · DOI
  58. Vivek, 2016, HER2 targeted breast cancer therapy with switchable “Off/On” multifunctional “Smart” magnetic polymer core–shell nanocomposites, ACS Applied Materials & Interfaces, 8, 2262, 10.1021/acsami.5b11103 · DOI
  59. Vivek, 2014, Multifunctional HER2-antibody conjugated polymeric nanocarrier-based drug delivery system for multi-drug-resistant breast cancer therapy, ACS Applied Materials & Interfaces, 6, 6469, 10.1021/am406012g · DOI
  60. Yu, 2013, Ferulic acid-loaded shellac microparticles prepared using electrohydrodynamic atomization, Advanced Materials Research, 675, 326, 10.4028/www.scientific.net/AMR.675.326 · DOI
  61. Zhang, 2013, Resveratrol nanodispersion with high stability and dissolution rate, LWT-Food Science and Technology, 50, 622, 10.1016/j.lwt.2012.07.041 · DOI

Cited by

Sorted by citations

See all 168

Metadata

Authors
Senthil Kumar, C., Thangam, R., Mary, S. A., Kannan, P. R., Arun, G., & Madhan, B.
Venue
Carbohydrate Polymers
Publisher
Elsevier BV
Published
2020-03
Volume
231
Pages
115682
ISSN
0144-8617
DOI
10.1016/j.carbpol.2019.115682
Cited by
168
References
3
Language
en
Licence
Funders
  • Department of Science and Technology, Government of Kerala
  • Department of Science and Technology, Ministry of Science and Technology, India (DST/INSPIRE/04/2016/002204)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review