Fabricating alginate/poly (caprolactone) nanofibers with enhanced bio-mechanical properties via cellulose nanocrystal incorporation
Abstract
In this research, cellulose nanocrystal (CNC) was synthesized from cotton waste using controlled hydrolysis against 64 % (w/w) sulfuric acid solution. The produced nanoparticles were then characterized using FTIR, XRD, TGA, and DLS analyses. Biaxial electrospinning technique was used to produce CNC incorporated PCL-PVA/NaAlg nanofibers. The sodium alginate portion was then crosslinked via submerging the samples in calcium chloride aqueous solution. The CNC incorporated and crosslinked sample was characterized using SEM, FTIR, and TGA techniques. Results confirmed the presence of CNC nanoparticles and alginate crosslinking reaction. Mechanical studies showed that CNC incorporation increases the tensile modulus by 65 %. Also, the crosslinked samples exhibited an increase in elongation at break. Water contact angle studies suggested that CNC incorporation and crosslinking improves nanofiber hydrophilicity. Cell viability of more than 90 % was observed in CNC incorporated PCL-CaAlg nanofibers. Also, SEM images of cells on nanofiber scaffolds showed better cell growth and attachment in PCL-CaAlg-CNC samples.
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PCL-based systems with nanocellulose exhibit increased stiffness and biodegradation rate, especially when surface-modified nanocellulose is used to improve interfacial adhesion with the hydrophobic PCL matrix.
“Similarly, PCL-based systems exhibited increased stiffness and biodegradation rate [20,21,22], especially when surface-modified NC is used to improve interfacial adhesion with the more hydrophobic PCL matrix [23]”
Solution/solvent casting facilitates better initial dispersion of NC in PCL but is limited by environmental and processing drawbacks.
“solution/solvent casting, often using chloroform or dichloromethane as solvents, facilitates better initial dispersion but is limited by environmental and processing drawbacks [20,22,23,36,67,68]”
Cites
Use of electrospinning technique for biomedical applications
Agarwal, S., Wendorff, J. H., & Greiner, A. (2008) · Polymer · doi:10.1016/j.polymer.2008.09.014 · Cited by 1,825 · see citing works
Nanocellulose: a new ageless bionanomaterial
Dufresne, A. (2013) · Materials Today · doi:10.1016/j.mattod.2013.06.004 · Cited by 1,704 · see citing works
Synthesis of polycaprolactone: A review
Labet, M., & Thielemans, W. (2009) · Chemical Society Reviews · doi:10.1039/b820162p · Cited by 1,673 · see citing works
Potential of Nanofiber Matrix as Tissue-Engineering Scaffolds
Ma, Z., Kotaki, M., Inai, R., & Ramakrishna, S. (2005) · Tissue Engineering · doi:10.1089/ten.2005.11.101 · Cited by 1,032 · see citing works
Preparation and properties of cellulose nanocrystals: Rods, spheres, and network
Lü, P., & Hsieh, Y. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.04.073 · Cited by 979 · see citing works
Jonoobi, M., Oladi, R., Davoudpour, Y., Oksman, K., Dufresne, A., Hamzeh, Y., & Davoodi, R. (2015) · Cellulose · doi:10.1007/s10570-015-0551-0 · Cited by 858 · see citing works
Alginate-based composites for environmental applications: a critical review
Wang, B., Wan, Y., Zheng, Y., Lee, X., Liu, T., Yu, Z., Huang, J. G., Ok, Y. S., Chen, J., & Gao, B. (2018) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2018.1547621 · Cited by 510 · see citing works
FT-IR spectra of alginic acid block fractions in three species of brown seaweeds
Leal, D., Matsuhiro, B., Rossi, M., & Caruso, F. (2007) · Carbohydrate Research · doi:10.1016/j.carres.2007.10.016 · Cited by 471 · see citing works
Versatile Application of Nanocellulose: From Industry to Skin Tissue Engineering and Wound Healing
Bačáková, L., Pajorová, J., Bačáková, M., Skogberg, A., Kallio, P. J., Kolářová, K., & Švorčı́k, V. (2019) · Nanomaterials · doi:10.3390/nano9020164 · Cited by 409 · see citing works
Evaluation of sodium alginate for bone marrow cell tissue engineering
Wang, L., Shelton, R. M., Cooper, P. R., Lawson, M. A., Triffitt, J. T., & Barralet, J. E. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00167-4 · Cited by 358 · see citing works
Effect of Cross-Linking with Calcium Ions on the Physical Properties of Alginate Films
Russo, R., Malinconico, M., & Santagata, G. (2007) · Biomacromolecules · doi:10.1021/bm700565h · Cited by 322 · see citing works
Sugarcane bagasse whiskers: Extraction and characterizations
Teixeira, E. D. M., Bondancia, T. J., Teodoro, K. B. R., Corrêa, A. C., Marconcini, J. M., & Mattoso, L. H. C. (2010) · Industrial Crops and Products · doi:10.1016/j.indcrop.2010.08.009 · Cited by 308 · see citing works
Bonino, C. A., Krebs, M. D., Saquing, C. D., Jeong, S. I., Shearer, K. L., Alsberg, E., & Khan, S. A. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.02.002 · Cited by 289 · see citing works
Rusli, R., & Eichhorn, S. J. (2008) · Applied Physics Letters · doi:10.1063/1.2963491 · Cited by 288 · see citing works
Ooi, S. Y., Ahmad, I. B., & Amin, M. C. I. M. (2015) · Industrial Crops and Products · doi:10.1016/j.indcrop.2015.11.082 · Cited by 268 · see citing works
Hajiali, F., Tajbakhsh, S., & Shojaei, A. (2017) · Journal of macromolecular science. Part C, Reviews in macromolecular chemistry and physics/Journal of macromolecular science. Reviews in macromolecular chemistry and physics · doi:10.1080/15583724.2017.1332640 · Cited by 267 · see citing works
Islam, M. S., & Karim, M. R. (2010) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2010.05.038 · Cited by 258 · see citing works
Reinforcing Poly(ε-caprolactone) Nanofibers with Cellulose Nanocrystals
Zoppe, J. O., Peresin, M. S., Habibi, Y., Venditti, R. A., & Rojas, O. J. (2009) · ACS Applied Materials & Interfaces · doi:10.1021/am9003705 · Cited by 248 · see citing works
Shi, Q., Zhou, C., Yue, Y., Guo, W., Wu, Y., & Wu, Q. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2012.05.042 · Cited by 229 · see citing works
Multiwall carbon nanotubes/polycaprolactone composites for bone tissue engineering application
Pan, L., Pei, X., He, R., Wan, Q., & Wang, J. (2012) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2012.01.011 · Cited by 216 · see citing works
Loh, E. Y. X., Mohamad, N., Fauzi, M. B., Ng, M. H., Ng, S. F., & Amin, M. C. I. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-21174-7 · Cited by 208 · see citing works
Poly(ε-caprolactone)/graphene oxide biocomposites: mechanical properties and bioactivity
Wan, C., & Chen, B. (2011) · Biomedical Materials · doi:10.1088/1748-6041/6/5/055010 · Cited by 205 · see citing works
Kumar, A., Lee, Y., Kim, D., Rao, K. M., Kim, J., Park, S., Haider, A., Lee, D. H., & Han, S. S. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.10.085 · Cited by 202 · see citing works
Alginate Based Scaffolds for Cartilage Tissue Engineering: A Review
Farokhi, M., Shariatzadeh, F. J., Solouk, A., & Mirzadeh, H. (2019) · International Journal of Polymeric Materials · doi:10.1080/00914037.2018.1562924 · Cited by 196 · see citing works
Wang, L.-F., Shankar, S., & Rhim, J. (2016) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2016.08.041 · Cited by 195 · see citing works
Joseph, B., Augustine, R., Kalarikkal, N., Thomas, S., Seantier, B., & Grohens, Y. (2019) · Materials Today Communications · doi:10.1016/j.mtcomm.2019.02.009 · Cited by 189 · see citing works
Adeli‐Sardou, M., Yaghoobi, M. M., Torkzadeh‐Mahani, M., & Dodel, M. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.11.237 · Cited by 186 · see citing works
Bacterial alginate production: an overview of its biosynthesis and potential industrial production
Urtuvia, V., Maturana, N., Acevedo, F., Peña, C., & Díaz‐Barrera, A. (2017) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-017-2363-x · Cited by 174 · see citing works
Zhang, J., Ji, Q., Shen, X., Xia, Y., Tan, L., & Kong, Q. (2011) · Polymer Degradation and Stability · doi:10.1016/j.polymdegradstab.2011.01.029 · Cited by 170 · see citing works
Zhang, C., Salick, M. R., Cordie, T. M., Ellingham, T., Dan, Y., & Turng, L. (2015) · Materials Science and Engineering C · doi:10.1016/j.msec.2015.01.024 · Cited by 169 · see citing works
Cross-linked cellulose nanocrystal aerogels as viable bone tissue scaffolds
Osorio, D. A., Lee, B. E. J., Kwiecień, J. M., Wang, X., Shahid, I., Hurley, A. L., Cranston, E. D., & Grandfield, K. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.01.049 · Cited by 163 · see citing works
Three-dimensional electrospun polycaprolactone (PCL)/alginate hybrid composite scaffolds
Kim, M. S., & Kim, G. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.08.008 · Cited by 159 · see citing works
A Review on Grafting of Biofibers for Biocomposites
Wei, L., & McDonald, A. G. (2016) · Materials · doi:10.3390/ma9040303 · Cited by 150 · see citing works
Rheological properties of cellulose nanocrystal-embedded polymer composites: a review
Ching, Y. C., Ali, M. E., Abdullah, L. C., Choo, K. W., Kuan, Y. C., Julaihi, S. J., Chuah, C. H., & Liou, N.-S. (2016) · Cellulose · doi:10.1007/s10570-016-0868-3 · Cited by 144 · see citing works
Materials for Biomedical Engineering
(2019) · Elsevier eBooks · doi:10.1016/c2017-0-04408-7 · Cited by 144 · see citing works
Controlled synthesis and structural stability of alginate-based nanofibers
Bhattarai, N., & Zhang, M. (2007) · Nanotechnology · doi:10.1088/0957-4484/18/45/455601 · Cited by 143 · see citing works
Electrospun polycaprolactone scaffolds for tissue engineering: a review
Janmohammadi, M., & Nourbakhsh, M. S. (2018) · International Journal of Polymeric Materials · doi:10.1080/00914037.2018.1466139 · Cited by 142 · see citing works
Cho, S. J., Jung, S. M., Kang, M., Shin, H. S., & Youk, J. H. (2015) · Polymer · doi:10.1016/j.polymer.2015.05.037 · Cited by 136 · see citing works
Drug release and biodegradability of electrospun cellulose nanocrystal reinforced polycaprolactone
Hivechi, A., Bahrami, S. H., & Siegel, R. A. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.10.037 · Cited by 136 · see citing works
Self-citationAnalysis of cellulose nanocrystal rod lengths by dynamic light scattering and electron microscopy
Boluk, Y., & Danumah, C. (2013) · Journal of Nanoparticle Research · doi:10.1007/s11051-013-2174-4 · Cited by 133 · see citing works
Baghersad, S., Bahrami, S. H., Ranjbar‐Mohammadi, M., Mojtahedi, M. R. M., & Milan, P. B. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.08.020 · Cited by 132 · see citing works
Self-citationZarekhalili, Z., Bahrami, S. H., Ranjbar‐Mohammadi, M., & Milan, P. B. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.10.042 · Cited by 129 · see citing works
Self-citationBionanocomposites based on gelatin matrix and nanocellulose
Mondragón, G., Peña-Rodríguez, C., González, A., Eceiza, A., & Arbelaiz, A. (2014) · European Polymer Journal · doi:10.1016/j.eurpolymj.2014.11.003 · Cited by 125 · see citing works
Xu, W., Renzhe, S., Yan, Y., & Gao, J. (2016) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2016.09.012 · Cited by 122 · see citing works
Zhang, X., Chen, Y., Han, J., Mo, J., Dong, P., Zhuo, Y.-H., & Feng, Y. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.06.172 · Cited by 120 · see citing works
Optimized extraction of cellulose nanocrystals from pristine and carded hemp fibres
Luzi, F., Fortunati, E., Puglia, D., Lavorgna, M., Santulli, C., Kenny, J. M., & Torre, L. (2014) · Industrial Crops and Products · doi:10.1016/j.indcrop.2014.03.006 · Cited by 116 · see citing works
Kim, Y. B., & Kim, G. (2014) · ACS Combinatorial Science · doi:10.1021/co500033h · Cited by 107 · see citing works
Nazeer, M. A., Yılgör, E., & Yılgör, İ. (2019) · Polymer · doi:10.1016/j.polymer.2019.02.023 · Cited by 105 · see citing works
Heidari, M., Bahrami, S. H., & Ranjbar‐Mohammadi, M. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.04.095 · Cited by 102 · see citing works
Self-citationAlginate based scaffolds for bone tissue engineering
Valente, J. F. A., Valente, T., Alves, P., Ferreira, P. C. N., da Silva, A. V., & Correia, I. J. (2012) · Materials Science and Engineering C · doi:10.1016/j.msec.2012.08.001 · Cited by 101 · see citing works
Pan, Y., Wang, W., Liu, L., Ge, H., Song, L., & Hu, Y. Z. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.04.065 · Cited by 101 · see citing works
Boujemaoui, A., Sánchez, C. C., Engström, J., Bruce, C., Fogelström, L., Carlmark, A., & Malmström, E. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b09009 · Cited by 93 · see citing works
Cell proliferation on PVA/sodium alginate and PVA/poly(γ-glutamic acid) electrospun fiber
Yang, J., Yang, J. H., Tsou, S. C., Ding, C. H., Hsu, C. C., Yang, K. C., Chen, S.-W., Chen, K.-S., Chen, S.-W., & Wang, J. (2016) · Materials Science and Engineering C · doi:10.1016/j.msec.2016.04.068 · Cited by 92 · see citing works
Zahedi, E., Esmaeili, A., Eslahi, N., Shokrgozar, M. A., & Simchi, A. (2019) · Marine Drugs · doi:10.3390/md17010027 · Cited by 92 · see citing works
Adhikari, U., An, X., Rijal, N. P., Hopkins, T., Khanal, S., Chavez, T., Tatu, R. R., Sankar, J., Little, K. J., Hom, D. B., et al. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.04.061 · Cited by 91 · see citing works
Applications of Nanocomposite Materials in Dentistry
(2018) · Elsevier eBooks · doi:10.1016/c2016-0-05060-x · Cited by 91 · see citing works
Gao, H., Zhong, Z., Xia, H., Hu, Q., Ye, Q., Wang, Y., Chen, L., Du, Y., Shi, X., & Zhang, L. (2019) · Biomaterials Science · doi:10.1039/c9bm00288j · Cited by 85 · see citing works
Pathak, T. S., Yun, J., Lee, J., & Paeng, K. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.03.025 · Cited by 81 · see citing works
Preparation and Characterization of Blend Films of Poly(Vinyl Alcohol) and Sodium Alginate
Çaykara, T., & Demirci, S. (2006) · Journal of Macromolecular Science Part A · doi:10.1080/10601320600740389 · Cited by 77 · see citing works
Han, X., Huo, P., Ding, Z., Kumar, P., & Liu, B. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11090449 · Cited by 67 · see citing works
Effect of calcium alginate concentration on viability and proliferation of encapsulated fibroblasts
Bohari, S. P. M., Hukins, D. W. L., & Grover, L. M. (2011) · Bio-Medical Materials and Engineering · doi:10.3233/bme-2011-0665 · Cited by 66 · see citing works
Shoba, E., Lakra, R., Kiran, M. S., & Korrapati, P. S. (2017) · Biomedical Materials · doi:10.1088/1748-605x/aa6684 · Cited by 65 · see citing works
Mirtič, J., Balažic, H., Zupančič, Š., & Kristl, J. (2019) · Polymers · doi:10.3390/polym11040692 · Cited by 65 · see citing works
Luo, W., Cheng, L., Yuan, C., Wu, Z., Yuan, G., Hou, M., Chen, J. Y., Luo, C., & Li, W. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.05.052 · Cited by 65 · see citing works
Shanmugarajah, B., Kiew, P. L., Chew, I. M. L., Choong, T. S. Y., & Tan, K. W. (2015) · Chemical engineering transactions · doi:10.3303/cet1545285 · Cited by 61 · see citing works
Preparation of sodium alginate/poly(ethylene oxide) blend nanofibers with lecithin
Park, S. A., Park, K. E., & Kim, W. D. (2010) · Macromolecular Research · doi:10.1007/s13233-010-0909-y · Cited by 60 · see citing works
Tabasum, S., Noreen, A., Kanwal, A., Zuber, M., Anjum, M. N., & Zia, K. M. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.01.078 · Cited by 56 · see citing works
Amirabad, L. M., Jonoobi, M., Mousavi, N. S., Oksman, K., Kaboorani, A., & Yousefi, H. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.02.041 · Cited by 50 · see citing works
Hwang, T. I., Kim, J. I., Joshi, M. K., Park, C. H., & Kim, C. S. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.01.085 · Cited by 49 · see citing works
Abdal‐hay, A., Taha, M., Mousa, H. M., Bartnikowski, M., Hassan, M. L., Dewidar, M., & Ivanovski, S. (2019) · Ceramics International · doi:10.1016/j.ceramint.2019.04.206 · Cited by 37 · see citing works
Electrochemical characterization of PVA/SA nanofibers obtained by electrospinning processing
Covelo, A., Gómez-Lizárraga, K. K., Corona-Lira, M. P., Ramírez-Reivich, A. C., & Hernández, M. Á. (2018) · Surface and Interface Analysis · doi:10.1002/sia.6412 · Cited by 21 · see citing works
Hivechi, A., Bahrami, S. H., & Akerdi, A. G. (2018) · Journal of the Textile Institute · doi:10.1080/00405000.2018.1469213 · Cited by 13 · see citing works
Self-citationSun, K., Liu, Z., Liu, C., Yu, T., Zhou, M., Liu, C., Ran, F., Pan, L., & Zhang, H. (2016) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33731 · Cited by 10 · see citing works
Carbon nanocomposites for implant dentistry and bone tissue engineering
Madanagopal, T. T., Agarwalla, S. V., & Rosa, V. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813742-0.00003-1 · Cited by 10 · see citing works
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Yuan, J. T., Lei, X., Yi, C., Jiang, H., Liu, F., & Cheng, G. J. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.132765 · Cited by 289 · see citing works
Structural and Functional Design of Electrospun Nanofibers for Hemostasis and Wound Healing
Yang, Y., Du, Y., Zhang, J., Zhang, H., & Guo, B. (2022) · Advanced Fiber Materials · doi:10.1007/s42765-022-00178-z · Cited by 245 · see citing works
Cellulose nanocrystals: Fundamentals and biomedical applications
Mali, P., & Sherje, A. P. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118668 · Cited by 242 · see citing works
Iacob, A.-T., Drăgan, M., Ionescu, O.-M., Profire, L., Ficai, A., Andronescu, E., Confederat, L. G., & Lupașcu, D. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12100983 · Cited by 190 · see citing works
Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing
Kaur, G., Narayanan, G., Garg, D., Sachdev, A., & Matai, I. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00035 · Cited by 185 · see citing works
Multi-material electrospinning: from methods to biomedical applications
Xing, J., Zhang, M., Liu, X., Wang, C., Xu, N.-N., & Xing, D. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100710 · Cited by 158 · see citing works
Electrospun hybrid nanofibers: Fabrication, characterization, and biomedical applications
Abadi, B., Goshtasbi, N., Bolourian, S., Tahsili, J., Adeli‐Sardou, M., & Forootanfar, H. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.986975 · Cited by 153 · see citing works
Hussein, M. A. M., Güler, E., Rayaman, E., Çam, M. E., Şahin, A., Grinholc, M., Mansuroğlu, D. S., Şahin, Y. M., Gündüz, O., Muhammed, M. A., et al. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118373 · Cited by 145 · see citing works
Nanomaterials for application in wound Healing: current state-of-the-art and future perspectives
Shalaby, M. A., Anwar, M. M., & Saeed, H. M. S. (2022) · Journal of Polymer Research · doi:10.1007/s10965-021-02870-x · Cited by 129 · see citing works
Alginate/polyvinyl alcohol films for wound healing: Advantages and challenges
Saraiva, M. M., Campelo, M. D. S., Neto, J. F. C., Lima, A. B. N., Silva, G. D. A., Dias, A. T. D. F. F., Ricardo, N. M. P. S., Kaplan, D. L., & Ribeiro, M. E. N. P. (2022) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.35146 · Cited by 121 · see citing works
Shuai, C., Yuan, X. F., Yang, W., Peng, S., Qian, G., & Zhao, Z. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.117937 · Cited by 108 · see citing works
Cinnamon extract loaded electrospun chitosan/gelatin membrane with antibacterial activity
Ahmadi, S., Hivechi, A., Bahrami, S. H., Milan, P. B., & Ashraf, S. S. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.01.156 · Cited by 106 · see citing works
Self-citationPolysaccharide Electrospun Nanofibers for Wound Healing Applications
Tan, G., Wang, L., Pan, W., & Chen, K. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s371900 · Cited by 105 · see citing works
Polymeric wound dressings, an insight into polysaccharide-based electrospun membranes
Gruppuso, M., Turco, G., Marsich, E., & Porrelli, D. (2021) · Applied Materials Today · doi:10.1016/j.apmt.2021.101148 · Cited by 104 · see citing works
In vitro and in vivo evaluation of a nanofiber wound dressing loaded with melatonin
Mirmajidi, T., Chogan, F., Rezayan, A. H., & Sharifi, A. M. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120213 · Cited by 101 · see citing works
Cheng, F., Song, D., Li, H., Ravi, S. K., & Tan, S. C. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202406950 · Cited by 101 · see citing works
Kassem, I., Ablouh, E., Bouchtaoui, F.-Z. E., Kassab, Z., Khouloud, M., Sehaqui, H., Ghalfi, H., Alami, J., & Achaby, M. E. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.08.093 · Cited by 99 · see citing works
Electropsun Polycaprolactone Fibres in Bone Tissue Engineering: A Review
Siddiqui, N., Kishori, B., Rao, S., Anjum, M. R., Hemanth, V., Das, S., & Jabbari, E. (2021) · Molecular Biotechnology · doi:10.1007/s12033-021-00311-0 · Cited by 98 · see citing works
Yuan, J. T., Yi, C., Jiang, H., Liu, F., & Cheng, G. J. (2021) · ACS Applied Polymer Materials · doi:10.1021/acsapm.0c01002 · Cited by 97 · see citing works
N’Gatta, K. M., Belaid, H., Hayek, J. E., Assanvo, E. F., Kajdan, M., Masquelez, N., Boa, D., Cavaillès, V., Bechelany, M., & Salameh, C. (2022) · Scientific Reports · doi:10.1038/s41598-022-25652-x · Cited by 93 · see citing works
Recent advances in biopolymer synthesis, properties, & commercial applications: a review
Getahun, M. J., Kassie, B. B., & Alemu, T. S. (2024) · Process Biochemistry · doi:10.1016/j.procbio.2024.06.034 · Cited by 91 · see citing works
Aparicio-Collado, J. L., García-San-Martín, N., Molina‐Mateo, J., Cabanilles, C. T., Quiles, V. D., Serrano‐Aroca, Á., & Serra, R. S. I. (2022) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2022.112455 · Cited by 90 · see citing works
Alven, S., & Aderibigbe, B. A. (2021) · Polymers · doi:10.3390/polym13132104 · Cited by 85 · see citing works
Biomedical applications of electrospun polycaprolactone-based carbohydrate polymers: A review
Rahimkhoei, V., Padervand, M., Hedayat, M., Seidi, F., Dawi, E. A., & Akbari, A. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126642 · Cited by 79 · see citing works
Nejad, Z. M., Zamanian, A., Saeidifar, M., Vanaei, H. R., & Amoli, M. S. (2021) · Polymers · doi:10.3390/polym13244442 · Cited by 78 · see citing works
Guo, D., Li, Y., Zhou, Q., Yu, Z., Liu, X., Dong, S., Zhang, S., Sung, H., Yao, Z., Li, Y., et al. (2024) · Nano Energy · doi:10.1016/j.nanoen.2024.109750 · Cited by 78 · see citing works
Mohammadi, A., Jafarpour, E., Mirzaei, K., Shojaei, A., Jafarpour, P., Eyni, M. B., Mirzaei, S., & Molavi, H. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c15524 · Cited by 73 · see citing works
Rahmani, P., Shojaei, A., & Dickey, M. D. (2024) · Journal of Materials Chemistry A · doi:10.1039/d3ta07424b · Cited by 69 · see citing works
Electrospun nanofiber-based drug delivery platform: advances in diabetic foot ulcer management
Dhondale, M. R., Jha, A., Kumar, M., Ajmal, G., Bonde, G. V., & Mishra, B. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2021.1823966 · Cited by 61 · see citing works
Kim, S. E., & Tiwari, A. P. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116880 · Cited by 55 · see citing works
Deng, Z., Wu, M., Shen, C., Yang, X., Wang, D., Li, J., Wu, D., & Chen, K. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.140707 · Cited by 51 · see citing works
Xu, C., Li, B., Sundarrajan, S., Zhou, Y., Fan, Y., Lu, C., Chu, F., & Ramakrishna, S. (2025) · Materials Today · doi:10.1016/j.mattod.2025.04.006 · Cited by 47 · see citing works
Pan, J., Meng, Q., Zhang, L., Zhang, C., Wu, S., & Zhai, H. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.114648 · Cited by 43 · see citing works
Li, S., Biswas, M. C., & Ford, E. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.120001 · Cited by 41 · see citing works
Meng, Y., Long, Z., He, Z., Fu, X., & Dong, C. (2021) · Biomacromolecules · doi:10.1021/acs.biomac.1c00595 · Cited by 41 · see citing works
Nayl, A. A., Abd-Elhamid, A. I., Awwad, N. S., Abdelgawad, M. A., Wu, J., Mo, X., Gomha, S. M., Aly, A. A., & Bräse, S. (2022) · Polymers · doi:10.3390/polym14081508 · Cited by 39 · see citing works
Cellulose nanocrystal based electrospun nanofiber for biomedical applications–A review
Ahmed, S., Khan, R. A., & Rashid, T. U. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.122838 · Cited by 34 · see citing works
Lin, D., Li, Y., Huang, Y., Qin, W., Loy, D. A., Chen, H., Zhang, Q. R., & Wu, Z. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.120116 · Cited by 34 · see citing works
Mohamadi, P., Hivechi, A., Bahrami, S. H., hemmatinegad, N., & Milan, P. B. (2021) · Journal of Industrial Textiles · doi:10.1177/1528083721991595 · Cited by 33 · see citing works
Self-citationChandika, P., Khan, F., Heo, S.-Y., Kim, Y., Yi, M., & Jung, W. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.213046 · Cited by 33 · see citing works
Hivechi, A., Milan, P. B., Modabberi, K., Amoupour, M., Ebrahimzadeh, K., Gholipour, A. R., Sedighi, F., Amini, N., Bahrami, S. H., Rezapour, A., et al. (2021) · Polymers · doi:10.3390/polym13060854 · Cited by 31 · see citing works
Self-citationSantos, R. P. D. O., Hao, J., Frollini, E., Savastano, H., & Rutledge, G. C. (2022) · Journal of Membrane Science · doi:10.1016/j.memsci.2022.120392 · Cited by 31 · see citing works
State-of-the-Art Review of Advanced Electrospun Nanofiber Composites for Enhanced Wound Healing
Abdelhakeem, E., Monir, S., Teaima, M. H. M., Rashwan, K. O., & El-Nabarawi, M. A. (2023) · AAPS PharmSciTech · doi:10.1208/s12249-023-02702-9 · Cited by 30 · see citing works
Shirehjini, L. M., Sharifi, F., Shojaei, S., & Irani, S. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103488 · Cited by 30 · see citing works
Hurtado, A., Cano-Vicent, A., Tuñón‐Molina, A., Aparicio-Collado, J. L., Salesa, B., Serra, R. S. I., & Serrano‐Aroca, Á. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.08.039 · Cited by 28 · see citing works
Santos, R. P. D. O., Ramos, L. A., & Frollini, E. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.07.064 · Cited by 27 · see citing works
Asadnia, M., & Sadat‐Shojai, M. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.139409 · Cited by 26 · see citing works
Tri‐layered alginate/poly(𝜀‐caprolactone) electrospun scaffold for cardiac tissue engineering
Karimi, S. N. H., Aghdam, R. M., Ebrahimi, S. A. S., & Chehrehsaz, Y. (2022) · Polymer International · doi:10.1002/pi.6371 · Cited by 26 · see citing works
Baghersad, S., Hivechi, A., Bahrami, S. H., Milan, P. B., Siegel, R. A., & Amoupour, M. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103536 · Cited by 26 · see citing works
Self-citationRecent progress in the conversion of agricultural waste into functional materials
Nqoro, X., Taziwa, R., & Popoola, A. P. I. (2023) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-023-05044-5 · Cited by 25 · see citing works
Mohamadi, P., Hivechi, A., Bahrami, S. H., Nezari, S., Milan, P. B., & Amoupour, M. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.213139 · Cited by 25 · see citing works
Self-citationTowards Enhanced Electrospinning of Alginate—Can Recent Strategies Overcome Limitations? A Review
Wróbel, P., Zwolińska, J., Szopa, D., & Witek‐Krowiak, A. (2025) · Polymers · doi:10.3390/polym17162255 · Cited by 22 · see citing works
Sharahi, M., Hivechi, A., Bahrami, S. H., Hemmatinejad, N., & Milan, P. B. (2021) · Cellulose · doi:10.1007/s10570-021-03709-w · Cited by 21 · see citing works
Self-citationYi, N., Wang, M., Li, S., Feng, F., Li, J., Xie, R., Zhao, Z., & Chen, W. (2023) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2023.113240 · Cited by 21 · see citing works
Fakhrghasemi, F., Shavisi, N., Shahbazi, Y., Yousefi, H., & Ullah, A. (2025) · Food and Bioprocess Technology · doi:10.1007/s11947-025-03947-x · Cited by 20 · see citing works
Biocompatible composites based on alginate, polycaprolactone, and nanocellulose - A review
Ikhtiarini, N., Kamil, M. Z., Bukit, B. F., Juliadmi, D., Prasetiyo, K. W., Fransiska, D., Sedayu, B. B., Subiyanto, B., Sulastiningsih, I. M., Rochima, E., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.143423 · Cited by 18 · see citing works
Wang, Y., Zhang, W., Karamergenova, A., & Lin, L. (2025) · Materials Today Communications · doi:10.1016/j.mtcomm.2025.113821 · Cited by 15 · see citing works
Microorganism-derived biological macromolecules for tissue engineering
Amini, N., Milan, P. B., Sarmadi, V. H., Derakhshanmehr, B., Hivechi, A., Khodaei, F., Hamidi, M., Ashraf, S., Larijani, G., & Rezapour, A. (2022) · Frontiers of Medicine · doi:10.1007/s11684-021-0903-0 · Cited by 15 · see citing works
Self-citationAneem, T. H., Sarker, M., Wong, S. Y., Lim, S., Li, X., Rashed, A., Chakravarty, S., & Arafat, M. T. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb00889h · Cited by 15 · see citing works
Ravichandran, S., & Radhakrishnan, J. (2022) · Nanotechnology · doi:10.1088/1361-6528/ac667b · Cited by 14 · see citing works
Hydrophilic/Hydrophobic Janus Nanofibers Containing Compound K for Cartilage Regeneration
Shin, H., Park, J., Kim, Y.-J., Kim, D., Jin, E., & Ryu, J. H. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s435156 · Cited by 14 · see citing works
Lima, T. D. P. D. L., Canelas, C. A. D. A., Dutra, J. D. C. F., Rodrigues, A. P. D., Brígida, R. T. S. S., Concha, V. O. C., da Costa, F. A. M., & Passos, M. F. (2023) · Polymers · doi:10.3390/polym15224403 · Cited by 13 · see citing works
Xu, F.-L., Gao, Y., Xin, H., Cao, C., Ma, W., Sun, W., & Ma, Q. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.139133 · Cited by 13 · see citing works
Hivechi, A., Yousefmoumji, H., Bahrami, S. H., & Milan, P. B. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140033 · Cited by 13 · see citing works
Self-citationMathew, M., Rad, M. A., Mata, J. P., Mahmodi, H., Kabakova, I. V., Raston, C. L., Tang, Y., Tipper, J. L., & Tavakoli, J. (2021) · Materials Today Chemistry · doi:10.1016/j.mtchem.2021.100656 · Cited by 13 · see citing works
Control of drug release from cotton fabric by nanofibrous mat
Goudarzi, Z. M., Soleimani, M., Ghasemi‐Mobarakeh, L., Sajkiewicz, P., Sharifianjazi, F., Esmaeilkhanian, A., & Khaksar, S. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.06.138 · Cited by 13 · see citing works
Electrospun nanofibers of carbohydrate polymers for neoteric wound dressing: a review
Salunke, M. R., Viswalingam, V., & Shinde, V. M. (2024) · International Journal of Polymeric Materials · doi:10.1080/00914037.2024.2316172 · Cited by 13 · see citing works
Sriyanti, I., Dani, R., Almafie, M. R., Partan, R. U., Idjan, M. K. N. A., & Marlina, L. (2024) · Case Studies in Chemical and Environmental Engineering · doi:10.1016/j.cscee.2024.101030 · Cited by 12 · see citing works
Karakaş, C. Y., & Özçimen, D. B. (2020) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.1977 · Cited by 12 · see citing works
Ghaffari‐Bohlouli, P., Jafari, H., Khatibi, A., Bakhtiari, M., Tavana, B., Zahedi, P., & Shavandi, A. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.04.029 · Cited by 12 · see citing works
Moharreri, P., Molavi, A. M., Gholami, A. A., Rahmani, S., Mokhtari, T., Gheybi, F., Haghir, H., Oskuee, R. K., & Babaloo, H. (2025) · Scientific Reports · doi:10.1038/s41598-025-19799-6 · Cited by 11 · see citing works
BMSC‐NFMC Model for Vascular Regulation and Interface Integration in Osteochondral Regeneration
Zhou, Q., Hou, M., Bai, B., Zhang, Y., Shen, Y., Jia, Z., Guo, Y., Zhou, G., & Liang, X. (2025) · Advanced Science · doi:10.1002/advs.202505222 · Cited by 11 · see citing works
Shang, S., Yu, Z. H., Wei, L., Liu, J., & Zhu, P. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.146726 · Cited by 11 · see citing works
Sam, S., Aguado, R. J., Fiol, N., Bastida, G. A., Delgado‐Aguilar, M., & Tarrés, Q. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.145721 · Cited by 10 · see citing works
Pompa-Monroy, D. A., Iglesias, A. L., Dastager, S. G., Thorat, M. N., Olivas, A., Castro, R. V., Hurtado-Ayala, L. A., Cornejo‐Bravo, J. M., Pérez-González, G. L., & Villarreal-Gómez, L. J. (2022) · Membranes · doi:10.3390/membranes12030327 · Cited by 10 · see citing works
Ngwenya, M., Gumede, T. P., Pérez Camargo, R. A., & Motloung, B. (2025) · Materials · doi:10.3390/ma18225172 · Cited by 9 · see citing works
“On the other hand, solution/solvent casting, often using chloroform or dichloromethane as solvents, facilitates better initial dispersion but is limited by environmental and processing drawbacks [20,22,23,36,67,68].”
Ouiyangkul, P., Hirun, N., Suknuntha, K., & Tantishaiyakul, V. (2023) · Polymers for Advanced Technologies · doi:10.1002/pat.6206 · Cited by 9 · see citing works
Ma, X., Men, J., Gao, T., Liu, W., Wang, X., & Lou, T. (2022) · Starch - Stärke · doi:10.1002/star.202200068 · Cited by 9 · see citing works
Meng, Z., Wang, L., Shen, L., Li, Z., Zhao, Z., & Wang, X. (2021) · Journal of Applied Polymer Science · doi:10.1002/app.51421 · Cited by 9 · see citing works
Rezaei, M., Nemati, N. H., Mehrabani, D., & Komeili, A. (2022) · Journal of Applied Polymer Science · doi:10.1002/app.52271 · Cited by 8 · see citing works
Alginate-based wound dressings for skin healing and regeneration
Nqoro, X., Alven, S., Buyana, B., Feketshane, Z., & Aderibigbe, B. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90514-5.00004-3 · Cited by 8 · see citing works
Skin Regeneration by Hybrid Carboxyl Methyl Cellulose/Calcium Alginate Fibers Electrospun Scaffold
Rezaie, M., Nemati, N. H., Mehrabani, D., & Komeili, A. (2021) · Journal of Natural Fibers · doi:10.1080/15440478.2021.2002764 · Cited by 7 · see citing works
Porous 3D-Biocomposite Adsorbent for Iron Reclamation and Use in Agricultural Applications
Meng, S., Wang, H., Li, Y. C., Li, T., Liu, G., Zhang, S., & Tong, Z. (2022) · ACS Applied Polymer Materials · doi:10.1021/acsapm.2c01198 · Cited by 7 · see citing works
Feng, C., Zhou, J., Xu, X., Jiang, Y., Shi, H., & Zhao, G. (2022) · BioResources · doi:10.15376/biores.17.4.6341-6357 · Cited by 6 · see citing works
Sowmya, B., & Panda, P. K. (2022) · Progress in Biomaterials · doi:10.1007/s40204-022-00205-7 · Cited by 6 · see citing works
Ma, X., Yue, Q., Wang, Q., Liu, C., Fu, S., & Luan, J. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202402331 · Cited by 6 · see citing works
Méndez‐López, M., Ramos-Hernández, A., Moreno‐Serna, V., Bonardd, S., Ramírez, O., Silva, H., Inostroza-Rivera, R., Díaz, D. D., Leiva, Á., & Saldías, C. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.10.018 · Cited by 6 · see citing works
Bo, W., Zhi-Peng, L., Yue, L., Qian-Ru, Y., Zhen-Rui, L., Wang, W., Xiao-Jie, C., & Fei-Xian, L. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.142890 · Cited by 5 · see citing works
Electrospun Biomaterials for Scarless Acne Wound Healing: Advances and Prospects
Chen, J., Zhou, L., Hang, Z., Bian, X., Huo, T., Peng, B., Li, H., Wen, Y., & Du, H. (2025) · Journal of Functional Biomaterials · doi:10.3390/jfb16090316 · Cited by 5 · see citing works
Patel, R., Annamalai, P. K., Raghava, R. B. T. S., & Patel, M. (2025) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2025.106552 · Cited by 5 · see citing works
Clerici, N. J., Daroit, D. J., Vencato, A. A., & Brandelli, A. (2024) · Fermentation · doi:10.3390/fermentation10120615 · Cited by 5 · see citing works
Eyni, M. B., Shojaei, A., & Khasraghi, S. S. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140232 · Cited by 5 · see citing works
Mathew, J. T., Tomlal Jose, E., Philip, P., Gayathri Mohan, M., & Cherian, S. K. (2022) · Polymer Science Series A · doi:10.1134/s0965545x23700633 · Cited by 3 · see citing works
Nanotechnology-enabled approaches for combating diabetic foot ulcer
Chary, P. S., Anuradha, U., Shaikh, S., Yadav, R., Bhavana, V., Rajana, N., & Mehra, N. K. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106593 · Cited by 3 · see citing works
Moradi, F., Gholipour‐Kanani, A., Najmoddin, N., Eslahi, N., Bahrami, S. H., & Rabbani, S. (2021) · Fibers and Polymers · doi:10.1007/s12221-021-0652-3 · Cited by 3 · see citing works
Self-citationProduction and Application of Biodegradable Nanofibers Using Electrospinning Techniques
Błachowicz, T., & Ehrmann, A. (2021) · Springer series on polymer and composite materials · doi:10.1007/978-3-030-79979-3_1 · Cited by 3 · see citing works
Antimicrobial textiles for skin and wound infection management
Abid, S., Hussain, T., & Nazir, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821485-5.00008-1 · Cited by 3 · see citing works
Ghoreyshi, S. M., Ghaee, A., Mirzaei, E., & Hosseinidoust, S. (2025) · Bioprinting · doi:10.1016/j.bprint.2025.e00462 · Cited by 2 · see citing works
Fawal, G. F. E., Sobhy, S. E., Hafez, H., Hafez, E. S. E., Nádaždy, P., Kleinová, A., Šišková, A. O., & Andicsová, A. E. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.147746 · Cited by 2 · see citing works
Controlled shape memory effects of magnetic polymer nanocomposites by induction heating
Frost, B. A., Carlton, H., Martinez, R., Lovett, E., Huitink, D. R., & Foster, E. J. (2021) · Green Materials · doi:10.1680/jgrma.20.00079 · Cited by 2 · see citing works
- Authors
- Rashtchian, M., Hivechi, A., Bahrami, S. H., Milan, P. B., & Simorgh, S.
- Affiliations
- Amirkabir University of Technology (IR)
- Iran University of Medical Sciences (IR)
- Corresponding author
- Hivechi, Ahmad
- Bahrami, S. Hajir
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 233
- Pages
- 115873
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W2998955581
- Cited by
- 112
- References
- 74
- Citations by year
- 2026: 6 · 2025: 20 · 2024: 18 · 2023: 8 · 2022: 30 · 2021: 25 · 2020: 5
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Materials Science › Biomaterials › Advanced Cellulose Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- cellulose nanocrystals, alginate, polycaprolactone, polyvinyl alcohol, nanofibers, electrospinning, mechanical properties, hydrophilicity, cell viability, cell attachment, cotton waste, hydrolysis, scaffolds
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