Cited by 18Advanced Cellulose Research Studiesbiodegradable polymer synthesis and propertiesHydrogels: synthesis, properties, applications

Biocompatible composites based on alginate, polycaprolactone, and nanocellulose - A review

Ikhtiarini, Nur, Kamil, Muhammad Zhorifansyah, Bukit, Bunga Fisikanta, Juliadmi, Dian, Prasetiyo, Kurnia Wiji, Fransiska, Dina, Sedayu, Bakti Berlyanto, Subiyanto, Bambang +4 more·2025·International Journal of Biological Macromolecules

Abstract

Biocompatible composite materials are gaining attention for biomedical applications due to their biodegradability, mechanical strength, and tunability. The fabrication techniques and applications significantly impact composite performance. This paper explores the synthesis of composites from alginate, polycaprolactone (PCL), and nanocellulose, emphasizing their distinct properties for biomedical use. Alginate provides excellent biocompatibility and gelling ability, PCL offers controlled mechanical strength, and nanocellulose enhances stability due to its superior mechanical properties. Key fabrication techniques include solution mixing, hot pressing, melt mixing/extrusion, electrospinning, and 3D printing, each influencing structural integrity, mechanical properties, and material dispersion. Optimizing fabrication methods is crucial for achieve desirable properties in specific applications. The choice of synthesis technique directly affects the final use, such as drug delivery systems, tissue engineering scaffolds, or wound dressings. This review discusses the challenges and prospects of developing alginate-, PCL-, and nanocellulose-based composites, offering insights into their future biomedical applications.

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Crossref · 10.1016/j.ijbiomac.2025.143423

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Authors
Ikhtiarini, N., Kamil, M. Z., Bukit, B. F., Juliadmi, D., Prasetiyo, K. W., Fransiska, D., Sedayu, B. B., Subiyanto, B., Sulastiningsih, I. M., Rochima, E., Arivendan, A., & Syamani, F. A.
Affiliations
  • National Research and Innovation Agency (ID)
  • University of Indonesia (ID)
  • Universitas Quality (ID)
  • Padjadjaran University (ID)
  • South China University of Technology (CN)
Corresponding author
Syamani, Firda Aulya
Venue
International Journal of Biological Macromolecules
Publisher
Elsevier BV
Published
2025-06
Volume
311
Issue
Pt 1
Pages
143423
ISSN
0141-8130 (ISSN-L)
OpenAlex
W4409661800
Cited by
18
References
131
Citations by year
2026: 15 · 2025: 3
FWCI
1.06
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Biological Macromolecules (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Research and Innovation Agency Republic of Indonesia (20/III.10/HK/2024)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Advanced Cellulose Research Studies
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
alginate, polycaprolactone, nanocellulose, biocompatible composites, biodegradable polymers, composite fabrication techniques, electrospinning, 3D printing, melt blending, hot pressing, tissue engineering scaffolds, drug delivery systems, wound dressings, mechanical properties
MeSH terms
Alginates, Biocompatible Materials, Cellulose, Humans, Polyesters, Tissue Engineering, Nanocomposites, Tissue Scaffolds

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