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Chitosan-glucuronic acid conjugate coated mesoporous silica nanoparticles: A smart pH-responsive and receptor-targeted system for colorectal cancer therapy
Abstract
Glycosylated pH-sensitive mesoporous silica nanoparticles (MSNs) of capecitabine (CAP) were developed for targeting colorectal cancer. The MSNs possessed an average pore diameter of 8.12 ± 0.43 nm, pore volume of 0.73 ± 0.21 cm 3/g, and particle size of 245.24 ± 5.75 nm. A high loading of 180.51 ± 5.23 mg/g attributed to the larger pore volume was observed. The surface of the drug-loaded MSNs were capped with chitosan-glucuronic acid (CHS-GCA) conjugate to combine two strategies viz. pH-sensitive, and lectin receptor mediated uptake. In vitro studies demonstrated a pH-sensitive and controlled release of CAP which was further enhanced in the presence of rat caecal content. Higher uptake of the (CAP-MSN)CHS-GCA was observed in HCT 116 cell lines. The glycosylated nanoparticles revealed reduction in the tumors, aberrant crypt foci, dysplasia and inflammation, and alleviation in the toxic features. This illustrated that the nanoparticles showed promising antitumor efficacy with reduced toxicity and may be used as a effective carrier against cancer.
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Metadata
- Authors
- Narayan, R., Gadag, S., Cheruku, S. P., Raichur, A. M., Day, C. M., Garg, S., Manandhar, S., Pai, K. S. R., Suresh, A., Mehta, C. H., Nayak, Y., Kumar, N., & Nayak, U. Y.
- Affiliations
- Manipal Academy of Higher Education (IN)
- Indian Institute of Science Bangalore (IN)
- University of South Australia (AU)
- Corresponding author
- Nayak, Usha Yogendra
- ORCID
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 261
- Pages
- 117893
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W3135707793
- Cited by
- 103
- References
- 71
- Citations by year
- 2026: 15 · 2025: 23 · 2024: 21 · 2023: 17 · 2022: 19 · 2021: 8
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- UniSA Research Outputs Repository (University of South Australia) (acceptedVersion)
- NOT FOUND REPOSITORY (Indian Institute of Science Bangalore) (acceptedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Materials Chemistry › Mesoporous Materials and Catalysis
- Keywords
- mesoporous silica nanoparticles, capecitabine, colorectal cancer, pH-responsive drug delivery, receptor-targeted drug delivery, controlled drug release, HCT116 cells, tumor growth inhibition, aberrant crypt foci, dysplasia, inflammation
- MeSH terms
- Capecitabine, Animals, Cell Survival, Delayed-Action Preparations, Drug Carriers, Female, Humans, Hydrogen-Ion Concentration, Particle Size, Silicon Dioxide, Colorectal Neoplasms, Porosity, Drug Delivery Systems, Rats, Wistar, Coated Materials, Biocompatible, Glucuronic Acid, Xenograft Model Antitumor Assays, HCT116 Cells, Cell Line, Tumor, Chitosan, Rats, Nanoparticles, Drug Liberation
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