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Locust bean gum and sodium alginate based interpenetrating polymeric network microbeads encapsulating Capecitabine: Improved pharmacokinetics, cytotoxicity &in vivo antitumor activity

Upadhyay, Mansi, Adena, Sandeep Kumar Reddy, Vardhan, Harsh, Yadav, Sarita K., Mishra, Brahmeshwar·2019·Materials Science and Engineering: C
DOI 10.1016/j.msec.2019.109958
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Abstract

A combination of biopolymers sodium alginate and locust bean gum has been used to prepare an interpenetrating polymeric network of an anticancer drug Capecitabine by ionotropic gelation method. For the optimization 3 2 levels, a full factorial design was employed to examine the influence of independent factors, i.e. polymer ratio and cross-linker concentration on responses particle size and drug entrapment. The obtained optimized formulation was examined for solid-state characterization, swelling study, in vitro drug release, SRB study, oral toxicity study, in vivo pharmacokinetic and in vivo antitumor study. The results of all the studies performed were found suitable in extending the release of a short elimination half-life drug with improved bioavailability and suggesting it to be safe and effective for oral drug delivery in treating colon cancer.

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Metadata

Authors
Upadhyay, M., Adena, S. K. R., Vardhan, H., Yadav, S. K., & Mishra, B.
Venue
Materials Science and Engineering: C
Publisher
Elsevier BV
Published
2019-11
Volume
104
Pages
109958
ISSN
0928-4931
DOI
10.1016/j.msec.2019.109958
Cited by
50
References
1
Language
en
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