The DOI matches its Crossref record; 256 of the 256 references it cites were found in a registry or an index.
Hyaluronic acid in ocular drug delivery
Abstract
As a naturally-occurring polysaccharide which could be found in various ophthalmic tissues, hyaluronic acid (HA) has a wide range of applications in the eye, including treatment of dry eye, vitreous substitutes and ophthalmic viscosurgical devices. Besides that, HA can be used as an effective drug carrier for ocular disease treatment due to its excellent biocompatibility, biodegradability, bioadhesion properties, viscoelasticity and receptor interaction characteristic. This review summarizes recent advances in HA-based drug delivery systems for ocular disease treatment in which it could be used as drug-polymer conjugate, drug carrier substrates, and surface modifications of the carrier. To achieve the optimum drug delivery efficacy under varied ophthalmic diseases, the molecular weight (MW) and amount of HA should be selected rationally and applied to design diverse delivery systems.
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“Additionally, HA has been shown to raise corneal adhesion and drug utilization due to its mucosal adhesion potential [95].”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [95]
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Metadata
- Authors
- Zhang, X., Wei, D., Xu, Y., & Zhu, Q.
- Affiliations
- Nantong University (CN)
- Corresponding author
- Zhu, Qiang
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 264
- Pages
- 118006
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W3151813161
- Cited by
- 196
- References
- 256
- Citations by year
- 2026: 26 · 2025: 41 · 2024: 50 · 2023: 49 · 2022: 22 · 2021: 8
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Jiangsu Province (BK20190922)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Ophthalmology › Ocular Surface and Contact Lens
- Keywords
- hyaluronic acid, ocular drug delivery, drug carriers, polymer-drug conjugates, ophthalmic viscosurgical devices, vitreous substitutes, dry eye, bioadhesion, molecular weight, surface modification, biodegradable polymers, receptor targeting
- MeSH terms
- Animals, Drug Carriers, Eye Diseases, Humans, Hyaluronic Acid, Micelles, Polymers, Dry Eye Syndromes, Drug Delivery Systems, Immunoconjugates, Hydrogels, Nanoparticles, Administration, Ophthalmic
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