Cited by 196Advanced Drug Delivery SystemsHydrogels: synthesis, properties, applicationsOcular Surface and Contact Lens

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Hyaluronic acid in ocular drug delivery

Zhang, Xiaodan, Wei, Danyi, Xu, Yang, Zhu, Qiang·2021·Carbohydrate Polymers

DOI 10.1016/j.carbpol.2021.118006

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Abstract

As a naturally-occurring polysaccharide which could be found in various ophthalmic tissues, hyaluronic acid (HA) has a wide range of applications in the eye, including treatment of dry eye, vitreous substitutes and ophthalmic viscosurgical devices. Besides that, HA can be used as an effective drug carrier for ocular disease treatment due to its excellent biocompatibility, biodegradability, bioadhesion properties, viscoelasticity and receptor interaction characteristic. This review summarizes recent advances in HA-based drug delivery systems for ocular disease treatment in which it could be used as drug-polymer conjugate, drug carrier substrates, and surface modifications of the carrier. To achieve the optimum drug delivery efficacy under varied ophthalmic diseases, the molecular weight (MW) and amount of HA should be selected rationally and applied to design diverse delivery systems.

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Understanding biophysicochemical interactions at the nano–bio interface
Nel, A. E., Mädler, L., Velegol, D., Xia, T., Hoek, E. M. V., Somasundaran, P., Klaessig, F., Castranova, V., & Thompson, M. (2009) · Nature Materials · doi:10.1038/nmat2442 · Cited by 7,083
CD44 is the principal cell surface receptor for hyaluronate
Aruffo, A. A., Stamenkovic, I., Melnick, M., Underhill, C. B., & Seed, B. (1990) · Cell · doi:10.1016/0092-8674(90)90694-a · Cited by 2,439
Hyaluronic Acid Hydrogels for Biomedical Applications
Burdick, J. A., & Prestwich, G. D. (2011) · Advanced Materials · doi:10.1002/adma.201003963 · Cited by 2,150
Ocular drug delivery
Gaudana, R., Ananthula, H. K., Parenky, A., & Mitra, A. K. (2010) · The AAPS Journal · doi:10.1208/s12248-010-9183-3 · Cited by 1,406
Cellular Uptake, Intracellular Trafficking, and Cytotoxicity of Nanomaterials
Zhao, F., Zhao, Y., Liu, Y., Chang, X., Chen, C., & Zhao, Y. (2011) · Small · doi:10.1002/smll.201100001 · Cited by 1,206
Binding of blood proteins to carbon nanotubes reduces cytotoxicity
Ge, C., Du, J., Zhao, L., Wang, L., Liu, Y., Li, D., Yang, Y., Zhou, R., Zhao, Y., Chai, Z., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105270108 · Cited by 938
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LUDWIG, A. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.07.005 · Cited by 925
Hyaluronic Acid in the Third Millennium
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Graça, M. F. P., Miguel, S. P., Cabral, ‪. S. D., & Correia, I. J. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116364 · Cited by 843
Physicochemical Properties Determine Nanomaterial Cellular Uptake, Transport, and Fate
Zhu, M., Nie, G., Meng, H., Xia, T., Nel, A. E., & Zhao, Y. (2012) · Accounts of Chemical Research · doi:10.1021/ar300031y · Cited by 822

Show all 256 references

Research works printed but not linked: 1

Rainer, 1996, Zusammenhange zwischen molekularen Parametern der Hyaluronsaure und der Viskoelastizitat der Synovia, Acta Medica Austriaca, 23, 133

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Pullulan as a sustained release carrier for ocular drug delivery: a review
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Authors: Zhang, X., Wei, D., Xu, Y., & Zhu, Q.
Affiliations: Nantong University (CN)
Corresponding author: Zhu, Qiang
ORCID: Zhang, Xiaodan
Xu, Yang
Zhu, Qiang
Venue: Carbohydrate Polymers
Publisher: Elsevier BV
Published: 2021-07
Volume: 264
Pages: 118006
ISSN: 0144-8617 (ISSN-L)
DOI: 10.1016/j.carbpol.2021.118006
OpenAlex: W3151813161
Cited by: 196
References: 256
Citations by year: 2026: 26 · 2025: 41 · 2024: 50 · 2023: 49 · 2022: 22 · 2021: 8
FWCI: 2.88
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Carbohydrate Polymers (publishedVersion)
PubMed (publishedVersion)
Funders: Natural Science Foundation of Jiangsu Province (BK20190922)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Health Sciences › Medicine › Ophthalmology › Ocular Surface and Contact Lens
Keywords: hyaluronic acid, ocular drug delivery, drug carriers, polymer-drug conjugates, ophthalmic viscosurgical devices, vitreous substitutes, dry eye, bioadhesion, molecular weight, surface modification, biodegradable polymers, receptor targeting
MeSH terms: Animals, Drug Carriers, Eye Diseases, Humans, Hyaluronic Acid, Micelles, Polymers, Dry Eye Syndromes, Drug Delivery Systems, Immunoconjugates, Hydrogels, Nanoparticles, Administration, Ophthalmic

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Hyaluronic acid in ocular drug delivery

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