The DOI matches its Crossref record; 256 of the 256 references it cites were found in a registry or an index.
Hyaluronic acid in ocular drug delivery
Abstract
As a naturally-occurring polysaccharide which could be found in various ophthalmic tissues, hyaluronic acid (HA) has a wide range of applications in the eye, including treatment of dry eye, vitreous substitutes and ophthalmic viscosurgical devices. Besides that, HA can be used as an effective drug carrier for ocular disease treatment due to its excellent biocompatibility, biodegradability, bioadhesion properties, viscoelasticity and receptor interaction characteristic. This review summarizes recent advances in HA-based drug delivery systems for ocular disease treatment in which it could be used as drug-polymer conjugate, drug carrier substrates, and surface modifications of the carrier. To achieve the optimum drug delivery efficacy under varied ophthalmic diseases, the molecular weight (MW) and amount of HA should be selected rationally and applied to design diverse delivery systems.
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“Additionally, HA has been shown to raise corneal adhesion and drug utilization due to its mucosal adhesion potential [95].”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [95]
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Cites
Understanding biophysicochemical interactions at the nano–bio interface
Nel, A. E., Mädler, L., Velegol, D., Xia, T., Hoek, E. M. V., Somasundaran, P., Klaessig, F., Castranova, V., & Thompson, M. (2009) · Nature Materials · doi:10.1038/nmat2442 · Cited by 7,083
CD44 is the principal cell surface receptor for hyaluronate
Aruffo, A. A., Stamenkovic, I., Melnick, M., Underhill, C. B., & Seed, B. (1990) · Cell · doi:10.1016/0092-8674(90)90694-a · Cited by 2,439
Hyaluronic Acid Hydrogels for Biomedical Applications
Burdick, J. A., & Prestwich, G. D. (2011) · Advanced Materials · doi:10.1002/adma.201003963 · Cited by 2,150
Gaudana, R., Ananthula, H. K., Parenky, A., & Mitra, A. K. (2010) · The AAPS Journal · doi:10.1208/s12248-010-9183-3 · Cited by 1,406
Cellular Uptake, Intracellular Trafficking, and Cytotoxicity of Nanomaterials
Zhao, F., Zhao, Y., Liu, Y., Chang, X., Chen, C., & Zhao, Y. (2011) · Small · doi:10.1002/smll.201100001 · Cited by 1,206
Binding of blood proteins to carbon nanotubes reduces cytotoxicity
Ge, C., Du, J., Zhao, L., Wang, L., Liu, Y., Li, D., Yang, Y., Zhou, R., Zhao, Y., Chai, Z., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105270108 · Cited by 938
The use of mucoadhesive polymers in ocular drug delivery
LUDWIG, A. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.07.005 · Cited by 925
Hyaluronic Acid in the Third Millennium
Fallacara, A., Baldini, E., Manfredini, S., & Vertuani, S. (2018) · Polymers · doi:10.3390/polym10070701 · Cited by 918
Hyaluronic acid—Based wound dressings: A review
Graça, M. F. P., Miguel, S. P., Cabral, . S. D., & Correia, I. J. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116364 · Cited by 843
Physicochemical Properties Determine Nanomaterial Cellular Uptake, Transport, and Fate
Zhu, M., Nie, G., Meng, H., Xia, T., Nel, A. E., & Zhao, Y. (2012) · Accounts of Chemical Research · doi:10.1021/ar300031y · Cited by 822
Research works printed but not linked: 1
- Rainer, 1996, Zusammenhange zwischen molekularen Parametern der Hyaluronsaure und der Viskoelastizitat der Synovia, Acta Medica Austriaca, 23, 133
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Natural Products from Herbal Medicine Self‐Assemble into Advanced Bioactive Materials
Guo, X., Luo, W., Wu, L., Zhang, L., Chen, Y., Li, T., Li, H., Zhang, W., Liu, Y., Zheng, J., et al. (2024) · Advanced Science · doi:10.1002/advs.202403388 · Cited by 250
Stimulus‐Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy
Yu, H., Gao, R.-Y., Liu, Y. L., Fu, L., Zhou, J., & Li, L. (2023) · Advanced Science · doi:10.1002/advs.202306152 · Cited by 212
Tailoring Hyaluronic Acid Hydrogels for Biomedical Applications
Luo, Z., Wang, Y., Li, J., Wang, J., Yu, Y., & Zhao, Y. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202306554 · Cited by 187
Bokatyi, A. N., Dubashynskaya, N. V., & Skorik, Y. А. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.122145 · Cited by 166
Considerations for Polymers Used in Ocular Drug Delivery
Allyn, M. M., Luo, R. H., Hellwarth, E. B., & Swindle‐Reilly, K. E. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.787644 · Cited by 167
Metadata
- Authors
- Zhang, X., Wei, D., Xu, Y., & Zhu, Q.
- Affiliations
- Nantong University (CN)
- Corresponding author
- Zhu, Qiang
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 264
- Pages
- 118006
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W3151813161
- Cited by
- 196
- References
- 256
- Citations by year
- 2026: 26 · 2025: 41 · 2024: 50 · 2023: 49 · 2022: 22 · 2021: 8
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Jiangsu Province (BK20190922)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Ophthalmology › Ocular Surface and Contact Lens
- Keywords
- hyaluronic acid, ocular drug delivery, drug carriers, polymer-drug conjugates, ophthalmic viscosurgical devices, vitreous substitutes, dry eye, bioadhesion, molecular weight, surface modification, biodegradable polymers, receptor targeting
- MeSH terms
- Animals, Drug Carriers, Eye Diseases, Humans, Hyaluronic Acid, Micelles, Polymers, Dry Eye Syndromes, Drug Delivery Systems, Immunoconjugates, Hydrogels, Nanoparticles, Administration, Ophthalmic
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