Cited by 196Advanced Drug Delivery SystemsHydrogels: synthesis, properties, applicationsOcular Surface and Contact Lens

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Hyaluronic acid in ocular drug delivery

Zhang, Xiaodan, Wei, Danyi, Xu, Yang, Zhu, Qiang·2021·Carbohydrate Polymers

DOI 10.1016/j.carbpol.2021.118006

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Abstract

As a naturally-occurring polysaccharide which could be found in various ophthalmic tissues, hyaluronic acid (HA) has a wide range of applications in the eye, including treatment of dry eye, vitreous substitutes and ophthalmic viscosurgical devices. Besides that, HA can be used as an effective drug carrier for ocular disease treatment due to its excellent biocompatibility, biodegradability, bioadhesion properties, viscoelasticity and receptor interaction characteristic. This review summarizes recent advances in HA-based drug delivery systems for ocular disease treatment in which it could be used as drug-polymer conjugate, drug carrier substrates, and surface modifications of the carrier. To achieve the optimum drug delivery efficacy under varied ophthalmic diseases, the molecular weight (MW) and amount of HA should be selected rationally and applied to design diverse delivery systems.

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See all 196

Authors: Zhang, X., Wei, D., Xu, Y., & Zhu, Q.
Affiliations: Nantong University (CN)
Corresponding author: Zhu, Qiang
ORCID: Zhang, Xiaodan
Xu, Yang
Zhu, Qiang
Venue: Carbohydrate Polymers
Publisher: Elsevier BV
Published: 2021-07
Volume: 264
Pages: 118006
ISSN: 0144-8617 (ISSN-L)
DOI: 10.1016/j.carbpol.2021.118006
OpenAlex: W3151813161
Cited by: 196
References: 256
Citations by year: 2026: 26 · 2025: 41 · 2024: 50 · 2023: 49 · 2022: 22 · 2021: 8
FWCI: 2.88
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Carbohydrate Polymers (publishedVersion)
PubMed (publishedVersion)
Funders: Natural Science Foundation of Jiangsu Province (BK20190922)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Health Sciences › Medicine › Ophthalmology › Ocular Surface and Contact Lens
Keywords: hyaluronic acid, ocular drug delivery, drug carriers, polymer-drug conjugates, ophthalmic viscosurgical devices, vitreous substitutes, dry eye, bioadhesion, molecular weight, surface modification, biodegradable polymers, receptor targeting
MeSH terms: Animals, Drug Carriers, Eye Diseases, Humans, Hyaluronic Acid, Micelles, Polymers, Dry Eye Syndromes, Drug Delivery Systems, Immunoconjugates, Hydrogels, Nanoparticles, Administration, Ophthalmic

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Hyaluronic acid in ocular drug delivery

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