RETRACTED: Chitosan-poly(lactide-co-glycolide)/poloxamer mixed micelles as a mucoadhesive thermo-responsive moxifloxacin eye drop to improve treatment efficacy in bacterial keratitis
Abstract
A mucoadhesive self-assembling polymeric system was developed to carry moxifloxacin (M) for treating bacterial keratitis (BK). Chitosan-PLGA (C) conjugate was synthesized, and poloxamers (F68/127) were mixed in different proportions (1: 5/10) to prepare moxifloxacin (M)-encapsulated mixed micelles (M@CF68/127(5/10)Ms), including M@CF68(5)Ms, M@CF68(10)Ms, M@CF127(5)Ms, and M@CF127(10)Ms. The corneal penetration and mucoadhesiveness were determined biochemically, in vitro using human corneal epithelial (HCE) cells in monolayers and spheroids, ex vivo using goat cornea, and in vivo via live-animal imaging. The antibacterial efficacy was studied on planktonic biofilms of P. aeruginosa and S. aureus (in vitro) and Bk-induced mice (in vivo). Both M@CF68(10)Ms and M@CF127(10)Ms demonstrated high cellular uptake, corneal retention, muco-adhesiveness, and antibacterial effect, with M@CF127(10)Ms exhibiting superior therapeutic effects in P. aeruginosa and S. aureus-infected BK mouse model by reducing the corneal bacterial load and preventing corneal damage. Therefore, the newly developed nanomedicine is promising for clinical translation in treating BK.
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M@CF68(10)Ms and M@CF127(10)Ms exhibited high cellular uptake rates, higher muco-adhesiveness and significant antibacterial effects.
“Both of them exhibited high cellular uptake rates, higher muco-adhesiveness and significant antibacterial effects.”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [135]
M@CF127(10)Ms harvested superior therapeutic outcomes in P. aeruginosa and S. aureus-infected BK mouse model by reducing corneal bacterial load while preventing corneal damage.
“Notably, M@CF127(10)Ms harvested superior therapeutic outcomes in P. aeruginosa and S. aureus-infected BK mouse model by effectively reducing corneal bacterial load while preventing corneal damage [135]”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [135]
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- Authors
- Ch, S., Padaga, S. G., Ghosh, B., Roy, S., & Biswas, S.
- Affiliations
- Birla Institute of Technology and Science - Hyderabad Campus (IN)
- L V Prasad Eye Institute (IN)
- Corresponding author
- Biswas, Swati
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2023-07
- Volume
- 312
- Pages
- 120822
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W4328053134
- Cited by
- 40
- References
- 64
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 11 · 2023: 6
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- Open access
- closed
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Indian Council of Medical Research
- Science and Engineering Research Board
- Department of Science and Technology (EMR/2016/001514)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- bacterial keratitis, moxifloxacin, poloxamer, mixed micelles, mucoadhesion, thermosensitive drug delivery, corneal drug delivery, corneal penetration, Pseudomonas aeruginosa, Staphylococcus aureus, eye drops, retracted article
- MeSH terms
- Moxifloxacin, Animals, Anti-Bacterial Agents, Humans, Keratitis, Micelles, Ophthalmic Solutions, Polyglactin 910, Staphylococcus aureus, Treatment Outcome, Poloxamer, Chitosan, Mice
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