Cited by 462Cardiac Ischemia and ReperfusionNitric Oxide and Endothelin EffectsNeuroprotection in Cerebral Ischemia

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Nitric oxide in myocardial ischemia/reperfusion injury

Schulz, R·2004·Cardiovascular Research

DOI 10.1016/j.cardiores.2003.09.019

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Abstract

Administration of nitric oxide (NO), NO donors or drugs that enhance NO release (statins, calcium antagonists, ACE-inhibitors, dexamethasone) prior to ischemia protects the myocardium against ischemia/reperfusion injury. While this exogenous administration of NO prior to ischemia can initiate a preconditioning-like phenomenon, endogenous NO-synthase (NOS)-derived NO is not involved in triggering or mediating the early phase of ischemic preconditioning's protection, but does play a pivotal role for initiating and mediating the delayed phase of ischemic preconditioning's protection. The present review now summarizes the importance of endogenous and exogenous NO when given at the time of reperfusion for vascular and myocardial function and morphological outcome following ischemia/reperfusion. Given the inconsistency of the published data, potential confounding factors that might affect experimental results on the role of NO in myocardial ischemia/reperfusion were identified, such as (1) the lack of characterization of the involved NOS isoforms in myocardial ischemia/reperfusion injury in different animal species, (2) the lack of direct measurements of myocardial NO concentration and/or NOS activity to assure sufficient NOS inhibition, (3) the lack of consideration of nonenzymatic NO production as a potential source of NO, and (4) the absence of plasma or blood components in in vitro studies influencing NO delivery and metabolism. Future research on the importance of NO in ischemia/reperfusion injury will have to focus more precisely on the identification and standardization of potential confounding experimental factors that influence synthesis, transport, and interaction of NO with various targets in blood and tissue.

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Hypertension in mice lacking the gene for endothelial nitric oxide synthase
Huang, P. L., Huang, Z., Mashimo, H., Bloch, K. D., Moskowitz, M. A., Bevan, J. A., & Fishman, M. C. (1995) · Nature · doi:10.1038/377239a0 · Cited by 2,070
Comparative pharmacology of endothelium‐derived relaxing factor, nitric oxide and prostacyclin in platelets
Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1987) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1987.tb11310.x · Cited by 811
Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms
Barouch, L. A., Harrison, R. W., Skaf, M. W., Rosas, G. O., Cappola, T. P., Kobeissi, Z. A., Hobai, I. A., Lemmon, C. A., Burnett, A. L. “., O'Rourke, B. P., et al. (2002) · Nature · doi:10.1038/416337a · Cited by 760
The Late Phase of Preconditioning
Bolli, R. (2000) · Circulation Research · doi:10.1161/01.res.87.11.972 · Cited by 751
Effects of Angiotensin II Infusion on the Expression and Function of NAD(P)H Oxidase and Components of Nitric Oxide/cGMP Signaling
Mollnau, H., Wendt, M., Szöcs, K., Lassègue, B., Schulz, E., Oelze, M., Li, H., Bodenschatz, M., August, M., Kleschyov, A. L., et al. (2002) · Circulation Research · doi:10.1161/01.res.0000012569.55432.02 · Cited by 676
Nitric oxide metabolism and breakdown
Kelm, M. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00020-1 · Cited by 673
Cardioprotective Function of Inducible Nitric Oxide Synthase and Role of Nitric Oxide in Myocardial Ischemia and Preconditioning: an Overview of a Decade of Research
Bolli, R. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1462 · Cited by 601
Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase
Hafezi‐Moghadam, A., Simoncini, T., Yang, Z., Limbourg, F. P., Plumier, J.-C., Rebsamen, M. C., Hsieh, C.-M., Chui, D.-S., Thomas, K. L., Prorock, A. J., et al. (2002) · Nature Medicine · doi:10.1038/nm0502-473 · Cited by 596
Measurement of Nitric Oxide and Peroxynitrite Generation in the Postischemic Heart
Wang, P., & Zweier, J. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.46.29223 · Cited by 542
Synthesis of nitric oxide from l -arginine by neutrophils. Release and interaction with superoxide anion
McCall, T., Boughton-Smith, N. K., Palmer, R. M. J., Whittle, B. J. R., & Moncada, S. (1989) · Biochemical Journal · doi:10.1042/bj2610293 · Cited by 518
Resident Cardiac Mast Cells Degranulate and Release Preformed TNF-α, Initiating the Cytokine Cascade in Experimental Canine Myocardial Ischemia/Reperfusion
Frangogiannis, N. G., Lindsey, M. L., Michael, L. H., Youker, K. A., Bressler, R. B., Mendoza, L. H., Spengler, R. N., Smith, C. W., & Entman, M. L. (1998) · Circulation · doi:10.1161/01.cir.98.7.699 · Cited by 512
Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans.
Stamler, J. S., Loh, E., Roddy, M.-A., Currie, K., & Creager, M. A. (1994) · Circulation · doi:10.1161/01.cir.89.5.2035 · Cited by 512
Regulation of Nitric Oxide-Sensitive Guanylyl Cyclase
Friebe, A., & Koesling, D. (2003) · Circulation Research · doi:10.1161/01.res.0000082524.34487.31 · Cited by 508
Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium.
L, X., Weyrich, A. S., Lefer, D. J., & Lefer, A. M. (1993) · Circulation Research · doi:10.1161/01.res.72.2.403 · Cited by 491
Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog.
Bolli, R., Jeroudi, M. O., Patel, B. S., DuBose, C. M., Lai, E. K., Roberts, R., & McCay, P. B. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.12.4695 · Cited by 469
Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase
Godber, B. L. J., Doel, J. J., Sapkota, G. P., Blake, D. R., Stevens, C. R., Eisenthal, R., & Harrison, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.7757 · Cited by 411
Concomitant S-, N-, and heme-nitros(yl)ation in biological tissues and fluids: implications for the fate of NO in vivo
Feelisch, M., Rassaf, T., Mnaimneh, S., Singh, N., Bryan, N. S., Jourd'Heuil, D., & Kelm, M. (2002) · The FASEB Journal · doi:10.1096/fj.02-0363com · Cited by 401
8-bromo-cGMP reduces the myofilament response to Ca2+ in intact cardiac myocytes.
Shah, A. M., Spurgeon, H. A., Sollott, S. J., Talo, A., & Lakatta, E. G. (1994) · Circulation Research · doi:10.1161/01.res.74.5.970 · Cited by 377
Vasoprotection by nitric oxide: mechanisms and therapeutic potential
Gewaltig, M. T. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00327-9 · Cited by 371
Tissue Expression and Immunolocalization of Tumor Necrosis Factor-α in Postinfarction Dysfunctional Myocardium
Irwin, M. W., Mak, S. S., Mann, D. L., Qu, R., Penninger, J. M., Yan, A. T.-K., Dawood, F., Wen, W.-H., Shou, Z., & Liu, P. J. (1999) · Circulation · doi:10.1161/01.cir.99.11.1492 · Cited by 368
Non-Enzymatic Nitric Oxide Synthesis in Biological Systems
Zweier, J. L., Samouilov, A., & Kuppusamy, P. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00018-3 · Cited by 363
Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts
Yasmin, W. M. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(96)00254-4 · Cited by 339
Simvastatin Preserves the Ischemic-Reperfused Myocardium in Normocholesterolemic Rat Hearts
Lefer, A. M., Campbell, B., Shin, Y.-K., Scalia, R. G., Hayward, R., & Lefer, D. J. (1999) · Circulation · doi:10.1161/01.cir.100.2.178 · Cited by 327
Signal transduction of ischemic preconditioning
Schulz, R. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00384-4 · Cited by 325
Self-citation
The role of L-arginine in ameliorating reperfusion injury after myocardial ischemia in the cat.
Weyrich, A. S., Ma, X. L., & Lefer, A. M. (1992) · Circulation · doi:10.1161/01.cir.86.1.279 · Cited by 320
Inhibition of Mitochondrial ATP Generation by Nitric Oxide Switches Apoptosis to Necrosis
Leist, M., Single, B., Naumann, H., Fava, E., Simon, B., Kühnle, S., & Nicotera, P. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4514 · Cited by 275
Activation of Distinct cAMP-Dependent and cGMP-Dependent Pathways by Nitric Oxide in Cardiac Myocytes
Petroff, M. V., Younès, A., Egan, J. M., Lakatta, E. G., & Sollott, S. J. (1999) · Circulation Research · doi:10.1161/01.res.84.9.1020 · Cited by 273
Antineutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion of dogs.
Lefer, D. J., Nakanishi, K., Johnston, W. E., & Vinten‐Johansen, J. (1993) · Circulation · doi:10.1161/01.cir.88.5.2337 · Cited by 271
Myocardial ischemia-reperfusion injury is exacerbated in absence of endothelial cell nitric oxide synthase
Jones, S. P., Girod, W. G., Palazzo, A. J., Granger, D. N., Grisham, M. B., Jourd’heuil, D., Huang, P. L., & Lefer, D. J. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.276.5.h1567 · Cited by 265
Peroxynitrite inhibits leukocyte-endothelial cell interactions and protects against ischemia-reperfusion injury in rats.
Lefer, D. J., Scalia, R. G., Campbell, B., Nossuli, T. O., Hayward, R., Salamon, M., Grayson, J., & Lefer, A. M. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119212 · Cited by 263
Cardiac Neuronal Nitric Oxide Synthase Isoform Regulates Myocardial Contraction and Calcium Handling
Sears, C. E., Bryant, S. M., Ashley, E. A., Lygate, C. A., Rakovic, S., Wallis, H. L., Neubauer, S., Terrar, D. A., & Casadei, B. (2003) · Circulation Research · doi:10.1161/01.res.0000064585.95749.6d · Cited by 250
Direct measurement of nitric oxide generation in the ischemic heart using electron paramagnetic resonance spectroscopy
Zweier, J. L., Wang, P., & Kuppusamy, P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.1.304 · Cited by 244
Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion.
Siegfried, M. R., Erhardt, J. A., Rider, T., L, X., & Lefer, A. M. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11348-7 · Cited by 234
Evidence for in vivo transport of bioactive nitric oxide in human plasma
Rassaf, T., Preik, M., Kleinbongard, P., Lauer, T., Heiß, C., Strauer, B. E., Feelisch, M., & Kelm, M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14995 · Cited by 224
Regulation of basal myocardial function by NO
Kojda, G. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00314-9 · Cited by 218
Cardioprotective effects of authentic nitric oxide in myocardial ischemia with reperfusion
Johnson, G., Tsao, P. S., & Lefer, A. M. (1991) · Critical Care Medicine · doi:10.1097/00003246-199102000-00021 · Cited by 217
Attenuation of Myocardial Ischemia/Reperfusion Injury by Superinduction of Inducible Nitric Oxide Synthase
Kanno, S., Lee, P. C., Zhang, Y., Ho, C., Griffith, B. P., Shears, L. L., & Billiar, T. R. (2000) · Circulation · doi:10.1161/01.cir.101.23.2742 · Cited by 199
Myocardial Dysfunction With Coronary Microembolization
Thielmann, M., Dörge, H., Martin, C., Belosjorow, S., Schwanke, U., van de Sand, A., Konietzka, I., Buechert, A., Krüger, A., Schulz, R., et al. (2002) · Circulation Research · doi:10.1161/01.res.0000014451.75415.36 · Cited by 193
Self-citation
Bradykinin limits infarction when administered as an adjunct to reperfusion in mouse heart: the role of PI3K, Akt and eNOS
Bell, R. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(02)00310-3 · Cited by 189
Decreased nitric-oxide synthase activity causes impaired endothelium-dependent relaxation in the postischemic heart
Giraldez, R. R., Panda, A., Xia, Y., Sanders, S. P., & Zweier, J. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.21420 · Cited by 180
Inhibition of nitric oxide synthesis protects the isolated working rabbit heart from ischaemia-reperfusion injury
Schulz, R., & Wambolt, R. B. (1995) · Cardiovascular Research · doi:10.1016/s0008-6363(95)00064-x · Cited by 175
Self-citation
Exogenous nitric oxide can trigger a preconditioned state through a free radical mechanism, but endogenous nitric oxide is not a trigger of classical ischemic preconditioning
Nakano, A., Liu, G. S., Heusch, G., Downey, J. M., & Cohen, M. V. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1152 · Cited by 171
Tumor necrosis factor-alpha is released from the isolated heart undergoing ischemia and reperfusion
Gurevitch, J., Frolkis, I., Yuhas, Y., Paz, Y., Matsa, M., Mohr, R., & Yakirevich, V. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(96)00105-2 · Cited by 168
Modulation of cardiac contraction, relaxation and rate by the endothelial nitric oxide synthase (eNOS): lessons from genetically modified mice
Massion, P. B., & Balligand, J. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.025973 · Cited by 159
Inhibition of Nitric Oxide Limits Infarct Size in the in Situ Rabbit Heart
Patel, V. C., Yellon, D. M., Singh, K. J., Neild, G. H., & Woolfson, R. G. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1809 · Cited by 158
Inhibition of Nitric Oxide Synthesis Reduces Infarct Size by an Adenosine-Dependent Mechanism
Woolfson, R. G., Patel, V. C., Neild, G. H., & Yellon, D. M. (1995) · Circulation · doi:10.1161/01.cir.91.5.1545 · Cited by 152
Nitric Oxide Attenuates Neutrophil-Mediated Myocardial Contractile Dysfunction After Ischemia and Reperfusion
Pabla, R., Buda, A. J., Flynn, D. M., Blessé, S. A., Shin, A. M., Curtis, M. J., & Lefer, D. J. (1996) · Circulation Research · doi:10.1161/01.res.78.1.65 · Cited by 142
Mitochondria as Targets for Nitric Oxide–Induced Protection During Simulated Ischemia and Reoxygenation in Isolated Neonatal Cardiomyocytes
Rakhit, R. D., Mojet, M. H., Marber, M. S., & Duchen, M. R. (2001) · Circulation · doi:10.1161/01.cir.103.21.2617 · Cited by 139
Endogenous Nitric Oxide and Myocardial Adaptation to Ischemia
Heusch, G., Post, H., Michel, M. C., Kelm, M., & Schulz, R. (2000) · Circulation Research · doi:10.1161/01.res.87.2.146 · Cited by 138
Self-citation
Classic Preconditioning Decreases the Harmful Accumulation of Nitric Oxide During Ischemia and Reperfusion in Rat Hearts
Csonka, C., Szilvássy, Z., Fülöp, F., Páli, T., Blasig, I. E., Tósaki, Á., Schulz, R., & Ferdinándy, P. (1999) · Circulation · doi:10.1161/01.cir.100.22.2260 · Cited by 137
Self-citation
Protection Against Ischemic Injury by Nonvasoactive Concentrations of Nitric Oxide Synthase Inhibitors in the Perfused Rabbit Heart
Depré, C., Vanoverschelde, J., Goudemant, J., Mottet, I., & Hue, L. (1995) · Circulation · doi:10.1161/01.cir.92.7.1911 · Cited by 134
Role of locally formed angiotensin II and bradykinin in the reduction of myocardial infarct size in dogs
Noda, K., Sasaguri, M., Ideishi, M., Ikeda, M., & Arakawa, K. (1993) · Cardiovascular Research · doi:10.1093/cvr/27.2.334 · Cited by 131
Attenuation of myocardial ischemia/reperfusion injury in mice with myocyte-specific overexpression of endothelial nitric oxide synthase
Brünner, F. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00649-1 · Cited by 131
Attenuation of myocardial stunning by the ACE inhibitor ramiprilat through a signal cascade of bradykinin and prostaglandins but not nitric oxide.
Ehring, T., Baumgart, D., Krajcar, M., Hümmelgen, M., Kompa, S., & Heusch, G. (1994) · Circulation · doi:10.1161/01.cir.90.3.1368 · Cited by 113
Mechanisms of cardioprotection by peroxynitrite in myocardial ischemia and reperfusion injury
Nossuli, T. O., Hayward, R., Jensen, D. E., Scalia, R. G., & Lefer, A. M. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.275.2.h509 · Cited by 109
Infarct Size and Nitric Oxide Synthase in Murine Myocardium
Sumeray, M. S., Rees, D. D., & Yellon, D. M. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1999.1050 · Cited by 108
Apoptosis induction by nitric oxide in adult cardiomyocytes via cGMP-signaling and its impairment after simulated ischemia
Taimor, G. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00272-2 · Cited by 108
Inhibition of nitric oxide production aggravates myocardial hypoperfusion during exercise in the presence of a coronary artery stenosis.
Duncker, D. J., & Bache, R. J. (1994) · Circulation Research · doi:10.1161/01.res.74.4.629 · Cited by 107
Constitutive nitric oxide release is impaired after ischemia and reperfusion
Engelman, D. T., Watanabe, M., Engelman, R. M., Rousou, J. A., Flack, J. E., Deaton, D. W., & Das, D. K. (1995) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(05)80173-4 · Cited by 106
Activation of nitric oxide synthase by ischaemia in the perfused heart
Depre, C. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(96)00176-9 · Cited by 106
Supplemental l-arginine during cardioplegic arrest and reperfusion avoids regional postischemic injury
Sato, H., Zhao, Z.-Q., McGee, D. S., Williams, M. W., Hammon, J. W., & Vinten‐Johansen, J. (1995) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(95)70226-1 · Cited by 105
Anesthetic preconditioning: triggering role of reactive oxygen and nitrogen species in isolated hearts
Novalija, E., Varadarajan, S. G., Camara, A. K. S., An, J., Chen, Q., Riess, M. L., Hogg, N., & Stowe, D. F. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01056.2001 · Cited by 105
Vascular Endothelial Growth Factor Attenuates Myocardial Ischemia-Reperfusion Injury
Luo, Z., Diaco, M., Murohara, T., Ferrara, N., Isner, J. M., & Symes, J. F. (1997) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(97)00715-7 · Cited by 104
Nitric oxide: a trigger for classic preconditioning?
Lochner, A., Marais, E., Genade, S., & Moolman, J. A. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.6.h2752 · Cited by 104
Peroxynitrite Reduces Myocardial Infarct Size and Preserves Coronary Endothelium After Ischemia and Reperfusion in Cats
Nossuli, T. O., Hayward, R., Scalia, R. G., & Lefer, A. M. (1997) · Circulation · doi:10.1161/01.cir.96.7.2317 · Cited by 99
Sustain inhibition of nitric oxide by NG-nitro-l-arginine improves myocardial function following ischemia/reperfusion in isolated perfused rat heart
NASEEM, S., Kontos, M. C., RAO, P., Jesse, R., HESS, M., & Kukreja, R. C. (1995) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(08)80038-7 · Cited by 98
Contribution of NO to Ischemia-Reperfusion Injury in the Saline-Perfused Heart: a Study in Endothelial NO Synthase Knockout Mice
Flögel, U., Decking, U. K. M., Gödecke, A., & Schrader, J. (1999) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1998.0921 · Cited by 96
Inducible nitric oxide synthase activation after ischemia/reperfusion contributes to myocardial dysfunction and extent of infarct size in rabbits: evidence for a late phase of nitric oxide-mediated reperfusion injury
Wildhirt, S. M. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00080-2 · Cited by 96
Differential response to myocardial reperfusion injury in eNOS-deficient mice
Sharp, B. R., Jones, S. P., Rimmer, D. M., & Lefer, D. J. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00855.2001 · Cited by 95
Direct electrochemical measurement of nitric oxide in vascular endothelium
Brovkovych, V. M., Stolarczyk, E. I., Oman, J., Tomboulian, P., & Maliñski, T. (1999) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(98)00090-9 · Cited by 92
Cyclosporine A limits myocardial infarct size even when administered after onset of ischemia
Weinbrenner, C., Liu, G. S., Downey, J. M., & Cohen, M. V. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00064-9 · Cited by 89
Cardioprotective effects of heparin or N-acetylheparin in an in vivo model of myocardial ischaemic and reperfusion injury
Black, S. C., Gralinski, M., Friedrichs, G. S., Kilgore, K. S., Driscoll, E. M., & Lucchesi, B. R. (1995) · Cardiovascular Research · doi:10.1016/s0008-6363(96)88632-9 · Cited by 86
Nitric oxide and calcium together inactivate mitochondrial complex I and induce cytochrome c release
Jekabsone, A. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00137-8 · Cited by 85
Heterogeneous Basal Expression of Nitric Oxide Synthase and Superoxide Dismutase Isoforms in Mammalian Heart
Brahmajothi, M. V., & Campbell, D. L. (1999) · Circulation Research · doi:10.1161/01.res.85.7.575 · Cited by 83
Role of adenosine in delayed preconditioning of myocardium
Baxter, G. F. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00280-8 · Cited by 82
Peroxynitrite aggravates myocardial reperfusion injury in the isolated perfused rat heart
Ma, X. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00179-x · Cited by 81
Adenosine Inhibits Lipopolysaccharide-Induced Secretion of Tumor Necrosis Factor-α in the Failing Human Heart
Wagner, D. R., McTiernan, C. F., Sanders, V. J., & Feldman, A. M. (1998) · Circulation · doi:10.1161/01.cir.97.6.521 · Cited by 81
S-nitrosoglutathione improves functional recovery in the isolated rat heart after cardioplegic ischemic arrest-evidence for a cardioprotective effect of nitric oxide.
Konorev, E. A., Tarpey, M. M., Joseph, J., Baker, J. E., & Kalyanaraman, B. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10551-x · Cited by 81
Inhibition of endothelium-derived relaxing factor enhances myocardial stunning in conscious dogs.
Hasebe, N., Shen, Y. T., & Vatner, S. F. (1993) · Circulation · doi:10.1161/01.cir.88.6.2862 · Cited by 80
Endogenous nitric oxide (NO) protects against ischaemia-reperfusion injury in the rabbit
Williams, M. W., Taft, C. S., Ramnauth, S., Zhao, Z., & Vinten-Johansen, J. (1995) · Cardiovascular Research · doi:10.1016/s0008-6363(95)00011-9 · Cited by 80
Inhibition of nitric oxide synthesis does not affect ischemic preconditioning in isolated perfused rat hearts
Weselcouch, E. O., Baird, A. J., Sleph, P. G., & Grover, G. J. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.268.1.h242 · Cited by 79
No Involvement of Endogenous Nitric Oxide In Classical Ischemic Preconditioning in Swine
Post, H., Schulz, R., Behrends, M., Gres, P., Umschlag, C., & Heusch, G. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1117 · Cited by 77
Self-citation
The cardioprotective and mitochondrial depolarising properties of exogenous nitric oxide in mouse heart
Bell, R. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00675-2 · Cited by 73
Intra-coronary administration of ?-arginine aggravates myocardial stunning through production of peroxynitrite in dogs
Mori, E. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00146-1 · Cited by 71
Expression of an endothelial-type nitric oxide synthase isoform in human neutrophils: modification by tumor necrosis factor-alpha and during acute myocardial infarction
de Frutos, T., de Miguel, L. S., Farré, J., Rivas, J. G., Romero, J., Marcos‐Alberca, P., Nuñez, A., Rico, L., & López-Farré, A. J. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)01185-2 · Cited by 71
Transcription activator protein 1 (AP‐1) mediates NO‐induced apoptosis of adult cardiomyocytes
Taimor, G., Rakow, A., & Piper, H. M. (2001) · The FASEB Journal · doi:10.1096/fj.01-0353fje · Cited by 67
Nitric oxide synthase protects the heart against ischemia-reperfusion injury in rabbits.
Hoshida, S., Yamashita, N., Igarashi, J., Nishida, M., Hori, M., Kamada, T., Kuzuya, T., & Tada, M. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10512-0 · Cited by 66
Non-Enzymatic Production of Nitric Oxide (NO) from NO Synthase Inhibitors
Moroz, L. L., Norby, S. W., Cruz, L., Sweedler, J. V., Gillette, R., & Clarkson, R. B. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9810 · Cited by 66
Intravenous administration of the natriuretic peptide urodilatin at low doses during coronary reperfusion limits infarct size in anesthetized pigs
Padilla, F. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00242-5 · Cited by 66
Kinin-Mediated Coronary Nitric Oxide Production Contributes to the Therapeutic Action of Angiotensin-Converting Enzyme and Neutral Endopeptidase Inhibitors and Amlodipine in the Treatment in Heart Failure
Zhang, X., Recchia, F. A., Bernstein, R. D., Xu, X., Nasjletti, A., & Hintze, T. H. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38015-2 · Cited by 65
L-Arginine reverses low coronary reflow and enhances postischaemic recovery of cardiac mechanical function
Amrani, M., Chester, A. H., Jayakumar, J., Schyns, C. J., & Yacoub, M. H. (1995) · Cardiovascular Research · doi:10.1016/s0008-6363(95)00021-6 · Cited by 62
Ischemia Increases Detectable Endothelial Nitric Oxide Synthase in Rat and Human Myocardium
Bloch, W., Mehlhorn, U., Krahwinkel, A., Reiner, M., Dittrich, M., Schmidt, A., & Addicks, K. (2001) · Nitric Oxide · doi:10.1006/niox.2000.0339 · Cited by 61
Inhibition of nitric oxide synthesis protects the isolated working rabbit heart from ischaemia-reperfusion injury*1
Schulz, R. (1995) · Cardiovascular Research · doi:10.1016/0008-6363(95)00064-x · Cited by 61
Self-citation
TNF-α antibodies are as effective as ischemic preconditioning in reducing infarct size in rabbits
Belosjorow, S., Bolle, I., Duschin, A., Heusch, G., & Schulz, R. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00374.2002 · Cited by 60
Self-citation
Delayed Enhanced Nitric Oxide–Mediated Coronary Vasodilation Following Brief Ischemia and Prolonged Reperfusion in Conscious Dogs
Kim, S., Ghaleh, B., Kudej, R. K., Huang, C.-H., Hintze, T. H., & Vatner, S. F. (1997) · Circulation Research · doi:10.1161/01.res.81.1.53 · Cited by 57
Experimental hypothermia and rewarming: changes in mechanical function and metabolism of rat hearts
Tveita, T., Skandfer, M., Refsum, H. E., & Kirsti Ytrehus, B. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.80.1.291 · Cited by 57
Adenosine production and its interaction with protection of ischemic and reperfusion injury of the myocardium
Obata, T. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)01993-8 · Cited by 56
The protective effect of L-arginine on myocardial injury and endothelial function following ischaemia and reperfusion in the pig
Pernow, J., Uriuda, Y., Wang, Q., LI, X. ‐., Nordlander, R., & Rydén, L. (1994) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a060456 · Cited by 56
Nitric oxide synthase inhibitors decrease coronary sinus-free radical concentration and ameliorate myocardial stunning in an ischemia-reperfusion model
Zhang, Y., Bissing, J. W., Xu, L., Ryan, A. J., Martin, S. M., Miller, F. J., Kregel, K. C., Buettner, G. R., & Kerber, R. E. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01400-0 · Cited by 54
Effects of l-Arginine and l-nitro-arginine methyl ester on recovery of neonatal lamb hearts after cold ischemia
Hiramatsu, T., Forbess, J. M., Miura, T., & Mayer, J. E. (1995) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(95)70423-x · Cited by 51
Bradykinin Protects Against Infarction but Does not Mediate Ischemic Preconditioning in the Isolated Rat Heart
Bugge, E., & Ytrehus, K. (1996) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1996.0226 · Cited by 51
Intracoronary nitric oxide improves postischemic coronary blood flow and myocardial contractile function
Pabla, R., Buda, A. J., Flynn, D. M., Salzberg, D. B., & Lefer, D. J. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.269.3.h1113 · Cited by 51
Effect of nitrovasodilators and inhibitors of nitric oxide synthase on ischaemic and reperfusion function of rat isolated hearts
Toit, E. F. D., McCarthy, J., Miyashiro, J. K., Opie, L. H., & Brunner, F. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701694 · Cited by 50
Effect of Endogenous Nitric Oxide on Cardiac Systolic and Diastolic Function During Ischemia and Reperfusion in the Rat Isolated Perfused Heart
Pabla, R. (1996) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1996.0203 · Cited by 49
Endogenous Protection Against Reperfusion-induced Ventricular Fibrillation: Role of Neuronal versus Non-neuronal Sources of Nitric Oxide and Species Dependence in the Rat versus Rabbit Isolated Heart
Pabla, R. (1996) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1996.0202 · Cited by 49
Comparison of tumor necrosis factor-α effect on the expression of iNOS in macrophage and cardiac myocytes
Sanders, D. B., Larson, D. F., Hunter, K., Gorman, M., & Yang, B. (2001) · Perfusion · doi:10.1177/026765910101600110 · Cited by 46
Deletion of Endothelial Nitric Oxide Synthase Exacerbates Myocardial Stunning in an Isolated Mouse Heart Model
Hannan, R. L., John, M. C., Kouretas, P. C., Hack, B., Matherne, G. P., & Laubach, V. E. (2000) · Journal of Surgical Research · doi:10.1006/jsre.2000.5953 · Cited by 44
Prostacyclin rather than endogenous nitric oxide is a tissue protective factor in myocardial ischemia
Woditsch, I., & Schrör, K. (1992) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1992.263.5.h1390 · Cited by 42
Cardioprotective activity of endogenous and exogenous nitric oxide on ischaemia reperfusion injury in isolated guinea pig hearts
Masini, E., Salvemini, D., Ndisang, J. F., Gai, P., Berni, L. A., Moncini, M., Bianchi, S., & Mannaioni, P. F. (1999) · Inflammation Research · doi:10.1007/s000110050504 · Cited by 39
Cardioprotection by Cyclosporine A in Experimental Ischemia and Reperfusion—Evidence for a Nitric Oxide-dependent Mechanism Mediated by Endothelin
Massoudy, P., Stefan Zahler, A., Kupatt, C., Reder, E., Becker, B. F., & Gerlach, E. (1997) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1996.0297 · Cited by 37
Inhibition of Nitric Oxide Synthesis Increases Adenosine Production via an Extracellular Pathway Through Activation of Protein Kinase C
Minamino, T., Kitakaze, M., Node, K., Funaya, H., & Hori, M. (1997) · Circulation · doi:10.1161/01.cir.96.5.1586 · Cited by 37
Critical timing of nitric oxide supplementation in cardioplegic arrest and reperfusion.
Engelman, D. T., Watanabe, M., Maulik, N., Engelman, R. M., Rousou, J. A., Flack, J. E., Deaton, D. W., & Das, D. K. (1996) · PubMed · Cited by 36
A protective role of nitric oxide in isolated ischaemic/reperfused rat heart
Berȩsewicz, A., Karwatowska‐Prokopczuk, E., Lewartowski, B., & Cedro-Ceremużyńska, K. (1995) · Cardiovascular Research · doi:10.1016/s0008-6363(95)00175-1 · Cited by 35
Reactive oxygen species and nitric oxide in myocardial ischemia and reperfusion
Becker, B. F., Kupatt, C., Massoudy, P., & Stefan Zahler, A. (2000) · Zeitschrift für Kardiologie · doi:10.1007/s003920070037 · Cited by 33
Cardioprotective Effects of Red Blood Cells on Ischemia and Reperfusion Injury in Isolated Rat Heart: Release of Nitric Oxide as a Potential Mechanism
Yang, B., Nichols, W. W., & Mehta, J. L. (1996) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/107424849600100405 · Cited by 32
Nitric oxide production by neutrophils obtained from patients during acute coronary syndromes: expression of the nitric oxide synthase isoforms
de Miguel, L. S., Arriero, M. A. M., Montón, M., López-Farré, A. J., Farré, J., Cabestrero, F., Martín, E. R., Romero, J., Jiménez, P., García‐Méndez, A., et al. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01828-9 · Cited by 32
Effect of ischemia on soluble and particulate guanylyl cyclase-mediated cGMP synthesis in cardiomyocytes
Agulló, L., David Garcia-dorado, A., Escalona, N., Ruiz‐Meana, M., Inserte, J., & Soler‐Soler, J. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00820.2002 · Cited by 31
Relation of Cyclic Nucleotide Ratios to Ischemic and Reperfusion Injury in Nitric Oxide–Donor Treated Rat Hearts
Toit, E. F. D., Meiring, J., & Opie, L. H. (2001) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200110000-00005 · Cited by 30
Evidence for in vivo transport of bioactive nitric oxide in human plasma
Rassaf, T., Preik, M., Kleinbongard, P., Lauer, T., Heiß, C., Strauer, B. E., Feelisch, M., & Kelm, M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200214995 · Cited by 30
Involvement of p38 Mitogen-Activated Protein Kinase and Apoptosis Signal-Regulating Kinase-1 in Nitric Oxide-Induced Cell Death in PC12 Cells
Han, O.-J., Joe, K. H., Kim, S. W., Lee, K. H., Kwon, N. S., Baek, K. J., & Yun, H. (2001) · Neurochemical Research · doi:10.1023/a:1010917129951 · Cited by 27
Role of Cellular Acidosis in Production of Nitric Oxide in Canine Ischemic Myocardium
Kitakaze, M., Node, K., Takashima, S., Asanuma, H., Asakura, M., Sanada, S., Shinozaki, Y., Mori, H., Sato, H., Kuzuya, T., et al. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1435 · Cited by 26
Inhibition of nitric oxide synthase prevents myocardial protection by ramiprilat.
Hartman, J. C., Kurc, G. M., Hullinger, T. G., Wall, T. M., Sheehy, R. M., & Shebuski, R. J. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22498-3 · Cited by 23
Cholinergic and alpha-adrenergic coronary vasomotion [corrected] with increasing ischemia-reperfusion injury
Ehring, T., Krajcar, M., Baumgart, D., Kompa, S., Hümmelgen, M., & Heusch, G. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.268.2.h886 · Cited by 22
Effect of endogenous nitric oxide on energy metabolism of rat heart mitochondria during ischemia and reperfusion
Abe, K., Hayashi, N., & Terada, H. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00222-6 · Cited by 22
Nitrous Oxide Impairs Functional Recovery of Stunned Myocardium in Barbiturate-Anesthetized, Acutely Instrumented Dogs
Siker, D., Pagel, P. S., Pelc, L. R., Kampine, J. P., Schmeling, W. T., & Warltier, D. C. (1992) · Anesthesia & Analgesia · doi:10.1213/00000539-199210000-00013 · Cited by 20
Inhibition of apoptotic responses after ischemic stress in isolated hearts and cardiomyocytes
Hofstaetter, B., Taimor, G., Inserte, J., García‐Dorado, D., & Piper, H. M. (2002) · Basic Research in Cardiology · doi:10.1007/s003950200053 · Cited by 20
No involvement of nitric oxide in the limitation of β-adrenergic inotropic responsiveness during ischemia
Post, H., Schulz, R., Gres, P., & Heusch, G. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.6.h2392 · Cited by 20
Self-citation
Nifedipine limits infarct size via NO-dependent mechanisms in dogs
Asanuma, H., Kitakaze, M., Funaya, H., Takashima, S., Minamino, T., Node, K., Sakata, Y., Asakura, M., Sanada, S., Shinozaki, Y., et al. (2001) · Basic Research in Cardiology · doi:10.1007/s003950170032 · Cited by 19
Intra-coronary administration of L-arginine aggravates myocardial stunning through production of peroxynitrite in dogs
森, 超. (1999) · Medical Entomology and Zoology · Cited by 18
Sodium Nitroprusside Exacerbates Myocardial Ischemia–Reperfusion Injury
Cope, J. T., Banks, D., Laubach, V. E., Binns, O. A. R., King, R. C., Richardson, R. M., Shockey, K. S., Tribble, C. G., & Kron, I. L. (1997) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(97)01089-8 · Cited by 17
INHIBITION OF NITRIC OXIDE DOES NOT AFFECT REPERFUSION-INDUCED MYOCARDIAL INJURY, BUT IT PREVENTS LIPID PEROXIDATION IN THE ISOLATED RAT HEART
Yang, B., & Mehta, J. L. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00378-0 · Cited by 17
Activation of myocardial constitutive nitric oxide synthase during coronary artery surgery
Mehlhorn, U., Bloch, W., Krahwinkel, A., LaRosé, K., Geißler, H.-J., Hekmat, K., Addicks, K., & de Vivie, E. R. (2000) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/s1010-7940(00)00337-7 · Cited by 17
Positive inotropy due to lowering cyclic GMP is also mediated by increases in cyclic AMP in control and hypertrophic hearts
Naim, K. L., Rabindranauth, P., Weiss, H. R., Tse, J., Leone, R. J., & Scholz, P. M. (1998) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-76-6-605 · Cited by 16
Cyclic GMP Reduces Ventricular Myocyte Stunning after Simulated Ischemia–Reperfusion
Gandhi, A., Yan, L., Scholz, P., Huang, M., & Weiss, H. R. (1999) · Nitric Oxide · doi:10.1006/niox.1999.0263 · Cited by 15
Intracoronary SIN-1C During Reperfusion Reduces Infarct Size in Dog
Schlack, W. S., Uebing, A. S., Schüfer, M., Bier, F., Grunert, S., Ebel, D., Piper, H. M., & Thämer, V. (1995) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199503000-00012 · Cited by 12
Simultaneous manipulation of the nitric oxide and prostanoid pathways reduces myocardial reperfusion injury
Wanna, F. S., Obayashi, D. Y., Young, J. N., & DeCampli, W. M. (1995) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(05)80174-6 · Cited by 10
Role of the nitric oxide pathway on ischemia-reperfusion injury in an isolated perfused guinea pig heart
Öz, E., Arsakay, G., Dinçer, S., & Erbaş, D. (2000) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(99)00044-0 · Cited by 4

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Authors: Schulz, R.
Affiliations: Essen University Hospital (DE)
Corresponding author: Schulz, R
ORCID: Schulz, R
Venue: Cardiovascular Research
Publisher: Oxford University Press (OUP)
Published: 2004-02-15
Volume: 61
Issue: 3
Pages: 402-413
ISSN: 0008-6363 (ISSN-L)
DOI: 10.1016/j.cardiores.2003.09.019
OpenAlex: W2119416582
Cited by: 462
References: 139
Citations by year: 2026: 10 · 2025: 10 · 2024: 12 · 2023: 19 · 2022: 11 · 2021: 17 · 2020: 16 · 2019: 19 · 2018: 24 · 2017: 16 · 2016: 20 · 2015: 24 · 2014: 20 · 2013: 28 · 2012: 20
FWCI: 10.71
Type: journal article
Language: en
Open access: closed
Locations: Cardiovascular Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Keywords: nitric oxide, myocardial ischemia-reperfusion injury, ischemic preconditioning, nitric oxide synthase isoforms, statins, calcium channel blockers, ACE inhibitors, dexamethasone, nitric oxide synthase inhibition
MeSH terms: Animals, Hypoxia, Endothelium, Vascular, Humans, Mammals, Myocardial Contraction, Nitric Oxide, Myocardial Reperfusion Injury, Apoptosis, Nitric Oxide Synthase, Nitric Oxide Donors, Models, Animal, Myocytes, Cardiac

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Nitric oxide in myocardial ischemia/reperfusion injury

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