The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis
Open accessAbstract
OBJECTIVE: The responses to bacterial lipopolysaccharide (LPS) damage mitochondria by generating oxidative stress within the organelles. We postulated that LPS damages heart mitochondrial DNA and protein by oxidation, and that this is recovered by oxidative mechanisms of mitochondrial biogenesis. METHODS AND RESULTS: Systemic crude E. coli LPS administration decreased mtDNA copy number and mtDNA gene transcription in rat heart caused by oxidant deletion of mtDNA. The fall in copy number was reflected in proteomic expression of several mitochondria-encoded subunits of Complexes I, IV, and V. Recovery of mtDNA copy number involved biogenesis as indicated by mitochondrial transcription factor A (Tfam) and DNA polymerase-gamma expression. The transcriptional response also included nuclear accumulation of peroxisome proliferator-activated receptor-gamma co-activator 1 (PGC-1) and mRNA expression for redox-regulated nuclear respiratory factors (NRF-1 and -2). CONCLUSIONS: These novel findings disclose a duality of reactive oxygen species (ROS) effect in the heart's response to LPS in which oxidative mitochondrial damage is opposed by oxidant stimulation of biogenesis.
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ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection
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Arany, Z., Novikov, M., Chin, S., Ma, Y., Rosenzweig, A., & Spiegelman, B. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603615103 · Cited by 374
Mitochondria as a Cellular Hub in Infection and Inflammation
Andrieux, P., Chevillard, C., Cunha-Neto, E., & Nunes, J. P. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111338 · Cited by 346
J. Romero-Bermejo, F., Ruiz-Bailen, M., Gil-Cebrian, J., & J. Huertos-Ranchal, M. (2011) · Current Cardiology Reviews · doi:10.2174/157340311798220494 · Cited by 287
Inflammation and mitochondrial dysfunction: A vicious circle in neurodegenerative disorders?
van Horssen, J., van Schaik, P., & Witte, M. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2017.06.050 · Cited by 283
Metadata
- Authors
- SULIMAN, H., WELTYWOLF, K., CARRAWAY, M., TATRO, L., & PIANTADOSI, C.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-11-01
- Volume
- 64
- Issue
- 2
- Pages
- 279-288
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2033729587
- Cited by
- 269
- References
- 51
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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