The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Inflammation and mitochondrial dysfunction: A vicious circle in neurodegenerative disorders?
Abstract
Experimental evidence supports an intricate association between inflammation and mitochondrial dysfunction as main contributors of neurological diseases. Inflammatory mediators produced by activated microglia and infiltrated immune cells trigger intracellular signalling cascades that can alter cellular mitochondrial metabolism. Cytokines, particularly tumor necrosis factor-alpha, impede mitochondrial oxidative phosphorylation and associated ATP production and instigate mitochondrial reactive oxygen species production. This culminates in mitochondrial membrane permeabilization, altered mitochondrial dynamics and might ultimately result in cell death. When severely injured mitochondria are not appropriately removed by mitophagy they can release their contents into the cytosol and extracellular environment and thereby amplify the inflammatory process. Here we provide a comprehensive overview on how inflammatory mediators impair mitochondrial metabolism and discuss how defective mitochondria can elicit and potentiate an inflammatory response.
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Cites
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Lin, T., Liu, G. A., Perez, E., Rainer, R. D., Febo, M., Cruz-Almeida, Y., & Ebner, N. C. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00236 · Cited by 138
Mitophagy and cGAS–STING crosstalk in neuroinflammation
Zhou, X., Wang, J., Yu, L., Qiao, G., Qin, D., Yuen-Kwan Law, B., Ren, F., Wu, J., & Wu, A. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.05.012 · Cited by 131
Metadata
- Authors
- van Horssen, J., van Schaik, P., & Witte, M.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2019-09
- Volume
- 710
- Pages
- 132931
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2727735765
- Cited by
- 283
- References
- 64
- FWCI
- 6.04
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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