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Cited by 346Mitochondrial Function and PathologyAutophagy in Disease and TherapyImmune Response and Inflammation

Mitochondria as a Cellular Hub in Infection and Inflammation

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Andrieux, Pauline, Chevillard, Christophe, Cunha-Neto, Edecio, Nunes, João Paulo Silva·2021·International Journal of Molecular Sciences
DOI 10.3390/ijms222111338PMC PMC8583510
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Abstract

Mitochondria are the energy center of the cell. They are found in the cell cytoplasm as dynamic networks where they adapt energy production based on the cell’s needs. They are also at the center of the proinflammatory response and have essential roles in the response against pathogenic infections. Mitochondria are a major site for production of Reactive Oxygen Species (ROS; or free radicals), which are essential to fight infection. However, excessive and uncontrolled production can become deleterious to the cell, leading to mitochondrial and tissue damage. Pathogens exploit the role of mitochondria during infection by affecting the oxidative phosphorylation mechanism (OXPHOS), mitochondrial network and disrupting the communication between the nucleus and the mitochondria. The role of mitochondria in these biological processes makes these organelle good targets for the development of therapeutic strategies. In this review, we presented a summary of the endosymbiotic origin of mitochondria and their involvement in the pathogen response, as well as the potential promising mitochondrial targets for the fight against infectious diseases and chronic inflammatory diseases.

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  • Pathogenic microorganisms such as viruses are usually detected by specific cell protein complexes through recognition of pathogen-associated molecular patterns (PAMPs), including LPS.

    “pathogenic microorganisms such as viruses are usually detected by specific cell protein complexes through the recognition of pathogen-associated molecular patterns (PAMPs), including LPS [51].”

    From Effects of Mangiferin on LPS-Induced Inflammation and SARS-CoV-2 Viral Adsorption in Human Lung Cells (2022) · cites this paper as [51]

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Authors
Andrieux, P., Chevillard, C., Cunha-Neto, E., & Nunes, J. P. S.
Affiliations
  • Inserm (FR)
  • Laboratory of Immunology, Heart Institute (InCor), Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo, São Paulo 05403-000, Brazil
Corresponding author
  • Chevillard, Christophe
  • Nunes, João Paulo Silva
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2021-10-20
Volume
22
Issue
21
Pages
11338
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms222111338
PMC
PMC8583510
OpenAlex
W3207310604
Cited by
346
References
266
Citations by year
2026: 56 · 2025: 115 · 2024: 91 · 2023: 62 · 2022: 22
FWCI
4.59
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL AMU (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • the Institut National de la Santé et de la Recherche Médicale (INSERM) (none)
  • the Aix-Marseille University (AMIDEX “International_2018” MITOMUTCHAGAS)
  • the French Agency for Research (Agence Nationale de la Recherche-ANR) (Br-Fr-Chagas, landscardio)
  • the CNPq (Brazilian Council for Scientific and Technological Development) (none)
  • the FAPESP (São Paulo State Research Funding Agency Brazil) (2013/50302-3, 2014/50890-5)
  • the National Institutes of Health/USA (2 P50 AI098461-02, 2U19AI098461-06)
  • the Inserm Cross-Cutting Project GOLD (none)
  • the Excellence Initiative of Aix-Marseille University - A*Midex (Institute MarMaRa AMX-19-IET-007)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
mitochondria, infection, inflammation, reactive oxygen species, oxidative phosphorylation, mitochondrial network, mitochondrial-nuclear communication, pathogen evasion, endosymbiotic origin of mitochondria, chronic inflammatory diseases, infectious diseases
MeSH terms
Animals, Energy Metabolism, Humans, Infections, Inflammation, Mitochondria, Mitochondrial Dynamics

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