Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

Wright, S. D., Ramos, R., Tobias, P. S., Ulevitch, R. J., & Mathison, J. C. (1990) · Science · doi:10.1126/science.1698311 · Cited by 3,996

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., & Akira, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.3749 · Cited by 3,374

Obesity and the risk of heart failure

Kenchaiah, S., Evans, J. C., Levy, D., Wilson, P. W. F., Benjamin, E. J., Larson, M. G., Kannel, W. B., & Vasan, R. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020245 · Cited by 3,093

Association of psychosocial risk factors with risk of acute myocardial infarction in 11 119 cases and 13 648 controls from 52 countries (the INTERHEART study): case-control study

Rosengren, A., Hawken, S., Ôunpuu, S., Sliwa, K., Zubaid, M., Almahmeed, W. A., Blackett, K. N., Sitthi-amorn, C., Sato, H., & Yusuf, S. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17019-0 · Cited by 2,414

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

Garg, U. C., & Hassid, A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114081 · Cited by 2,154

Hemostatic Factors and the Risk of Myocardial Infarction or Sudden Death in Patients with Angina Pectoris

Thompson, S. G., Kienast, J., Pyke, S., Haverkate, F., & van de Loo, J. C. W. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321003 · Cited by 1,819

Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?

Yudkin, J. S., Kumari, M., Humphries, S. E., & Mohamed-Ali, V. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00463-3 · Cited by 1,775

Fibrinogen as a Risk Factor for Stroke and Myocardial Infarction

Wilhelmsen, L., Svärdsudd, K., Korsan-Bengtsen, K., Larsson, B., Welin, L., & Tibblin, G. (1984) · New England Journal of Medicine · doi:10.1056/nejm198408233110804 · Cited by 1,645

The mechanistic basis linking cytokine storm to thrombosis in COVID-19

Wolf, A. J., Khimani, F., Yoon, B., Gerhart, C. R. B., Endsley, D., Ray, A., Yango, A. F., Flynn, S. D., Lip, G. Y. H., Gonzalez, S. A., et al. (2022) · Thrombosis Update · doi:10.1016/j.tru.2022.100110 · Cited by 18

Altered Interaction Between Plasminogen Activator Inhibitor Type 1 Activity and Sympathetic Nerve Activity With Aging

Otowa, K., Takamura, M., Murai, H., Maruyama, M., Nakano, M., Ikeda, T., Kobayashi, D., Ootsuji, H., Okajima, M., Furushou, H., et al. (2008) · Circulation Journal · doi:10.1253/circj.72.458 · Cited by 18

Age and aerobic training status effects on plasma and skeletal muscle tPA and PAI-1

Francis, R. M., Romeyn, C. L., Coughlin, A. M., Nagelkirk, P. R., Womack, C. J., & Lemmer, J. T. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-2857-2 · Cited by 17

Increased expression of plasminogen activator inhibitor-1 (PAI-1) is associated with depression and depressive phenotype in C57Bl/6J mice

Girard, R., Chauhan, P. S., Tucker, T. A., Allen, T., Kaur, J., Jeffers, A., Koenig, K. B., Florova, G., Komissarov, A. A., Gaidenko, T. A., et al. (2019) · Experimental Brain Research · doi:10.1007/s00221-019-05682-0 · Cited by 17

Role of plasminogen activator inhibitor-1 (PAI-1) in age-related cardiovascular pathophysiology

Khoddam, A., Vaughan, D. E., & Wilsbacher, L. D. (2025) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2024.38 · Cited by 15

Mechanisms of endothelial senescence and vascular aging

Qiao, L., Qian, Z., Huang, Y., Yang, X. F., Yang, J., Xiao, N., Liang, G., Zhang, H., Fu, Y., Yan, L., et al. (2025) · Biogerontology · doi:10.1007/s10522-025-10279-y · Cited by 21

Influence of Renin‐Angiotensin‐Aldosterone System‐Blocking Drugs on Peritoneal Membrane in Peritoneal Dialysis Patients

Rupnik, A. T., Pajek, J., Guček, A., Osredkar, J., Kovač, D., Bren, A. F., Klančič, D., Saksida, S., Rus, I., Globokar, M., et al. (2013) · Therapeutic Apheresis and Dialysis · doi:10.1111/1744-9987.12091 · Cited by 16

The Pro/Pro genotype of the p53 codon 72 polymorphism modulates PAI-1 plasma levels in ageing

Testa, R., Bonfigli, A. R., Salvioli, S., Invidia, L., Pierini, M., Sirolla, C., Marra, M., Testa, I., Fazioli, F., Recchioni, R., et al. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.06.001 · Cited by 16

Age-Related Increase of Collagen/Fibrin Deposition and High PAI-1 Production in Human Nasal Polyps

Jo, A., Choi, T. G., Han, J. Y., Tabor, M. H., Kolliputi, N., Lockey, R. F., & Cho, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.845324 · Cited by 15

Further evaluation of uPA and PAI-1 as biomarkers for prostatic diseases

Akudugu, J., Serafin, A. M., & Böhm, L. (2014) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-014-1848-3 · Cited by 15

Saturated Fatty Acid Intake Can Influence Increase in Plasminogen Activator Inhibitor-1 in Obese Adolescents

Masquio, D. C. L., de Piano, A., Campos, R. M. D. S., Sanches, P. D. L., Corgosinho, F. C., Carnier, J., Oyama, L. M., do Nascimento, C., de Mello, M. T., Tufik, S., et al. (2014) · Hormone and Metabolic Research · doi:10.1055/s-0034-1370908 · Cited by 15

Cold atmospheric plasma-enabled platelet vesicle incorporated iron oxide nano-propellers for thrombolysis

Jheng, P., Chiang, C.-C., Kang, J., Fan, Y., Wu, K. C. ‐., Chen, Y., Liang, J., Bolouki, N., Lee, J., Hsieh, J. H., et al. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100876 · Cited by 13

Phytochemicals in obesity control

Mukherjee, A. K., Mukherjee, S., Biswas, J., & Roy, M. (2015) · Cited by 13

PAI-1 is a common driver of aging and diverse diseases

Khoddam, A., Miyata, T., & Vaughan, D. E. (2025) · Biomedical Journal · doi:10.1016/j.bj.2025.100892 · Cited by 12

CO-Induced TTP Activation Alleviates Cellular Senescence and Age-Dependent Hepatic Steatosis via Downregulation of PAI-1.

Park, J., Chen, Y., Kim, J., Hwang, E., Park, G. H., Yang, C. H., Ryter, S. W., Park, J. W., Chung, H., & Joe, Y. (2023) · PubMed Central · doi:10.14336/ad.2023.0120 · Cited by 13

Physiology of Hemostasis: With Relevance to Current and Future Laboratory Testing

Kriz, N. J., Rinder, C. S., & Rinder, H. M. (2009) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2009.06.004 · Cited by 12

Overview of Blood Coagulation and the Pathophysiology of Blood Coagulation Disorders

Cardenas, J. C., Rein, C. M., & Church, F. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-394447-4.10079-3 · Cited by 12

The Human Extracellular Matrix Diseasome Reveals Genotype–Phenotype Associations with Clinical Implications for Age-Related Diseases

Statzer, C., Luthria, K. D., Sharma, A., Kann, M. G., & Ewald, C. Y. (2023) · Biomedicines · doi:10.3390/biomedicines11041212 · Cited by 10

CircMYO9A inhibits influenza A virus replication by dampening haemagglutinin cleavage via increasing SERPINE1/PAI-1 expression

Zheng, Y., Zhang, X., Liu, Z., Fan, M., Deng, L., & Ping, J. (2025) · Emerging Microbes & Infections · doi:10.1080/22221751.2025.2502007 · Cited by 9

Visceral fat‐specific regulation of plasminogen activator inhibitor‐1 in aged septic mice

Bruno, M. E. C., Mukherjee, S., Stromberg, A. J., Saitō, H., & Starr, M. E. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30551 · Cited by 10

Inflammation and hemostasis in older octogenarians: implication in 5-year survival

Cubedo, J., Padró, T., Formiga, F., Ferrer, A., Padrós, G., Peña, E., & Badimón, L. (2017) · Translational research · doi:10.1016/j.trsl.2017.04.003 · Cited by 10

The Laterality of Deep Vein Thrombosis in the Pelvic and Lower Extremity Veins

Shin, H. S., & Park, J. K. (2014) · Vascular Specialist International · doi:10.5758/vsi.2014.30.2.56 · Cited by 10

The Evaluation of Antithrombotic and Fibrinolytic Activities of Nattokinase from Bacillus subtilis Natto

Lee, D.-L., Hong, S., Jang, Y.-S., Jang, H.-W., Maeng, C. J., Yoo, C.-B., & Baek, D.-H. (2012) · KSBB Journal · doi:10.7841/ksbbj.2012.27.6.375 · Cited by 9

Von Willebrand factor and von Willebrand disease in ageing: mechanisms, evolving phenotypes, and clinical implications

Seidizadeh, O., Atiq, F., Connell, N. T., Alavi, P., Castaman, G., Lillicrap, D., & Peyvandi, F. (2025) · The Lancet Haematology · doi:10.1016/s2352-3026(25)00262-5 · Cited by 9

WRN polymorphisms affect expression levels of plasminogen activator inhibitor type 1 in cultured fibroblasts

Castro, E., Oviedo‐Rodriguez, V., & Angel-Chávez, L. I. (2008) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-8-5 · Cited by 9

p38 Mitogen-Activated Protein Kinase Is Required for Glucosamine-Induced Endothelial Nitric Oxide Synthase Uncoupling and Plasminogen-Activator Inhibitor Expression

Wu, Z., Xiong, Y., Gajanayake, T., Ming, X., & Yang, Z. (2012) · Circulation Journal · doi:10.1253/circj.cj-12-0016 · Cited by 9

Circadian Rhythms and Acute Coronary Syndrome in the Elderly

Rueda, C. D., Díez‐Villanueva, P., Bonanad, C., & Alfonso, F. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2703082 · Cited by 8

Iberian cured-ham consumption improves endothelial function in healthy subjects

Sabán-Ruiz, J., Fabregate, M., Fabregate, M., Andrés-Castillo, A., Palomino‐Antolín, A., Barrio‐Carreras, D., Martín-Fernández, L., Altamirano, F., Fernández-Fernández, C., & Andrés‐Lacueva, C. (2016) · The journal of nutrition health & aging · doi:10.1007/s12603-016-0848-1 · Cited by 8

Does angiotensin receptor blockade ameliorate the prothrombotic tendency in hypertensive patients with atrial fibrillation? breaking the vicious cycle

Takeshita, K., & Murohara, T. (2014) · Hypertension Research · doi:10.1038/hr.2014.48 · Cited by 8

How to manage bleeding disorders in aging patients needing surgery

Abou‐Ismail, M. Y., & Connell, N. T. (2021) · Hematology · doi:10.1182/hematology.2021000288 · Cited by 7

A New Method for In Vivo Visualization of Vessel Remodeling Using a Near‐Infrared Dye

Billaud, M., ROSS, J. A., Greyson, M. A., Bruce, A. C., Seaman, S. A., Heberlein, K. R., Han, J., Best, A. K., Peirce, S. M., & Isakson, B. E. (2011) · Microcirculation · doi:10.1111/j.1549-8719.2011.00085.x · Cited by 7

The risk for post-thrombotic syndrome of subjects with deep vein thrombosis in an Indonesian referral hospital: a retrospective cohort study

Ariyanti, F., Sukrisman, L., Antono, D., & Harimurti, K. (2023) · Thrombosis Journal · doi:10.1186/s12959-023-00482-7 · Cited by 7

Increased Serum PAI-1 Levels in Subjects with Metabolic Syndrome and Long-Term Adverse Mental Symptoms: A Population-Based Study

Huotari, A., Lehto, S. M., NISKANEN, L. K., Herzig, K., Hintikka, J. J., Koivumaa-Honkanen, H. T., Tolmunen, T., Honkalampi, K. M., Kaikkonen, N., & Viinamäki, H. T. (2010) · Cardiovascular Psychiatry and Neurology · doi:10.1155/2010/501349 · Cited by 7

Self-reported sleep disturbance is associated with elevated levels of PAI-1 in individuals with a recorded history of depressive symptoms

Elomaa, A.-P., Koivumaa-Honkanen, H. T., NISKANEN, L. K., Honkalampi, K. M., Valkonen‐Korhonen, M., Herzig, K., Viinamäki, H. T., & Lehto, S. M. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.07.017 · Cited by 7

Plasminogen activator Inhibitor-1 in systemic sclerosis: A nexus of fibrosis, vasculopathy, and senescence

Takahashi, T., Takahashi, T., & Asano, Y. (2025) · Biomedical Journal · doi:10.1016/j.bj.2025.100906 · Cited by 6

Molecular and Functional Alterations in the Cerebral Microvasculature in an Optimized Mouse Model of Sepsis-Associated Cognitive Dysfunction

Ávila‐Gómez, P., Shingai, Y., Dash, S., Liu, C., Callegari, K., Meyer, H. C., Khodarkovskaya, A., Aburakawa, D., Uchida, H., Faraco, G., et al. (2024) · eNeuro · doi:10.1523/eneuro.0426-23.2024 · Cited by 7

Fibrinolytic effects of peroneal nerve stimulation in patients with lower limb vascular disease

Barnes, R., Madden, L. A., & Chetter, I. C. (2015) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0000000000000409 · Cited by 6

The Effects of Pharmacologic Plasminogen Activator Inhibitor-1 Inhibition in Acute and Chronic Rejection in Murine Cardiac Allografts

Ogawa, M., Suzuki, J., Yamaguchi, Y., Muto, S., Itai, A., Hirata, Y., Isobe, M., & Nagai, R. (2010) · Transplantation · doi:10.1097/tp.0b013e3181fd3c0f · Cited by 6

Lyophilized MSC-EVs attenuates COVID-19 pathogenesis by regulating the JAK/STAT pathway

Ebrahim, N., AlSaihati, H., Alali, Z., Mahmoud, S. Y., Rabaan, A. A., Dessouky, A. A., Salim, R. F., Shamaa, A., Abdallah, A. N., Elsherbiny, N. M., et al. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04284-8 · Cited by 6

Antithrombotic strategies in elderly patients with acute coronary syndrome

Dillinger, J., Laine, M., Bouajila, S., Paganelli, F. F., Henry, P., & Bonello, L. (2021) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2020.12.002 · Cited by 5

How I treat von Willebrand disorders in older adults

Poston, J. N., & Kruse‐Jarres, R. (2023) · Blood · doi:10.1182/blood.2022018534 · Cited by 5

MicroRNAs and Endothelial Dysfunction in Relation to Obesity and Type 2 Diabetes

Karolina, D. S. (2014) · Journal of Molecular and Genetic Medicine · doi:10.4172/1747-0862.s1-011 · Cited by 5

The Physical Burden of Immunoperception

Saghazadeh, A., & Rezaei, N. (2019) · Springer eBooks · doi:10.1007/978-3-030-10620-1_10 · Cited by 5

Perioperative glycemic status is linked to postoperative complications in non-intensive care unit patients with type-2 diabetes: a retrospective study

Oba, T., Nagao, M., Kobayashi, S., Yamaguchi, Y., Nagamine, T., Tanimura‐Inagaki, K., Fukuda, I., & Sugihara, H. (2022) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188221099349 · Cited by 5

Coagulation and wound repair during COVID-19

Menachery, V. D., & Gralinski, L. E. (2021) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2021.06.006 · Cited by 5

Atrial Fibrillation and Stroke in Elderly Patients

Dang, G., Jahangir, I. A., Sra, J. S., Tajik, A. J., & Jahangir, A. (2016) · Journal of patient-centered research and reviews · doi:10.17294/2330-0698.1409 · Cited by 5

Endothelial Dysfunction and Hemostatic System Activation in Relation to Shift Workers, Social Jetlag, and Chronotype in Female Nurses

Saharov, G., Salti, B., Bareya, M., Keren‐Politansky, A., Fodi, M., Shochat, T., & Nadir, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020482 · Cited by 4

Involvement of plasminogen activator inhibitor-1 in p300/p53-mediated age-related atrial fibrosis

Lai, Y., He, J., Gao, X., Peng, D., Zhou, H., Xu, Y., Luo, X., Yang, H., Zhang, M., Deng, C., et al. (2023) · PeerJ · doi:10.7717/peerj.16545 · Cited by 4

Unconventional localization of PAI-1 in PML bodies: A possible link with cellular growth of endothelial cells

Gehlot, P., Brünnert, D., Kaushik, V., Yadav, A., Bage, S., Gaur, K., Saini, M. R., Ehrhardt, J., Manjunath, G. K., Kumar, A., et al. (2024) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2024.101793 · Cited by 4

Sulodexide and Alzheimer’s Disease: A Preliminary Prospective Study

Lasierra-Cirujeda, J., Pascual-Salcedo, M. J. A., & Aza‐Pascual‐Salcedo, M. (2016) · World Journal of Cardiovascular Diseases · doi:10.4236/wjcd.2016.62007 · Cited by 4

Embryonic Stem Cells: Prospects of Regenerative Medicine for the Treatment of Human Aging

West, M. D. (2010) · Springer eBooks · doi:10.1007/978-90-481-3999-6_14 · Cited by 4

Impact of Plasminogen Activator Inhibitor-1 Serum Levels and the -675 4G/5G Variant in the SERPINE1 Gene on Systemic Sclerosis in a Mexican Population

Lomelí-Nieto, J. Á., Muñóz-Valle, J. F., Navarro‐Zarza, J. E., Baños‐Hernández, C. J., Gutiérrez-Brito, J. A., Renteria-Cabrera, V., Horta-Chávez, E. A., Morales‐Núñez, J. J., García‐Arellano, S., Parra‐Rojas, I., et al. (2024) · Life · doi:10.3390/life14091056 · Cited by 3

Inflammation as an exacerbation marker and target for prophylaxis against Coronavirus Disease 2019-related thrombosis

Ono, D., Ohno, Y., Izumida, Y., Ohno, H., Oka, H., & Takeshita, K. (2023) · International Journal of Medical Sciences · doi:10.7150/ijms.78911 · Cited by 3

Associations of Thrombotic-Hemostatic Factors with Cardiovascular Disease~!2009-10-29~!2009-12-22~!2010-04-08~!

Lioudaki, E., & Ganotakis, E. S. (2012) · The Open Clinical Chemistry Journal · doi:10.2174/1874241601003010025 · Cited by 3

Plasminogen Activator Inhibitor-1 as a Therapeutic Target for Healthy Longevity, Immunosenescence, and Age-Related Disease: Translational Development of the Small-Molecule Inhibitor TM5614

Abdelhakim, M., & Miyata, T. (2026) · Cells · doi:10.3390/cells15100941 · Cited by 2

Feeble awake effects of plasminogen activator inhibitor type-1 in mice

Sakakibara, H., Romanowski, C. P. N., Jakubcakova, V., Flachskamm, C., Shimoi, K., & Kimura, M. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.02.023 · Cited by 2

Immunohistochemical expression of plasminogen activator inhibitor-1 in subcutaneous versus omental adipose tissue in patients after elective abdominal surgery

Yildiz, M., Bozkurtlar, E. B., Azizy, A., & Ağırbaşlı, M. A. (2019) · Autopsy and Case Reports · doi:10.4322/acr.2019.121 · Cited by 2

Supplementation of selenium-enriched yeast attenuates age-dependent transcriptional changes of heart in mitochondrial DNA mutator mice

Xiao, R., Spangler, L., Routt, K., Lan, Z., Johnson, C. A., Prolla, T. A., & Power, R. F. (2014) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v4i3.22 · Cited by 2

Common Genetic Determinants of Coagulation and Fibrinolysis

Carter, A. M., Standeven, K. F., & Grant, P. J. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-383834-6.00060-4 · Cited by 2

Coagulation/Fibriolytic system and vascular disorder

Nagai, N. (2011) · Japanese Journal of Thrombosis and Hemostasis · doi:10.2491/jjsth.22.41 · Cited by 2

Aging: Thromboembolic Disease, Metabolic Syndrome, Type 2 Diabetes Mellitus, and Alzheimer’s Disease

Lasierra-Cirujeda, J., Pascual-Salcedo, M. J. A., Lasierra-Ibañez, A., AZA, C. L., & Aza‐Pascual‐Salcedo, M. (2016) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2016.45001 · Cited by 3

A contemporary review of plasminogen activator inhibitor 1 in cardiovascular disease and broader disease state implications

Becerra, M., Soogoor, N., Vu, J., Wortley, J., & Sathyamoorthy, M. (2026) · Blood Vessels Thrombosis & Hemostasis · doi:10.1016/j.bvth.2026.100141 · Cited by 1

Novel Cerebrovascular Disease Blood Biomarkers Identified by Targeted Proteomics in a High-Risk Native American Population

Wesley, U. V., Madrid, A., Riesenberg, A., Wilbrand, S. M., Nelson, D. E., Danforth, D., Blohowiak, C. J., Vandenberg, C., Lane, K., Maybock, J., et al. (2026) · World Neurosurgery · doi:10.1016/j.wneu.2026.124821 · Cited by 1

Hematologic Changes with Aging

Fischer, P. E., DeLoughery, T. G., & Schreiber, M. A. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8501-8_7 · Cited by 1

Evaluation of Nattokinase for Antithrombotic Effect and Pharmacological Efficacy by a Biological Test and Clinical Trial

Kim, J.-B., Yoo, C.-B., Shin, H., Jung, J., & Jang, H.-W. (2011) · KSBB Journal · doi:10.7841/ksbbj.2011.26.5.393 · Cited by 1

Plasminogen activator inhibitor-1 as a marker of cardiovascular response in professional mountain ultra-marathon runners

Lombardi, G., Vernillo, G., Sansoni, V., Perego, S., Barbuti, A., Merati, G., Schena, F. F., Banfi, G., & Torre, A. L. (2016) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2016-0295 · Cited by 1

Plasminogen Activator Inhibitor-1, Body Fat and Insulin Action in Aging Women.

McMillin, S. L., & Ryan, A. S. (2014) · PubMed · Cited by 1

Aging and thrombotic tendency

Yamamoto, K. (2015) · Japanese Journal of Thrombosis and Hemostasis · doi:10.2491/jjsth.26.265 · Cited by 1

Nutraceutical COMP-4 confers protection against endothelial dysfunction through the eNOS/iNOS-NO-cGMP pathway

Ferrini, M. G., Abraham, A., Millán, R. L., Graciano, L., Eleswarapu, S. V., & Rajfer, J. (2025) · PLoS ONE · doi:10.1371/journal.pone.0316798 · Cited by 1

Age features of the hemostatic system in people with insulin resistance and prediabetic carbohydrate metabolism disorders

Korkushko, O. V., Lugovskoy, E. V., Shatilo, V. B., Колесникова, И. Н., Ischuk, V. A., & Наскалова, С. (2015) · Advances in Gerontology · doi:10.1134/s2079057015040128 · Cited by 1

Hubungan antara Kadar Plasminogen Activator Inhibitor-1 Serum dengan Derajat Kontrol Penderita Asma

Yanti, A. K. E. (2019) · UMI Medical Journal · doi:10.33096/umj.v3i1.31 · Cited by 1

Recent Insights into the Molecular and Cellular Contributions to Venous Thrombosis

Henke, P. K., Diaz, J. A., Myers, D. D., & Wakefield, T. W. (2012) · Humana Press eBooks · doi:10.1007/978-1-61779-906-8_3 · Cited by 1

A clinical cardiology perspective of thrombophilias

Becker, R. C. (2010) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-010-0511-3 · Cited by 1

Commentary on “The suboptimal fibrinolytic response in COVID‐19 is dictated by high PAI‐1”

von Meijenfeldt, F. A. (2022) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.15839 · Cited by 1

EFFECT OF DEXAMETHASONE TREATMENT ON PAI-1 PRODUCTION BY HUMAN LUNG FIBROBLASTS

Takahashi, K., Kobayashi, K., Mitsui, M., Odaka, T., Nakamura, H., & Matsuoka, T. (2008) · doi:10.11418/jtca.27.149

A pathological role of PAI-1 in metabolic syndrome

Yamamoto, K. (2006) · Japanese Journal of Thrombosis and Hemostasis · doi:10.2491/jjsth.17.120

Dietary effects on gene regulation and function in human adipose tissue in obesity

Nordström, E. A. (2007) · Figshare

MicroRNAs and Endothelial Dysfunction in Relation to Obesity and Type

Maskomani, S., Armugam, A., & Jeyaseelan, K. (2014)

Aging of the Vasculature and Related Systems

Marı́n-Garcı́a, J., Goldenthal, M. J., & Moe, G. W. P. L. (2007) · Springer eBooks · doi:10.1007/978-0-387-74072-0_5

The Role of proteases and chaperones in extracellular proteostasis

Constantinescu, P. (2015) · Research Online (University of Wollongong)

PAI-I as a therapeutic target of a prothrombotic state：Insights from a murine model

Takeshita, K. (2013) · Japanese Journal of Thrombosis and Hemostasis · doi:10.2491/jjsth.24.516

Stress-induced thrombosis

Takeshita, K. (2013) · Japanese Journal of Thrombosis and Hemostasis · doi:10.2491/jjsth.24.56

Hematological Changes with Aging

Fischer, P. E., DeLoughery, T. G., Gesin, G., & Schreiber, M. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-48687-1_8

The Aging Heart

Marı́n-Garcı́a, J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-404599-6.00019-6

The Physiopathological Crossroads of Aging

Lasierra-Cirujeda, J., Coronel, P., Pascual-Salcedo, M. J. A., Gimeno, M., Salcedo, M. M. A. P., Lasierra-Ibañez, A., & AZA, C. L. (2019) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2019.76007

Thromboembolic disease: a geriatric syndrome

Galdi, F., Pedone, C., & Incalzi, R. A. (2020) · Journal of Gerontology and Geriatrics · doi:10.36150/2499-6564-437

Hematology and hemostasis in the pediatric, geriatric, and pregnant populations

Goossen, L. H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-53045-3.00052-0

Anti-Hypertensive Effects of Black Raspberry (Rubus occidentalis) in Spontaneously Hypertensive Rats (SHR)

Lee, J., Choi, H. R., Lee, S. J., Lee, M. J., Jang, J. E., Kwon, J., Park, P. J., & Lee, T.-B. (2015) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2015.44.4.483

Contents

(2009) · Clinics in Laboratory Medicine · doi:10.1016/s0272-2712(09)00106-1

Chemoresistance and metastasis in colorectal cancer

Wong, S. Q. R. (2022) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/155418

The Aging Heart: A Post-Genomic Appraisal

Marı́n-Garcı́a, J. (2007) · Elsevier eBooks · doi:10.1016/b978-012373698-7/50019-x

Overview of Blood Coagulation and the Pathophysiology of Blood Coagulation Disorders

Cardenas, J. C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00160-7

Risk factors of thrombosis in Chinese subjects with myelodysplastic syndromePreprint

han, H., sun, X., ge, H., & feng, J. (2023) · Research Square · doi:10.21203/rs.3.rs-2852520/v1

Treatment of stroke in aged male and female rats with Vepoloxamer and tPA reduces neurovascular damage

Zhang, L., Luo, H., Li, C., Teng, H., Powell, B., Lü, M., Chopp, M., & Zhang, Z. G. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1282736

Additional file 1 of DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function

Matías‐García, P. R., Ward-Caviness, C. K., Raffield, L. M., Gao, X., Zhang, Y., Wilson, R., Gao, X. Y., Nano, J., Bostom, A. G., Colicino, E., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14722140

The significance of PAI-1 expression in chronic diseases: from metabolic syndrome, emotional stress and chronic kidney disease to aging

Takeshita, K. (2025) · Japanese Journal of Thrombosis and Hemostasis · doi:10.2491/jjsth.36.396

A 3D Human Neuron‐on‐Chip Platform to Monitor Neuronal Injury Responses

Tang, R., Latchoumane, C.-F. V., Chopra, A., Sarkar, M. M., Kim, C., Gonsalves, N., Wu, H., Sentmanat, J. C., Liu, A., Mhatre‐Winters, I., et al. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.202503457

THROMBOELASTOGRAPHY IN THE ASSESSMENT OF COAGULATION CHANGES IN PERIPHERAL VASCULAR DISEASE

Shankar, V. K. (2010)

Additional file 2 of DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function

Matías‐García, P. R., Ward-Caviness, C. K., Raffield, L. M., Gao, X., Zhang, Y., Wilson, R., Gào, X., Nano, J., Bostom, A. G., Colicino, E., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14722143

Additional file 3 of DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function

Matías‐García, P. R., Ward-Caviness, C. K., Raffield, L. M., Gao, X., Zhang, Y., Wilson, R., Gào, X., Nano, J., Bostom, A. G., Colicino, E., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14722146

Plasminogen Activator Inhibitor-1 in Aging

Takeshita, K., Saito, H., & Yamamoto, K. (2014) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0034-1384635 · Cited by 70

Increased Expression of Plasminogen Activator Inhibitor-1 with Fibrin Deposition in a Murine Model of Aging, "Klotho" Mouse

Takeshita, K., Yamamoto, K., Ito, M., Kondo, T., Matsushita, T., Hirai, M., Kojima, T., Nishimura, M., Nabeshima, Y., Loskutoff, D. J., et al. (2002) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2002-36699 · Cited by 86

REVIEW: Plasminogen Activator Inhibitor‐1 (PAI‐1): A Key Factor Linking Fibrinolysis and Age‐Related Subclinical and Clinical Conditions

Cesari, M., Pahor, M., & Incalzi, R. A. (2010) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2010.00171.x · Cited by 470

Plasminogen activator inhibitor-1 is a major stress-regulated gene: Implications for stress-induced thrombosis in aged individuals

Yamamoto, K., Takeshita, K., Shimokawa, T., Yi, H., Isobe, K., Loskutoff, D. J., & Saito, H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022608799 · Cited by 163

A contemporary review of plasminogen activator inhibitor 1 in cardiovascular disease and broader disease state implications

Becerra, M., Soogoor, N., Vu, J., Wortley, J., & Sathyamoorthy, M. (2026) · Blood Vessels Thrombosis & Hemostasis · doi:10.1016/j.bvth.2026.100141 · Cited by 1