Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

Wright, S. D., Ramos, R., Tobias, P. S., Ulevitch, R. J., & Mathison, J. C. (1990) · Science · doi:10.1126/science.1698311 · Cited by 3,986

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., & Akira, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.3749 · Cited by 3,374

Obesity and the risk of heart failure

Kenchaiah, S., Evans, J. C., Levy, D., Wilson, P. W. F., Benjamin, E. J., Larson, M. G., Kannel, W. B., & Vasan, R. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020245 · Cited by 3,093

Association of psychosocial risk factors with risk of acute myocardial infarction in 11 119 cases and 13 648 controls from 52 countries (the INTERHEART study): case-control study

Rosengren, A., Hawken, S., Ôunpuu, S., Sliwa, K., Zubaid, M., Almahmeed, W. A., Blackett, K. N., Sitthi-amorn, C., Sato, H., & Yusuf, S. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17019-0 · Cited by 2,414

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

Garg, U. C., & Hassid, A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114081 · Cited by 2,154

Hemostatic Factors and the Risk of Myocardial Infarction or Sudden Death in Patients with Angina Pectoris

Thompson, S. G., Kienast, J., Pyke, S., Haverkate, F., & van de Loo, J. C. W. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321003 · Cited by 1,819

Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?

Yudkin, J. S., Kumari, M., Humphries, S. E., & Mohamed-Ali, V. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00463-3 · Cited by 1,775

Fibrinogen as a Risk Factor for Stroke and Myocardial Infarction

Wilhelmsen, L., Svärdsudd, K., Korsan-Bengtsen, K., Larsson, B., Welin, L., & Tibblin, G. (1984) · New England Journal of Medicine · doi:10.1056/nejm198408233110804 · Cited by 1,645

Postmortem examination of COVID‐19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction

Menter, T., Haslbauer, J. D., Nienhold, R., Savic, S., Hopfer, H., Deigendesch, N., Frank, S., Turek, D., Willi, N., Pargger, H., et al. (2020) · Histopathology · doi:10.1111/his.14134 · Cited by 1,239

Determinants and Time Course of the Postthrombotic Syndrome after Acute Deep Venous Thrombosis

Kahn, S. R., Shrier, I., Julian, J. A., Ducruet, T., Arsenault, L., Miron, M. ‐., Roussin, A., Desmarais, S., Joyal, F., Kassis, J., et al. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-149-10-200811180-00004 · Cited by 850

Aging and vascular endothelial function in humans

Seals, D. R., Jablonski, K. L., & Donato, A. J. (2011) · Clinical Science · doi:10.1042/cs20100476 · Cited by 725

Circadian misalignment increases cardiovascular disease risk factors in humans

Morris, C. J., Purvis, T. E., Hu, K., & Scheer, F. A. J. L. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516953113 · Cited by 691

REVIEW: Plasminogen Activator Inhibitor‐1 (PAI‐1): A Key Factor Linking Fibrinolysis and Age‐Related Subclinical and Clinical Conditions

Cesari, M., Pahor, M., & Incalzi, R. A. (2010) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2010.00171.x · Cited by 470

An aberrant STAT pathway is central to COVID-19

Matsuyama, T., Kubli, S. P., Yoshinaga, S. K., Pfeffer, K., & Mak, T. W. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00633-7 · Cited by 294

Thrombosis in Coronavirus disease 2019 (COVID-19) through the prism of Virchow’s triad

Ahmed, S., Zimba, O., & Gasparyan, A. Y. (2020) · Clinical Rheumatology · doi:10.1007/s10067-020-05275-1 · Cited by 251

Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19

D’Agnillo, F., Walters, K.-A., Xiao, Y., Sheng, Z.-M., Scherler, K., Park, J., Gygli, S., Rosas, L. A., Sadtler, K., Kalish, H., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abj7790 · Cited by 237

Aging, Cellular Senescence, and Alzheimer’s Disease

Liu, R.-M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23041989 · Cited by 267

Plasminogen Activator Inhibitor Type‐1 as a Regulator of Fibrosis

Rabieian, R., Boshtam, M., Zareei, M., Kouhpayeh, S., Masoudifar, A., & Mirzaei, H. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26146 · Cited by 159

Hypercoagulability after trauma: Hemostatic changes and relationship to venous thromboembolism

Selby, R., Geerts, W., Ofosu, F. A., Craven, S. J., Dewar, L., Phillips, A., & Szalai, J. P. (2008) · Thrombosis Research · doi:10.1016/j.thromres.2008.10.002 · Cited by 151

Hemostasis and aging

Franchini, M. (2006) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2006.06.004 · Cited by 145

Hemostasis factors and aging

Mari, D., Coppola, R., & Provenzano, R. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.06.014 · Cited by 147

Aging Hemostasis: Changes to Laboratory Markers of Hemostasis As We Age—A Narrative Review

Franchini, M., Lippi, G., & Favaloro, E. J. (2014) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0034-1384631 · Cited by 145

Oxidative Stress in Aging-Matters of the Heart and Mind

Venkataraman, K., Khurana, S., & Tai, T. C. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140917897 · Cited by 146

Plasminogen Activator Inhibitor-1 Antagonist TM5441 Attenuates N ω -Nitro- l -Arginine Methyl Ester–Induced Hypertension and Vascular Senescence

Boe, A. E., Eren, M., Murphy, S. B., Kamide, C., Ichimura, A., Terry, D. B., McAnally, D., Smith, L. H., Miyata, T., & Vaughan, D. E. (2013) · Circulation · doi:10.1161/circulationaha.113.003192 · Cited by 132

The Plasminogen–Activator Plasmin System in Physiological and Pathophysiological Angiogenesis

Ismail, A. A., Shaker, B. T., & Bajou, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010337 · Cited by 141

Sustained prothrombotic changes in COVID-19 patients 4 months after hospital discharge

von Meijenfeldt, F. A., Havervall, S., Adelmeijer, J., Lundström, A., Magnusson, M., Mackman, N., Thålin, C., & Lisman, T. (2021) · Blood Advances · doi:10.1182/bloodadvances.2020003968 · Cited by 131

A Serpin With a Finger in Many PAIs: PAI-1's Central Function in Thromboinflammation and Cardiovascular Disease

Morrow, G. B., Whyte, C. S., & Mutch, N. J. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.653655 · Cited by 121

Atherothrombosis and Oxidative Stress: Mechanisms and Management in Elderly

Violi, F., Loffredo, L., Carnevale, R., Pignatelli, P., & Pastori, D. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6963 · Cited by 125

Adipose Tissue‐Derived Plasminogen Activator Inhibitor‐1 Function and Regulation

Kaji, H. (2016) · Comprehensive physiology · doi:10.1002/cphy.c160004 · Cited by 117

Cell non-autonomous regulation of health and longevity

Miller, H. A., Dean, E. S., Pletcher, S. D., & Leiser, S. F. (2020) · eLife · doi:10.7554/elife.62659 · Cited by 102

COVID-19 Vasculopathy: Mounting Evidence for an Indirect Mechanism of Endothelial Injury

Nicosia, R. F., Ligresti, G., Caporarello, N., Akilesh, S., & Ribatti, D. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.05.007 · Cited by 103

Knockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimer's disease

Liu, R., Groen, T. V., Katre, A. K., Cao, D., Kadisha, I., Ballinger, C. A., Wang, L., Carroll, S. L., & Li, L. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.06.003 · Cited by 97

Stress Augments Insulin Resistance and Prothrombotic State

Uchida, Y., Takeshita, K., Yamamoto, K., Kikuchi, R., Nakayama, T., Nomura, M., Cheng, X. W., Egashira, K., Matsushita, T., Nakamura, H., et al. (2012) · Diabetes · doi:10.2337/db11-0828 · Cited by 90

Metabolic, inflammatory, endothelial and haemostatic markers in a group of Italian obese children and adolescents

Giordano, P., Vecchio, G., Cecinati, V., Delvecchio, M., Altomare, M., Palma, F. D., Mattia, D. D., Cavallo, L., & Faienza, M. F. (2011) · European Journal of Pediatrics · doi:10.1007/s00431-010-1356-7 · Cited by 90

Predictors of the post‐thrombotic syndrome with non‐invasive venous examinations in patients 6 weeks after a first episode of deep vein thrombosis

Tick, L. W., Doggen, C. J. M., Rosendaal, F. R., Faber, W. R., Bousema, M. T., Mackaay, A. J. C., van Balen, P., & Kramer, M. H. H. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.04065.x · Cited by 88

PAI-1, the Plasminogen System, and Skeletal Muscle

Rahman, F. A., & Krause, M. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197066 · Cited by 88

Angiotensin receptor blocker irbesartan reduces stress-induced intestinal inflammation via AT1a signaling and ACE2-dependent mechanism in mice

Yisireyili, M., Uchida, Y., Yamamoto, K., Nakayama, T., Cheng, X. W., Matsushita, T., Nakamura, S., Murohara, T., & Takeshita, K. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.11.010 · Cited by 85

The aging venous system: from varicosities to vascular cognitive impairment

Molnár, A., Nádasy, G. L., Dörnyei, G., Patai, B. B., DelFavero, J., Fülöp, G., Kirkpatrick, A. C., Ungvari, Z. I., & Merkely, B. P. (2021) · GeroScience · doi:10.1007/s11357-021-00475-2 · Cited by 74

The pathophysiology of chronic subdural hematoma revisited: emphasis on aging processes as key factor

Weigel, R., Schilling, L., & Krauss, J. K. (2022) · GeroScience · doi:10.1007/s11357-022-00570-y · Cited by 70

Plasminogen Activator Inhibitor-1 as a Predictor of Postoperative Atrial Fibrillation After Cardiopulmonary Bypass

Pretorius, M., Donahue, B. S., Yu, C., Greelish, J. P., Roden, D. M., & Brown, N. J. (2007) · Circulation · doi:10.1161/circulationaha.106.677906 · Cited by 69

Electronic cigarette exposure causes vascular endothelial dysfunction due to NADPH oxidase activation and eNOS uncoupling

El‐Mahdy, M. A., Ewees, M. G., Eid, M. S., Mahgoup, E. M., Khaleel, S. A., & Zweier, J. L. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00460.2021 · Cited by 69

Intra-Arterial Recanalization Techniques for Patients 80 Years or Older with Acute Ischemic Stroke: Pooled Analysis from 4 Prospective Studies

Qureshi, A. I., Suri, M. F., Georgiadis, A., Vazquez, G., & Janjua, N. A. (2009) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1503 · Cited by 60

Plasminogen activator inhibitor-1 is an aggregate response factor with pleiotropic effects on cell signaling in vascular disease and the tumor microenvironment

Gramling, M., & Church, F. (2010) · Thrombosis Research · doi:10.1016/j.thromres.2009.11.034 · Cited by 58

Post-challenge hyperglycaemia, nitric oxide production and endothelial dysfunction: the putative role of asymmetric dimethylarginine (ADMA).

Siervo, M., Corander, M., Stranges, S., & Bluck, L. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.10.003 · Cited by 55

Role of oxidative stress on platelet hyperreactivity during aging

Eduardo Fuentes, Q., & Palomo, I. F. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.02.026 · Cited by 55

Impaired ECM Remodeling and Macrophage Activity Define Necrosis and Regeneration Following Damage in Aged Skeletal Muscle

Rahman, F. A., Angus, S. A., Stokes, K., Karpowicz, P. A., & Krause, M. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134575 · Cited by 57

Comorbidity-associated glutamine deficiency is a predisposition to severe COVID-19

Matsuyama, T., Yoshinaga, S. K., Shibue, K., & Mak, T. W. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00892-y · Cited by 54

Silibinin as potential tool against SARS‐Cov ‐2: In silico spike receptor‐binding domain and main protease molecular docking analysis, and in vitro endothelial protective effects

Speciale, A., Muscarà, C., Molonia, M. S., Cimino, F., Saija, A., & Giofrè, S. V. (2021) · Phytotherapy Research · doi:10.1002/ptr.7107 · Cited by 52

Circulating Inflammatory Markers and Hemostatic Factors in Age-Related Maculopathy: A Population-Based Case–Control Study

Wu, K. H. C., Tan, A. G., Rochtchina, E., Favaloro, E. J., Williams, A., Mitchell, P., & Wang, J. J. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0223 · Cited by 53

The Central Role of Fibrinolytic Response in COVID-19—A Hematologist’s Perspective

Kwaan, H. C., & Lindholm, P. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031283 · Cited by 50

Cerebral venous thrombosis in COVID-19

Ghosh, R., Roy, D., Mandal, A., Pal, S. K., Swaika, B. C., Naga, D., Pandit, A., Ray, B. K., & Benito‐León, J. (2021) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2021.04.026 · Cited by 51

Markers of endothelial cell activation and neutrophil extracellular traps are elevated in immune thrombocytopenia but are not enhanced by thrombopoietin receptor agonists

Garabet, L., Henriksson, C. E., Lozano, M. L., Ghanima, W., Bussel, J. B., Brodin, E. E., Fernández-Pérez, M. P., Martı́nez, C., Gónzález‐Conejero, R., Mowinckel, M., et al. (2019) · Thrombosis Research · doi:10.1016/j.thromres.2019.11.031 · Cited by 49

The Aging Heart: A Molecular and Clinical Challenge

Lazzeroni, D., Villatore, A., Souryal, G., Pili, G., & Peretto, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232416033 · Cited by 52

Gene expression profile of mouse white adipose tissue during inflammatory stress: age‐dependent upregulation of major procoagulant factors

Starr, M. E., Hu, Y., Stromberg, A. J., Carmical, J. R., Wood, T. G., Evers, B. M., & Saitō, H. (2012) · Aging Cell · doi:10.1111/acel.12040 · Cited by 46

The Molecular Mechanisms of Intestinal Inflammation and Fibrosis in Crohn’s Disease

Hayashi, Y., & Nakase, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.845078 · Cited by 46

Aging is associated with impaired thrombus resolution in a mouse model of stasis induced thrombosis

McDonald, A. P., Meier, T. R., Hawley, A. E., Thibert, J. N., Farris, D. M., Wrobleski, S. K., Henke, P. K., Wakefield, T. W., & Myers, D. D. (2009) · Thrombosis Research · doi:10.1016/j.thromres.2009.06.005 · Cited by 44

Post-thrombotic syndrome 3 years after deep venous thrombosis in the Thrombosis and Pulmonary Embolism in Out-Patients (TULIPA) PLUS Registry

Hach-Wunderle, V., Bauersachs, R. M., Gerlach, H.-E., Eberle, S., Schellong, S., Riess, H. B., Carnarius, H., & Rabe, E. (2013) · Journal of Vascular Surgery Venous and Lymphatic Disorders · doi:10.1016/j.jvsv.2012.07.003 · Cited by 42

Platelets in aging and cancer—“double-edged sword”

Faria, A. V. S., Andrade, S. S., Peppelenbosch, M. P., Ferreira-Halder, C. V., & Fuhler, G. M. (2020) · Cancer and Metastasis Reviews · doi:10.1007/s10555-020-09926-2 · Cited by 38

Comparison of Plasminogen Activator Inhibitor-1, Tissue Type Plasminogen Activator Antigen, Fibrinogen, and D-Dimer Levels in Various Age Decades in Patients With Type 2 Diabetes Mellitus and Stable Coronary Artery Disease (from the BARI 2D Trial)

McBane, R. D., Hardison, R. M., & Sobel, B. E. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.08.643 · Cited by 40

Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase

Garcia, V. G., Park, E. J., Siragusa, M., Fröhlich, F., Haque, M. M., Pascale, J. V., Heberlein, K. R., Isakson, B. E., Stuehr, D. J., & Sessa, W. C. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1918761117 · Cited by 37

DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function

Matías‐García, P. R., Ward-Caviness, C. K., Raffield, L. M., Gao, X., Zhang, Y., Wilson, R., Gao, X. Y., Nano, J., Bostom, A. G., Colicino, E., et al. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01082-w · Cited by 37

Aging hearts and vessels: Masters of adaptation and survival

Pepe, S., & Lakatta, E. G. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.03.004 · Cited by 39

The Role of PAI-1 and Adiponectin on the Inflammatory State and Energy Balance in Obese Adolescents with Metabolic Syndrome

Corgosinho, F. C., de Piano, A., Sanches, P. D. L., Campos, R. M. D. S., Silva, P. L., Carnier, J., Oyama, L. M., Tock, L., Tufik, S., de Mello, M. T., et al. (2011) · Inflammation · doi:10.1007/s10753-011-9397-2 · Cited by 38

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Chukowry, P., Spittle, D. A., & Turner, A. M. (2021) · International Journal of COPD · doi:10.2147/copd.s280157 · Cited by 39

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Badran, M., & Gozal, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105516 · Cited by 38

Primary and secondary haemostasis changes related to aging

Sepúlveda, C., Palomo, I. F., & Eduardo Fuentes, Q. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.08.006 · Cited by 36

Fibrinolysis for Intermediate-Risk Pulmonary Embolism

Meyer, G., Vicaut, É., & Konstantinides, S. (2014) · New England Journal of Medicine · doi:10.1056/nejmc1406283 · Cited by 38

Docosahexaenoic acid prevented tumor necrosis factor alpha-induced endothelial dysfunction and senescence

Yamagata, K., Suzuki, S., & Tagami, M. (2015) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2015.10.006 · Cited by 35

Hemostasis and Thrombosis in the Oldest Old

Hoffman, R., Monréal, M., & Tzoran, I. (2018) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0038-1657779 · Cited by 35

Endothelial PPARγ Is Crucial for Averting Age-Related Vascular Dysfunction by Stalling Oxidative Stress and ROCK

Uddin, M. S., Kabir, M. T., Jakaria, M., Mamun, A. A., Niaz, K., Amran, M. S., Barreto, G. E., & Ashraf, G. M. (2019) · Neurotoxicity Research · doi:10.1007/s12640-019-00047-5 · Cited by 34

The plasminogen activating system in the pathogenesis of Alzheimer’s disease

Yepes, M. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.308076 · Cited by 33

Management of Venous Thromboembolism in the Elderly

Spyropoulos, A. C., & Merli, G. J. (2006) · Drugs & Aging · doi:10.2165/00002512-200623080-00003 · Cited by 33

Platelet oxidative stress as a novel target of cardiovascular risk in frail older people

Fuentes, F., Palomo, I. F., & Eduardo Fuentes, Q. (2017) · Vascular Pharmacology · doi:10.1016/j.vph.2017.07.003 · Cited by 35

Plasma markers of inflammation and hemostatic and endothelial activity in naturally overweight and obese dogs

Rafaj, R. B., Kuleš, J., Marinculić, A., Tvarijonaviciute, A., Cerón, J. M. C., Mihaljević, Ž., Tumpa, A., & Mrljak, V. (2016) · BMC Veterinary Research · doi:10.1186/s12917-016-0929-8 · Cited by 33

The beneficial effects of aerobic and concurrent training on metabolic profile and body composition after detraining: a 1-year follow-up in postmenopausal women

Rossi, F. E., Diniz, T. A., Neves, L. M., Fortaleza, A. C. D. S., Gerosa-Neto, J., Inoue, D. S., Buonani, C., Cholewa, J. M., Lira, F. S., & Júnior, I. F. F. (2017) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2016.263 · Cited by 33

Plasminogen activator inhibitor-1 is elevated in patients with COPD independent of metabolic and cardiovascular function

Waschki, B., Watz, H., Holz, O., MAGNUSSEN, H., Olejnicka, B. T., Welte, T., Rabe, K. F., & Janciauskiene, S. M. (2017) · International Journal of COPD · doi:10.2147/copd.s128689 · Cited by 33

Ablation of Angiotensin IV Receptor Attenuates Hypofibrinolysis via PAI-1 Downregulation and Reduces Occlusive Arterial Thrombosis

Numaguchi, Y., Ishii, M., Kubota, R., Morita, Y., Yamamoto, K., Matsushita, T., Okumura, K., & Murohara, T. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.195057 · Cited by 31

Thrombosis and Aging: Fibrin Clot Properties and Oxidative Stress

Konieczyńska, M., Natorska, J., & Undas, A. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0365 · Cited by 33

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von Meijenfeldt, F. A., & Lisman, T. (2021) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0040-1718924 · Cited by 30

Dysregulation of Pulmonary Responses in Severe COVID-19

Wu, D., & Yang, X. O. (2021) · Viruses · doi:10.3390/v13060957 · Cited by 29

PAI-1 Regulation of p53 Expression and Senescence in Type II Alveolar Epithelial Cells

Rana, T., Jiang, C., Banerjee, S., Yi, N., Zmijewski, J. W., Liu, G., & Liu, R.-M. (2023) · Cells · doi:10.3390/cells12152008 · Cited by 32

TP53/miR-34a-associated signaling targets SERPINE1 expression in human pancreatic cancer

Akula, S. M., Ruvolo, P. P., & McCubrey, J. A. (2020) · Aging · doi:10.18632/aging.102776 · Cited by 29

Endothelial and Metabolic Function Interactions in Overweight/Obese Children:

Ciccone, M. M., Faienza, M. F., Altomare, M., Nacci, C., Montagnani, M., Valente, F., Cortese, F., Gesualdo, M., Zito, A., Mancarella, R., et al. (2016) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.31740 · Cited by 29

Transforming growth factor-beta 1 levels in women with prior history of gestational diabetes mellitus

Yener, S., Demir, T., Akıncı, B., Bayraktar, F., Kebapçılar, L., Özcan, M. A., Biberoǧlu, S., & Yeşil, S. (2006) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2006.08.014 · Cited by 29

Lifelong dietary omega-3 fatty acid suppresses thrombotic potential through gut microbiota alteration in aged mice

Saravi, S. S. S., Bonetti, N. R., Pugin, B., Constancias, F., Pasterk, L., Gobbato, S., Akhmedov, A. T., Liberale, L., Lüscher, T. F., Camici, G. G., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102897 · Cited by 28

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Xu, S., Piao, L., Wan, Y., Huang, Z., Meng, X., Inoue, A., Wang, H., Yue, X., Jin, X., Shi, G., et al. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.318455 · Cited by 28

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