Cited by 214Blood Coagulation and Thrombosis MechanismsProtease and Inhibitor MechanismsBlood properties and coagulation

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Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly

YAMAMOTO, K, TAKESHITA, K, KOJIMA, T, TAKAMATSU, J, SAITO, H·2005·Cardiovascular Research

DOI 10.1016/j.cardiores.2004.11.013

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Abstract

Thrombotic cardiovascular diseases increase in incidence in the elderly, a tendency dependent on the age-related changes in vascular and hemostatic systems that include platelets, coagulation, and fibrinolytic factors as well as in the endothelium. The hypercoagulability of and advanced sclerotic changes in the vascular wall may contribute to the increased incidence of thrombosis in the elderly. One of the important key genes for aging-associated thrombosis is plasminogen activator inhibitor-1 (PAI-1), a principal inhibitor of fibrinolysis. The expression of PAI-1 is not only elevated in the elderly but also significantly induced in a variety of pathologies associated with the process of aging. These conditions include obesity, insulin resistance, emotional stress, immune responses, and vascular sclerosis/remodeling. Several cytokines and hormones, including tumor necrosis factor-alpha, transforming growth factor-beta, angiotensin II, and insulin, positively regulate the gene expression of PAI-1. The recent epidemic in obesity with aging in the industrialized society may heighten the risk for thrombotic cardiovascular disease because adipose tissue is a primary source of PAI-1 and cytokines. Emotional or psychosocial stress and inflammation also cause the elevated expression of PAI-1 in an age-specific pattern. Thus, PAI-1 could play a key role in the progression of cardiovascular aging by promoting thrombosis and vascular (athero)sclerosis. Further studies on the genetic mechanism of aging-associated PAI-1 induction will be necessary to define the basis for cardiovascular aging in relation to thrombosis.

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CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein
Wright, S. D., Ramos, R., Tobias, P. S., Ulevitch, R. J., & Mathison, J. C. (1990) · Science · doi:10.1126/science.1698311 · Cited by 3,986
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543
Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product
Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., & Akira, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.3749 · Cited by 3,374
Obesity and the risk of heart failure
Kenchaiah, S., Evans, J. C., Levy, D., Wilson, P. W. F., Benjamin, E. J., Larson, M. G., Kannel, W. B., & Vasan, R. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020245 · Cited by 3,093
Association of psychosocial risk factors with risk of acute myocardial infarction in 11 119 cases and 13 648 controls from 52 countries (the INTERHEART study): case-control study
Rosengren, A., Hawken, S., Ôunpuu, S., Sliwa, K., Zubaid, M., Almahmeed, W. A., Blackett, K. N., Sitthi-amorn, C., Sato, H., & Yusuf, S. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17019-0 · Cited by 2,414
Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.
Garg, U. C., & Hassid, A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114081 · Cited by 2,154
Hemostatic Factors and the Risk of Myocardial Infarction or Sudden Death in Patients with Angina Pectoris
Thompson, S. G., Kienast, J., Pyke, S., Haverkate, F., & van de Loo, J. C. W. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321003 · Cited by 1,819
Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?
Yudkin, J. S., Kumari, M., Humphries, S. E., & Mohamed-Ali, V. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00463-3 · Cited by 1,775
Fibrinogen as a Risk Factor for Stroke and Myocardial Infarction
Wilhelmsen, L., Svärdsudd, K., Korsan-Bengtsen, K., Larsson, B., Welin, L., & Tibblin, G. (1984) · New England Journal of Medicine · doi:10.1056/nejm198408233110804 · Cited by 1,645
PLASMINOGEN ACTIVATOR INHIBITOR IN PLASMA: RISK FACTOR FOR RECURRENT MYOCARDIAL INFARCTION
Hamsten, A., Walldius, G., Szamosi, A., Blombäck, M., de Faire, U., Dahlén, G. H., Landou, C., & Wiman, B. (1987) · The Lancet · doi:10.1016/s0140-6736(87)93050-9 · Cited by 1,474
Increased Plasma Levels of a Rapid Inhibitor of Tissue Plasminogen Activator in Young Survivors of Myocardial Infarction
Hamsten, A., Wiman, B., Fairé, U. D., & Blombäck, M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198512193132501 · Cited by 1,339
The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R., & Simsolo, R. B. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117899 · Cited by 1,305
Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction
Celermajer, D. S., Sørensen, K. E., Bull, C., Robinson, J. T. C., & Deanfield, J. E. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90141-4 · Cited by 1,228
The Pathophysiologic Roles of Interleukin-6 in Human Disease
Papanicolaou, D. A., Wilder, R. L., Manolagas, S. C., & Chrousos, G. P. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-2-199801150-00009 · Cited by 1,146
Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis
Koster, T., Vandenbroucke, J. P., Rosendaal, F. R., Briët, E., Rosendaal, F. R., & Blann, A. D. (1995) · The Lancet · doi:10.1016/s0140-6736(95)90166-3 · Cited by 1,131
Enhanced expression of PAI–1 in visceral fat: Possible contributor to vascular disease in obeisty
Shimomura, I., Funahasm, T., Takahashi, M., Maeda, K., Kotani, K., Nakamura, T., Yamashita, S., Miura, M., Fukuda, Y., Takemura, K., et al. (1996) · Nature Medicine · doi:10.1038/nm0796-800 · Cited by 890
Plasminogen-Activator Inhibitor Type 1 and Coronary Artery Disease
Kohler, H. P., & Grant, P. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006153422406 · Cited by 805
Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure
Heymans, S. R. B., Luttun, A., Nuyens, D., Theilmeier, G., Creemers, E. E., Moons, L., Dyspersin, G. D., Cleutjens, J. P. M., Shipley, M., Angellilo, A., et al. (1999) · Nature Medicine · doi:10.1038/13459 · Cited by 793
Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction.
Eriksson, P. O., Kallin, B., Hooft, F. M. V. '., Båvenholm, P., & Hamsten, A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.6.1851 · Cited by 737
Age-Related Reduction of NO Availability and Oxidative Stress in Humans
Taddei, S., Virdis, A., Ghiadoni, L., Salvetti, G., Bernini, G., Magagna, A., & Salvetti, A. (2001) · Hypertension · doi:10.1161/01.hyp.38.2.274 · Cited by 664
Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation
Carmeliet, P., Moons, L., Lijnen, R. H., Baes, M. I., Lemaı̂tre, V., Tipping, P. G., Drew, A. F., Eeckhout, Y., Shapiro, S. D., Lupu, F., et al. (1997) · Nature Genetics · doi:10.1038/ng1297-439 · Cited by 660
Nitric Oxide Insufficiency, Platelet Activation, and Arterial Thrombosis
Loscalzo, J. (2001) · Circulation Research · doi:10.1161/hh0801.089861 · Cited by 612
Matrix Metalloproteinase Inhibition After Myocardial Infarction
Creemers, E. E., Cleutjens, J. P. M., Smits, J. F. M., & Daemen, M. J. A. P. (2001) · Circulation Research · doi:10.1161/hh1501.094396 · Cited by 598
Fibrinolytic Factors and the Risk of Myocardial Infarction or Sudden Death in Patients With Angina Pectoris
Juhan-Vague, I., Pyke, S., Alessi, M., Jespersen, J., Haverkate, F., & Thompson, S. G. (1996) · Circulation · doi:10.1161/01.cir.94.9.2057 · Cited by 551
Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries.
Schneiderman, J., Sawdey, M., Keeton, M., Bordin, G. M., Bernstein, E. F., Dilley, R. B., & Loskutoff, D. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.15.6998 · Cited by 543
Angiotensin II regulates the expression of plasminogen activator inhibitor-1 in cultured endothelial cells. A potential link between the renin-angiotensin system and thrombosis.
Vaughan, D. E., Lazos, S. A., & Tong, K. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117809 · Cited by 528
Promotion and Subsequent Inhibition of Plasminogen Activation after Administration of Intravenous Endotoxin to Normal Subjects
Suffredini, A. F., Harpel, P. C., & Parrillo, J. E. (1989) · New England Journal of Medicine · doi:10.1056/nejm198905043201802 · Cited by 486
Associations of Factor VIII and von Willebrand Factor with Age, Race, Sex, and Risk Factors for Atherosclerosis
Conlan, M. G., Folsom, A. R., Finch, A., DAVIS, C. E., Sorlie, P. D., Marcucci, G., Wu, K. K., & For the ARIC Study Investigators (1993) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1649589 · Cited by 438
Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-alpha, and transforming growth factor-beta.
Sawdey, M., & Loskutoff, D. J. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115440 · Cited by 412
Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis.
Carmeliet, P., Stassen, J. M., Schoonjans, L., Neugeboren, B. I., van den Oord, J. J., Mol, M. D., Mulligan, R. C., & Collen, D. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116893 · Cited by 388
High levels of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosolic extracts of breast carcinomas are associated with poor prognosis.
Grøndahl-Hansen, J., Christensen, I. J., Rosenquist, C., Brünner, N., Mouridsen, H. T., Danø, K., & Blichert-Toft, M. (1993) · PubMed · Cited by 380
Epidemiological Study on Factor VII, Factor VIII and Fibrinogen in an Industrial Population: I. Baseline Data on the Relation to Age, Gender, Body-Weight, Smoking, Alcohol, Pill-Using, and Menopause
Balleisen, L., Bailey, J., Epping, P.-H., Schulte, H., & van de Loo, J. (1985) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1657877 · Cited by 345
Alterations of Nitric Oxide Synthase Expression With Aging and Hypertension in Rats
Chou, T.-C., Yen, M., Li, C., & Ding, Y.-A. (1998) · Hypertension · doi:10.1161/01.hyp.31.2.643 · Cited by 342
Factors Responsible for Impaired Fibrinolysis in Obese Subjects and NIDDM Patients
McGill, J. B., Schneider, D. J., Arfken, C. L., Lucore, C. L., & Sobel, B. E. (1994) · Diabetes · doi:10.2337/diab.43.1.104 · Cited by 310
Elevated Expression of Transforming Growth Factor-β in Adipose Tissue from Obese Mice
Samad, F., Yamamoto, K., Pandey, M., & Loskutoff, D. J. (1997) · Molecular Medicine · doi:10.1007/bf03401666 · Cited by 303
Self-citation
Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-alpha and lipopolysaccharide.
Samad, F., Yamamoto, K., & Loskutoff, D. J. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118404 · Cited by 301
Self-citation
Factor VII and Fibrinogen Levels as Risk Factors for Venous Thrombosis
Koster, T., Rosendaal, F. R., Reitsma, P. H., van der Velden, P. A., Briët, E., & Vandenbroucke, J. P. (1994) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1642511 · Cited by 294
Prognostic impact of urokinase, urokinase receptor, and type 1 plasminogen activator inhibitor in squamous and large cell lung cancer tissue.
Pedersen, H., Brünner, N., Francis, D., Østerlind, K., Rønne, E., Hansen, H. H., Danø, K., & Grøndahl-Hansen, J. (1994) · PubMed · Cited by 286
Effect of Activation and Inhibition of the Renin-Angiotensin System on Plasma PAI-1
Brown, N. J., Ağırbaşlı, M. A., Williams, G. H., Litchfield, W. R., & Vaughan, D. E. (1998) · Hypertension · doi:10.1161/01.hyp.32.6.965 · Cited by 269
Complete Deficiency of Plasminogen-Activator Inhibitor Type 1 Due to a Frame-Shift Mutation
Fay, W. P., Shapiro, A. D., Shih, J. L., Schleef, R. R., & Ginsburg, D. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212103272406 · Cited by 269
Type 1 plasminogen activator inhibitor
Mimuro, J. (1990) · Japanese Journal of Thrombosis and Hemostasis · doi:10.2491/jjsth.1.17 · Cited by 268
Identification and distribution of fibrinogen, fibrin, and fibrin(ogen) degradation products in atherosclerosis. Use of monoclonal antibodies.
Bini, A., Fenoglio, J. J., Mesa‐Tejada, R., Kudryk, B. J., & Kaplan, K. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.1.109 · Cited by 267
Type 1 plasminogen activator inhibitor
三室, 淳. (1990) · Medical Entomology and Zoology · Cited by 266
Development of venous occlusions in mice transgenic for the plasminogen activator inhibitor-1 gene
Erickson, L. A., Fici, G. J., Lund, J. E., Boyle, T. P., Polites, H. G., & Marotti, K. R. (1990) · Nature · doi:10.1038/346074a0 · Cited by 266
Effects of Ramipril on Plasma Fibrinolytic Balance in Patients With Acute Anterior Myocardial Infarction
Vaughan, D. E., Rouleau, J. L., Ridker, P. M., Arnold, J. M. O., Menapace, F. J., & Pfeffer, M. A. (1997) · Circulation · doi:10.1161/01.cir.96.2.442 · Cited by 264
Human aging: Changes in structure and function
Lakatta, E. G., Mitchell, J. H., Pomerance, A., & Rowe, G. G. (1987) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(87)80447-3 · Cited by 263
Hypercoagulability in centenarians: the paradox of successful aging
Mari, D., Mannucci, P. M., Coppola, R., Bottasso, B., Bauer, K. A., & ROSENBERG, R. D. (1995) · Blood · doi:10.1182/blood.v85.11.3144.bloodjournal85113144 · Cited by 257
Aging Increases Aortic MMP-2 Activity and Angiotensin II in Nonhuman Primates
Wang, M., Takagi, G., Asai, K., Resuello, R. G., Natividad, F. F., Vatner, D. E., Vatner, S. F., & Lakatta, E. G. (2003) · Hypertension · doi:10.1161/01.hyp.0000073843.56046.45 · Cited by 235
Tumor necrosis factor α is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1
Samad, F., Uysal, K. T., Wiesbrock, S. M., Pandey, M., Hotamisligil, G. S., & Loskutoff, D. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6902 · Cited by 226
The cardiovascular risk factor plasminogen activator inhibitor type 1 is related to insulin resistance
van Loon, B. J. P., Kluft, C., Radder, J. K., Blankenstein, M. A., & Meinders, A. E. (1993) · Metabolism · doi:10.1016/0026-0495(93)90005-9 · Cited by 225
Aging and Thrombosis
Wilkerson, W. R., & Sane, D. C. (2002) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2002-36700 · Cited by 210
Bleeding diathesis due to decreased functional activity of type 1 plasminogen activator inhibitor.
Schleef, R. R., Higgins, D. L., Pillemer, E., & Levitt, L. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114076 · Cited by 209
The Natural Course of Atherosclerosis
Kiechl, S. J., & Willeit, J. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.6.1491 · Cited by 209
Changes of Plasma Coagulation and Fibrinolysis in Response to Mental Stress
Jern, C., Eriksson, E., Tengborn, L., Risberg, B., Wadenvik, H., & Jern, S. (1989) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646899 · Cited by 206
Arterial and Venous Thrombosis Is Not Associated With the 4G/5G Polymorphism in the Promoter of the Plasminogen Activator Inhibitor Gene in a Large Cohort of US Men
Ridker, P. M., Hennekens, C. H., Lindpaintner, K., Stampfer, M. J., & Miletich, J. P. (1997) · Circulation · doi:10.1161/01.cir.95.1.59 · Cited by 202
Prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in completely resected gastric cancer.
Nekarda, H., Schmitt, M., Ulm, K., Wenninger, A., Vogelsang, H., Becker, K., Roder, J. D., Fink, U., & Siewert, J. R. (1994) · PubMed · Cited by 201
Plasminogen Activator Inhibitor 1: A New Prognostic Marker in Septic Shock
Pralong, G., Calandra, T., Glausef, M.-P., Schellekens, J. F. P., Verhoef, J., Bachmann, F., & Kruithof, E. K. O. (1989) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646614 · Cited by 199
Aging-associated changes in indices of thrombin generation and protein C activation in humans. Normative Aging Study.
Bauer, K. A., Weiss, L. M., Sparrow, D., Vokonas, P., & ROSENBERG, R. D. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113238 · Cited by 198
Evidence for a Causal Role of the Renin-Angiotensin System in Vascular Dysfunction Associated With Insulin Resistance
Shinozaki, K., Ayajiki, K., Nishio, Y., Sugaya, T., Kashiwagi, A., & Okamura, T. (2003) · Hypertension · doi:10.1161/01.hyp.0000111136.86976.26 · Cited by 198
Fibrin deposition in tissues from endotoxin-treated mice correlates with decreases in the expression of urokinase-type but not tissue-type plasminogen activator.
Yamamoto, K., & Loskutoff, D. J. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118691 · Cited by 191
Self-citation
Tissue Distribution and Regulation of Plasminogen Activator Inhibitor-1 in Obese Mice
Samad, F., & Loskutoff, D. J. (1996) · Molecular Medicine · doi:10.1007/bf03401641 · Cited by 189
Obesity and the risk of heart failure
Kenchaiah, S. (2003) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(03)00066-0 · Cited by 186
Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery
Eitzman, D. T., Westrick, R. J., Xu, Z., Tyson, J. A., & Ginsburg, D. (2000) · Blood · doi:10.1182/blood.v96.13.4212 · Cited by 182
Altered Regulation of Matrix Metalloproteinase-2 in Aortic Remodeling During Aging
Wang, M., & Lakatta, E. G. (2002) · Hypertension · doi:10.1161/01.hyp.0000014506.13322.66 · Cited by 174
Age-Dependent Spontaneous Coronary Arterial Thrombosis in Transgenic Mice That Express a Stable Form of Human Plasminogen Activator Inhibitor-1
Eren, M., Painter, C., Atkinson, J. B., Declerck, P. J., & Vaughan, D. E. (2002) · Circulation · doi:10.1161/01.cir.0000023186.60090.fb · Cited by 170
Identification and distribution of fibrinogen, fibrin and fibrin (ogen) degradation products in atherosclerosis
Bini, A. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · Cited by 169
Determinants of Plasminogen Activator Inhibitor 1 Activity in Treated NIDDM and Its Relation to a Polymorphism in the Plasminogen Activator Inhibitor 1 Gene
Panahloo, A., Mohamed‐Ali, V., Lane, A. M., Green, F. R., Humphries, S. E., & Yudkin, J. S. (1995) · Diabetes · doi:10.2337/diab.44.1.37 · Cited by 167
Metformin Decreases the High Plasminogen Activator Inhibition Capacity, Plasma Insulin and Triglyceride Levels in Non-Diabetic Obese Subjects
Vague, P., Juhan-Vague, I., Alessi, M., Badier, C., & Valadier, J. (1987) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1651126 · Cited by 164
Coagulation Factor VII and the Risk of Coronary Heart Disease in Healthy Men
Junker, R., Heinrich, J., Schulte, H., van de Loo, J., & Assmann, G. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.8.1539 · Cited by 164
Plasminogen activator inhibitor-1 is a major stress-regulated gene: Implications for stress-induced thrombosis in aged individuals
Yamamoto, K., Takeshita, K., Shimokawa, T., Yi, H., Isobe, K., Loskutoff, D. J., & Saito, H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022608799 · Cited by 163
Self-citation
Plasminogen Activator Inhibitor-1 Deficiency Prevents Hypertension and Vascular Fibrosis in Response to Long-term Nitric Oxide Synthase Inhibition
Kaikita, K., Fogo, A. B., Ma, L., Schoenhard, J. A., Brown, N. J., & Vaughan, D. E. (2001) · Circulation · doi:10.1161/hc3301.092803 · Cited by 159
Acute Release of Plasminogen Activator Inhibitor-1 in ST-Segment Elevation Myocardial Infarction Predicts Mortality
Collet, J., Montalescot, G., Vicaut, É., Ankri, A., Walylo, F., Lesty, C., Choussat, R., Beygui, F., Borentain, M., Vignolles, N., et al. (2003) · Circulation · doi:10.1161/01.cir.0000083471.33820.3c · Cited by 158
Murine CD14 gene expression in vivo: extramyeloid synthesis and regulation by lipopolysaccharide.
Fearns, C., Kravchenko, V. V., Ulevitch, R. J., & Loskutoff, D. J. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.3.857 · Cited by 157
Plasminogen Activator Inhibitor-1 (PAI-1) Promoter Polymorphism and Coronary Artery Disease in Non-Insulin-Dependent Diabetes
Mansfield, M. W., Stickland, M. H., & Grant, P. J. (1995) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1649875 · Cited by 151
Plasminogen Activator Inhibitor-1 Promoter 4G/5G Genotype and Plasma Levels in Relation to a History of Myocardial Infarction in Patients Characterized by Coronary Angiography
Ossei‐Gerning, N., Mansfield, M. W., Stickland, M. H., Wilson, I., & Grant, P. J. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.1.33 · Cited by 142
Effect of plasminogen activator inhibitor–1 in diabetes mellitus and cardiovascular disease
Lyon, C. J., & Hsueh, W. A. (2003) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.08.014 · Cited by 131
Increased Expression of Plasminogen Activator Inhibitor-1 in Cardiomyocytes Contributes to Cardiac Fibrosis after Myocardial Infarction
Takeshita, K., Hayashi, M., Iino, S., Kondo, T., Inden, Y., Iwase, M., Kojima, T., Hirai, M., Ito, M., Loskutoff, D. J., et al. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63135-5 · Cited by 126
Self-citation
Increase of Plasminogen Activator Inhibitor Levels Predicts Outcome of Leukocytopenic Patients with Sepsis
Mesters, R. M., Flörke, N., Ostermann, H., & Kienast, J. (1996) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1650392 · Cited by 125
Angiotensin II type 1 receptor−153A/G and 1166A/C gene polymorphisms and increase in aortic stiffness with age in hypertensive subjects
Lajemi, M., Labat, C., Gautier, S., Lacolley, P. J., Safar, M. E., Asmar, R. G., Cambien, F., & Bénétos, A. (2001) · Journal of Hypertension · doi:10.1097/00004872-200103000-00008 · Cited by 125
Plasminogen activator inhibitor‐1 regulates cell adhesion by binding to the somatomedin B domain of vitronectin
Deng, G. G., Curriden, S. A., Hu, G., Czekay, R., & Loskutoff, D. J. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1133 · Cited by 124
Enhanced in vivo platelet “release reaction” in old healthy individuals
Zahavi, J., Jones, N. A. G., Leyton, J., Dubiel, M., & Kakkar, V. V. (1980) · Thrombosis Research · doi:10.1016/0049-3848(80)90067-5 · Cited by 115
Factors influencing the accumulation in fibrous plaques of lipid derived from low density lipoprotein
Smith, E. B., Keen, G. A., & GRANT, A. (1990) · Atherosclerosis · doi:10.1016/0021-9150(90)90087-y · Cited by 115
Relationship between age and plasma t-PA, PA-inhibitor, and PA activity
Hashimoto, Y., Kobayashi, A., Yamazaki, N., Sugawara, Y., Takada, Y., & Takada, A. (1987) · Thrombosis Research · doi:10.1016/0049-3848(87)90264-7 · Cited by 111
Plasminogen Activator Inhibitor-1 Expression in Human Liver and Healthy or Atherosclerotic Vessel Walls
Chomiki, N., Henry, M., Alessi, M., Anfosso, F. J., & Juhan-Vague, I. (1994) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1648809 · Cited by 108
Association of Chronic Stress With Plasminogen Activator Inhibitor–1 in Healthy Middle-aged Men
Räikkönen, K., Lassila, R., Keltikangas‐Järvinen, L., & Hautanen, A. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.3.363 · Cited by 96
Activation of neurohumoral systems following acute myocardial infarction
Rouleau, J. L., Moyé, L. A., de Champlain, J., Klein, M. D., Bichet, D. G., Packer, M., Sussex, B. A., Arnold, J. M. O., Sestier, F., Parker, J. O., et al. (1991) · The American Journal of Cardiology · doi:10.1016/0002-9149(91)90264-l · Cited by 96
Age-related changes in the hemostatic system
Abbate, R., Prisco, D., Rostagno, C., Boddi, M., & Gensini, G. F. (1993) · International Journal of Clinical & Laboratory Research · doi:10.1007/bf02592271 · Cited by 95
Cardiac Senescence Is Associated with Enhanced Expression of Angiotensin II Receptor Subtypes1
Heymes, C., Silvestre, J., Llorens‐Cortés, C., Marotte, F., Chevalier, B., Levy, B. I., Bernard Swynghedauw, A., & Samuel, J. (1998) · Endocrinology · doi:10.1210/endo.139.5.6023 · Cited by 93
Thrombin-Activatable Fibrinolysis Inhibitor Antigen Levels and Cardiovascular Risk Factors
Juhan-Vague, I., Renucci, J. F., Grimaux, M., Morange, P., Gouvernet, J., Gourmelin, Y., & Alessi, M. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.9.2156 · Cited by 92
Factors responsible for impaired fibrinolysis in obese subjects and NIDDM patients
McGill, J. B., Schneider, D. J., Arfken, C. L., et al. (1994) · Diabetes · doi:10.2337/diabetes.43.1.104 · Cited by 89
Increased Expression of Plasminogen Activator Inhibitor-1 with Fibrin Deposition in a Murine Model of Aging, "Klotho" Mouse
Takeshita, K., Yamamoto, K., Ito, M., Kondo, T., Matsushita, T., Hirai, M., Kojima, T., Nishimura, M., Nabeshima, Y., Loskutoff, D. J., et al. (2002) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2002-36699 · Cited by 86
Self-citation
Oxidative Stress Activates the Plasminogen Activator Inhibitor Type 1 (PAI-1) Promoter through an AP-1 Response Element and Cooperates with Insulin for Additive Effects on PAI-1 Transcription
Vulin, A. I., & Stanley, F. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403184200 · Cited by 86
Obesity, fat distribution and cardiovascular disease.
Larsson, B. (1991) · PubMed · Cited by 85
Platelet activity and phosphoinositide turnover increase with advancing age
Bastyr, E. J., Kadrofske, M. M., & Vinik, A. I. (1990) · The American Journal of Medicine · doi:10.1016/0002-9343(90)90525-i · Cited by 83
Aging Accelerates Endotoxin-Induced Thrombosis
Yamamoto, K., Shimokawa, T., Yi, H., Isobe, K., Kojima, T., Loskutoff, D. J., & Saito, H. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64457-4 · Cited by 76
Self-citation
The Distribution of coagulation factors VII and VIII and fibrinogen in adults over 65 years results from the cardiovascular health study
Tracy, R. P., Bovill, E. G., Fried, L. P., HEISS, G. M., Lee, M. H., Polak, J. F., Psaty, B. M., & Savage, P. J. (1992) · Annals of Epidemiology · doi:10.1016/1047-2797(92)90100-5 · Cited by 76
Thrombin‐activatable fibrinolysis inhibitor in young patients with myocardial infarction and its relationship with the fibrinolytic function and the protein C system
Zorio, E., Castelló, R., Falcó, C., España, F., Osa, A., Bonet, L. A., Aznar, J., & Estellés, A. (2003) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.04549.x · Cited by 75
In vivo modulation of coagulation and fibrinolysis by recombinant glycosylated human interleukin-6 in baboons.
Mestries, J. C., Kruithof, E. K. O., Gascon, M.-P., Hérodin, F., Agay, D., & Ythier, A. (1994) · PubMed · Cited by 73
Correlates of Thrombin Markers in an Elderly Cohort Free of Clinical Cardiovascular Disease
Cushman, M., Psaty, B. M., Macy, E., Bovill, E. G., Cornell, E. S., Kuller, L. H., & Tracy, R. P. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.9.1163 · Cited by 71
Aging, Carotid Artery Distensibility, and the Ser422Gly Elastin Gene Polymorphism in Humans
Hanon, O., Luong, V., Mourad, J., Bortolotto, L. A., Jeunemaı̂tre, X., & Girerd, X. J. (2001) · Hypertension · doi:10.1161/hy1101.096802 · Cited by 69
Genetic Mechanisms of Age Regulation of Human Blood Coagulation Factor IX
Kurachi, S., Deyashiki, Y., Takeshita, J., & Kurachi, K. (1999) · Science · doi:10.1126/science.285.5428.739 · Cited by 68
A pathological role of increased expression of plasminogen activator inhibitor-1 in human or animal disorders.
Yamamoto (1998) · International Journal of Hematology · doi:10.1016/s0925-5710(98)00094-2 · Cited by 67
Insulin Continues to Induce Plasminogen Activator Inhibitor 1 Gene Expression in Insulin-Resistant Mice and Adipocytes
Samad, F., Pandey, M., Bell, P. A., & Loskutoff, D. J. (2000) · Molecular Medicine · doi:10.1007/bf03402048 · Cited by 66
The Tissue Factor and Plasminogen Activator Inhibitor Type-1 Response in Pediatric Sepsis-induced Multiple Organ Failure
Green, J., Doughty, L., Kaplan, S. S., Sasser, H. C., & Carcillo, J. A. (2002) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1612976 · Cited by 66
Stressful events as a trigger of sudden death: a study of 43 medico-legal autopsy cases
Lecomte, D., Fornés, P., & Nicolas, G. (1996) · Forensic Science International · doi:10.1016/0379-0738(95)01873-5 · Cited by 65
Natural anticoagulants, aging, and thromboembolism
Sagripanti, A., & Carpi, A. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00047-3 · Cited by 64
Correlates of Antithrombin, Protein C, Protein S, and TFPI in a Healthy Elderly Cohort
Sakkinen, P. A., Cushman, M., Psaty, B. M., Kuller, L. H., Bajaj, S. P., Sabharwal, A., Boineau, R., Macy, E., & Tracy, R. P. (1998) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1615152 · Cited by 64
Hyperglycemia induces PAI-1 gene expression in adipose tissue by activation of the hexosamine biosynthetic pathway
Gabriely, I., Yang, X. M., Cases, J. A., Xiao, H., Rossetti, L., & Barzilai, N. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(01)00574-3 · Cited by 62
Plasminogen activator inhibitor-1 messenger RNA expression is induced in rat hepatocytes in vivo by dexamethasone
Konkle, B. A., Schuster, S. J., Kelly, M., Harjes, K., Hassett, D., Bohrer, M., & Tavassoli, M. (1992) · Blood · doi:10.1182/blood.v79.10.2636.2636 · Cited by 61
Determinants of plasminogen activator inhibitor 1 activity in treated NIDDM and its relation to a polymorphism in the plasminogen activator inhibitor 1 gene
Panahloo, A., Mohamed‐Ali, LANE, A., et al. (1995) · Diabetes · doi:10.2337/diabetes.44.1.37 · Cited by 59
Direct attenuation of plasminogen activator inhibitor type-1 expression in human adipose tissue by thiazolidinediones
Leugers, A., Lohrmann, J., Ernst, S., Sobel, B. E., Bode, C., Nordt, T. K., & Zirlik, A. (2004) · Thrombosis and Haemostasis · doi:10.1160/th03-06-0384 · Cited by 58
Substrate-bound fibrinogen, fibrin and other cell attachment-promoting proteins as a scaffold for cultured vascular smooth muscle cells
Naito, M., FUNAKI, C., Hayashi, T., Yamada, K., Asai, K., Yoshimine, N., & Kuzuya, F. (1992) · Atherosclerosis · doi:10.1016/0021-9150(92)90069-s · Cited by 57
Elevated Plasminogen Activator Inhibitor (PAI), a Cause of Thrombophilia? – A Study in 203 Patients with Familial or Sporadic Venous Thrombophilia
Engesser, L., Brommer, E. J. P., Kluft, C., & Briët, E. (1989) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646881 · Cited by 52
Influence of Metoprolol Treatment on Sympatho-Adrenal Activation of Fibrinolysis
Larsson, P. T., Wiman, B., Olsson, G., Angelin, B., & Hjemdahl, P. (1990) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1645070 · Cited by 48
Plasminogen activator inhibitor-1 messenger RNA expression is induced in rat hepatocytes in vivo by dexamethasone
Konkle, B., Schuster, S. J., Kelly, M., et al. (1992) · Blood · doi:10.1182/blood.v79.10.2636.bloodjournal79102636 · Cited by 48
Thrombosis and cardiovascular risk in the elderly.
Tracy, R., & BOVILL, E. G. (1992) · PubMed · Cited by 46
Aging and obesity augment the stress-induced expression of tissue factor gene in the mouse
Yamamoto, K., Shimokawa, T., Yi, H., Isobe, K., Kojima, T., Loskutoff, D. J., & Saito, H. (2002) · Blood · doi:10.1182/blood-2002-03-0945 · Cited by 38
Self-citation
Sympathetic nervous system activity and α-adrenergic responsiveness in older hypertensive humans
Supiano, M. A., Hogikyan, R. V., Sidani, M. A., Gałecki, A. T., & Krueger, J. L. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.3.e519 · Cited by 37
Cardiac Senescence Is Associated with Enhanced Expression of Angiotensin II Receptor Subtypes
Heymes, C. (1998) · Endocrinology · doi:10.1210/en.139.5.2579 · Cited by 26
Age related changes of platelet prostacyclin receptors in humans
Modesti, P. A., Fortini, A., Abbate, R., & Gensini, G. F. (1985) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1985.tb00169.x · Cited by 25
Genetic Mechanisms of Age Regulation of Protein C and Blood Coagulation
Zhang, K., Kurachi, S., & Kurachi, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109524200 · Cited by 25
Augmented Age-associated Innate Immune Responses Contribute to Negative Inotropic and Lusitropic Effects of Lipopolysaccharide and Interferon γ
Rosas, G. O., Zieman, S. J., Donabedian, M., Vandegaer, K. M., & Hare, J. M. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1448 · Cited by 23
266 Plasminogen activator inhibitor-1: A new prognostic marker in septic shock
Pralong, G., Calandra, T., Glauser, M. P., Bachmann, F., & Kruithof, E. K. O. (1988) · Fibrinolysis and Proteolysis · doi:10.1016/0268-9499(88)90613-3 · Cited by 18
Association of functional thrombin‐activatable fibrinolysis inhibitor (TAFI) with conventional cardiovascular risk factors and its correlation with other hemostatic factors in a Spanish population
Santamaría, A., Borrell, M., Oliver, A., Ortín, R., Forner, R., Coll, I., Mateo, J., Souto, J. C., & Fontcuberta, J. (2004) · American Journal of Hematology · doi:10.1002/ajh.20108 · Cited by 17
On the Fibrinolytic System in Aged Rats, and Its Reactivity to Endotoxin and Cytokines
Emeis, J. J., Brouwer, A., Barelds, R. J., Horan, M. A., Durham, S. R., & Kooistra, T. (1992) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1648525 · Cited by 16
Elevated Plasminogen Activator Inhibitor Levels Found in Patients with Malignant Conditions
Newland, J. R., & Haire, W. D. (1991) · American Journal of Clinical Pathology · doi:10.1093/ajcp/96.5.602 · Cited by 14
Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery
Eitzman, D. T., Westrick, R. J., Xu, Z., et al. (2000) · Blood · doi:10.1182/blood.v96.13.4212.h8004212_4212_4215 · Cited by 14
Increased susceptibility of aged rats to haemorrhage and intravascular hypercoagulation following endotoxin administered in a generalized Shwartzman regime
Carthew, P., Dorman, B. M., & Edwards, R. (1991) · Journal of Comparative Pathology · doi:10.1016/s0021-9975(08)80200-9 · Cited by 8
The fibrinolytic system in aged rats, and its reactivity to endotoxin and cytokines
Emeis, J. J., Brouwer, A., Horan, M. A., Durham, S. K., & Kooistra, T. (1992) · Fibrinolysis and Proteolysis · doi:10.1016/0268-9499(92)90028-g · Cited by 5
[On measuring instability in demography].
Pirozhkov, S. I., & Gl, S. (1991) · PubMed · Cited by 2

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Authors: YAMAMOTO, K., TAKESHITA, K., KOJIMA, T., TAKAMATSU, J., & SAITO, H.
Affiliations: Nagoya University Hospital (JP)
Nagoya University (JP)
Nagoya Medical Center (JP)
Corresponding author: YAMAMOTO, K
ORCID: YAMAMOTO, K
TAKESHITA, K
SAITO, H
Venue: Cardiovascular Research
Publisher: Oxford University Press (OUP)
Published: 2005-05-01
Volume: 66
Issue: 2
Pages: 276-285
ISSN: 0008-6363 (ISSN-L)
DOI: 10.1016/j.cardiores.2004.11.013
OpenAlex: W2034413738
Cited by: 214
References: 128
Citations by year: 2026: 13 · 2025: 10 · 2024: 3 · 2023: 16 · 2022: 16 · 2021: 26 · 2020: 14 · 2019: 8 · 2018: 1 · 2017: 11 · 2016: 12 · 2015: 9 · 2014: 12 · 2013: 10 · 2012: 7
FWCI: 2.73
Type: journal article
Language: en
Open access: closed
Locations: Cardiovascular Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Health Sciences › Medicine › Hematology › Blood properties and coagulation
Keywords: plasminogen activator inhibitor-1, aging, thrombosis, cardiovascular aging, hypercoagulability, fibrinolysis, vascular sclerosis, obesity, insulin resistance, emotional stress, inflammation, cytokines, angiotensin II, insulin, atherosclerosis
MeSH terms: Adipose Tissue, Aged, Aging, Arteriosclerosis, Fibrinolysis, Humans, Obesity, Stress, Psychological, Thrombosis, Plasminogen Activator Inhibitor 1, Oxidative Stress

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Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly

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