The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism
Abstract
OBJECTIVE: Insulin resistance (IR) was reported to be associated with chronic heart failure (CHF). Adiponectin, an insulin-sensitizing hormone with anti-inflammatory activity, improves energy metabolism via AMP-activated protein kinase (AMPK). AMPK deficiency is associated with depressed cardiac function under stress conditions. However, it is not clear whether adiponectin plays an important role in CHF. We hypothesize that deficiency of adiponectin might result in deterioration of heart failure. METHODS: Using adiponectin null mice and their littermates, we examined the effects of adiponectin on LV pressure overload-induced cardiac hypertrophy and failure, and investigated the mechanisms involved. RESULTS: Three weeks after transverse aortic constriction (TAC), cardiac hypertrophy (evaluated from the heart-to-body weight ratio: 7.62+/-0.27 in wild-type (WT) mice, 9.97+/-1.13 in knockout (KO) mice, P<0.05) and pulmonary congestion (lung-to-body weight ratio: 9.05+/-1.49 in WT mice, 14.95+/-2.36 in KO mice, P<0.05) were significantly greater in adiponectin KO mice than WT mice. LV dimensions were also increased in KO mice. Compared with WT TAC mice, expression of AMPKalpha protein was lower, while IR was higher in KO TAC mice. CONCLUSION: These findings indicate that adiponectin deficiency leads to progressive cardiac remodeling in pressure overloaded condition mediated via lowing AMPK signaling and impaired glucose metabolism.
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“With the use of adiponectin KO mice, it was shown that adiponectin deficiency enhanced progressive cardiac remodeling induced by surgical aortic constriction (208).”
From Cardiac remodeling in obesity (2008) · cites this paper as [208]
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Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625
Self-citationAdiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction
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Adiponectin as an anti-inflammatory factor
Ouchi, N., & Walsh, K. X. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.01.026 · Cited by 910
Self-citationAbel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736
Fuster, J. J., Ouchi, N., Gokce, N., & Walsh, K. X. (2016) · Circulation Research · doi:10.1161/circresaha.115.306885 · Cited by 691
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Metadata
- Authors
- LIAO, Y., TAKASHIMA, S., MAEDA, N., OUCHI, N., KOMAMURA, K., SHIMOMURA, I., HORI, M., MATSUZAWA, Y., FUNAHASHI, T., & KITAKAZE, M.
- Affiliations
- The University of Osaka (JP)
- National Cerebral and Cardiovascular Center (JP)
- Corresponding author
- KITAKAZE, M
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-09-01
- Volume
- 67
- Issue
- 4
- Pages
- 705-713
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2148710672
- Cited by
- 236
- References
- 48
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 1 · 2023: 8 · 2022: 9 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 13 · 2017: 9 · 2016: 9 · 2015: 15 · 2014: 13 · 2013: 10 · 2012: 16
- FWCI
- 13.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cardiovascular Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adiponectin, heart failure, AMPK, AMPKα, insulin resistance, glucose metabolism, cardiac hypertrophy, pressure overload, transverse aortic constriction, cardiac remodeling, adiponectin knockout mice, pulmonary congestion
- MeSH terms
- Adenylate Kinase, Animals, Blood Glucose, Echocardiography, Fasting, Heart Failure, Insulin, Insulin Resistance, Male, Myocardium, Blotting, Western, Mice, Knockout, Mice, Adiponectin
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