Shimomura, Iichiro

Increased oxidative stress in obesity and its impact on metabolic syndrome

Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation

Adipokines, Inflammation, and Metabolic DiseasesRedox biology and oxidative stress

Cited by 5,508

Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity

Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 4,856

Suppression of Aging in Mice by the Hormone Klotho

Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science

Genetics, Aging, and Longevity in Model OrganismsParathyroid Disorders and Treatments

Cited by 1,935

Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin

Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 1,906

Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial

Davies, M., Færch, L., Jeppesen, O. K., Pakseresht, A., Pedersen, S. D., Perreault, L., Rosenstock, J., Shimomura, I., Viljoen, A., Wadden, T. A., et al. (2021) · The Lancet

Pharmacology and Obesity TreatmentDiabetes Treatment and Management

Cited by 1,419

Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation

Hosogai, N., Fukuhara, A., Oshima, K., Miyata, Y., Tanaka, S., Segawa, K., Furukawa, S., Tochino, Y., Komuro, R., Matsuda, M., et al. (2007) · Diabetes

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 1,257

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S., & Goldstein, J. L. (1999) · Nature

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,038

Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein

Nishizawa, H., Shimomura, I., Kishida, K., Maeda, N., Kuriyama, H., Nagaretani, H., Matsuda, M., Kondo, H., Furuyama, N., Kihara, S., et al. (2002) · Diabetes

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 837

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

Shimomura, I., Hammer, R. E., Richardson, J. A., Ikemoto, S., Bashmakov, Y., Goldstein, J. L., & Brown, M. S. (1998) · Genes & Development

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 790

Adiponectin Replenishment Ameliorates Obesity-Related Hypertension

Ohashi, K., Kihara, S., Ouchi, N., Kumada, M., Fujita, K., Hiuge, A., Hibuse, T., Ryo, M., Nishizawa, H., Maeda, N., et al. (2006) · Hypertension

Adipokines, Inflammation, and Metabolic DiseasesBlood Pressure and Hypertension Studies

Cited by 400

Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in type 2 diabetes (J-DOIT3): an open-label, randomised controlled trial

Ueki, K., Sasako, T., Okazaki, Y., Kato, M., Okahata, S., Katsuyama, H., Haraguchi, M., Morita, A., Ohashi, K., Hara, K., et al. (2017) · The Lancet Diabetes & Endocrinology

Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 313

Angiopoietin-Like Protein3 Regulates Plasma HDL Cholesterol Through Suppression of Endothelial Lipase

Shimamura, M., Matsuda, M., Yasumo, H., Okazaki, M., Fujimoto, K., Kono, K., Shimizugawa, T., Ando, Y., Koishi, R., Kohama, T., et al. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology

Lipid metabolism and disordersCholesterol and Lipid Metabolism

Cited by 297

Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism

LIAO, Y., TAKASHIMA, S., MAEDA, N., OUCHI, N., KOMAMURA, K., SHIMOMURA, I., HORI, M., MATSUZAWA, Y., FUNAHASHI, T., & KITAKAZE, M. (2005) · Cardiovascular Research

Cardiac Fibrosis and RemodelingAdipokines, Inflammation, and Metabolic Diseases

Cited by 236

Renal function is associated with blood neurofilament light chain level in older adults

Akamine, S., Marutani, N., Kanayama, D., Gotoh, S., Maruyama, R., Yanagida, K., Sakagami, Y., Mori, K., Adachi, H., Kozawa, J., et al. (2020) · Scientific Reports

Hereditary Neurological DisordersDementia and Cognitive Impairment Research

Cited by 213

Absolute value of visceral fat area measured on computed tomography scans and obesity-related cardiovascular risk factors in large-scale Japanese general population (the VACATION-J study)

Hiuge-Shimizu, A., Kishida, K., Funahashi, T., Ishizaka, Y., Oka, R., Okada, M., Suzuki, S., Takaya, N., Nakagawa, T., Fukui, T., et al. (2012) · Annals of Medicine

Diabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Disease and Adiposity

Cited by 205

Musclin, a novel skeletal muscle-derived secretory factor

Nishizawa, H., Matsuda, M., Yamada, Y., Kawai, K., Suzuki, E., Makishima, M., Kitamura, T., & Shimomura, I. (2004) · Journal of Biological Chemistry

Muscle Physiology and DisordersAdipokines, Inflammation, and Metabolic Diseases

Cited by 182

Retraction

Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2007) · Science

Cited by 150

Oxidative stress inhibits healthy adipose expansion through suppression of SREBF1-mediated Lipogenic pathway

Okuno, Y., Fukuhara, A., Hashimoto, E., Kobayashi, H., Kobayashi, S., Otsuki, M., & Shimomura, I. (2018) · Diabetes

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 124

Adiponectin promotes muscle regeneration through binding to T-cadherin

Tanaka, Y., Kita, S., Nishizawa, H., Fukuda, S., Fujishima, Y., Obata, Y., Nagao, H., Masuda, S., Nakamura, Y., Shimizu, Y., et al. (2019) · Scientific Reports

Muscle Physiology and DisordersAdipose Tissue and Metabolism

Cited by 103

Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy

Yamamuro, T., Kawabata, T., Fukuhara, A., Saita, S., Nakamura, S., Takeshita, H., Fujiwara, M., Enokidani, Y., Yoshida, G., Tabata, K., et al. (2020) · Nature Communications

Autophagy in Disease and TherapyAdipose Tissue and Metabolism

Cited by 97

High prevalence and clinical impact of dynapenia and sarcopenia in Japanese patients with type 1 and type 2 diabetes: Findings from the Impact of Diabetes Mellitus on Dynapenia study

Mori, H., Kuroda, A., Yoshida, S., Yasuda, T., Umayahara, Y., Shimizu, S., Ryomoto, K., Yoshiuchi, K., Yamamoto, T., Matsuoka, T., et al. (2021) · Journal of Diabetes Investigation

Nutrition and Health in AgingDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 90

Short-Term Effects of Liraglutide on Visceral Fat Adiposity, Appetite, and Food Preference: A Pilot Study of Obese Japanese Patients with Type 2 Diabetes

Inoue, K., Maeda, N., Kashine, S., Fujishima, Y., Kozawa, J., Hiuge-Shimizu, A., Okita, K., Imagawa, A., Funahashi, T., & Shimomura, I. (2011) · Cardiovascular Diabetology

Diabetes Treatment and ManagementPharmacology and Obesity Treatment

Cited by 89

Global use of SGLT2 inhibitors and GLP-1 receptor agonists in type 2 diabetes. Results from DISCOVER

Arnold, S. V., Tang, F., Cooper, A., Chen, H., Gomes, M. B., Rathmann, W., Shimomura, I., Vora, J., Watada, H., Khunti, K., et al. (2022) · BMC Endocrine Disorders

Diabetes Treatment and ManagementDiabetes Management and Research

Cited by 86

Molecular Mechanisms of Diabetes and Atherosclerosis: Role of Adiponectin

Kishida, K., Funahashi, T., & Shimomura, I. (2012) · Endocrine, Metabolic & Immune Disorders - Drug Targets

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 78