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Cited by 65Cardiac electrophysiology and arrhythmiasIon channel regulation and functionIon Transport and Channel Regulation

Cardiac ankyrins: Essential components for development and maintenance of excitable membrane domains in heart

CUNHA, S, MOHLER, P·2006·Cardiovascular Research
DOI 10.1016/j.cardiores.2006.03.018
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Abstract

Ankyrins are intracellular proteins required for the biogenesis and maintenance of membrane domains in both excitable and non-excitable cells. Ankyrin family polypeptides have been implicated in the targeting and stabilization of membrane proteins including ion channels, transporters, exchangers and cell adhesion molecules in diverse tissues and cell types including the erythrocyte, kidney, lung and brain. Dysfunction in ankyrin-based pathways has previously been linked to abnormalities in vertebrate physiology including spherocytosis and anemia, ataxia and axonal degeneration. Recent findings have illuminated the importance of ankyrin-based pathways in excitable cells of the heart. Specifically, two ankyrin gene products, 220-kDa ankyrin-B and 190-kDa ankyrin-G, have been implicated in the targeting of structurally diverse membrane ion channels and transporters to excitable membrane domains in cardiomyocytes. Moreover, findings in humans and mice have determined the critical nature of ankyrin-based pathways for normal cardiac excitability. Reduction of ankyrin-B expression levels in mice or the presence of ankyrin-B loss-of-function mutations in humans leads to 'ankyrin-B syndrome', a cardiac disease with a spectrum of clinical presentations including bradycardia, ventricular tachycardia and sudden cardiac death in response to catecholaminergic stimuli. Ankyrin-G is required for expression of the major cardiac voltage-gated Na(v) channel, Na(v)1.5, at specialized cardiac membrane domains. Human variants in SCN5A (encodes Na(v)1.5) that block Na(v)1.5 interaction with ankyrin-G lead to loss of Na(v)1.5 membrane expression and Brugada syndrome. Together, these recent findings in heart reinforce the importance of ankyrin-based pathways for normal vertebrate physiology and raise exciting new questions regarding the cellular roles for ankyrin polypeptides in cardiac and other excitable cells. While ankyrins have only been recently identified in heart, our current understanding suggests that elucidating the roles of ankyrins in organizing and targeting protein complexes to excitable membrane domains will yield important insights into the molecular basis of cardiac arrhythmias.

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  • ASD and cardiac arrhythmia might be common manifestations of a distinct nosological entity.

    “As most ANK2 missense mutations in patients with cardiac arrhythmia map to both cardiac and neuronal isoforms (88), ASD and cardiac arrhythmia might be common manifestations of a distinct nosological entity.”

    From Genetics and genomics of autism spectrum disorder: embracing complexity (2015) · cites this paper as [88]

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Research works printed but not linked: 2

  1. Kordeli E, Lambert S, Bennett V, Ankyrin G. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier. J Biol Chem 1995;270:2352 -9.
  2. Mohler PJ, Gramolini AO, Bennett V. Ankyrins. J Cell Sci 2002; 115:1565 -6.

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Authors
CUNHA, S., & MOHLER, P.
Affiliations
Vanderbilt University (US)
Corresponding author
MOHLER, P
ORCID
MOHLER, P
Venue
Cardiovascular Research
Publisher
Oxford University Press (OUP)
Published
2006-07-01
Volume
71
Issue
1
Pages
22-29
ISSN
0008-6363 (ISSN-L)
DOI
10.1016/j.cardiores.2006.03.018
OpenAlex
W1999432204
Cited by
65
References
77
Citations by year
2026: 1 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 2 · 2019: 1 · 2017: 6 · 2016: 4 · 2015: 4 · 2014: 1 · 2013: 2 · 2012: 7
FWCI
1.11
Type
journal article
Language
en
Open access
closed
Locations
  • Cardiovascular Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Vanderbilt University
  • National Institutes of Health (5r01hl083422-11)
  • National Heart, Lung, and Blood Institute (1R01HL083422)
  • National Institute of Mental Health (T32MH065215)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords
ankyrin, ankyrin-B, ankyrin-G, cardiomyocytes, membrane protein stabilization, Brugada syndrome, sudden cardiac death, cardiac arrhythmias, cardiac excitability
MeSH terms
Animals, Arrhythmias, Cardiac, Electrocardiography, Heart Conduction System, Humans, Myocardium, Ion Channel Gating, Ankyrins

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