The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
Vascular smooth muscle cell senescence in atherosclerosis
Abstract
Markers of cell senescence have been identified in both the blood and vessel wall of patients with atherosclerosis. In particular, vascular smooth muscle cells (VSMCs) derived from human plaques show numerous features of senescence both in culture and in vivo. This review summarises the evidence for VSMC senescence in atherosclerosis, and outlines the mechanisms and triggers leading to their senescence.
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“In addition, senescent endothelial and smooth muscle cells have been implicated in the genesis or promotion of age-related cardiovascular disease (126, 127).”
From Aging, Cellular Senescence, and Cancer (2013) · cites this paper as [127]
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“Unstable mature plaques show low VSMC proliferation and clear evidence of VSMC senescence 191 .”
From Vascular smooth muscle cells in atherosclerosis (2019) · cites this paper as [191]
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Aging, Cellular Senescence, and Cancer
Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954
“In addition, senescent endothelial and smooth muscle cells have been implicated in the genesis or promotion of age-related cardiovascular disease (126, 127).”
BackgroundSenescent intimal foam cells are deleterious at all stages of atherosclerosis
Childs, B. G., Baker, D. J., Wijshake, T., Conover, C. A., Campisi, J., & van Deursen, J. M. (2016) · Science · doi:10.1126/science.aaf6659 · Cited by 1,195
Vascular smooth muscle cells in atherosclerosis
Basatemur, G. L., Jørgensen, H. F., Clarke, M. C. H., Bennett, M. R., & Mallat, Z. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0227-9 · Cited by 1,099
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Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis
Grootaert, M. O. J., Moulis, M., Roth, L., Martinet, W., Vindis, C., Bennett, M. R., & De Meyer, G. R. Y. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy007 · Cited by 606
Self-citation
Metadata
- Authors
- GORENNE, I., KAVURMA, M., SCOTT, S., & BENNETT, M.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- BENNETT, M
- ORCID
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-10-01
- Volume
- 72
- Issue
- 1
- Pages
- 9-17
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2155554546
- Cited by
- 196
- References
- 108
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 11 · 2023: 7 · 2022: 14 · 2021: 15 · 2020: 13 · 2019: 14 · 2018: 9 · 2017: 16 · 2016: 11 · 2015: 12 · 2014: 11 · 2013: 12 · 2012: 8
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cardiovascular Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- vascular smooth muscle cells, cellular senescence, atherosclerosis, atherosclerotic plaque, senescence markers, senescence mechanisms, plaque macrophages
- MeSH terms
- beta-Galactosidase, Cell Cycle, Humans, Muscle, Smooth, Vascular, Telomere, Cellular Senescence, Cell Proliferation, Atherosclerosis
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