Cited by 196Telomeres, Telomerase, and SenescenceAtherosclerosis and Cardiovascular DiseasesNitric Oxide and Endothelin Effects

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Vascular smooth muscle cell senescence in atherosclerosis

GORENNE, I, KAVURMA, M, SCOTT, S, BENNETT, M·2006·Cardiovascular Research

DOI 10.1016/j.cardiores.2006.06.004

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Abstract

Markers of cell senescence have been identified in both the blood and vessel wall of patients with atherosclerosis. In particular, vascular smooth muscle cells (VSMCs) derived from human plaques show numerous features of senescence both in culture and in vivo. This review summarises the evidence for VSMC senescence in atherosclerosis, and outlines the mechanisms and triggers leading to their senescence.

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Authors: GORENNE, I., KAVURMA, M., SCOTT, S., & BENNETT, M.
Affiliations: University of Cambridge (GB)
Corresponding author: BENNETT, M
ORCID: KAVURMA, M
BENNETT, M
Venue: Cardiovascular Research
Publisher: Oxford University Press (OUP)
Published: 2006-10-01
Volume: 72
Issue: 1
Pages: 9-17
ISSN: 0008-6363 (ISSN-L)
DOI: 10.1016/j.cardiores.2006.06.004
OpenAlex: W2155554546
Cited by: 196
References: 108
Citations by year: 2026: 4 · 2025: 8 · 2024: 11 · 2023: 7 · 2022: 14 · 2021: 15 · 2020: 13 · 2019: 14 · 2018: 9 · 2017: 16 · 2016: 11 · 2015: 12 · 2014: 11 · 2013: 12 · 2012: 8
FWCI: 0.62
Type: journal article
Language: en
Open access: closed
Locations: Cardiovascular Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: vascular smooth muscle cells, cellular senescence, atherosclerosis, atherosclerotic plaque, senescence markers, senescence mechanisms, plaque macrophages
MeSH terms: beta-Galactosidase, Cell Cycle, Humans, Muscle, Smooth, Vascular, Telomere, Cellular Senescence, Cell Proliferation, Atherosclerosis

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Vascular smooth muscle cell senescence in atherosclerosis

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