Cited by 400Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionAngiogenesis and VEGF in Cancer

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Life history of eNOS: Partners and pathways

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DUDZINSKI, D, MICHEL, T·2007·Cardiovascular Research

DOI 10.1016/j.cardiores.2007.03.023PMC PMC2682334

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Abstract

The complex regulation of eNOS (endothelial nitric oxide synthase) in cardiovascular physiology occurs at multiple stages. eNOS mRNA levels are controlled both at the transcriptional and post-transcriptional phases, and epigenetic mechanisms appear to modulate tissue-specific eNOS expression. The eNOS enzyme reversibly associates with a diverse family of protein partners that regulate eNOS sub-cellular localization, catalytic function, and biological activity. eNOS enzyme activity and sub-cellular localization are intimately controlled by post-translational modifications including phosphorylation, nitrosylation, and acylation. The multiple extra-cellular stimuli affecting eNOS function coordinate their efforts through these key modifications to dynamically control eNOS and NO bioactivity in the vessel wall. This review will focus on the biochemical partners and perturbations of the eNOS protein as this vital enzyme undergoes modulation by diverse signal transduction pathways in the vascular endothelium.

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Dudzinski DM, Michel T. The vascular biology of nitric oxide and nitric oxide synthases. In: Colman RW, George JN, Goldhaber SZ, Marder VJ, Clowes AW, editors. Hemostasis and thrombosis: basic principles and clinical practice. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 653-66.
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Authors: DUDZINSKI, D., & MICHEL, T.
Affiliations: Harvard University (US)
Brigham and Women's Hospital (US)
Corresponding author: MICHEL, T
ORCID: DUDZINSKI, D
MICHEL, T
Venue: Cardiovascular Research
Publisher: Oxford University Press (OUP)
Published: 2007-07-15
Volume: 75
Issue: 2
Pages: 247-260
ISSN: 0008-6363 (ISSN-L)
DOI: 10.1016/j.cardiores.2007.03.023
PMC: PMC2682334
OpenAlex: W2129195977
Cited by: 400
References: 143
Citations by year: 2026: 5 · 2025: 10 · 2024: 9 · 2023: 11 · 2022: 15 · 2021: 13 · 2020: 5 · 2019: 10 · 2018: 19 · 2017: 19 · 2016: 23 · 2015: 17 · 2014: 40 · 2013: 30 · 2012: 42
FWCI: 3.19
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Cardiovascular Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL046457, P01HL048743)
National Institute of General Medical Sciences (R01GM036259)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: endothelial nitric oxide synthase, nitric oxide, post-translational modification, phosphorylation, nitrosylation, acylation, subcellular localization, epigenetic regulation, transcriptional regulation, post-transcriptional regulation, signal transduction, vascular endothelium, cardiovascular physiology
MeSH terms: Acetylation, Animals, Endothelium, Vascular, Humans, Nitric Oxide, Phosphorylation, Protein Processing, Post-Translational, Signal Transduction, Nitrosation, Nitric Oxide Synthase Type III

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