Cited by 400Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionAngiogenesis and VEGF in Cancer

The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.

Life history of eNOS: Partners and pathways

Open access

DUDZINSKI, D, MICHEL, T·2007·Cardiovascular Research

DOI 10.1016/j.cardiores.2007.03.023PMC PMC2682334

Open this paper in CoChat — free account Open PDF

Abstract

The complex regulation of eNOS (endothelial nitric oxide synthase) in cardiovascular physiology occurs at multiple stages. eNOS mRNA levels are controlled both at the transcriptional and post-transcriptional phases, and epigenetic mechanisms appear to modulate tissue-specific eNOS expression. The eNOS enzyme reversibly associates with a diverse family of protein partners that regulate eNOS sub-cellular localization, catalytic function, and biological activity. eNOS enzyme activity and sub-cellular localization are intimately controlled by post-translational modifications including phosphorylation, nitrosylation, and acylation. The multiple extra-cellular stimuli affecting eNOS function coordinate their efforts through these key modifications to dynamically control eNOS and NO bioactivity in the vessel wall. This review will focus on the biochemical partners and perturbations of the eNOS protein as this vital enzyme undergoes modulation by diverse signal transduction pathways in the vascular endothelium.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.cardiores.2007.03.023

Cites

144 of 144 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., & Zeiher, A. M. (1999) · Nature · doi:10.1038/21224 · Cited by 3,591
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
Fulton, D. J., Gratton, J., McCabe, T. J. D., Fontana, J. T., Fujio, Y., Walsh, K. X., Franke, T. F., Papapetropoulos, A., & Sessa, W. C. (1999) · Nature · doi:10.1038/21218 · Cited by 2,616
Caveolin, a protein component of caveolae membrane coats
Rothberg, K. G., Heuser, J. E., Donzell, W. C., Ying, Y., Glenney, J. R., & Anderson, R. G. W. (1992) · Cell · doi:10.1016/0092-8674(92)90143-z · Cited by 2,259
Protein S-nitrosylation: Purview and parameters
Hess, D. T., Matsumoto, A., Kim, S.-O., Marshall, H. E., & Stamler, J. S. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1569 · Cited by 2,153
Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice
Dráb, M., Verkade, P., Elger, M., Kasper, M. E., Löhn, M., Lauterbach, B., Menne, J., Lindschau, C., Mende, F., Luft, F. C., et al. (2001) · Science · doi:10.1126/science.1062688 · Cited by 1,555
The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.
Kureishi, Y., Luo, Z., Shiojima, I., Bialik, A., Fulton, D. J., Lefer, D. J., Sessa, W. C., & Walsh, K. X. (2000) · Nature Medicine · doi:10.1038/79510 · Cited by 1,438
Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
Simoncini, T., Hafezi‐Moghadam, A., Brazil, D. P., Ley, K. F., Chin, W. W., & Liao, J. K. (2000) · Nature · doi:10.1038/35035131 · Cited by 1,436
Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.
Steinberg, H. O., Brechtel, G., Johnson, A., Fineberg, N. S., & Baron, A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117433 · Cited by 1,216
Dynamic activation of endothelial nitric oxide synthase by Hsp90
García‐Cardeña, G., Fan, R., Shah, V. H., Sorrentino, R., Cirino, G., Papapetropoulos, A., & Sessa, W. C. (1998) · Nature · doi:10.1038/33934 · Cited by 1,029
Modulation of Akt kinase activity by binding to Hsp90
Sato, S., Fujita, N., & Tsuruo, T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.170276797 · Cited by 967

Show all 143 references

Research works printed but not linked: 3

Dudzinski DM, Michel T. The vascular biology of nitric oxide and nitric oxide synthases. In: Colman RW, George JN, Goldhaber SZ, Marder VJ, Clowes AW, editors. Hemostasis and thrombosis: basic principles and clinical practice. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 653-66.
Montagnani M, Chen H, Barr VA, Quon MJ. Insulin-stimulated activation of eNOS in independent of Ca 2+ but requires phosphor- ylation by Akt at Ser 1179 . J Biol Chem 2001;276:30392-8.
Toporsian M, Gros R, Kabir MG, Vera S, Govindaraju K, Eidelman DH, et al. A role for endoglin in coupling eNOS activity and regulating vascular tone revealed in hereditary hemorrhagic telangi- ectasia. Circ Res 2005;96:684-92.

Sorted by citations

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis
Gimbrone, M. A., & García‐Cardeña, G. (2016) · Circulation Research · doi:10.1161/circresaha.115.306301 · Cited by 3,694
Role of insulin resistance in endothelial dysfunction
Muniyappa, R., & Sowers, J. R. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-012-9229-1 · Cited by 539
Molecular Basis for the Regulation of Angiogenesis by Thrombospondin-1 and -2
Lawler, P. R., & Lawler, J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006627 · Cited by 532
eNOS activation by physical forces: from short-term regulation of contraction to chronic remodeling of cardiovascular tissues
Balligand, J.-L., Feron, O., & Dessy, C. (2009) · Physiological Reviews · doi:10.1152/physrev.00042.2007 · Cited by 477
Endothelial dysfunction : the early predictor of atherosclerosis
Mudau, M., Genis, A., Lochner, A., & Strijdom, H. (2012) · Cardiovascular Journal of Africa · doi:10.5830/cvja-2011-068 · Cited by 521
GAPDH mediates nitrosylation of nuclear proteins
Kornberg, M. D., Sen, N., Hara, M. R., Juluri, K. R., Nguyen, J. V., Snowman, A. M., Law, L., Hester, L. D., & Snyder, S. H. (2010) · Nature Cell Biology · doi:10.1038/ncb2114 · Cited by 407
Insulin resistance and cardiovascular disease
Kosmas, C. E., Bousvarou, M. D., Kostara, C. E., Papakonstantinou, E. J., Salamou, E., & Guzman, E. (2023) · Journal of International Medical Research · doi:10.1177/03000605231164548 · Cited by 434
Collateral circulation
Schaper, W. K. A. (2008) · Basic Research in Cardiology · doi:10.1007/s00395-008-0760-x · Cited by 388
Redox Control of Endothelial Function and Dysfunction: Molecular Mechanisms and Therapeutic Opportunities
Thomas, S. R., Witting, P. K., & Drummond, G. R. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2027 · Cited by 383
Redox control of inflammation in macrophages
Brüne, B., Dehne, N., Grossmann, N., Jung, M., Namgaladze, D., Schmid, T., von Knethen, A., & Weigert, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4785 · Cited by 377
What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology
Hill, B. G., Dranka, B. P., Bailey, S. M., Lancaster, J. R., & Darley-Usmar, V. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.101618 · Cited by 310
Regulation of nitric oxide signalling by thrombospondin 1: implications for anti-angiogenic therapies
Isenberg, J. S., Martin‐Manso, G., Maxhimer, J. B., & Roberts, D. D. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2561 · Cited by 301
Cellular signaling and NO production
Michel, T. M., & Vanhoutte, P. M. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0765-9 · Cited by 296
Regulation of obesity and insulin resistance by nitric oxide
Sansbury, B. E., & Hill, B. G. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.016 · Cited by 274
“highest relative abundance in the vascular endothelium, but has also been found in neurons, epithelial cells, and cardiomyocytes [66] as well as adipocytes [67,68] and hepatocytes [69–71].”
Background
Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down‐regulation of NADPH oxidase
Durrant, J., Seals, D. R., Connell, M. L., Russell, M. J., Lawson, B. R., Folian, B. J., Donato, A. J., & Lesniewski, L. A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.169771 · Cited by 250
An Integrated View of Insulin Resistance and Endothelial Dysfunction
Muniyappa, R., Iantorno, M., & Quon, M. J. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.06.001 · Cited by 227
The endothelium: influencing vascular smooth muscle in many ways
Triggle, C. R., Samuel, S. M., Ravishankar, S., Marei, I., Arunachalam, G., & Ding, H. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y2012-073 · Cited by 229
Uncoupling of Endothelial Nitric Oxide Synthase in Perivascular Adipose Tissue of Diet-Induced Obese Mice
Xia, N., Horke, S., Habermeier, A., Closs, E. I., Reifenberg, G., Gericke, A., Mikhed, Y., Münzel, T. F., Daiber, A., Förstermann, U., et al. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.306263 · Cited by 210
Nitric oxide: role in tumour biology and iNOS/NO-based anticancer therapies
Singh, S., & Gupta, A. K. (2011) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-011-1654-4 · Cited by 215
The coordination of S-sulfhydration, S-nitrosylation, and phosphorylation of endothelial nitric oxide synthase by hydrogen sulfide
Altaany, Z., Ju, Y., Yang, G., & Wang, R. (2014) · Science Signaling · doi:10.1126/scisignal.2005478 · Cited by 216
Antioxidant Effects of Resveratrol in Cardiovascular, Cerebral and Metabolic Diseases
Carrizzo, A., Forte, M., Damato, A., Trimarco, V., Salzano, F., Bartolo, M., Maciag, A., Puca, A. A., & Vecchione, C. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.07.021 · Cited by 203
The Cerebral Circulation
Cipolla, M. J. (2009) · Colloquium Series on Integrated Systems Physiology From Molecule to Function · doi:10.4199/c00005ed1v01y200912isp002 · Cited by 223
The Endothelium, Part I: Multiple Functions of the Endothelial Cells -- Focus on Endothelium-Derived Vasoactive Mediators
Félétou, M. (2011) · Colloquium Series on Integrated Systems Physiology From Molecule to Function · doi:10.4199/c00031ed1v01y201105isp019 · Cited by 224
Intrauterine growth restriction decreases pulmonary alveolar and vessel growth and causes pulmonary artery endothelial cell dysfunction in vitro in fetal sheep
Rozance, P. J., Seedorf, G., Brown, A., Roe, G. B., O'Meara, M. C., Gien, J., Tang, J., & Abman, S. H. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00197.2011 · Cited by 200
Emerging Role of Nitric Oxide and Heat Shock Proteins in Insulin Resistance
Molina, M. N., Ferder, L., & Manucha, W. A. (2015) · Current Hypertension Reports · doi:10.1007/s11906-015-0615-4 · Cited by 203
Vasodilator interactions in skeletal muscle blood flow regulation
Hellsten, Y., Nyberg, M., Jensen, L. G., & Mortensen, S. P. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.240762 · Cited by 197
Endothelial Dysfunction Driven by Hypoxia—The Influence of Oxygen Deficiency on NO Bioavailability
Janaszak‐Jasiecka, A., Siekierzycka, A., Płoska, A., Dobrucki, I. T., & Kalinowski, L. (2021) · Biomolecules · doi:10.3390/biom11070982 · Cited by 197
Effects of the Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 on the Tumor Vasculature: Implications for Clinical Imaging
Schnell, C., Stauffer, F., ALLEGRINI, P. R., O’Reilly, T., McSheehy, P. M. J., Dartois, C., Stumm, M., Cozens, R. M., Littlewood-Evans, A. J., Garcia-Echeverria, C., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1044 · Cited by 178
The eNOS signalosome and its link to endothelial dysfunction
Siragusa, M., & Fleming, I. (2016) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-016-1839-0 · Cited by 180
Regulation of eNOS Enzyme Activity by Posttranslational Modification
Heiß, E. H., & Dirsch, V. M. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660745 · Cited by 171
Modulation of endothelial nitric oxide by plant-derived products
Schmitt, C. A., & Dirsch, V. M. (2009) · Nitric Oxide · doi:10.1016/j.niox.2009.05.006 · Cited by 177
Recent Advances in the Study on Resveratrol
Nakata, R., Takahashi, S., & Inoue, H. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.35.273 · Cited by 171
Bile Acid Receptor TGR5 Agonism Induces NO Production and Reduces Monocyte Adhesion in Vascular Endothelial Cells
Kida, T., Tsubosaka, Y., Hori, M., Ozaki, H., & Murata, T. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301565 · Cited by 174
Nitric oxide: Orchestrator of endothelium-dependent responses
Félétou, M., Köhler, R., & Vanhoutte, P. M. (2011) · Annals of Medicine · doi:10.3109/07853890.2011.585658 · Cited by 169
Differential regulation of inducible and endothelial nitric oxide synthase by kinin B1 and B2 receptors
Kuhr, F., Lowry, J., Zhang, Y., Brovkovych, V. M., & Skidgel, R. A. (2010) · Neuropeptides · doi:10.1016/j.npep.2009.12.004 · Cited by 154
Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation
Bauer, E. M., Yan, Q., Miller, T. W., Bandle, R., Csányi, G., Pagano, P. J., Bauer, P. M., Schnermann, J. B., Roberts, D. D., & Isenberg, J. S. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq218 · Cited by 152
Endothelial nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo
Kellogg, D. L., Zhao, J. L., & Wu, Y. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00082.2008 · Cited by 148
Lipid Rafts and Caveolae and Their Role in Compartmentation of Redox Signaling
Patel, H. H., & Insel, P. A. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2365 · Cited by 139
De Novo Lipogenesis Maintains Vascular Homeostasis through Endothelial Nitric-oxide Synthase (eNOS) Palmitoylation*
Wei, X., Schneider, J. G., Shenouda, S. M., Lee, A., Towler, D. A., Chakravarthy, M. V., Vita, J. A., & Semenkovich, C. F. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.193037 · Cited by 132
Vascular Aging in Women: is Estrogen the Fountain of Youth?
Novella, S., Dantas, A. P., Segarra, G., Medina, P., & Hermenegildo, C. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00165 · Cited by 148
Endothelial nitric oxide synthase in the microcirculation
Shu, X. H., Keller, T. C. S., Begandt, D., Butcher, J. T., Biwer, L. A., Keller, A., Columbus, L. M., & Isakson, B. E. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2021-0 · Cited by 128
Nitric oxide–dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition
Chen, Z., Bakhshi, F. R., Shajahan‐Haq, A. N., Sharma, T., Mao, M., Trane, A., Bernatchez, P. N., Amerongen, G. P. V. N., Bonini, M. G., Skidgel, R. A., et al. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-09-0811 · Cited by 132
The protective effects of Schisandra chinensis fruit extract and its lignans against cardiovascular disease: A review of the molecular mechanisms
Chun, J. N., Cho, M., So, I., & Jeon, J. (2014) · Fitoterapia · doi:10.1016/j.fitote.2014.06.014 · Cited by 127
Caveolin-1 Is a Critical Determinant of Autophagy, Metabolic Switching, and Oxidative Stress in Vascular Endothelium
Shiroto, T., Romero, N., Sugiyama, T., Sartoretto, J. L., Kalwa, H., Yan, Z., Shimokawa, H., & Michel, T. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087871 · Cited by 125
Impairment of both nitric oxide‐mediated and EDHF‐type relaxation in small mesenteric arteries from rats with streptozotocin‐induced diabetes
Leo, C., Hart, J. L., & Woodman, O. L. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01023.x · Cited by 122
Specificity in S-Nitrosylation: A Short-Range Mechanism for NO Signaling?
Martı́nez-Ruiz, A., Araújo, I. M., Izquierdo-Álvarez, A., Hernansanz‐Agustín, P., Lamas, S., & Serrador, J. M. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.5066 · Cited by 126
Aging-Associated miR-217 Aggravates Atherosclerosis and Promotes Cardiovascular Dysfunction
de Yébenes, V. G., Briones, A. M., Martos-Folgado, I., Mur, S. M., Oller, J., Bilal, F., González‐Amor, M., Méndez‐Barbero, N., Silla-Castro, J. C., Were, F., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314333 · Cited by 123
Circulating Blood Endothelial Nitric Oxide Synthase Contributes to the Regulation of Systemic Blood Pressure and Nitrite Homeostasis
Wood, K. C., Cortese-Krott, M. M., Kovacic, J. C., Noguchi, A. C., Liu, V. B., Wang, X., Raghavachari, N., Boehm, M., Kato, G. J., Kelm, M., et al. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.301068 · Cited by 126
Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain
Stuehr, D. J., Tejero, J., & Haque, M. M. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07120.x · Cited by 125
Differential Modulation of Nitric Oxide Synthases in Aging: Therapeutic Opportunities
Cáu, S. B. D. A., Carneiro, F. S., & Tostes, R. C. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00218 · Cited by 131
Nanocosmetics and Nanomedicines
(2011) · doi:10.1007/978-3-642-19792-5 · Cited by 116
Nitric oxide and endothelial cellular senescence
Hayashi, T., Yano, K., Matsui‐Hirai, H., Yokoo, H., Hattori, Y., & Iguchi, A. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.09.002 · Cited by 116
The effects of acute and chronic exercise on the vasculature
Whyte, J. J., & Laughlin, M. H. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02127.x · Cited by 119
Molecular Regulation of Tumor Angiogenesis and Perfusion via Redox Signaling
Miller, T. W., Isenberg, J. S., & Roberts, D. D. (2009) · Chemical Reviews · doi:10.1021/cr8005125 · Cited by 113
The matricellular protein thrombospondin-1 globally regulates cardiovascular function and responses to stress via CD47
Roberts, D. D., Miller, T. W., Rogers, N. M., Yao, M., & Isenberg, J. S. (2012) · Matrix Biology · doi:10.1016/j.matbio.2012.01.005 · Cited by 117
Emerging role of PKA/eNOS pathway in therapeutic angiogenesis for ischaemic tissue diseases
Bir, S. C., Xiong, Y., Kevil, C. G., & Luo, J. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs143 · Cited by 110
Role of Vitamin D Deficiency in the Pathogenesis of Cardiovascular and Cerebrovascular Diseases
Pál, É., Ungvari, Z. I., Benyó, Z., & Várbı́ró, S. (2023) · Nutrients · doi:10.3390/nu15020334 · Cited by 117
Exercise restores endothelial function independently of weight loss or hyperglycaemic status in db/db mice
Moien‐Afshari, F., Ghosh, S., Khazaei, M., Kieffer, T. J., Brownsey, R. W., & Laher, I. (2008) · Diabetologia · doi:10.1007/s00125-008-0996-x · Cited by 113
TRPV1 agonism inhibits endothelial cell inflammation via activation of eNOS/NO pathway
Wang, Y., Cui, L., Xu, H., Liu, S., Zhu, F.-Y., Yan, F., Shen, S., & Zhu, M. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.03.016 · Cited by 107
Endothelial primary cilia inhibit atherosclerosis
Dinsmore, C. J., & Reiter, J. F. (2016) · EMBO Reports · doi:10.15252/embr.201541019 · Cited by 106
Ascorbate prevents placental oxidative stress and enhances birth weight in hypoxic pregnancy in rats
Richter, H. G., Camm, E. J., Modi, B., Naeem, F., Cross, C. M., Cindrová‐Davies, T., Spasic‐Boskovic, O., Dunster, C., Mudway, I., Kelly, F. J., et al. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.226340 · Cited by 106
Mechanism of Purinergic Activation of Endothelial Nitric Oxide Synthase in Endothelial Cells
da Silva, C. G., Specht, A., Wegiel, B., Ferran, C. J., & Kaczmarek, E. (2009) · Circulation · doi:10.1161/circulationaha.108.764571 · Cited by 105
The Cerebral Circulation
Cipolla, M. J. (2016) · Cited by 105
Endothelial Cell Autophagy Maintains Shear Stress–Induced Nitric Oxide Generation via Glycolysis-Dependent Purinergic Signaling to Endothelial Nitric Oxide Synthase
Bharath, L. P., Cho, J. M., Park, S.-K., Ruan, T., Li, Y., Mueller, R., Bean, T., Reese, V. R., Richardson, R. S., Cai, J., et al. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309510 · Cited by 98
Human serum albumin improves endothelial dysfunction and survival during experimental endotoxemia: Concentration-dependent properties*
Kremer, H., Baron‐Menguy, C., Tesse, A., Gallois, Y., Mercat, A., Henrion, D., Andriantsitohaina, R., Asfar, P., & Meziani, F. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e318211ff6e · Cited by 92
The nitric oxide pathway – evidence and mechanisms for protection against liver ischaemia reperfusion injury
Abu‐Amara, M., Yang, S. Y., Seifalian, A. M., Davidson, B. R., & Fuller, B. J. (2012) · Liver International · doi:10.1111/j.1478-3231.2012.02755.x · Cited by 91
Salvianolic acid B and Tanshinone IIA attenuate myocardial ischemia injury in mice by NO production through multiple pathways
Pan, C., Lou, L., Huo, Y., Singh, G., Chen, M., Zhang, D., Wu, A., Zhao, M., Wang, S., & Li, J. (2011) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944710396538 · Cited by 86
The ubiquitin-proteasome pathway and endothelial (dys)function
Stangl, K., & Stangl, V. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp315 · Cited by 89
Infectious Spleen and Kidney Necrosis Virus (a Fish Iridovirus) Enters Mandarin Fish Fry Cells via Caveola-Dependent Endocytosis
Guo, C.-J., Wu, Y., Yang, L., Yang, X.-B., He, J. G., Mi, S., Jia, K., Weng, S., Yu, X., & He, J. (2011) · Journal of Virology · doi:10.1128/jvi.06947-11 · Cited by 83
Vascular Protection Following Cerebral Ischemia and Reperfusion
Palomares, S. M., & Cipolla, M. J. (2011) · Journal of Neurology & Neurophysiology · doi:10.4172/2155-9562.s1-004 · Cited by 80
Vascular targeting of nanoparticles for molecular imaging of diseased endothelium
Atukorale, P. U., Covarrubias, G., Bauer, L., & Karathanasis, E. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.09.006 · Cited by 82
Endothelial nitric oxide synthase regulates N-Ras activation on the Golgi complex of antigen-stimulated T cells
Ibiza, S., Pérez-Rodríguez, A., Ortega, Á., Martı́nez-Ruiz, A., Barreiro, O., García-Domínguez, C. A., Víctor, V. M., Esplugues, J. V., Rojas, J. M., Sánchez‐Madrid, F., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711062105 · Cited by 77
Current concepts on the role of nitric oxide in portal hypertension
Hu, L. S. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i11.1707 · Cited by 81
New Insights into the Pathophysiology of Sickle Cell Disease-Associated Priapism
Bivalacqua, T. J., Musicki, B., Kutlu, Ö., & Burnett, A. L. “. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2011.02288.x · Cited by 74
Interaction between nitric oxide signaling and gap junctions: Effects on vascular function
Looft‐Wilson, R. C., Billaud, M., Johnstone, S. R., Straub, A. C., & Isakson, B. E. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2011.07.031 · Cited by 71
Diallyl disulfide and diallyl trisulfide protect endothelial nitric oxide synthase against damage by oxidized low‐density lipoprotein
Lei, Y., Liu, C., Sheen, L., Chen, H., & Lii, C. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900278 · Cited by 70
Grb-2–associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A–endothelial NOS pathway
Lu, Y., Xiong, Y., Huo, Y., Han, J., Yang, X. Y., Zhang, R., Zhu, D., Klein‐Hessling, S., Li, J., Zhang, X., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009395108 · Cited by 70
Adverse Effects of Simulated Hyper- and Hypo-Phosphatemia on Endothelial Cell Function and Viability
Peng, A., Wu, T., Caihong, Z., Rakheja, D., Zhu, J., Ye, T., Hutcheson, J., Vaziri, N. D., Liu, Z., Mohan, C., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023268 · Cited by 71
Inhibition of eNOS phosphorylation mediates endothelial dysfunction in renal failure: new effect of asymmetric dimethylarginine
Kajimoto, H., Kai, H., Aoki, H., Yasuoka, S., Anegawa, T., Aoki, Y., Ueda, S., Okuda, S., & Imaizumi, T. (2012) · Kidney International · doi:10.1038/ki.2011.476 · Cited by 72
Endothelial AMP-Activated Protein Kinase Regulates Blood Pressure and Coronary Flow Responses Through Hyperpolarization Mechanism in Mice
Enkhjargal, B., Godo, S., Sawada, A., Nergui, S., Saito, H., Noda, K., Satoh, K., & Shimokawa, H. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303735 · Cited by 70
Membrane rafts and caveolae in cardiovascular signaling
Insel, P. A., & Patel, H. H. (2008) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e3283186f82 · Cited by 69
Nitrosation‐Dependent Caveolin 1 Phosphorylation, Ubiquitination, and Degradation and its Association with Idiopathic Pulmonary Arterial Hypertension
Bakhshi, F. R., Mao, M., Shajahan‐Haq, A. N., Piegeler, T., Chen, Z., Chernaya, O., Sharma, T., Elliott, W. M., Szulcek, R., Bogaard, H. J., et al. (2013) · Pulmonary Circulation · doi:10.1086/674753 · Cited by 68
Protective effects of AMP‐activated protein kinase in the cardiovascular system
Xu, Q., & Si, L. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01179.x · Cited by 68
Involvement of free radicals in breast cancer
Ríos‐Arrabal, S., Artacho‐Cordón, F., León, J., Elisa, R.-M., Salinas-Asensio, M. D. M., Calvente, I., & Núñez, M. I. (2013) · SpringerPlus · doi:10.1186/2193-1801-2-404 · Cited by 72
Modulation of Endothelial Function by TMAO, a Gut Microbiota-Derived Metabolite
Querio, G., Antoniotti, S., Geddo, F., Levi, R. C., & Gallo, M. P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065806 · Cited by 70
Role of endothelial nitric oxide synthase in remote ischemic preconditioning of the mouse liver
Abu‐Amara, M., Yang, S. Y., Quaglia, A., Rowley, P., Fuller, B. J., Seifalian, A. M., & Davidson, B. R. (2011) · Liver Transplantation · doi:10.1002/lt.22272 · Cited by 66
Critical role of hydrogen peroxide signaling in the sequential activation of p38 MAPK and eNOS in laminar shear stress
Bretón-Romero, R., González de Orduña, C., Romero, N., Sánchez-Gómez, F. J., de Álvaro, C., Porras, A., Rodríguez-Pascual, F., Laranjinha, J., Radi, R., & Lamas, S. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.12.026 · Cited by 66
Vaspin Increases Nitric Oxide Bioavailability through the Reduction of Asymmetric Dimethylarginine in Vascular Endothelial Cells
Jung, C. H., Lee, W. J., Hwang, J. Y., Lee, M. J., Seol, S. M., Kim, Y., Lee, Y. L., Kim, H. S., Kim, M., & Park, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052346 · Cited by 68
The cAMP effectors PKA and Epac activate endothelial NO synthase through PI3K/Akt pathway in human endothelial cells
García‐Morales, V., Luaces-Regueira, M., & Campos‐Toimil, M. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.09.004 · Cited by 65
Discordance between eNOS phosphorylation and activation revealed by multispectral imaging and chemogenetic methods
Eroğlu, E., Saravi, S. S. S., Sorrentino, A., Steinhorn, B. S., & Michel, T. M. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1910942116 · Cited by 63
Endothelial Sphingolipid De Novo Synthesis Controls Blood Pressure by Regulating Signal Transduction and NO via Ceramide
Cantalupo, A., Sasset, L., Gargiulo, A., Rubinelli, L., Gaudio, I. D., Benvenuto, D., Wadsack, C., Jiang, X.-C., Bucci, M. R., & Lorenzo, A. D. (2020) · Hypertension · doi:10.1161/hypertensionaha.119.14507 · Cited by 64
Obesity, type 2 diabetes, and impaired insulin-stimulated blood flow: role of skeletal muscle NO synthase and endothelin-1
Reynolds, L. J., Credeur, D. P., Manrique, C. M., Padilla, J., Fadel, P. J., & Thyfault, J. P. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00286.2016 · Cited by 63
Role of endothelial primary cilia as fluid mechanosensors on vascular health
Luu, V. Z., Chowdhury, B., Al-Omran, M., Hess, D. A., & Verma, S. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.06.818 · Cited by 66
Endothelial Nitric-oxide Synthase Activation Generates an Inducible Nitric-oxide Synthase-like Output of Nitric Oxide in Inflamed Endothelium
Lowry, J., Brovkovych, V. M., Zhang, Y., & Skidgel, R. A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.436022 · Cited by 63
Endothelial cell respiration is affected by the oxygen tension during shear exposure: role of mitochondrial peroxynitrite
Jones, C. I., Han, Z., Presley, T. D., Varadharaj, S., Zweier, J. L., Ilangovan, G., & Alevriadou, B. R. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00549.2007 · Cited by 61
Genome-Wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis
Hager, J., Kamatani, Y., Cazier, J., Youhanna, S. C., Ghassibe‐Sabbagh, M., Platt, D. E., Abchee, A., Romanos, J., Khazen, G., Othman, R., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038663 · Cited by 59
N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF-mediated activation of endothelial nitric oxide synthase
Hou, H., Hammock, B. D., Su, K.-H., Morisseau, C. H. P., Kou, Y. R., Imaoka, S., Oguro, A., Shyue, S., Zhao, J., & Lee, T. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr267 · Cited by 58
Provascular strategy: Targeting functional adaptations of mature blood vessels in tumors to selectively influence the tumor vascular reactivity and improve cancer treatment
Sonveaux, P. (2008) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2008.01.024 · Cited by 58
Myocardial protection against reperfusion injury: The cGMP pathway
Agulló, L., Sartório, C. L., Ruiz‐Meana, M., & David Garcia-dorado, A. (2009) · Thrombosis and Haemostasis · doi:10.1160/th08-11-0764 · Cited by 57
Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase
Chung, B.-H., Kim, S., Kim, J.-D., Lee, J. J., Baek, Y.-Y., Jeoung, D., Lee, H., Choe, J., Ha, K., Won, M., et al. (2012) · Experimental & Molecular Medicine · doi:10.3858/emm.2012.44.3.014 · Cited by 57

Authors: DUDZINSKI, D., & MICHEL, T.
Affiliations: Harvard University (US)
Brigham and Women's Hospital (US)
Corresponding author: MICHEL, T
ORCID: DUDZINSKI, D
MICHEL, T
Venue: Cardiovascular Research
Publisher: Oxford University Press (OUP)
Published: 2007-07-15
Volume: 75
Issue: 2
Pages: 247-260
ISSN: 0008-6363 (ISSN-L)
DOI: 10.1016/j.cardiores.2007.03.023
PMC: PMC2682334
OpenAlex: W2129195977
Cited by: 400
References: 143
Citations by year: 2026: 5 · 2025: 10 · 2024: 9 · 2023: 11 · 2022: 15 · 2021: 13 · 2020: 5 · 2019: 10 · 2018: 19 · 2017: 19 · 2016: 23 · 2015: 17 · 2014: 40 · 2013: 30 · 2012: 42
FWCI: 3.19
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Cardiovascular Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL046457, P01HL048743)
National Institute of General Medical Sciences (R01GM036259)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: endothelial nitric oxide synthase, nitric oxide, post-translational modification, phosphorylation, nitrosylation, acylation, subcellular localization, epigenetic regulation, transcriptional regulation, post-transcriptional regulation, signal transduction, vascular endothelium, cardiovascular physiology
MeSH terms: Acetylation, Animals, Endothelium, Vascular, Humans, Nitric Oxide, Phosphorylation, Protein Processing, Post-Translational, Signal Transduction, Nitrosation, Nitric Oxide Synthase Type III

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Life history of eNOS: Partners and pathways

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks