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Cited by 420

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation

Open access
CAI, W, WANG, M, MOORE, P, JIN, H, YAO, T, ZHU, Y·2007·Cardiovascular Research
DOI 10.1016/j.cardiores.2007.05.026
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Abstract

OBJECTIVE: Hydrogen sulfide (H(2)S) has been reported to be a gasotransmitter which regulates cardiovascular homeostasis. The present study aims to examine the hypothesis that hydrogen sulfide is able to promote angiogenesis. METHODS: Angiogenesis was assessed using in vitro parameters (i.e. endothelial cell proliferation, adhesion, transwell migration assay, scratched wound healing and formation of tube-like structure) and in vivo by assessing neovascularization in mice. Phosphorylation of Akt was measured using Western blot analysis. RESULTS: Exogenously administered NaHS (H(2)S donor) concentration-dependently (10-20 micromol/l) increased cell growth, migration, scratched wound healing and tube-like structure formation in cultured endothelial cells. These effects of NaHS on endothelial wound healing and tube-like structure formation were prevented by either the phosphatidylinositol 3-kinase (PI3K) inhibitor LY 294002 (5 micromol/l) or transfection of a dominant-negative mutant of Akt. NaHS increased Akt phosphorylation and this effect was also blocked by either LY 294002 or wortmannin (25 nmol/l). NaHS did not significantly alter the levels of vascular endothelial growth factor, mRNA expression of fibroblast growth factor and angiopoietin-1, or nitric oxide metabolites. NaHS treatment (10 and 50 micromol kg(-1) day(-1)) significantly promoted neovascularization in vivo in mice. CONCLUSION: The present study reports a novel proangiogenic role of H(2)S which is dependent on activation of Akt.

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Metadata

Authors
CAI, W., WANG, M., MOORE, P., JIN, H., YAO, T., & ZHU, Y.
Venue
Cardiovascular Research
Publisher
Oxford University Press (OUP)
Published
2007-10-01
Volume
76
Issue
1
Pages
29-40
ISSN
0008-6363 (ISSN-L)
DOI
10.1016/j.cardiores.2007.05.026
OpenAlex
W2106962270
Cited by
420
References
37
FWCI
6.15
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation. https://app.cochat.ai/papers/10.1016/j.cardiores.2007.05.026
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CAI, W., WANG, M., MOORE, P., JIN, H., YAO, T., & ZHU, Y. (2007). The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation. Cardiovascular Research. https://doi.org/10.1016/j.cardiores.2007.05.026

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.