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Cited by 25Nitric Oxide and Endothelin EffectsCoronary Interventions and DiagnosticsCardiovascular Health and Disease Prevention

Effects of tetrahydrobiopterin on coronary vascular reactivity in atherosclerotic human coronary arteries☆

WORTHLEY, M, KANANI, R, SUN, Y, SUN, Y, GOODHART, D, CURTIS, M, ANDERSON, T·2007·Cardiovascular Research
DOI 10.1016/j.cardiores.2007.07.009
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Abstract

OBJECTIVES: Reduced nitric oxide (NO) bioavailability is a key mechanism in the development of endothelial dysfunction. The NO synthase cofactor, tetrahydrobiopterin (BH4), increases NO availability, yet its effect in the human coronary circulation, particularly following PCI, remains uncertain. This study was designed to evaluate the effects of intracoronary BH4 in human coronary arteries with non-critical coronary artery disease or following percutaneous coronary intervention (PCI). METHODS: The study group consisted of 57 stable patients, 10 of which were controls. Active drug was administered in 47 patients, with either de novo non-critical coronary disease (non-stent group; n=25) or following PCI (stent group; n=22). Coronary blood flow (CBF) was measured (0.014-inch Doppler flow wire) in each of these groups in response to sequential intracoronary infusions of acetylcholine (Ach, 10(-7) & 10(-6) M), BH4 (250 microg/min & 500 microg/min) and a co-infusion of BH4 (500 microg/min) and Ach (10(-7) & 10(-6) M). The primary endpoint evaluated the % change in CBF to Ach compared to co-infusion of Ach and BH4. RESULTS: Mean age was 60+/-10 years (M 45:F 12). Regarding the primary hypothesis, no difference was observed between Ach response compared to co-infusion of BH4 and Ach in the % change in CBF in either the non-stent group (Ach 97+/-122%, Ach/BH4 87+/-95%) or the stent group (Ach 77+/-105%, Ach/BH4 55+/-97%). CONCLUSIONS: In native non-critical coronary artery disease or following PCI, coronary microvascular endothelial function is not improved by co-administration of Ach and BH4.

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  • The red blood cell expresses a functional eNOS that contributes in part to systemic blood pressure responses.

    “a number of recent studies using chimeric cross bone marrow transplant mouse models have shown that the red blood cell also expresses a functional eNOS that contributes in part to systemic blood pressure responses”

    From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [1025]

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Authors
WORTHLEY, M., KANANI, R., SUN, Y., SUN, Y., GOODHART, D., CURTIS, M., & ANDERSON, T.
Affiliations
University of Calgary (CA)
Corresponding author
ANDERSON, T
Venue
Cardiovascular Research
Publisher
Oxford University Press (OUP)
Published
2007-12-01
Volume
76
Issue
3
Pages
539-546
ISSN
0008-6363 (ISSN-L)
DOI
10.1016/j.cardiores.2007.07.009
OpenAlex
W1987672331
Cited by
25
References
50
Citations by year
2025: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 2 · 2013: 3 · 2012: 1
FWCI
1.56
Type
journal article
Language
en
Open access
closed
Locations
  • Cardiovascular Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Heart and Stroke Foundation of Canada
  • Fondation pour la Recherche Médicale
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords
tetrahydrobiopterin, nitric oxide bioavailability, coronary vascular reactivity, endothelial dysfunction, percutaneous coronary intervention, coronary microvascular function, acetylcholine response, coronary blood flow, coronary artery disease, nitric oxide synthase cofactor
MeSH terms
Acetylcholine, Aged, Biopterins, Combined Modality Therapy, Coronary Vessels, Drug Therapy, Combination, Endothelium, Vascular, Female, Humans, Male, Middle Aged, Regional Blood Flow, Vasodilator Agents, Stents, Angioplasty, Balloon, Coronary, Treatment Outcome, Atherosclerosis

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