Tetrahydrobiopterin in Cardiovascular Health and Disease

Bendall, Jennifer K.; Douglas, Gillian; McNeill, Eileen; Channon, Keith M.; Crabtree, Mark J.

doi:10.1089/ars.2013.5566

Cited by 234Nitric Oxide and Endothelin EffectsFolate and B Vitamins ResearchMetabolism and Genetic Disorders

Tetrahydrobiopterin in Cardiovascular Health and Disease

Open access

Bendall, Jennifer K., Douglas, Gillian, McNeill, Eileen, Channon, Keith M., Crabtree, Mark J.·2014·Antioxidants & Redox Signaling

DOI 10.1089/ars.2013.5566PMC PMC4038990

Open this paper in CoChat — free account

Abstract

Tetrahydrobiopterin (BH4) functions as a cofactor for several important enzyme systems, and considerable evidence implicates BH4 as a key regulator of endothelial nitric oxide synthase (eNOS) in the setting of cardiovascular health and disease. BH4 bioavailability is determined by a balance of enzymatic de novo synthesis and recycling, versus degradation in the setting of oxidative stress. Augmenting vascular BH4 levels by pharmacological supplementation has been shown in experimental studies to enhance NO bioavailability. However, it has become more apparent that the role of BH4 in other enzymatic pathways, including other NOS isoforms and the aromatic amino acid hydroxylases, may have a bearing on important aspects of vascular homeostasis, inflammation, and cardiac function. This article reviews the role of BH4 in cardiovascular development and homeostasis, as well as in pathophysiological processes such as endothelial and vascular dysfunction, atherosclerosis, inflammation, and cardiac hypertrophy. We discuss the therapeutic potential of BH4 in cardiovascular disease states and attempt to address how this modulator of intracellular NO-redox balance may ultimately provide a powerful new treatment for many cardiovascular diseases. Antioxid. Redox Signal. 20, 3040–3077.

Integrity signals

Registry

Crossref · 10.1089/ars.2013.5566

Cites

345 of 345 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

BH4 plays a critical role in the catalytic cycle of NOS.
“In addition, BH4 plays a critical role in the catalytic cycle of NOS (87, 204, 377, 904, 933, 1000, 1007).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [87]

Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725 · see citing works
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
Dellinger, R. P., Levy, M. M., Carlet, J. M., Bion, J., Parker, M. M., Jaeschke, R., Reinhart, K., Angus, D. C., Brun‐Buisson, C., Beale, R. J., et al. (2007) · Intensive Care Medicine · doi:10.1007/s00134-007-0934-2 · Cited by 6,722 · see citing works
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504 · see citing works
Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
Griffith, O. W. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90139-6 · Cited by 4,628 · see citing works
Nitric oxide synthases: regulation and function
Forstermann, U., & Sessa, W. C. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr304 · Cited by 4,409 · see citing works
Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress
Cai, H., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.87.10.840 · Cited by 3,839 · see citing works
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.
Bredt, D. S., & Snyder, S. H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.2.682 · Cited by 3,308 · see citing works
C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
(2010) · The Lancet · doi:10.1016/s0140-6736(09)61717-7 · Cited by 2,546 · see citing works
Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications
Flier, J. S., Underhill, L. H., Brownlee, M., Cerami, A., & Vlassara, H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805193182007 · Cited by 2,512 · see citing works
Glutamate, nitric oxide and cell-cell signalling in the nervous system
Garthwaite, J. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90022-m · Cited by 2,401 · see citing works
The reaction of NO with superoxide
Huie, R. E., & Padmaja, S. (1993) · Free Radical Research Communications · doi:10.3109/10715769309145868 · Cited by 2,121 · see citing works
Hypertension in mice lacking the gene for endothelial nitric oxide synthase
Huang, P. L., Huang, Z., Mashimo, H., Bloch, K. D., Moskowitz, M. A., Bevan, J. A., & Fishman, M. C. (1995) · Nature · doi:10.1038/377239a0 · Cited by 2,070 · see citing works
Endothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace
Förstermann, U., & Münzel, T. (2006) · Circulation · doi:10.1161/circulationaha.105.602532 · Cited by 1,957 · cited 1× · see citing works
“Elevated ADMA may inhibit NO synthesis by eNOS or even result in eNOS uncoupling, which would further enhance oxidative stress (75).”
Role of endothelium-derived nitric oxide in the regulation of blood pressure.
Rees, D. D., Palmer, R. M. J., & Moncada, S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.9.3375 · Cited by 1,827 · see citing works
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.
Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L., & Ross, R. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.133 · Cited by 1,693 · see citing works
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
Landmesser, U., Dikalov, S., Price, S. R., McCann, L., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200314172 · Cited by 1,660 · see citing works
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
Landmesser, U., Dikalov, S., Price, S. R., McCann, L. A., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci14172 · Cited by 1,652 · see citing works
Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors
Vásquez-Vivar, J., Kalyanaraman, B., Martásek, P., Hogg, N., Masters, B. S. S., Karoui, H., Tordo, P., & Pritchard, K. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9220 · Cited by 1,484 · see citing works
Role of oxidative stress in cardiovascular diseases
Dhalla, N. S., Temsah, R. M., & Netticadan, T. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018060-00002 · Cited by 1,467 · see citing works
A Stable Nonfluorescent Derivative of Resorufin for the Fluorometric Determination of Trace Hydrogen Peroxide: Applications in Detecting the Activity of Phagocyte NADPH Oxidase and Other Oxidases
Zhou, M., Diwu, Z. J., Panchuk-Voloshina, N., & Haugland, R. P. (1997) · Analytical Biochemistry · doi:10.1006/abio.1997.2391 · Cited by 1,400 · see citing works
Nitric oxide synthase structure and mechanism
Marletta, M. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31375-9 · Cited by 1,341 · see citing works
Estrogen and coronary heart disease in women
Barrett-Connor, E. (1991) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1991.03460140089033 · Cited by 1,241 · see citing works
Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.
Murohara, T., Asahara, T., Silver, M., Bauters, C., Masuda, H., Kalka, C., Kearney, M., Chen, D., Symes, J. F., Fishman, M. C., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1560 · Cited by 1,201 · see citing works
Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.
Papapetropoulos, A., García‐Cardeña, G., Madri, J. A., & Sessa, W. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119868 · Cited by 1,192 · see citing works
Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus
Hink, U., Li, H., Mollnau, H., Oelze, M., Matheis, E., Hartmann, M., Skatchkov, M. P., Thaiss, F., Stahl, R. A. K., Warnholtz, A., et al. (2001) · Circulation Research · doi:10.1161/01.res.88.2.e14 · Cited by 1,176 · see citing works
Subpopulations of Mouse Blood Monocytes Differ in Maturation Stage and Inflammatory Response
Sunderkötter, C., Nikolic, T., Dillon, M. J., van Rooijen, N., Stehling, M., Drevets, D. A., & Leenen, P. J. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4410 · Cited by 1,124 · see citing works
Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation.
Faggiotto, A., Ross, R., & Harker, L. A. (1984) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.4.4.323 · Cited by 990 · see citing works
Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus
Guzik, T. J., Mussa, S., Gastaldi, D., Sadowski, J., Ratnatunga, C., Pillai, R. G., & Channon, K. M. (2002) · Circulation · doi:10.1161/01.cir.0000012748.58444.08 · Cited by 979 · see citing works
Self-citation
Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences
Stout, R. D., Jiang, C., Matta, B., Tietzel, I., Watkins, S. K., & Suttles, J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.342 · Cited by 968 · see citing works
Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples
Baker, M. A., Cerniglia, G. J., & Zaman, A. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90208-q · Cited by 921 · see citing works
Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients with septic shock*
López, A., Lorente, J. A., Steingrub, J. S., Bakker, J., McLuckie, A., Willatts, S. M., Brockway, M., Anzueto, A., Holzapfel, L., Breen, D. P., et al. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000105581.01815.c6 · Cited by 917 · see citing works
Upregulation of VCAM-1 and ICAM-1 at Atherosclerosis-Prone Sites on the Endothelium in the ApoE-Deficient Mouse
Nakashima, Y., Raines, E. W., Plump, A. S., Breslow, J. L., & Ross, R. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.5.842 · Cited by 917 · see citing works
Tetrahydrobiopterin biosynthesis, regeneration and functions
Thöny, B., Auerbach, G., & Blau, N. (2000) · Biochemical Journal · doi:10.1042/bj3470001 · Cited by 867 · see citing works
Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture)
Félétou, M., & Vanhoutte, P. M. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00292.2006 · Cited by 818 · cited 1× · see citing works
“Endothelial dysfunction is a hallmark of multiple disease states such as diabetes, atherosclerosis, and hypertension, and it is characterized by impaired endothelial dependent vasodilatation (69).”
Suppression of Apoptosis by Nitric Oxide via Inhibition of Interleukin-1β–converting Enzyme (ICE)-like and Cysteine Protease Protein (CPP)-32–like Proteases
Dimmeler, S., Haendeler, J., Nehls, M. C., & Zeiher, A. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.4.601 · Cited by 806 · see citing works
Role of Oxidative Stress in Cardiac Hypertrophy and Remodeling
Takimoto, E., & Kass, D. A. (2006) · Hypertension · doi:10.1161/01.hyp.0000254415.31362.a7 · Cited by 772 · see citing works
High Glucose Increases Nitric Oxide Synthase Expression and Superoxide Anion Generation in Human Aortic Endothelial Cells
Cosentino, F., Hishikawa, K., Katušić, Z. S., & Lüscher, T. F. (1997) · Circulation · doi:10.1161/01.cir.96.1.25 · Cited by 762 · see citing works
Endothelial Regulation of Vasomotion in ApoE-Deficient Mice: Implications for Interactions Between Peroxynitrite and Tetrahydrobiopterin
Laursen, J. B., Somers, M., Kurz, S., McCann, L., Warnholtz, A., Freeman, B. A., Tarpey, M., Fukai, T., & Harrison, D. G. (2001) · Circulation · doi:10.1161/01.cir.103.9.1282 · Cited by 721 · see citing works
Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols
Kuzkaya, N., Weissmann, N., Harrison, D. G., & Dikalov, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302227200 · Cited by 692 · see citing works
Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and Nitrate
Tayeh, M. A., & Marletta, M. A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47163-9 · Cited by 687 · see citing works
Endothelial Nitric Oxide Synthase Targeting to Caveolae
Féron, O., Belhassen, L., Kobzik, L., Smith, T. W., Kelly, R. A., & Michel, T. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.37.22810 · Cited by 676 · see citing works
Effects of Angiotensin II Infusion on the Expression and Function of NAD(P)H Oxidase and Components of Nitric Oxide/cGMP Signaling
Mollnau, H., Wendt, M., Szöcs, K., Lassègue, B., Schulz, E., Oelze, M., Li, H., Bodenschatz, M., August, M., Kleschyov, A. L., et al. (2002) · Circulation Research · doi:10.1161/01.res.0000012569.55432.02 · Cited by 676 · see citing works
Structure of Nitric Oxide Synthase Oxygenase Dimer with Pterin and Substrate
Crane, B. R., Arvai, A. S., Ghosh, D. K., Wu, C., Getzoff, E. D., Stuehr, D. J., & Tainer, J. A. (1998) · Science · doi:10.1126/science.279.5359.2121 · Cited by 668 · see citing works
Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.
Iyengar, R., Stuehr, D. J., & Marletta, M. A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.18.6369 · Cited by 664 · see citing works
Control of cardiac muscle cell function by an endogenous nitric oxide signaling system.
Balligand, J., Kelly, R. A., Marsden, P. A., Smith, T. W., & Michel, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.1.347 · Cited by 659 · see citing works
Patterns of Vascular Cell Adhesion Molecule-1 and Intercellular Adhesion Molecule-1 Expression in Rabbit and Mouse Atherosclerotic Lesions and at Sites Predisposed to Lesion Formation
Iiyama, K., Hajra, L., Iiyama, M., Li, H., DiChiara, M. R., Medoff, B. D., & Cybulsky, M. I. (1999) · Circulation Research · doi:10.1161/01.res.85.2.199 · Cited by 633 · see citing works
Accelerated Atherosclerosis, Aortic Aneurysm Formation, and Ischemic Heart Disease in Apolipoprotein E/Endothelial Nitric Oxide Synthase Double-Knockout Mice
Kuhlencordt, P. J., Gyurko, R., Han, F., Scherrer‐Crosbie, M., Aretz, T. H., Hajjar, R. J., Picard, M. H., & Huang, P. L. (2001) · Circulation · doi:10.1161/hc2901.091399 · Cited by 631 · see citing works
NADPH Oxidases in Cardiovascular Health and Disease
Cave, A. C., Brewer, A. C., Narayanapanicker, A., Ray, R., Grieve, D. J., Walker, S., & Shah, A. M. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.691 · Cited by 630 · see citing works
The macrophage: Past, present and future
Gordon, S. (2007) · European Journal of Immunology · doi:10.1002/eji.200737638 · Cited by 625 · see citing works
Nitric oxide as a unique signaling molecule in the vascular system: a historical overview.
Ignarro, L. J. (2002) · PubMed · Cited by 623 · see citing works
Crystal Structure of Constitutive Endothelial Nitric Oxide Synthase
Raman, C. S., Li, H., Pavel Martasek, E., Král, V., Masters, B. S. S., & Poulos, T. L. (1998) · Cell · doi:10.1016/s0092-8674(00)81718-3 · Cited by 621 · see citing works
Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites.
Bredt, D. S., Ferris, C. D., & Snyder, S. H. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49862-1 · Cited by 609 · see citing works
Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite
Zou, M., Shi, C., & Cohen, R. A. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14442 · Cited by 603 · see citing works
INHIBITION OF NITRIC OXIDE SYNTHASE AS A POTENTIAL THERAPEUTIC TARGET
Hobbs, A. J., Higgs, A., & Moncada, S. (1999) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.39.1.191 · Cited by 596 · see citing works
Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.
Stroes, E. S. G., Kastelein, J. J. P., Cosentino, F., Erkelens, W. D., Wever, R. M. F., Koomans, H. A., Lüscher, T. F., & Rabelink, T. J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119131 · Cited by 588 · see citing works
Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages
Kwon, N. S., Nathan, C. F., & Stuehr, D. J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47089-0 · Cited by 570 · see citing works
Cardiovascular Biology of the Asymmetric Dimethylarginine:Dimethylarginine Dimethylaminohydrolase Pathway
Vallance, P., & Leiper, J. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000128897.54893.26 · Cited by 553 · see citing works
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
Tegeder, I., Costigan, M., Griffin, R. S., Abele, A., Belfer, I., Schmidt, H., Ehnert, C., Nejim, J. A., Marian, C., Scholz, J., et al. (2006) · Nature Medicine · doi:10.1038/nm1490 · Cited by 548 · see citing works
Noradrenaline is essential for mouse fetal development
THOMAS, S. A., Matsumoto, A. M., & Palmiter, R. D. (1995) · Nature · doi:10.1038/374643a0 · Cited by 534 · see citing works
The high-output nitric oxide pathway: role and regulation
Xie, Q. W., & Nathan, C. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.56.5.576 · Cited by 512 · see citing works
Tetrahydrobiopterin: biochemistry and pathophysiology
Werner, E. R., Blau, N., & Thöny, B. (2011) · Biochemical Journal · doi:10.1042/bj20110293 · Cited by 493 · see citing works
Oxidation of Tetrahydrobiopterin by Peroxynitrite: Implications for Vascular Endothelial Function
Milstien, S., & Katušić, Z. S. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1422 · Cited by 488 · see citing works
Expression of Multiple Isoforms of Nitric Oxide Synthase in Normal and Atherosclerotic Vessels
Wilcox, J. N., Subramanian, R. R., Sundell, C. L., Tracey, W. R., Pollock, J. S., Harrison, D. G., & Marsden, P. A. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.2479 · Cited by 478 · see citing works
Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation.
Fischmann, T. O., Hruza, A. W., Niu, X. D., Fossetta, J. D., Lunn, C. A., Dolphin, E., Prongay, A., Reichert, P., Lundell, D. J., Narula, S. K., et al. (1999) · Nature Structural Biology · doi:10.1038/6675 · Cited by 463 · see citing works
Expression and Characterization of the Chemokine Receptors CCR2 and CCR5 in Mice
Mack, M., Cihak, J., Simonis, C., Luckow, B., Proudfoot, A. E. I., Plachý, J., Brühl, H., Frink, M., Anders, H., Vielhauer, V., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.7.4697 · Cited by 459 · see citing works
Tetrahydrobiopterin Improves Endothelium-Dependent Vasodilation in Chronic Smokers
Heitzer, T. A., Brockhoff, C. J., Mayer, B., Warnholtz, A., Mollnau, H., Henne, S., Meinertz, T., & Münzel, T. F. (2000) · Circulation Research · doi:10.1161/01.res.86.2.e36 · Cited by 449 · see citing works
Oxidant stress from nitric oxide synthase–3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load
Takimoto, E., Champion, H. C., Li, M., Ren, S. V., Rodríguez, E. R., Tavazzi, B., Lazzarino, G., Paolocci, N., Gabrielson, K. L., Wang, Y., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci21968 · Cited by 446 · see citing works
Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development
Zhou, Q., Quaife, C. J., & Palmiter, R. D. (1995) · Nature · doi:10.1038/374640a0 · Cited by 445 · see citing works
Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.
Gross, S. S., & Levi, R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35667-9 · Cited by 443 · see citing works
Cardiovascular Effects of Exercise Training
Gielen, S., Schuler, G. C., & Adams, V. (2010) · Circulation · doi:10.1161/circulationaha.110.939959 · Cited by 434 · see citing works
Transcriptional and Posttranscriptional Regulation of Endothelial Nitric Oxide Synthase Expression by Hydrogen Peroxide
Drummond, G. R., Cai, H., Davis, M. E., Ramasamy, S., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.86.3.347 · Cited by 430 · see citing works
Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus
Heitzer, T., Krohn, K., Albers, S., & Meinertz, T. (2000) · Diabetologia · doi:10.1007/s001250051551 · Cited by 427 · see citing works
Macrophage Diversity and Polarization in Atherosclerosis: A Question of Balance
Mantovani, A., Garlanda, C., & Locati, M. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.180497 · Cited by 426 · see citing works
Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia
Heitzer, T. A., Ylä‐Herttuala, S., Luoma, J., Kurz, S. K., Münzel, T. F., Just, H., Olschewski, M., & Drexler, H. (1996) · Circulation · doi:10.1161/01.cir.93.7.1346 · Cited by 410 · see citing works
Superoxide Anion Production Is Increased in a Model of Genetic Hypertension
Kerr, S., Brosnan, M. J., McIntyre, M., Reid, J. L., Dominiczak, A. F., & Hamilton, C. (1999) · Hypertension · doi:10.1161/01.hyp.33.6.1353 · Cited by 407 · see citing works
eNOS uncoupling and endothelial dysfunction in aged vessels
Yang, Y., Huang, A., Kaley, G., & Sun, D. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00230.2009 · Cited by 370 · see citing works
Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity.
Rosenkranz-Weiss, P., Sessa, W. C., Milstien, S., Kaufman, S., Watson, C. A., & Pober, J. S. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117221 · Cited by 362 · see citing works
Mechanisms of Disease: atherosclerosis in autoimmune diseases
Sherer, Y., & Shoenfeld, Y. (2006) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0092 · Cited by 357 · see citing works
Spectral characterization of brain and macrophage nitric oxide synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical.
Stuehr, D. J., & Ikeda‐Saito, M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36718-3 · Cited by 348 · see citing works
Improvement in Stroke Mortality in Canada and the United States, 1990 to 2002
Yang, Q.-H., Botto, L., Erickson, J., Berry, R., Sambell, C., Johansen, H., & Friedman, J. (2006) · Circulation · doi:10.1161/circulationaha.105.570846 · Cited by 346 · see citing works
The Diabetic Zucker Fatty Rat
Clark, J. B., Palmer, C. J., & Shaw, W. N. (1983) · Experimental Biology and Medicine · doi:10.3181/00379727-173-41611 · Cited by 342 · see citing works
Endothelial dihydrofolate reductase: Critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase
Chalupský, K., & Cai, H. “. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409594102 · Cited by 338 · see citing works
Reactive Oxygen Species Mediate Amplitude-Dependent Hypertrophic and Apoptotic Responses to Mechanical Stretch in Cardiac Myocytes
Pimentel, D. R., Amin, J. K., Xiao, L., Miller, T. A., Viereck, J. C., Oliver-Krasinski, J. M., Baliga, R. R., Wang, J., Siwik, D. A., Singh, K., et al. (2001) · Circulation Research · doi:10.1161/hh1701.096615 · Cited by 333 · see citing works
Endothelial Nitric-oxide Synthase
Rodríguez‐Crespo, I., Gerber, N. C., & de Montellano, P. R. O. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.19.11462 · Cited by 323 · see citing works
Efficacy of sapropterin dihydrochloride (tetrahydrobiopterin, 6R-BH4) for reduction of phenylalanine concentration in patients with phenylketonuria: a phase III randomised placebo-controlled study
Levy, H. L., Milanowski, A., Chakrapani, A., Cleary, M., Lee, P., Trefz, F. K., Whitley, C. B., Feillet, F., Feigenbaum, A. S. J., Bebchuk, J. D., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61234-3 · Cited by 323 · see citing works
Mitochondrial Aconitase Is a Source of Hydroxyl Radical
Vasquez-Vivar, J. M., Kalyanaraman, B., & Kennedy, M. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.19.14064 · Cited by 317 · see citing works
Endothelium-derived nitric oxide and vascular physiology and pathology
Arnal, J.-F., Dinh-Xuan, A.-T., Pueyo, M., Darblade, B., & Rami, J. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050358 · Cited by 313 · see citing works
The Protective Effect of Late Preconditioning Against Myocardial Stunning in Conscious Rabbits Is Mediated by Nitric Oxide Synthase
Bolli, R., Manchikalapudi, S., Tang, X., Takano, H., Qiu, Y., Guo, Y., Zhang, Q., & Jadoon, A. K. (1997) · Circulation Research · doi:10.1161/01.res.81.6.1094 · Cited by 313 · see citing works
Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice
Ozaki, M., Kawashima, S., Yamashita, T., Hirase, T., Namiki, M., Inoue, N., Hirata, K., Yasui, H., Sakurai, H., Yoshida, Y., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15215 · Cited by 312 · see citing works
Nitric oxide synthesis in the lung. Regulation by oxygen through a kinetic mechanism.
Dweik, R. A., Laskowski, D. M., Abu‐Soud, H. M., Kaneko, F., Hutte, R. S., Stuehr, D. J., & ERZURUM, S. C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1378 · Cited by 307 · see citing works
Mechanism of Endothelial Cell NADPH Oxidase Activation by Angiotensin II
Li, J., & Shah, A. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209793200 · Cited by 307 · see citing works
Anticancer Antifolates: Current Status and Future Directions
McGuire, J. J. (2003) · Current Pharmaceutical Design · doi:10.2174/1381612033453712 · Cited by 305 · see citing works
Tetrahydrobiopterin and Dysfunction of Endothelial Nitric Oxide Synthase in Coronary Arteries
Cosentino, F., & Katušić, Z. S. (1995) · Circulation · doi:10.1161/01.cir.91.1.139 · Cited by 294 · see citing works
Paracrine and autocrine effects of nitric oxide on myocardial function
Shah, A. M. (2000) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(99)00072-8 · Cited by 293 · see citing works
Structural analysis of porcine brain nitric oxide synthase reveals a role for tetrahydrobiopterin and L‐arginine in the formation of an SDS‐resistant dimer.
Klatt, P., Schmidt, K., Lehner, D., Glatter, O., Bächinger, H. P., & Mayer, B. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00038.x · Cited by 292 · see citing works
Constitutive and inducible nitric oxide synthases incorporate molecular oxygen into both nitric oxide and citrulline.
Leone, A., Palmer, R. M. J., Knowles, R. G., Francis, P. L., Ashton, D., & Moncada, S. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54352-0 · Cited by 290 · see citing works
Regulation of T cell activation, anxiety, and male aggression by RGS2
Oliveira-dos-Santos, A., Matsumoto, G., Snow, B. E., Bai, D., Houston, F. P., Whishaw, I. Q., Mariathasan, S., Sasaki, T., Wakeham, A. C., Ohashi, P. S., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220414397 · Cited by 290 · see citing works
The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study
Vasquez-Vivar, J. M., Pavel Martasek, E., Whitsett, J., Joseph, J., & Kalyanaraman, B. (2002) · Biochemical Journal · doi:10.1042/0264-6021:3620733 · Cited by 287 · see citing works
The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study
VÁSQUEZ-VIVAR, J., MARTÁSEK, P., WHITSETT, J., JOSEPH, J., & KALYANARAMAN, B. (2002) · Biochemical Journal · doi:10.1042/bj3620733 · Cited by 287 · see citing works
Estrogen and coronary heart disease in women
Barrett‐Connor, E. (1991) · JAMA · doi:10.1001/jama.265.14.1861 · Cited by 274 · see citing works
Ca 2+ -Independent Activation of the Endothelial Nitric Oxide Synthase in Response to Tyrosine Phosphatase Inhibitors and Fluid Shear Stress
Fleming, I., Bauersachs, J. K., Fißlthaler, B., & Busse, R. (1998) · Circulation Research · doi:10.1161/01.res.82.6.686 · Cited by 265 · see citing works
Uncoupled Cardiac Nitric Oxide Synthase Mediates Diastolic Dysfunction
Silberman, G. A., Fan, T. M., Liu, H., Jiao, Z., Xiao, H., Lovelock, J. D., Boulden, B. M., Widder, J. D., Fredd, S., Bernstein, K. E., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.883777 · Cited by 254 · see citing works
Genetic Deficiency of Inducible Nitric Oxide Synthase Reduces Atherosclerosis and Lowers Plasma Lipid Peroxides in Apolipoprotein E–Knockout Mice
Kuhlencordt, P. J., Chen, J., Han, F., Astern, J., & Huang, P. L. (2001) · Circulation · doi:10.1161/01.cir.103.25.3099 · Cited by 252 · see citing works
Cardiac Neuronal Nitric Oxide Synthase Isoform Regulates Myocardial Contraction and Calcium Handling
Sears, C. E., Bryant, S. M., Ashley, E. A., Lygate, C. A., Rakovic, S., Wallis, H. L., Neubauer, S., Terrar, D. A., & Casadei, B. (2003) · Circulation Research · doi:10.1161/01.res.0000064585.95749.6d · Cited by 250 · see citing works
Oral Administration of Tetrahydrobiopterin Prevents Endothelial Dysfunction and Vascular Oxidative Stress in the Aortas of Insulin-Resistant Rats
Shinozaki, K., Nishio, Y., Okamura, T., Yoshida, Y., Maegawa, H., Kojima, H., Masada, M., Toda, N., Kikkawa, R., & Kashiwagi, A. (2000) · Circulation Research · doi:10.1161/01.res.87.7.566 · Cited by 242 · see citing works
Reversal of Cardiac Hypertrophy and Fibrosis From Pressure Overload by Tetrahydrobiopterin
Moens, A. L., Takimoto, E., Tocchetti, C. G., Chakir, K., Bedja, D., Cormaci, G., Ketner, E., Majmudar, M. D., Gabrielson, K., Halushka, M. K., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.737031 · Cited by 235 · see citing works
Self-citation
Atrial Sources of Reactive Oxygen Species Vary With the Duration and Substrate of Atrial Fibrillation
Reilly, S. N., Jayaram, R., Nahar, K., Antoniades, C. A., Verheule, S., Channon, K. M., Alp, N. J., Schotten, U., & Casadei, B. (2011) · Circulation · doi:10.1161/circulationaha.111.029223 · Cited by 228 · see citing works
Self-citation
Development of Heart Failure and Congenital Septal Defects in Mice Lacking Endothelial Nitric Oxide Synthase
Feng, Q., Song, W., Lu, X., Hamilton, J. A., Lei, M., Peng, T., & Yee, S. (2002) · Circulation · doi:10.1161/01.cir.0000024114.82981.ea · Cited by 226 · see citing works
Targeted Disruption of the Tyrosine Hydroxylase Locus Results in Severe Catecholamine Depletion and Perinatal Lethality in Mice
Kobayashi, K., Morita, S., Sawada, H., Mizuguchi, T., Yamada, K., Nagatsu, I., Hata, T., Watanabe, Y., Fujita, K., & Nagatsu, T. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.27235 · Cited by 223 · see citing works
Acute Amelioration of Diabetic Endothelial Dysfunction with a Derivative of the Nitric Oxide Synthase Cofactor, Tetrahydrobiopterin
Pieper, G. M. (1997) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199701000-00002 · Cited by 222 · see citing works
Rapid, Direct Effects of Statin Treatment on Arterial Redox State and Nitric Oxide Bioavailability in Human Atherosclerosis via Tetrahydrobiopterin-Mediated Endothelial Nitric Oxide Synthase Coupling
Antoniades, C., Bakogiannis, C., Leeson, P., Guzik, T. J., Zhang, M.-H., Tousoulis, D., Antonopoulos, A. S., Demosthenous, M., Marinou, K., Hale, A., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.985150 · Cited by 219 · see citing works
Self-citation
The Role of Tetrahydrobiopterin in Superoxide Generation from eNOS: Enzymology and Physiological Implications
Vasquez-Vivar, J. M., Kalyanaraman, B., & Martásek, P. (2003) · Free Radical Research · doi:10.1080/1071576021000040655 · Cited by 218 · see citing works
Tetrahydrobiopterin Improves Endothelial Function in Patients with Coronary Artery Disease
Maier, W., Cosentino, F., Lütolf, R. B., Fleisch, M., Seiler, C., Hess, O. M., Meier, B., & Lüscher, T. F. (2000) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200002000-00001 · Cited by 217 · see citing works
Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS
Crabtree, M. J., Smith, C. L., Lam, G., Goligorsky, M. S., & Gross, S. S. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00823.2007 · Cited by 213 · see citing works
Self-citation
Critical Role for Tetrahydrobiopterin Recycling by Dihydrofolate Reductase in Regulation of Endothelial Nitric-oxide Synthase Coupling
Crabtree, M. J., Tatham, A. L., Hale, A. B., Alp, N. J., & Channon, K. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.041483 · Cited by 210 · see citing works
Self-citation
Stoichiometric Relationships Between Endothelial Tetrahydrobiopterin, Endothelial NO Synthase (eNOS) Activity, and eNOS Coupling in Vivo
Bendall, J. K., Alp, N. J., Warrick, N., Cai, S., Adlam, D., Rockett, K. A., Yokoyama, M., Kawashima, S., & Channon, K. M. (2005) · Circulation Research · doi:10.1161/01.res.0000187447.03525.72 · Cited by 209 · see citing works
Self-citation
Formation of a Pterin Radical in the Reaction of the Heme Domain of Inducible Nitric Oxide Synthase with Oxygen
Hurshman, A. R., Krebs, C., Edmondson, D. E., Huynh, B. H., & Marletta, M. A. (1999) · Biochemistry · doi:10.1021/bi992026c · Cited by 208 · see citing works
Deficiency in Inducible Nitric Oxide Synthase Results in Reduced Atherosclerosis in Apolipoprotein E-Deficient Mice
Detmers, P. A., Hernandez, M., Mudgett, J. S., Hassing, H., Burton, C. A., Mundt, S. S., Chun, S. H., Fletcher, D. S., Card, D., Lisnock, J., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3430 · Cited by 206 · see citing works
Oxidative Stress-Induced Signal Transduction Pathways in Cardiac Myocytes: Involvement of ROS in Heart Diseases
Takano, H., Zou, Y., Hasegawa, H., Akazawa, H., Nagai, T., & Komuro, I. (2003) · Antioxidants and Redox Signaling · doi:10.1089/152308603770380098 · Cited by 205 · see citing works
Supplemention With Tetrahydrobiopterin Suppresses the Development of Hypertension in Spontaneously Hypertensive Rats
Hong, H.-J., Hsiao, G., Cheng, T.-H., & Yen, M.-H. (2001) · Hypertension · doi:10.1161/hy1101.095331 · Cited by 203 · see citing works
Quantitative Regulation of Intracellular Endothelial Nitric-oxide Synthase (eNOS) Coupling by Both Tetrahydrobiopterin-eNOS Stoichiometry and Biopterin Redox Status
Crabtree, M. J., Tatham, A. L., Al-Wakeel, Y., Warrick, N., Hale, A. B., Cai, S., Channon, K. M., & Alp, N. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m805403200 · Cited by 200 · see citing works
Self-citation
Tetrahydrobiopterin biosynthesis, regeneration and functions
Thöny, B., Auerbach, G., & Blau, N. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3470001 · Cited by 195 · see citing works
Increased Endothelial Tetrahydrobiopterin Synthesis by Targeted Transgenic GTP-Cyclohydrolase I Overexpression Reduces Endothelial Dysfunction and Atherosclerosis in ApoE-Knockout Mice
Alp, N. J., McAteer, M. A., Khoo, J., Choudhury, R. P., & Channon, K. M. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000115637.48689.77 · Cited by 194 · see citing works
Self-citation
Myocardial ischemia results in tetrahydrobiopterin (BH 4 ) oxidation with impaired endothelial function ameliorated by BH 4
Dumitrescu, C., Biondi, R., Xia, Y., Cardounel, A. J., Druhan, L. J., Ambrosio, G., & Zweier, J. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702986104 · Cited by 192 · see citing works
Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency
Meininger, C. J., MARINOS, R. S., Hatakeyama, K., Martı́nez–Zaguilán, R., Rojas, J. D., Kelly, K. A., & Wu, G. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3490353 · Cited by 189 · see citing works
Origin of superoxide production by endothelial nitric oxide synthase
Stroes, E. S. G., Hijmering, M. L., van Zandvoort, M. A. M. J., Wever, R. M. F., Rabelink, T. J., & van Faassen, E. E. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01292-7 · Cited by 188 · see citing works
Mutations in the BH4-metabolizing genes GTP cyclohydrolase I, 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase, carbinolamine-4a-dehydratase, and dihydropteridine reductase
Thöny, B., & Blau, N. (2006) · Human Mutation · doi:10.1002/humu.20366 · Cited by 185 · see citing works
Resveratrol Reverses Endothelial Nitric-Oxide Synthase Uncoupling in Apolipoprotein E Knockout Mice
Xia, N., Daiber, A., Habermeier, A., Closs, E. I., Thum, T., Spanier, G., Lü, Q., Oelze, M. W., Torzewski, M., Lackner, K. J., et al. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.168724 · Cited by 183 · see citing works
Neuronal nitric oxide synthase, a modular enzyme formed by convergent evolution: structure studies of a cysteine thiolate‐liganded heme protein that hydroxylates L‐arginine to produce NO as a cellular signal
Masters, B. S. S., McMillan, K., Sheta, E. A., Nishimura, J. S., Roman, L. J., & Pavel Martasek, E. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.5.8621055 · Cited by 180 · see citing works
Role of nitric oxide in the regulation of cardiovascular autonomic control
Chowdhary, S., & Townend, J. (1999) · Clinical Science · doi:10.1042/cs0970005 · Cited by 176 · see citing works
Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals
Higashi, Y., Sasaki, S., Nakagawa, K., Fukuda, Y., Matsuura, H., Oshima, T., & Chayama, K. (2002) · American Journal of Hypertension · doi:10.1016/s0895-7061(01)02317-2 · Cited by 173 · see citing works
Macrophage nitric oxide synthase: relationship between enzyme-bound tetrahydrobiopterin and synthase activity
Hevel, J. M., & Marletta, M. A. (1992) · Biochemistry · doi:10.1021/bi00146a019 · Cited by 173 · see citing works
Tetrahydrobiopterin augments endothelium‐dependent dilatation in sedentary but not in habitually exercising older adults
Eskurza, I., Myerburgh, L. A., Kahn, Z. D., & Seals, D. R. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.092734 · Cited by 172 · see citing works
Reactive Oxygen Species Mediate Endothelium-Dependent Relaxations in Tetrahydrobiopterin-Deficient Mice
Cosentino, F., Barker, J. E., Brand, M. P., Heales, S., Werner, E. R., Tippins, J. R., West, N. E. J., Channon, K. M., Volpe, M., & Lüscher, T. F. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.4.496 · Cited by 171 · see citing works
Self-citation
Reaction of Neuronal Nitric-oxide Synthase with Oxygen at Low Temperature
Bec, N., Gorren, A. C. F., Völker, C., Mayer, B., & Lange, R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13502 · Cited by 167 · see citing works
Systemic and Vascular Oxidation Limits the Efficacy of Oral Tetrahydrobiopterin Treatment in Patients With Coronary Artery Disease
Cunnington, C., Van Assche, T., Shirodaria, C., Kylintireas, I., Lindsay, A. C., Lee, J. M., Antoniades, C., Margaritis, M., Lee, R., Cerrato, R., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.038919 · Cited by 166 · see citing works
Self-citation
Stimulation of NADPH Oxidase by Oxidized Low-Density Lipoprotein Induces Proliferation of Human Vascular Endothelial Cells
Heinloth, A. N., Heermeier, K., Raff, U., Wanner, C., & Galle, J. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v11101819 · Cited by 166 · see citing works
Mutation of N-myristoylation site converts endothelial cell nitric oxide synthase from a membrane to a cytosolic protein.
Sessa, W. C., Barber, C. M., & Lynch, K. R. (1993) · Circulation Research · doi:10.1161/01.res.72.4.921 · Cited by 166 · see citing works
Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells
CAI, S., Khoo, J., & Channon, K. M. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.10.040 · Cited by 165 · see citing works
Self-citation
Feedback Regulation Mechanisms for the Control of GTP Cyclohydrolase I Activity
Harada, T., Kagamiyama, H., & Hatakeyama, K. (1993) · Science · doi:10.1126/science.8502995 · Cited by 163 · see citing works
Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine.
Giovanelli, J., Campos, K. L., & Kaufman, S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.7091 · Cited by 162 · see citing works
Inhibitors of brain nitric oxide synthase. Binding kinetics, metabolism, and enzyme inactivation.
Klatt, P., Schmidt, K., Brünner, F., & Mayer, B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42080-1 · Cited by 158 · see citing works
Increased expression of iNOS is associated with endothelial dysfunction and impaired pressor responsiveness in streptozotocin-induced diabetes
Nagareddy, P. R., Xia, Z., McNeill, J. H., & MacLeod, K. M. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00591.2005 · Cited by 158 · see citing works
Effects of ageing and exercise training on eNOS uncoupling in skeletal muscle resistance arterioles
Sindler, A. L., Delp, M. D., Reyes, R., Wu, G., & Muller‐Delp, J. M. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.172221 · Cited by 156 · see citing works
An inhibitor of nitric oxide synthesis prevents memory formation in the chick
Hölscher, C., & Rose, S. P. R. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90012-v · Cited by 156 · see citing works
Regulation of Inducible Nitric Oxide Synthase (iNOS) and its Potential Role in Insulin Resistance, Diabetes and Heart Failure
Šoškić, S., Dobutović, B. D., Sudar-Milovanovic, E. M., Obradovic, M. M., Nikolić, D., Djordjevic, J. D., Radak, D. J., Mikhailidis, D. P., & Isenović, E. R. (2011) · The Open Cardiovascular Medicine Journal · doi:10.2174/1874192401105010153 · Cited by 156 · see citing works
Vascular smooth muscle and nitric oxide synthase
Buchwalow, I., Podzuweit, T., Böcker, W., Samoilova, V. E., Thomas, S., Wellner, M., Baba, H. A., Robenek, H., Schnekenburger, J., & Lerch, M. M. (2002) · The FASEB Journal · doi:10.1096/fj.01-0842com · Cited by 155 · see citing works
Tetrahydrobiopterin restores endothelial function in long-term smokers
Ueda, S., Matsuoka, H., Miyazaki, H., Usui, M., Okuda, S., & Imaizumi, T. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00523-9 · Cited by 154 · see citing works
Endothelial Dysfunction of Coronary Resistance Arteries Is Improved by Tetrahydrobiopterin in Atherosclerosis
Tiefenbacher, C., Bleeke, T., Vahl, C. F., Amann, K., Vogt, A. M., & Kübler, W. (2000) · Circulation · doi:10.1161/01.cir.102.18.2172 · Cited by 154 · see citing works
Pivotal Role for Endothelial Tetrahydrobiopterin in Pulmonary Hypertension
Khoo, J. P., Zhao, L., Alp, N. J., Bendall, J. K., Nicoli, T., Rockett, K. A., Wilkins, M. R., & Channon, K. M. (2005) · Circulation · doi:10.1161/01.cir.0000162470.26840.89 · Cited by 153 · see citing works
Self-citation
Altered Plasma Versus Vascular Biopterins in Human Atherosclerosis Reveal Relationships Between Endothelial Nitric Oxide Synthase Coupling, Endothelial Function, and Inflammation
Antoniades, C., Shirodaria, C., Crabtree, M., Rinze, R., Alp, N., Cunnington, C., Diesch, J., Tousoulis, D., Stefanadis, C., Leeson, P., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.704155 · Cited by 153 · see citing works
Self-citation
Macrophage NO synthase: characterization of isolated oxygenase and reductase domains reveals a head-to-head subunit interaction
Ghosh, D. K., & Stuehr, D. J. (1995) · Biochemistry · doi:10.1021/bi00003a013 · Cited by 152 · see citing works
Dystonia with motor delay in compound heterozygotes for GTP‐cyclohydrolase I gene mutations
Furukawa, Y., Kish, S. J., Bebin, E. M., Jacobson, R. D., Fryburg, J. S., Wilson, W. G., Shimadzu, M., Hyland, Κ., & Trugman, J. M. (1998) · Annals of Neurology · doi:10.1002/ana.410440107 · Cited by 149 · see citing works
Defective Lung Vascular Development and Fatal Respiratory Distress in Endothelial NO Synthase-Deficient Mice
Han, R. N. N., Babaei, S., Robb, M. J., Lee, T., Ridsdale, R. A., Ackerley, C. A., Post, M., & Stewart, D. J. (2004) · Circulation Research · doi:10.1161/01.res.0000125624.85852.1e · Cited by 146 · see citing works
Comparative Functioning of Dihydro- and Tetrahydropterins in Supporting Electron Transfer, Catalysis, and Subunit Dimerization in Inducible Nitric Oxide Synthase
Presta, A., Siddhanta, U., Wu, C., Sennequier, N., Huang, L., Abu‐Soud, H. M., ERZURUM, S. C., & Stuehr, D. J. (1998) · Biochemistry · doi:10.1021/bi971944c · Cited by 145 · see citing works
In vivo activation of JAK2/STAT‐3 pathway during angiogenesis induced by GM‐CSF
Valdembri, D., Serini, G., Vacca, A., Ribatti, D., & Bussolino, F. (2002) · The FASEB Journal · doi:10.1096/fj.01-0633fje · Cited by 144 · see citing works
Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia
Cosentino, F., Hürlimann, D., Delli Gatti, C., Chenevard, R., Blau, N., Alp, N. J., Channon, K. M., Eto, M., Lerch, P., Enseleit, F., et al. (2008) · Heart · doi:10.1136/hrt.2007.122184 · Cited by 143 · see citing works
Self-citation
Role of Myocardial Neuronal Nitric Oxide Synthase–Derived Nitric Oxide in β-Adrenergic Hyporesponsiveness After Myocardial Infarction–Induced Heart Failure in Rat
Bendall, J. K., Damy, T., Ratajczak, P., Loyer, X., Monceau, V., Marty, I., Milliez, P., Robidel, E., Marotte, F., Samuel, J., et al. (2004) · Circulation · doi:10.1161/01.cir.0000145160.04084.ac · Cited by 142 · see citing works
Self-citation
THE ORIGIN OF THE NITRATES IN THE URINE
Mitchell, H. H., Shonle, H. A., & Grindley, H. S. (1916) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)87531-7 · Cited by 142 · see citing works
Physiology and pathophysiology of nitric oxide.
IGNARRO, L. (1996) · PubMed · Cited by 141 · see citing works
Restoration of Endothelium-Dependent Vasodilation After Reperfusion Injury by Tetrahydrobiopterin
Tiefenbacher, C., Chilian, W. M., Mitchell, M., & DeFily, D. V. (1996) · Circulation · doi:10.1161/01.cir.94.6.1423 · Cited by 140 · see citing works
Untitled work
Urano (2001) · doi:10.1074/jbc.m102237200 · Cited by 139 · see citing works
Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus
Wenzel, P., Daiber, A., Oelze, M. W., Brandt, M., Closs, E. I., Xu, J., Thum, T., Bauersachs, J. K., Ertl, G., Zou, M., et al. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.10.003 · Cited by 131 · see citing works
Biosynthesis and metabolism of pterins in peripheral blood mononuclear cells and leukemia lines of man and mouse
Schoedon, G., Troppmair, J., FONTANA, A., Huber, C., Curtius, H., & Niederwieser, A. (1987) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1987.tb13515.x · Cited by 130 · see citing works
Rapid Kinetic Studies Link Tetrahydrobiopterin Radical Formation to Heme-dioxy Reduction and Arginine Hydroxylation in Inducible Nitric-oxide Synthase
Wei, C., Wang, Z., Wang, Q., Meade, A. L., Hemann, C. F., Hille, R., & Stuehr, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008441200 · Cited by 129 · see citing works
Neuronal Nitric Oxide Synthase Regulates Basal Microvascular Tone in Humans In Vivo
Seddon, M. D., Chowienczyk, P. J., Brett, S. E., Casadei, B., & Shah, A. M. (2008) · Circulation · doi:10.1161/circulationaha.107.744540 · Cited by 129 · see citing works
Tetrahydrobiopterin-Free Neuronal Nitric Oxide Synthase: Evidence for Two Identical Highly Anticooperative Pteridine Binding Sites
Gorren, A. C. F., List, B. M., Schrammel, A., Pitters, E., Hemmens, B., Werner, E. R., Schmidt, K., & Mayer, B. (1996) · Biochemistry · doi:10.1021/bi961931j · Cited by 128 · see citing works
White Adipose Tissue Nitric Oxide Synthase: A Potential Source for NO Production
Ribière, C., Jaubert, A., Gaudiot, N., Sabourault, D., Marcus, M. L., Boucher, J., Denis-Henriot, D., & Giudicelli, Y. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0824 · Cited by 128 · see citing works
Conversion of L-tyrosine to 3,4-dihydroxyphenylalanine by cell-free preparations of brain and sympathetically innervated tissues
Nagatsu, T., Levitt, M., & Udenfriend, S. (1964) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(64)90266-9 · Cited by 127 · see citing works
HMG-CoA Reductase Inhibitor Increases GTP Cyclohydrolase I mRNA and Tetrahydrobiopterin in Vascular Endothelial Cells
Hattori, Y., Nakanishi, N., Akimoto, K., Yoshida, M., & Kasai, K. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000054659.72231.a1 · Cited by 127 · see citing works
Increased Neopterin in Patients With Chronic and Acute Coronary Syndromes
Schumacher, M., Halwachs, G., Tatzber, F., Fruhwald, F. M., Zweiker, R., Watzinger, N., Eber, B., Wilders-Truschnig, M. M., Esterbauer, H., & Klein, W. W. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00172-1 · Cited by 123 · see citing works
Nitric Oxide Down-regulates MKP-3 mRNA Levels
Rössig, L., Haendeler, J., Hermann, C., Malchow, P., Urbich, C., Zeiher, A. M., & Dimmeler, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002283200 · Cited by 122 · see citing works
Altered Tetrahydrobiopterin Metabolism in Atherosclerosis
Vasquez-Vivar, J. M., Duquaine, D. C., Whitsett, J., Kalyanaraman, B., & Rajagopalan, S. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000029122.79665.d9 · Cited by 121 · see citing works
Nitric oxide promotes endothelial cell survival signaling through S-nitrosylation and activation of dynamin-2
Kang, N., Cao, S., Chatterjee, S., Yao, J. Z., Egan, L. J., Semela, D., Mukhopadhyay, D., & Shah, V. H. (2007) · Journal of Cell Science · doi:10.1242/jcs.03361 · Cited by 121 · see citing works
Biosynthesis of tetrahydrobiopterin by de novo and salvage pathways in adrenal medulla extracts, mammalian cell cultures, and rat brain in vivo.
Nichol, C. A., Lee, C. L., EDELSTEIN, M. P., Chao, J. Y., & Duch, D. S. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.6.1546 · Cited by 120 · see citing works
Eliminating Atherogenesis in Mice by Switching Off Hepatic Lipoprotein Secretion
Lieu, H. D., Withycombe, S. K., Walker, Q. M., Rong, J. X., Walzem, R. L., Wong, J. S., Hamilton, R. L., Fisher, E. A. A., & Young, S. G. (2003) · Circulation · doi:10.1161/01.cir.0000054781.50889.0c · Cited by 118 · see citing works
Nitric oxide and autonomic control of heart rate: a question of specificity
Paton, J. F. R., Kasparov, S., & Paterson, D. J. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02261-0 · Cited by 116 · see citing works
AT1-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats
Wenzel, P., Schulz, E., Oelze, M. W., Müller, J., Schuhmacher, S., Alhamdani, M. S. S., Debrezion, J., Hortmann, M., Reifenberg, K., Fleming, I., et al. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.05.009 · Cited by 115 · see citing works
Inducible nitric oxide synthase colocalizes with signs of lipid oxidation/peroxidation in human atherosclerotic plaques
Cromheeke, K. M. C. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00148-0 · Cited by 114 · see citing works
Regulation of Tetrahydrobiopterin Biosynthesis by Shear Stress
Widder, J. D., Chen, W., Li, L., Dikalov, S., Thöny, B., Hatakeyama, K., & Harrison, D. G. (2007) · Circulation Research · doi:10.1161/circresaha.107.153809 · Cited by 114 · see citing works
Tetrahydrobiopterin restores endothelial dysfunction induced by an oral glucose challenge in healthy subjects
Ihlemann, N., Rask-Madsen, C., Perner, A., Dominguez, H., Hermann, T., Køber, L., & Torp-Pedersen, C. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00008.2003 · Cited by 113 · see citing works
Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical
Vásquez-Vivar, J., Whitsett, J., Martásek, P., Hogg, N., & Kalyanaraman, B. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00680-3 · Cited by 112 · see citing works
Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype
Tegeder, I., Adolph, J., Schmidt, H., Woolf, C. J., Geißlinger, G., & Lötsch, J. (2008) · European Journal of Pain · doi:10.1016/j.ejpain.2008.02.004 · Cited by 110 · see citing works
Acute Inhibition of Guanosine Triphosphate Cyclohydrolase 1 Uncouples Endothelial Nitric Oxide Synthase and Elevates Blood Pressure
Wang, S., Xu, J., Song, P., Wu, Y., Zhang, J., Choi, H. C., & Zou, M. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.112094 · Cited by 110 · see citing works
Characteristics of 24 h Telemetered Blood Pressure in eNOS‐Knockout and C57Bl/6J Control Mice
Vliet, B. N. V., Chafe, L. L., & Montani, J. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.041897 · Cited by 110 · see citing works
Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production
Higashi, Y., Sasaki, S., Nakagawa, K., Kimura, M., Noma, K., Hara, K., Jitsuiki, D., Goto, C., Oshima, T., Chayama, K., et al. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.07.025 · Cited by 109 · see citing works
Tetrahydrobiopterin and Cytokines
Werner, E. R., Werner‐Felmayer, G., & WACHTER, H. (1993) · Experimental Biology and Medicine · doi:10.3181/00379727-203-43566a · Cited by 108 · see citing works
Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy
Nzila, A. M., Ward, S. A., Marsh, K., Sims, P. F. G., & Hyde, J. E. (2005) · Trends in Parasitology · doi:10.1016/j.pt.2005.04.002 · Cited by 108 · see citing works
Angiotensin II type 1 receptor blocker ameliorates uncoupled endothelial nitric oxide synthase in rats with experimental diabetic nephropathy
Satoh, M., Fujimoto, S., Arakawa, S., Yada, T., Namikoshi, T., Haruna, Y., Horike, H., Sasaki, T., & Kashihara, N. (2008) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfn357 · Cited by 106 · see citing works
Activation of NADPH oxidase is required for macrophage-mediated oxidation of low-density lipoprotein
Aviram, M., Rosenblat, M., Etzioni, A., & Lévy, R. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90005-0 · Cited by 105 · see citing works
Mechanistic insights into folic acid-dependent vascular protection: Dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: A novel HPLC-based fluorescent assay for DHFR activity
Gao, L., Chalupský, K., Stefani, E., & Cai, H. “. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.07.025 · Cited by 105 · see citing works
A Specific Role for eNOS-Derived Reactive Oxygen Species in Atherosclerosis Progression
Takaya, T., Hirata, K., Yamashita, T., Shinohara, M., Sasaki, N., Inoue, N., Yada, T., Goto, M., Fukatsu, A., Hayashi, T., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.142182 · Cited by 102 · see citing works
Self-citation
Involvement of nitric oxide in the endothelium‐dependent relaxation induced by hydrogen peroxide in the rabbit aorta
Zembowicz, A., Hatchett, R. J., Jakubowski, A., & Gryglewski, R. J. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb13785.x · Cited by 101 · see citing works
Perinatal Development of Endothelial Nitric Oxide Synthase-Deficient Mice1
Hefler, L., Reyes, C., O’Brien, W. E., & Gregg, A. R. (2001) · Biology of Reproduction · doi:10.1095/biolreprod64.2.666 · Cited by 100 · see citing works
Tetrahydrobiopterin: a novel antihypertensive therapy
Porkert, M., Sher, S., Reddy, U., Cheema, F. H., Niessner, C., Kolm, P., Jones, D. P., Hooper, C. W., Taylor, W. R., Harrison, D. G., et al. (2008) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002329 · Cited by 99 · see citing works
Uterine Artery Remodeling and Reproductive Performance Are Impaired in Endothelial Nitric Oxide Synthase-Deficient Mice1
van der Heijden, O. W. H., Essers, Y. P. G., Fazzi, G. E., Peeters, L. L. H., Mey, J. G. R. D., & van Eys, G. J. J. M. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.104.033985 · Cited by 97 · see citing works
Redox regulation of vascular prostanoid synthesis by the nitric oxide-superoxide system
Bachschmid, M. M., Schildknecht, S., & Ullrich, V. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.157 · Cited by 95 · see citing works
Effects of Chronic Treatment With l -Arginine on Atherosclerosis in ApoE Knockout and ApoE/Inducible NO Synthase Double-Knockout Mice
Chen, J., Kuhlencordt, P. J., Urano, F., Ichinose, H., Astern, J., & Huang, P. L. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000040223.74255.5a · Cited by 95 · see citing works
Tetrahydrobiopterin Recycling, a Key Determinant of Endothelial Nitric-oxide Synthase-dependent Signaling Pathways in Cultured Vascular Endothelial Cells
Sugiyama, T., Levy, B. D., & Michel, T. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809295200 · Cited by 94 · see citing works
Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia
Fukuda, Y. (2002) · Heart · doi:10.1136/heart.87.3.264 · Cited by 93 · see citing works

Flagged first, then by citations

Sorted by citations

Coronary Microvascular Dysfunction
Crea, F., Lanza, G. A., & Camici, P. G. (2013) · Springer eBooks · doi:10.1007/978-88-470-5367-0 · Cited by 1,295 · see citing works
B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review
Kennedy, D. (2016) · Nutrients · doi:10.3390/nu8020068 · Cited by 1,055 · see citing works
Endothelial Cell Metabolism in Normal and Diseased Vasculature
Eelen, G., de Zeeuw, P., Simons, M., & Carmeliet, P. (2015) · Circulation Research · doi:10.1161/circresaha.116.302855 · Cited by 619 · see citing works
Endothelial Cell Metabolism
Eelen, G., de Zeeuw, P., Treps, L., Harjes, U., Wong, B. W., & Carmeliet, P. (2017) · Physiological Reviews · doi:10.1152/physrev.00001.2017 · Cited by 591 · see citing works
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works
ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways
de Almeida, A. J. P. O., de Oliveira, J. C. P. L., Pontes, L. V. D. S., Júnior, J. F. D. S., Gonçalves, T. A. F., Dantas, S. H., Feitosa, M. S. D. A., Silva, A. O., & de Medeiros, I. A. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1225578 · Cited by 521 · see citing works
Overview of OxLDL and Its Impact on Cardiovascular Health: Focus on Atherosclerosis
Poznyak, A. V., Nikiforov, N. G., Markin, A. M., Kashirskikh, D. A., Myasoedova, V. A., Владимировна, Г. Е., & Orekhov, A. N. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.613780 · Cited by 379 · see citing works
Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets
Janaszak-Jasiecka, A., Płoska, A., Wierońska, J. M., Dobrucki, L. W., & Kalinowski, L. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00423-2 · Cited by 358 · see citing works
Antioxidants, inflammation and cardiovascular disease
Mangge, H. (2014) · World Journal of Cardiology · doi:10.4330/wjc.v6.i6.462 · Cited by 339 · see citing works
European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
Egea, J., Fabregat, I., Frapart, Y., Ghezzi, P., Görlach, A., Kietzmann, T., Kubaichuk, K. I., Knaus, U. G., López, M. G., González, G. O., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.05.007 · Cited by 311 · see citing works
New Therapeutic Implications of Endothelial Nitric Oxide Synthase (eNOS) Function/Dysfunction in Cardiovascular Disease
Daiber, A., Xia, N., Steven, S., Oelze, M. W., Hanf, A., Kröller‐Schön, S., Münzel, T. F., & Li, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20010187 · Cited by 312 · see citing works
The Adverse Effects of Environmental Noise Exposure on Oxidative Stress and Cardiovascular Risk
Münzel, T. F., Sørensen, M., Schmidt, F. P., Schmidt, E. R., Steven, S., Kröller‐Schön, S., & Daiber, A. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7118 · Cited by 284 · see citing works
Oxidative stress and the role of redox signalling in chronic kidney disease
Kishi, S., Nagasu, H., Kidokoro, K., & Kashihara, N. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00775-0 · Cited by 283 · see citing works
Nitric oxide bioavailability dysfunction involves in atherosclerosis
Chen, J.-Y., Ye, Z.-X., Wang, X.-F., Chang, J., Yang, M.-W., Zhong, H.-H., Hong, F.-F., & Yang, S.-L. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.10.122 · Cited by 216 · see citing works
Arterial stiffness and vascular aging: mechanisms, prevention, and therapy
Herzog, M. J., Müller, P., Lechner, K., Stiebler, M., Arndt, P., Kunz, M., Ahrens, D., Schmeißer, A., Schreiber, S., & Braun-Dullaeus, R. C. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02346-0 · Cited by 246 · see citing works
Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease
Goveia, J., Stapor, P. C., & Carmeliet, P. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201404156 · Cited by 199 · see citing works
Plaque angiogenesis and intraplaque hemorrhage in atherosclerosis
Parma, L., Baganha, F., Quax, P. H. A., & de Vries, M. R. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.04.028 · Cited by 183 · see citing works
Effects of inorganic nitrate and beetroot supplementation on endothelial function: a systematic review and meta-analysis
Lara, J., Ashor, A. W., Oggioni, C., Ahluwalia, A., Mathers, J. C., & Siervo, M. (2016) · European Journal of Nutrition · doi:10.1007/s00394-015-0872-7 · Cited by 163 · see citing works
Vascular endothelium dysfunction: a conservative target in metabolic disorders
Jamwal, S., & Sharma, S. (2018) · Inflammation Research · doi:10.1007/s00011-018-1129-8 · Cited by 158 · see citing works
Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation
McNeill, E., Crabtree, M. J., Sahgal, N., Patel, J., Chuaiphichai, S., Iqbal, A. J., Hale, A., Greaves, D. R., & Channon, K. M. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.10.575 · Cited by 150 · see citing works
Self-citation
Oxidative stress and inflammation contribute to traffic noise-induced vascular and cerebral dysfunction via uncoupling of nitric oxide synthases
Daiber, A., Kröller‐Schön, S., Oelze, M. W., Hahad, O., Li, H., Schulz, R., Steven, S., & Münzel, T. F. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101506 · Cited by 130 · see citing works
Myocardial protection from ischemia-reperfusion injury post coronary revascularization
Binder, A., Ali, A., Chawla, R., Aziz, H. A., Abbate, A., & Jovin, I. S. (2015) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2015.1070669 · Cited by 117 · see citing works
Endothelial dysfunction, endothelial nitric oxide bioavailability, tetrahydrobiopterin, and 5-methyltetrahydrofolate in cardiovascular disease. Where are we with therapy?
Yuyun, M. F., Ng, L. L., & Ng, G. A. (2018) · Microvascular Research · doi:10.1016/j.mvr.2018.03.012 · Cited by 114 · see citing works
Newborn metabolomic signatures of maternal per- and polyfluoroalkyl substance exposure and reduced length of gestation
Taibl, K. R., Dunlop, A. L., Barr, D. B., Li, Y., Eick, S. M., Kannan, K., Ryan, P. B., Schroder, M., Rushing, B. R., Fennell, T. R., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38710-3 · Cited by 115 · see citing works
Nitric oxide signalling in the brain and its control of bodily functions
Chachlaki, K., & Prévot, V. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14800 · Cited by 108 · see citing works
Role of dietary antioxidants in the preservation of vascular function and the modulation of health and disease
Varadharaj, S., Kelly, O. J., Khayat, R. N., Kumar, P. S., Ahmed, N., & Zweier, J. L. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00064 · Cited by 101 · see citing works
The Use of Coenzyme Q10 in Cardiovascular Diseases
Rabanal‐Ruiz, Y., Llanos-González, E., & Alcain, F. J. (2021) · Antioxidants · doi:10.3390/antiox10050755 · Cited by 100 · see citing works
Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease
Ushio‐Fukai, M., Ash, D., Nagarkoti, S., de Chantemèle, E. J. B., Fulton, D. J., & Fukai, T. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8161 · Cited by 96 · see citing works
Oxidative Stress and Erectile Dysfunction: Pathophysiology, Impacts, and Potential Treatments
Kaltsas, A., Zikopoulos, A., Dimitriadis, F., Sheshi, D., Politis, M., Moustakli, E., Symeonidis, E. N., Chrisofos, M., Sofikitis, N., & Zachariou, A. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46080521 · Cited by 95 · see citing works
Biological signaling by small inorganic molecules
Basudhar, D., Ridnour, L. A., Cheng, R. Y. S., Kesarwala, A. H., Heinecke, J. L., & Wink, D. A. (2015) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2015.06.001 · Cited by 92 · see citing works
Arrhythmogenic Mechanisms in Heart Failure: Linking β-Adrenergic Stimulation, Stretch, and Calcium
Johnson, D. M., & Antoons, G. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01453 · Cited by 84 · see citing works
Endothelial dysfunction in neuroprogressive disorders—causes and suggested treatments
Morris, G., Puri, B. K., OLIVE, L. S., Carvalho, A. F., Berk, M., Walder, K. R., Gustad, L. T., & Maes, M. H. J. (2020) · BMC Medicine · doi:10.1186/s12916-020-01749-w · Cited by 83 · see citing works
The Roles of Nitric Oxide Synthase/Nitric Oxide Pathway in the Pathology of Vascular Dementia and Related Therapeutic Approaches
Zhu, H.-Y., Hong, F.-F., & Yang, S.-L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094540 · Cited by 84 · see citing works
Endothelial cell metabolism: A novel player in atherosclerosis? Basic principles and therapeutic opportunities
Pircher, A., Treps, L., Bodrug, N., & Carmeliet, P. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.08.011 · Cited by 82 · see citing works
Sex-gender-related therapeutic approaches for cardiovascular complications associated with diabetes
Campesi, I., Franconi, F., Seghieri, G., & Meloni, M. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.01.023 · Cited by 78 · see citing works
Functional implications of vascular endothelium in regulation of endothelial nitric oxide synthesis to control blood pressure and cardiac functions
Kumar, G., Dey, S. K., & Kundu, S. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118377 · Cited by 68 · see citing works
Nitric Oxide Releasing Nanomaterials for Cardiovascular Applications
Tabish, T. A., Crabtree, M. J., Townley, H. E., Winyard, P. G., & Lygate, C. A. (2023) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2023.07.017 · Cited by 63 · see citing works
Self-citation
Inflammation, oxidative stress, and cardiovascular disease risk factors in adults with cystic fibrosis
Reverri, E. J., Morrissey, B. M., Cross, C. E., & Steinberg, F. M. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.08.005 · Cited by 60 · see citing works
Therapeutic potential of pteridine derivatives: A comprehensive review
Carmona‐Martínez, V., Ruiz‐Alcaraz, A. J., Vera, M., Guirado, A., Martinez‐Esparza, M., & García–Peñarrubia, P. (2018) · Medicinal Research Reviews · doi:10.1002/med.21529 · Cited by 59 · see citing works
Elevated Plasma Phenylalanine Predicts Mortality in Critical Patients with Heart Failure
Chen, W., Wang, C., Cheng, C., Liu, M., Chu, C., Wu, H.-P., Huang, P., Lin, Y., Ko, T., Chen, W., et al. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12896 · Cited by 58 · see citing works
Redox signaling in heart failure and therapeutic implications
Weissman, D., & Maack, C. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.05.013 · Cited by 59 · see citing works
Phenylalanine- and leucine-defined metabolic types identify high mortality risk in patients with severe infection
Huang, S.-S., Lin, J.-Y., Chen, W.-S., Liu, M., Cheng, C., Cheng, M., & Wang, C. (2019) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2019.05.030 · Cited by 57 · see citing works
Promotion of nitric oxide production: mechanisms, strategies, and possibilities
Gonzalez, M., Clayton, S., Wauson, E., Christian, D., & Tran, Q. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1545044 · Cited by 56 · see citing works
A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance
Bailey, J. D., Shaw, A., Fischer, R., Ryan, B. J., Kessler, B. M., McCullagh, J., Wade‐Martins, R., Channon, K. M., & Crabtree, M. J. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.012 · Cited by 53 · see citing works
Self-citation
Physical-Exercise-Induced Antioxidant Effects on the Brain and Skeletal Muscle
Souza, J., da Silva, R. A., Scheffer, D. D. L., dos Santos, R. P., Solano, A. F., Barros, L., Budde, H., Trostchansky, A., & Latini, A. (2022) · Antioxidants · doi:10.3390/antiox11050826 · Cited by 52 · see citing works
Oxidative Stress and Early Atherosclerosis: Novel Antioxidant Treatment
Tousoulis, D., Ψαλτοπούλου, Θ., Androulakis, E. S., Παπαγεωργίου, Ν., Papaioannou, S., Oikonomou, E. K., Synetos, A. G., & Stefanadis, C. (2014) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-014-6562-5 · Cited by 51 · see citing works
Neopterin and biopterin levels and tryptophan degradation in patients with diabetes
Gürcü, S., Girgin, G., Yorulmaz, G., Kilicarslan, B., Efe, B., & Baydar, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-74183-w · Cited by 41 · see citing works
The Nitric Oxide System in Peripheral Artery Disease: Connection with Oxidative Stress and Biopterins
Ismaeel, A., Papoutsi, E., Miserlis, D., Lavado, R., Haynatzki, G. R., Casale, G. P., Bohannon, W. T., SMITH, R. S., Eidson, J. L., Brumberg, R. S., et al. (2020) · Antioxidants · doi:10.3390/antiox9070590 · Cited by 49 · see citing works
Tetrahydrobiopterin in energy metabolism and metabolic diseases
Kim, H. K., & Han, J. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104827 · Cited by 47 · see citing works
A requirement for Gch1 and tetrahydrobiopterin in embryonic development
Douglas, G., Hale, A., Crabtree, M. J., Ryan, B. J., Hansler, A., Watschinger, K., Gross, S. S., Lygate, C. A., Alp, N. J., & Channon, K. M. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.12.025 · Cited by 45 · see citing works
Self-citation
Endothelial dysfunction in the early postoperative period after major colon cancer surgery
Ekeloef, S., Larsen, M. H. H., Schou‐Pedersen, A. M. V., Lykkesfeldt, J., Rosenberg, J., & Gögenür, I. (2016) · British Journal of Anaesthesia · doi:10.1093/bja/aew410 · Cited by 45 · see citing works
From comorbidities to heart failure with preserved ejection fraction: a story of oxidative stress
Franssen, C., Chen, H. S., Hamdani, N., & Paulus, W. J. (2015) · Heart · doi:10.1136/heartjnl-2015-307787 · Cited by 45 · see citing works
Say NO to ROS: Their Roles in Embryonic Heart Development and Pathogenesis of Congenital Heart Defects in Maternal Diabetes
Engineer, A., Saiyin, T., Greco, E. R., & Feng, Q. (2019) · Antioxidants · doi:10.3390/antiox8100436 · Cited by 43 · see citing works
The Critical Role of Tetrahydrobiopterin (BH4) Metabolism in Modulating Radiosensitivity: BH4/NOS Axis as an Angel or a Devil
Feng, Y., Feng, Y., Gu, L., Liu, P., Cao, J., & Zhang, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.720632 · Cited by 44 · see citing works
l-Arginine and B vitamins improve endothelial function in subjects with mild to moderate blood pressure elevation
Menzel, D., Haller, H. G., Wilhelm, M. G., & Robenek, H. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1342-6 · Cited by 43 · see citing works
Understanding Endothelial Dysfunction and Its Role in Ischemic Stroke After the Outbreak of Recanalization Therapies
de la Riva, P., Marta-Enguita, J., Rodríguez-Antigüedad, J., Bergareche, A., & de Munaín, A. L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111631 · Cited by 47 · see citing works
Endothelial function does not improve with high-intensity continuous exercise training in SHR: implications of eNOS uncoupling
Battault, S., Singh, F., Gayrard, S., Zoll, J., Reboul, C., & Meyer, G. (2015) · Hypertension Research · doi:10.1038/hr.2015.114 · Cited by 40 · see citing works
Stachydrine protects eNOS uncoupling and ameliorates endothelial dysfunction induced by homocysteine
Xie, X., Zhang, Z., Wang, X., Luo, Z., Lai, B., Xiao, L., & Wang, N. (2018) · Molecular Medicine · doi:10.1186/s10020-018-0010-0 · Cited by 40 · see citing works
COVID-19: A Redox Disease—What a Stress Pandemic Can Teach Us About Resilience and What We May Learn from the Reactive Species Interactome About Its Treatment
Cumpstey, A. F., Clark, A. D., Santolini, J., Jackson, A. A., & Feelisch, M. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0017 · Cited by 40 · see citing works
Impaired Systemic Tetrahydrobiopterin Bioavailability and Increased Dihydrobiopterin in Adult Falciparum Malaria: Association with Disease Severity, Impaired Microvascular Function and Increased Endothelial Activation
Yeo, T. W., Lampah, D. A., Kenangalem, E., Tjitra, E., Price, R. N., Weinberg, J. B., Hyland, Κ., Granger, D. L., & Anstey, N. M. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004667 · Cited by 38 · see citing works
Vascular Redox Signaling, Endothelial Nitric Oxide Synthase Uncoupling, and Endothelial Dysfunction in the Setting of Transportation Noise Exposure or Chronic Treatment with Organic Nitrates
Münzel, T. F., & Daiber, A. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0006 · Cited by 38 · see citing works
Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin
McNeill, E., Stylianou, E., Crabtree, M. J., Harrington-Kandt, R., Kolb, A.-L., Diotallevi, M., Hale, A., Bettencourt, P. J. G., Tanner, R., O’Shea, M. K., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07714-9 · Cited by 35 · see citing works
Self-citation
Endogenous Hemoprotein-Dependent Signaling Pathways of Nitric Oxide and Nitrite
Dent, M. R., DeMartino, A. W., Tejero, J., & Gladwin, M. T. (2021) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.1c01048 · Cited by 35 · see citing works
Context‐dependent function of ROS in the vascular endothelium: The role of the Notch pathway and shear stress
Sega, F. V. D., Aquila, G., Fortini, F., Vaccarezza, M., Secchiero, P., Rizzo, P., & Campo, G. C. (2017) · BioFactors · doi:10.1002/biof.1359 · Cited by 35 · see citing works
Gaseous Signaling Molecules in Cardiovascular Function: From Mechanisms to Clinical Translation
Lee, S. R., Nilius, B., & Han, J. (2018) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2017_7 · Cited by 35 · see citing works
The role of neurovascular coupling dysfunction in cognitive decline of diabetes patients
Feng, L., & Gao, L. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1375908 · Cited by 37 · see citing works
Tetrahydrobiopterin Protects Against Hypertrophic Heart Disease Independent of Myocardial Nitric Oxide Synthase Coupling
Hashimoto, T., Sivakumaran, V., Carnicer, R., Zhu, G., Hahn, V. S., Bedja, D., Récalde, A., Duglan, D., Channon, K. M., Casadei, B., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003208 · Cited by 34 · see citing works
Self-citation
Pharmacological modulation of vascular ageing: A review from VascAgeNet
Roth, L., Doğan, S., Tuna, B. G., Arányi, T., Benı́tez, S., Borrell-Pagés, M., Bozaykut, P., Meyer, G. R. Y. D., Duca, L., Durmuş, N., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102122 · Cited by 36 · see citing works
Sapropterin Treatment Prevents Congenital Heart Defects Induced by Pregestational Diabetes Mellitus in Mice
Engineer, A., Saiyin, T., Lu, X., Kucey, A. S., Urquhart, B. L., Drysdale, T. A., Norozi, K., & Feng, Q. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.009624 · Cited by 29 · see citing works
Micro-Raman spectroscopy study of blood samples from myocardial infarction patients
John, R. V., Devasia, T., Mithun, N., Lukose, J., & Chidangil, S. (2022) · Lasers in Medical Science · doi:10.1007/s10103-022-03604-1 · Cited by 31 · see citing works
Diabetic cardiomyopathy: the need for adjusting experimental models to meet clinical reality
Lezoualc’h, F., Badimón, L., Baker, H. E., Bernard, M., Czibik, G., de Boer, R. A., d’Humières, T., Kergoat, M., Kowala, M. C., Rieusset, J., et al. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac152 · Cited by 29 · see citing works
Entacapone is an Antioxidant More Potent than Vitamin C and Vitamin E for Scavenging of Hypochlorous Acid and Peroxynitrite, and the Inhibition of Oxidative Stress-Induced Cell Death
Chen, A. Y., Lü, J.-M., Yao, Q. C., & Chen, C. (2016) · Medical Science Monitor · doi:10.12659/msm.896462 · Cited by 30 · see citing works
CTRP13 Preserves Endothelial Function by Targeting GTP Cyclohydrolase 1 in Diabetes
Wang, C., Chao, Y., Xu, W., Liang, M., Deng, S., Zhang, D., & Huang, K. (2019) · Diabetes · doi:10.2337/db19-0635 · Cited by 30 · see citing works
Tetrahydrobiopterin oral therapy recouples eNOS and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs
Dikalova, A., Aschner, J. L., Kaplowitz, M. R., Summar, M. L., & Fike, C. D. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00238.2016 · Cited by 29 · see citing works
Dual-Targeting EGCG/NO-Supplying protein assembled nanoparticles with Multi-Synergistic effects against atherosclerosis
Lin, C., Cheng, T.-M., Liu, Y., Hsu, F.-Y., Shih, C.-M., Tsai, M., Shih, C.-C., & Mi, F. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.152755 · Cited by 28 · see citing works
Sulfa Drugs Inhibit Sepiapterin Reduction and Chemical Redox Cycling by Sepiapterin Reductase
Yang, S., Jan, Y.-H., Mishin, V. M., Richardson, J. R., Hossain, M. M., Heindel, N. D., Heck, D. E., Laskin, D. L., & Laskin, J. D. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.221572 · Cited by 27 · see citing works
Molecular mechanisms by which iNOS uncoupling can induce cardiovascular dysfunction during sepsis: Role of posttranslational modifications (PTMs)
Sharawy, N., & Lehmann, C. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117821 · Cited by 28 · see citing works
Cardiomyocyte GTP Cyclohydrolase 1 Protects the Heart Against Diabetic Cardiomyopathy
Wu, H.-E., Baumgardt, S. L., Fang, J., Paterson, M. R., Liu, Y., Du, J., Shi, Y., Qiao, S., Bosnjak, Z. J., Warltier, D. C., et al. (2016) · Scientific Reports · doi:10.1038/srep27925 · Cited by 28 · see citing works
Atherosclerosis as Mitochondriopathy: Repositioning the Disease to Help Finding New Therapies
Shemiakova, T. S., Ivanova, E. A., Wu, W., Kirichenko, T. V., Starodubova, A. V., & Orekhov, A. N. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.660473 · Cited by 26 · see citing works
Endothelial Nitric Oxide Synthase–Derived Nitric Oxide Prevents Dihydrofolate Reductase Degradation via Promoting S-Nitrosylation
Cai, Z., Lu, Q., Ding, Y., Wang, Q., Xiao, L., Song, P., & Zou, M. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305796 · Cited by 26 · see citing works
Biological Assessment of the NO-Dependent Endothelial Function
Boughaleb, H., Lobysheva, I. I., Zotti, F. D., Balligand, J., & Montiel, V. (2022) · Molecules · doi:10.3390/molecules27227921 · Cited by 25 · see citing works
GTP cyclohydroxylase1 (GCH1): Role in neurodegenerative diseases
Gupta, P., & Kumar, R. (2023) · Gene · doi:10.1016/j.gene.2023.147749 · Cited by 25 · see citing works
Identification of Novel Serological Autoantibodies in Takayasu Arteritis Patients Using HuProt Arrays
Wen, X., Song, G., Hu, C., Pan, J., Wu, Z., Li, L., Liu, C., Tian, X., Zhang, F., Qian, J. X., et al. (2020) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra120.002119 · Cited by 24 · see citing works
Factors associated with elevated plasma phenylalanine in patients with heart failure
Cheng, C., Liu, M., Tang, H.-Y., Cheng, M., & Wang, C. (2021) · Amino Acids · doi:10.1007/s00726-020-02933-1 · Cited by 24 · see citing works
Tetrahydrobiopterin deficiency in the pathogenesis of Fabry disease
Shen, J., Arning, E., West, M. L., Day, T. S., Chen, S., Meng, X., Forni, S., McNeill, N., Göker-Alpan, Ö., Wang, X., et al. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx032 · Cited by 24 · see citing works
Tetrahydrobiopterin metabolism attenuates ROS generation and radiosensitivity through LDHA S-nitrosylation: novel insight into radiogenic lung injury
Feng, Y., Feng, Y., Gu, L., Mo, W., Wang, X., Song, B., Hong, M., Geng, F., Huang, P., Yang, H., et al. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01208-z · Cited by 23 · see citing works
Insights into Molecular Structure of Pterins Suitable for Biomedical Applications
Buglak, A. A., Kapitonova, M. A., Vechtomova, Y. L., & Telegina, T. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315222 · Cited by 23 · see citing works
L-Arginine and tetrahydrobiopterin supported nitric oxide production is crucial for the microbicidal activity of neutrophils
Nagarkoti, S., Sadaf, S., Awasthi, D., Chandra, T., Jagavelu, K., Kumar, S., & Dikshit, M. (2019) · Free Radical Research · doi:10.1080/10715762.2019.1566605 · Cited by 22 · see citing works
Imbalance between nitric oxide and superoxide anion induced by uncoupled nitric oxide synthase contributes to human melanoma development
Gonçalves, D. A., de Sousa, R. X., Gonçalves, J. D., Silva, D. B., Soares, J. P. M., Icimoto, M. Y., Correa, C. S. A., Gimenez, M., Angelis, K. D., Llesuy, S., et al. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.105592 · Cited by 21 · see citing works
The interplay between aryl hydrocarbon receptor, H. pylori, tryptophan, and arginine in the pathogenesis of gastric cancer
Pirzadeh, M., Khalili, N., & Rezaei, N. (2020) · International Reviews of Immunology · doi:10.1080/08830185.2020.1851371 · Cited by 20 · see citing works
Regulation of MAP kinase-mediated endothelial dysfunction in hyperglycemia via arginase I and eNOS dysregulation
Mazrouei, S., Sharifpanah, F., Caldwell, R. W., Franz, M., Shatanawi, A., Muessig, J. M., Fritzenwanger, M., Schulze, P. C., & Jung, C. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2019.05.004 · Cited by 21 · see citing works
Porphyromonas gingivalis infection alters Nrf2‐phase II enzymes and nitric oxide in primary human aortic endothelial cells
Sampath, C., Okoro, E. U., Gipson, M. J., Chukkapalli, S. S., Farmer‐Dixon, C. M., & Gangula, P. R. (2020) · Journal of Periodontology · doi:10.1002/jper.20-0444 · Cited by 20 · see citing works
Human Ischemic Cardiomyopathy Shows Cardiac Nos1 Translocation and its Increased Levels are Related to Left Ventricular Performance
Roselló‐Lletí, E., Carnicer, R., Tarazón, E., Ortega, A., Gil‐Cayuela, C., Lago, F., González‐Juanatey, J. R., Portolés, M., & Rivera, M. (2016) · Scientific Reports · doi:10.1038/srep24060 · Cited by 20 · see citing works
GCH1 attenuates cardiac autonomic nervous remodeling in canines with atrial‐tachypacing via tetrahydrobiopterin pathway regulated by microRNA‐206
Wei, J., Zhang, Y., Li, Z., Wang, X., Chen, L., Du, J., Liu, J., Liu, J., & Hou, Y. (2018) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.13289 · Cited by 20 · see citing works
PPARδ agonist prevents endothelial dysfunction via induction of dihydrofolate reductase gene and activation of tetrahydrobiopterin salvage pathway
Zhang, Z., Xie, X., Yao, Q., Liu, J., Tian, Y., Yang, C., Xiao, L., & Wang, N. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14745 · Cited by 20 · see citing works
Nitric oxide: A potential etiological agent for vaso-occlusive crises in sickle cell disease
Gupta, P., & Kumar, R. (2024) · Nitric Oxide · doi:10.1016/j.niox.2024.01.008 · Cited by 21 · see citing works
Transgenic overexpression of GTP cyclohydrolase 1 in cardiomyocytes ameliorates post-infarction cardiac remodeling
Liu, Y., Baumgardt, S. L., Fang, J., Shi, Y., Qiao, S., Bosnjak, Z. J., Vasquez-Vivar, J. M., Xia, Z., Warltier, D. C., Kersten, J. R., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03234-6 · Cited by 19 · see citing works
Marginal BH4 deficiencies, iNOS, and self-perpetuating oxidative stress in post-acute sequelae of Covid-19
Villaume, W. A. (2022) · Medical Hypotheses · doi:10.1016/j.mehy.2022.110842 · Cited by 18 · see citing works
Endothelial dysfunction and myocardial injury after major emergency abdominal surgery: a prospective cohort study
Ekeloef, S., Oreskov, J. O., Falkenberg, A., Burcharth, J., Schou‐Pedersen, A. M. V., Lykkesfeldt, J., & Gögenür, I. (2020) · BMC Anesthesiology · doi:10.1186/s12871-020-00977-0 · Cited by 18 · see citing works
Epigenetic modifications induced by exercise: Drug-free intervention to improve cognitive deficits associated with obesity
Barros, L., Eichwald, T., Solano, A. F., Scheffer, D. D. L., da Silva, R. A., Gaspar, J. M., & Latini, A. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.03.009 · Cited by 18 · see citing works

Tetrahydrobiopterin: pleiotropic roles in cardiovascular pathophysiology
Cunnington, C., & Channon, K. M. (2010) · Heart · doi:10.1136/hrt.2009.180430 · Cited by 52 · see citing works
Self-citation
Tetrahydrobiopterin Regulation of eNOS Redox Function
Chen, D., Chen, L., Xie, J.-B., Shu, C., Yang, T., Zhou, S., Yuan, H., & Chen, A. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660747 · Cited by 33 · see citing works
Targeting endothelial and myocardial dysfunction with tetrahydrobiopterin
Moens, A. L., Kietadisorn, R., Lin, J. Y., & Kass, D. A. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.03.009 · Cited by 41 · see citing works
Tetrahydrobiopterin Improves Endothelial Function in Cardiovascular Disease: A Systematic Review
Wang, Q., Yang, M., Han, X., & Yu, J. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/850312 · Cited by 23 · see citing works
Therapeutic Potential of Tetrahydrobiopterin for Treating Vascular and Cardiac Disease
Moens, A. L., & Kass, D. A. (2007) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e318123f854 · Cited by 83 · see citing works

Authors: Bendall, J. K., Douglas, G., McNeill, E., Channon, K. M., & Crabtree, M. J.
Affiliations: John Radcliffe Hospital (GB)
ORCID: Douglas, Gillian
McNeill, Eileen
Channon, Keith M.
Crabtree, Mark J.
Venue: Antioxidants & Redox Signaling
Publisher: SAGE Publications
Published: 2014-06
Volume: 20
Issue: 18
Pages: 3040-3077
ISSN: 1523-0864 (ISSN-L)
1557-7716
DOI: 10.1089/ars.2013.5566
PMC: PMC4038990
OpenAlex: W2092784951
Cited by: 231
References: 340
Citations by year: 2026: 12 · 2025: 21 · 2024: 15 · 2023: 22 · 2022: 26 · 2021: 20 · 2020: 21 · 2019: 18 · 2018: 18 · 2017: 21 · 2016: 15 · 2015: 12 · 2014: 9 · 2013: 1
FWCI: 1.36
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Antioxidants and Redox Signaling (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust (090532)
National Institute for Health and Care Research (NF-SI-0508-10247)
British Heart Foundation (RE/08/004, RG/12/5/29756, RG/12/5/29576)
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
Keywords: tetrahydrobiopterin, BH4, endothelial nitric oxide synthase, nitric oxide bioavailability, oxidative stress, aromatic amino acid hydroxylases, atherosclerosis, endothelial dysfunction, vascular dysfunction, inflammation, cardiac hypertrophy, cardiovascular disease, BH4 supplementation, cardiovascular homeostasis
MeSH terms: Biopterins, Cardiovascular Diseases, Cardiovascular System, Cardiomegaly, Humans, Inflammation, Oxidation-Reduction, Atherosclerosis, Nitric Oxide Synthase Type III

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Tetrahydrobiopterin in Cardiovascular Health and Disease

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks