Oxidopamine and oxidative stress: Recent advances in experimental physiology and pharmacology
Abstract
Oxidopamine (6-hydroxydopamine, 6-OHDA) is a toxin commonly used for the creation of experimental animal models of Parkinson's disease, attention-deficit hyperactivity disorder, and Lesch-Nyhan syndrome. Its exact mechanism of action is not completely understood, although there are many indications that it is related to the generation of reactive oxygen species (ROS), primarily in dopaminergic neurons. In certain experimental conditions, oxidopamine may also cause programmed cell death via various signaling pathways. Oxidopamine may also have a significant impact on chromatin structure and nuclear structural organization in some cells. Today, many researchers use oxidopamine-associated oxidative damage to evaluate different antioxidant-based pharmacologically active compounds as drug candidates for various neurological and non-neurological diseases. Additional research is needed to clarify the exact biochemical pathways associated with oxidopamine toxicity, related ROS generation and apoptosis. In this short review, we focus on the recent research in experimental physiology and pharmacology, related to the cellular and animal experimental models of oxidopamine - mediated toxicity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
6-OHDA is mainly distributed around the injection site due to its inability to freely cross the blood-brain barrier and cytomembrane.
“Due to its inability to freely cross the BBB and cytomembrane, 6-OHDA is mainly distributed around the injection site [76]”
From Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity <i>via</i> AMPK/SOD2 Pathway (2023) · cites this paper as [76]
Cites
1 retracted
Haddadi, R., Brooshghalan, S. E., Nayebi, A. M., Sabahi, M., & Ahmadi, S. A. (2020) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-020-01954-7 · Cited by 20 · see citing works
RetractedFerroptosis: past, present and future
Li, J., Cao, F., Yin, H.-L., Huang, Z.-J., Lin, Z.-T., Mao, N., Sun, B., & Wang, G. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-2298-2 · Cited by 4,171 · see citing works
Blum, D. L., Torch, S., Lambeng, N., Nissou, M.-F., Benabid, A., Sadoul, R., & Verna, J. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00003-x · Cited by 1,246 · see citing works
Classic toxin-induced animal models of Parkinson?s disease: 6-OHDA and MPTP
Schober, A. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0938-y · Cited by 803 · see citing works
Modeling Parkinson's Disease in Rats: An Evaluation of 6-OHDA Lesions of the Nigrostriatal Pathway
Deumens, R., Blokland, A., & Prickaerts, J. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7891 · Cited by 760 · see citing works
Scialò, F., Fernández-Ayala, D. J., & Sanz, A. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00428 · Cited by 517 · see citing works
A Guide to Neurotoxic Animal Models of Parkinson's Disease
Tieu, K. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a009316 · Cited by 483 · see citing works
Neuroinflammation as a risk factor for attention deficit hyperactivity disorder
Dunn, G. A., Nigg, J. T., & Sullivan, E. L. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.05.005 · Cited by 299 · see citing works
Andrew, R., Watson, D. G., Best, S. A., Midgley, J. M., Wenlong, H., & Petty, R. (1993) · Neurochemical Research · doi:10.1007/bf00978370 · Cited by 226 · see citing works
Breese, G. R., & Traylor, T. D. (1972) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1972.tb07257.x · Cited by 207 · see citing works
Sun, Y., He, L., Wang, T., Wan, H., Qin, H., Wang, J., Wang, L., Gu, W., Li, T., Li, N., et al. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02049-3 · Cited by 164 · see citing works
Cabral, M. D. I., Liu, S., & Soares, N. (2020) · Translational Pediatrics · doi:10.21037/tp.2019.09.08 · Cited by 133 · see citing works
Holtz, W. A., Turetzky, J. M., Jong, Y.-J. I., & O’Malley, K. L. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04025.x · Cited by 126 · see citing works
Breese, G. R., Baumeister, A. A., McCown, T. J., Emerick, S. G., Frye, G. D., & Mueller, R. A. (1984) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(84)80110-0 · Cited by 106 · see citing works
MAZZIO, E. A., Reams, R., & Soliman, K. F. A. (2004) · Brain Research · doi:10.1016/j.brainres.2003.12.034 · Cited by 102 · see citing works
Dopamine and the motivation of cognitive control
Cools, R., Froböse, M. I., Aarts, E., & Hofmans, L. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804281-6.00007-0 · Cited by 93 · see citing works
Lesch-Nyhan Syndrome: Models, Theories, and Therapies
Bell, S., Kolobova, I., Crapper, L., & Ernst, C. (2016) · Molecular Syndromology · doi:10.1159/000449296 · Cited by 82 · see citing works
Parkinson’s disease mouse models in translational research
Antony, P. M. A., Diederich, N. J., & Balling, R. (2011) · Mammalian Genome · doi:10.1007/s00335-011-9330-x · Cited by 79 · see citing works
6-Hydroxydopamine: a far from simple neurotoxin
Varešlija, D., Tipton, K. F., Davey, G. P., & McDonald, A. G. (2020) · Journal of Neural Transmission · doi:10.1007/s00702-019-02133-6 · Cited by 77 · see citing works
Esteves, A. R., Lu, J., Rodova, M., Onyango, I. G., Lezi, E., Dubinsky, R., Lyons, K. E., Pahwa, R., Burns, J. M., Cardoso, S. M., et al. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06631.x · Cited by 76 · see citing works
Attention Deficit Hyperactivity Disorder and oxidative stress: A short term follow up study
Güney, E., Çetin, F. H., Alışık, M., Tunca, H., Torun, Y. T., İşeri, E., Taner, Y. I., Çaycı, B., & Erel, Ö. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.07.003 · Cited by 71 · see citing works
Bouchatta, O., Manouze, H., Bouali‐Benazzouz, R., Kerekes, N., Ba-M’hamed, S., Fossat, P., Landry, M., & Bennis, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-33778-0 · Cited by 67 · see citing works
Jiménez-Del-Río, M., & Velez‐Pardo, C. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00907-8 · Cited by 61 · see citing works
Duan, W., Liang, L., Pan, M., Lu, D.-H., Wang, T.-M., Li, S.-B., Zhong, H., Yang, X., Cheng, Y., Liu, B., et al. (2020) · Phytomedicine · doi:10.1016/j.phymed.2020.153281 · Cited by 61 · see citing works
Södersten, E., Toskas, K., Rraklli, V., Tiklová, K., Björklund, Å. K., Ringnér, M., Perlmann, T., & Holmberg, J. (2018) · Nature Communications · doi:10.1038/s41467-018-03538-9 · Cited by 52 · see citing works
Caspase-4 is partially cleaved by calpain via the impairment of Ca2+ homeostasis under the ER stress
Matsuzaki, S., Hiratsuka, T., Kuwahara, R., Katayama, T., & Tohyama, M. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.11.007 · Cited by 51 · see citing works
Ramazani, E., YazdFazeli, M., Emami, S. A., Mohtashami, L., Javadi, B., Asili, J., & Tayarani‐Najaran, Z. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05284-y · Cited by 51 · see citing works
Tai, S., Zheng, Q., Zhai, S., Cai, T., Xu, L., Yang, L., Jiao, L., & Zhang, C. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00612 · Cited by 50 · see citing works
Clozapine antagonism of D-1 and D-2 dopamine receptor-mediated behaviors
Criswell, H. E., Mueller, R. A., & Breese, G. R. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90698-5 · Cited by 47 · see citing works
Borah, A., & Mohanakumar, K. P. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.05.008 · Cited by 40 · see citing works
Brain Injury and Mental Retardation: Psychopharmacology and Neuropsychiatry
Gualtieri, C. T. (2002) · Cited by 38 · see citing works
Self-injurious behaviour in movement disorders: systematic review
Fischer, J.-F., Mainka, T., Worbe, Y., Pringsheim, T. M., Bhatia, K. P., & Ganos, C. (2020) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2019-322569 · Cited by 37 · see citing works
Coelho-Santos, V., Socodato, R., Portugal, C., Leitão, R. A., Rito, M., Barbosa, M., Couraud, P.-O., Romero, I. A., Weksler, B., Minshall, R. D., et al. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2301-3 · Cited by 36 · see citing works
L-linalool exerts a neuroprotective action on hemiparkinsonian rats
de Lucena, J. D., Gadelha-Filho, C. V. J., da Costa, R. O., de Araújo, D. P., Lima, F. A. V., Neves, K. R. T., & Viana, G. S. D. B. (2020) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-019-01793-1 · Cited by 36 · see citing works
Lu, M., Tan, L., Zhou, X., Yang, Z., Zhu, Q. C., Chen, J., Luo, H., & Wu, G.-S. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1293935 · Cited by 32 · see citing works
Sanphui, P., Das, A. K., & Biswas, S. C. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.14969 · Cited by 30 · see citing works
Borah, A., & Mohanakumar, K. P. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.11.008 · Cited by 29 · see citing works
Tambirajoo, K., Furlanetti, L. L., Hasegawa, H., Raslan, A. M. T., Gimeno, H., Lin, J., Selway, R., & Ashkan, K. (2020) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13217 · Cited by 29 · see citing works
Chen, H., Cao, J., Zha, L., Wang, P., Liu, Z., Guo, B., Zhang, G., Sun, Y., Zhang, Z., & Wang, Y. (2019) · Aging · doi:10.18632/aging.103551 · Cited by 29 · see citing works
Pantic, I. V., Dimitrijevic, D., Nešić, D., & Petrovic, D. (2016) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2016.07.018 · Cited by 28 · see citing works
Self-citationIntrastriatal Hypoxanthine Reduces Na+,K+-ATPase Activity and Induces Oxidative Stress in the Rats
Bavaresco, C. S., Chiarani, F., Wannmacher, C. M. D., Netto, C. A., & Wyse, Â. T. D. S. (2007) · Metabolic Brain Disease · doi:10.1007/s11011-006-9037-y · Cited by 26 · see citing works
Zhai, H., Kang, Z., Zhang, H., Ma, J., & Chen, G. (2019) · Journal of Integrative Neuroscience · doi:10.31083/j.jin.2019.04.192 · Cited by 26 · see citing works
Protective effects of valproic acid on 6‐hydroxydopamine‐induced neuroinjury
Hsu, S., Hsu, P., CHANG, W.-S., Yu, C., Wang, Y., Yang, J., Tsai, F., Chen, K., Tsai, C., & Bau, D. (2020) · Environmental Toxicology · doi:10.1002/tox.22920 · Cited by 25 · see citing works
Ossola, B., Lantto, T. A., Puttonen, K. A., Tuominen, R. K., Raasmaja, A., & Männistö, P. T. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22791 · Cited by 22 · see citing works
Bouchatta, O., Manouze, H., Ba-M’hamed, S., Landry, M., & Bennis, M. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00027 · Cited by 20 · see citing works
Darabi, S., Noori-Zadeh, A., Abbaszadeh, H., Rajaei, F., & Bakhtiyari, S. (2019) · PubMed Central · doi:10.22037/ijpr.2019.2387 · Cited by 19 · see citing works
Liao, P., Kuo, Y., Chang, Y., Lin, C., Cherng, C. G., & Yu, L. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-002-0829-x · Cited by 16 · see citing works
Zhu, M., Tian, Y., Zhang, H., Ma, X., Shang, B., Zhang, J., Jiao, Y., Zhang, Y., Hu, J., & Wang, Y. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.01.027 · Cited by 16 · see citing works
Offenburger, S.-L., & Gartner, A. (2018) · BIO-PROTOCOL · doi:10.21769/bioprotoc.3025 · Cited by 16 · see citing works
Zhang, S., Tao, K., Wang, J., Duan, Y., Wang, B., & Liu, X. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00216 · Cited by 16 · see citing works
The Use of Perinatal 6-Hydroxydopamine to Produce a Rodent Model of Lesch–Nyhan Disease
Knapp, D. J., & Breese, G. R. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_444 · Cited by 15 · see citing works
Goggi, J., Qiu, L., Liao, M.-C., Khanapur, S., Jiang, L., Ramasamy, B., Hartimath, S. V., Cheng, P. K. C., Yong, F., Soh, V., et al. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01868-4 · Cited by 15 · see citing works
Nikolovski, D., Cumic, J., & Pantic, I. V. (2019) · Microscopy and Microanalysis · doi:10.1017/s1431927619014594 · Cited by 14 · see citing works
Self-citationEvaluation of Risperidone in the Neonatal 6-Hydroxydopamine Model of Lesch-Nyhan Syndrome
Allen, S. M. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00411-5 · Cited by 13 · see citing works
Neuroprotective effects of atomoxetine against traumatic spinal cord injury in rats.
Hou, Q., Yu, L., Tian, S.-Q., Jiang, C.-J., Yang, W., & Wang, Z. (2016) · PubMed Central · Cited by 12 · see citing works
Lukkes, J. L., Freund, N., Thompson, B. S., Meda, S., & Andersen, S. L. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.06.003 · Cited by 11 · see citing works
Bonilla-Porras, A. R., Jiménez-Del-Río, M., & Velez‐Pardo, C. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-04897-2 · Cited by 11 · see citing works
Sampaio, T. B., Marques, N. F., Binder, L. B., Tasca, C. I., & Prediger, R. D. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8324565 · Cited by 10 · see citing works
Aufmerksamkeitsdefizit‑/Hyperaktivitätsstörung im Kindes- und Jugendalter
Häge, A., Hohmann, S., Millenet, S., & Banaschewski, T. (2020) · Der Nervenarzt · doi:10.1007/s00115-020-00904-1 · Cited by 9 · see citing works
Altered gastrointestinal motility in an animal model of Lesch-Nyhan disease
Zizzo, M. G., Frinchi, M., Nuzzo, D., Jinnah, H. A., Mudò, G., Condorelli, D. F., Caciagli, F., Ciccarelli, R., Iorio, P. D., Mulè, F., et al. (2017) · Autonomic Neuroscience · doi:10.1016/j.autneu.2017.12.007 · Cited by 7 · see citing works
Travaglione, S., Loizzo, S., Vona, R., Ballan, G., Rivabene, R., Giordani, D., Guidotti, M., Dupuis, M. L., Maroccia, Z., Baiula, M., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093390 · Cited by 7 · see citing works
Martínez-Torres, N. I., González-Tapia, D., Vázquez-Hernández, N., & González‐Burgos, I. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.09.010 · Cited by 6 · see citing works
Cai, M., Zhuang, W., Lyu, E., & Fu, W. (2020) · PubMed · Cited by 6 · see citing works
Liu, X., Lü, J., Tian, Y., Zhang, G.-Y., Zhao, C.-P., Wang, T., Li, X., & Zhu, M. (2020) · PubMed · doi:10.13703/j.0255-2930.20190620-k0002 · Cited by 5 · see citing works
Nanagiri, A., & Shabbir, N. (2021) · StatPearls · Cited by 1 · see citing works
Flagged first, then by citations
4 of the 69 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Xie, Z., Zhang, M., Luo, Y., Jin, D., Guo, X., Yang, W., Zheng, J., Zhang, H., Zhang, L., Deng, C., et al. (2023) · Aging and disease · doi:10.14336/ad.2023.0309 · Cited by 80 · see citing works
CRLF1 and CLCF1 in Development, Health and Disease
Crisponi, L., Buers, I., & Rutsch, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020992 · Cited by 47 · see citing works
Artificial intelligence approaches to the biochemistry of oxidative stress: Current state of the art
Pantic, I. V., Paunović-Pantić, J., Pejić, S., Drakulić, D., Todorović, A., Stankovic, S. D., Vučević, D. B., Cumic, J., & Radosavljević, T. S. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.109888 · Cited by 46 · see citing works
Self-citationDNA Damage and Parkinson’s Disease
Pfeifer, G. P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084187 · Cited by 31 · see citing works
Cao, X., Rao, C., Cui, H., Sun, D., Li, L., Guo, S., Zhou, J., Yuan, R., Yang, S., & Chen, J. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.134691 · Cited by 17 · see citing works
Valjarević, S., Jovanovic, M. B., Miladinović, N., Cumic, J., Dugalić, S., Corridon, P. R., & Pantic, I. V. (2023) · Microscopy and Microanalysis · doi:10.1093/micmic/ozad042 · Cited by 17 · see citing works
Self-citationFu, R., Hong, S., & Chen, H. (2023) · Cells · doi:10.3390/cells12182310 · Cited by 16 · see citing works
Protective effects of 24-epibrassinolide against the 6-OHDA zebrafish model of Parkinson's disease
Gomes, A., Monteiro, S. M., Venâncio, C. A. S., & Félix, L. M. (2023) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2023.109630 · Cited by 14 · see citing works
IRE1/JNK Is the Leading UPR Pathway in 6-OHDA-Induced Degeneration of Differentiated SH-SY5Y Cells
Siwecka, N., Galita, G., Granek, Z., Wiese, W., Majsterek, I., & Rozpędek‐Kamińska, W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147679 · Cited by 13 · see citing works
Monoamine Oxidase Inhibitors in Toxic Models of Parkinsonism
Бунеева, О. А., & Medvedev, A. E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031248 · Cited by 9 · see citing works
Pantic, I. V., Topalović, N., Corridon, P. R., & Paunović-Pantić, J. (2023) · Fractal and Fractional · doi:10.3390/fractalfract7100771 · Cited by 8 · see citing works
Self-citationGastrointestinal dysmotility in rodent models of Parkinson’s disease
Pellegrini, C., & Travagli, R. A. (2024) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00225.2023 · Cited by 8 · see citing works
Wang, W., Tai, S., Tao, J., Yang, L., Cheng, X., & Zhou, J. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101295 · Cited by 9 · see citing works
Zhou, P., Yu, X., Song, T., & Hou, X. (2024) · PLoS ONE · doi:10.1371/journal.pone.0296926 · Cited by 7 · see citing works
Vallucci, M., Boutin, J. A., Janda, E., Blandel, F., Musgrove, R. E., Monte, D. A. D., Ferry, G., Michel, P. P., & Hirsch, É. C. (2023) · Journal of Neural Transmission · doi:10.1007/s00702-023-02709-3 · Cited by 5 · see citing works
Santana‐Gomez, C., Pérez‐Pérez, D., Fonseca‐Barriendos, D., Arias-Carrión, Ó., Besio, W. G., & Rocha, L. (2021) · Pharmaceuticals · doi:10.3390/ph14080706 · Cited by 5 · see citing works
Topalović, N., Mazic, S. D., Nešić, D., Vuković, O., Cumic, J., Laketić, D., Karličić, I. S., & Pantic, I. V. (2021) · Microscopy and Microanalysis · doi:10.1017/s143192762101240x · Cited by 5 · see citing works
Self-citationApplication of fractal and textural analysis in medical physiology, pathophysiology and pathology
Pantic, I. V., Paunović-Pantić, J., & Radojevic-Skodric, S. M. (2022) · Medicinska istrazivanja · doi:10.5937/medi55-40351 · Cited by 5 · see citing works
Self-citationApryatin, S. A., Traktirov, D. S., Karpenko, M. N., Ivleva, I. S., Pestereva, N. S., Bolshakova, M. V., Трофимов, А. Н., Fesenko, Z. S., & Клименко, В. М. (2023) · Journal of Neuroscience Research · doi:10.1002/jnr.25228 · Cited by 4 · see citing works
Pandur, E., Gulyás‐Fekete, G., Kulcsár, G., & Huber, I. (2025) · Antioxidants · doi:10.3390/antiox14091057 · Cited by 3 · see citing works
Zhang, M., Zhang, Y., Chen, Y., Cen, Z., Li, J., Li, S., Li, H., Wan, L., Xiao, X. H., & Long, Q. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106130 · Cited by 2 · see citing works
Carneiro, P., Pais, P., Oliveira, I. V., Monteiro, S. M., Venâncio, C. A. S., & Félix, L. M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27062590 · Cited by 2 · see citing works
Liu, J., Hu, D., Wang, Y., Zhou, X., Jiang, L., Wang, P., Lai, H., Wang, Y., & Xiao, H. (2024) · Journal of Burn Care & Research · doi:10.1093/jbcr/irae018 · Cited by 3 · see citing works
COA-Cl Evokes Protective Responses Against H2O2-and 6-OHDA-Induced Toxic Injury in PC12 Cells
Jamal, M., Tsukamoto, I., Takata, M., Takei, S., Konishi, R., & Kinoshita, H. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00587-3 · Cited by 2 · see citing works
Neroev, V. V., Pavlenko, T. A., Chesnokova, N. B., Валерьевна, Б. О., Okhotsimskaya, T. D., & Panova, A. Y. (2024) · Russian Ophthalmological Journal · doi:10.21516/2072-0076-2024-17-1-74-82 · Cited by 1 · see citing works
DNA Damage Repair: A Crucial Link to Neurological Disorders
Yang, H., Deng, Y., Chen, W., Zhu, W., & Lu, X. (2026) · The FASEB Journal · doi:10.1096/fj.202504689r · Cited by 1 · see citing works
dos Santos, T. C., Obando, J. M. C., Silva, J., Santos, A. L. V. P., Martins, R. C. C., Cavalcanti, D. N., Pedrosa, R., & Alves, C. (2025) · Antioxidants · doi:10.3390/antiox14121403
Research progress of exosomes in renal ischemia-reperfusion injury
Tai, S., Wang, W. Q., Luo, G., Tao, J.-H., Liang, C., & Zhou, J. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1763241
- Authors
- Pantic, I., Cumic, J., Skodric, S. R., Dugalic, S., & Brodski, C.
- Affiliations
- University of Belgrade (RS)
- Ben-Gurion University of the Negev (IL)
- Corresponding author
- Pantic, Igor
- Venue
- Chemico-Biological Interactions
- Publisher
- Elsevier BV
- Published
- 2021-02
- Volume
- 336
- Pages
- 109380
- ISSN
- 0009-2797 (ISSN-L)
- OpenAlex
- W3118996488
- Cited by
- 28
- References
- 69
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2023: 7 · 2022: 5 · 2021: 2
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Chemico-Biological Interactions (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (175059, 92018, III41027)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- 6-hydroxydopamine, oxidative stress, reactive oxygen species, dopaminergic neurons, Parkinson's disease, attention deficit hyperactivity disorder, Lesch-Nyhan syndrome, neurotoxicity, apoptosis, chromatin structure, nuclear organization, animal models of disease
- MeSH terms
- Animals, Humans, Oxidopamine, Reactive Oxygen Species, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
