A Guide to Neurotoxic Animal Models of Parkinson's Disease

Parkinson's Disease

Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469 · see citing works

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

Langston, J. W., Ballard, P., Tetrud, J. W., & Irwin, I. (1983) · Science · doi:10.1126/science.6823561 · Cited by 4,914 · see citing works

Handbook of Chemical Neuroanatomy

Stern, C. D. (1986) · Neurochemistry International · doi:10.1016/0197-0186(86)90021-5 · Cited by 4,159 · see citing works

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

Betarbet, R., Sherer, T., Mackenzie, G., Garcia-Osuna, M., Panov, A., & Greenamyre, J. (2000) · Nature Neuroscience · doi:10.1038/81834 · Cited by 3,797 · see citing works

Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

West, M. J., Slomianka, L., & Gundersen, H. J. G. (1991) · The Anatomical Record · doi:10.1002/ar.1092310411 · Cited by 2,994 · see citing works

Stages in the development of Parkinson’s disease-related pathology

Braak, H., Ghebremedhin, E., Rüb, U., Bratzke, H., & Del Tredici, K. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0956-9 · Cited by 2,689 · see citing works

Mitochondrial Complex I Deficiency in Parkinson's Disease

Schapira, A. H. V., Cooper, J. M., Dexter, D., Clark, J. B., Jenner, P., & Marsden, C. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb02325.x · Cited by 2,283 · see citing works

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J., Knapp, D. J., & Crews, F. T. (2007) · Glia · doi:10.1002/glia.20467 · Cited by 2,144 · see citing works

Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system

Ungerstedt, U., & Arbuthnott, G. W. (1970) · Brain Research · doi:10.1016/0006-8993(70)90187-3 · Cited by 1,993 · see citing works

Neuroinflammation in Parkinson’s disease: A target for neuroprotection?

Hirsch, E. C., & Hunot, S. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70062-6 · Cited by 1,984 · see citing works

MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE

Schapira, A. H. V., Cooper, J. A. D., Dexter, D. T., Jenner, P. G., Clark, J. B., & MARSDEN, C. D. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92366-0 · Cited by 1,757 · see citing works

A Note on a Simple Apparatus for Detecting Neurological Deficit in Rats and Mice**College of Pharmacy, University of Nebraska, Lincoln 8.

Dunham, N. W., & Miya, T. S. (1957) · Journal of the American Pharmaceutical Association (Scientific ed ) · doi:10.1002/jps.3030460322 · Cited by 1,713 · see citing works

6-Hydroxy-dopamine induced degeneration of central monoamine neurons.

Ungerstedt, U. (1968) · European Journal of Pharmacology · doi:10.1016/0014-2999(68)90164-7 · Cited by 1,516 · see citing works

Rotenone, Paraquat, and Parkinson’s Disease

Tanner, C. M., Kamel, F., Ross, G. W., Hoppin, J. A., Goldman, S. M., Korell, M., Marras, C., Bhudhikanok, G. S., Kasten, M., Chade, A. R., et al. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1002839 · Cited by 1,485 · see citing works

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

Davis, G. C., Williams, A. C., Markey, S. P., Ebert, M. H., Caine, E. D., Reichert, C. M., & Kopin, I. J. (1979) · Psychiatry Research · doi:10.1016/0165-1781(79)90006-4 · Cited by 1,377 · see citing works

3,4-Dihydroxyphenylalanine and 5-Hydroxytryptophan as Reserpine Antagonists

Carlsson, A., Lindqvist, M., & Magnusson, T. (1957) · Nature · doi:10.1038/1801200a0 · Cited by 1,272 · see citing works

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

Nicklas, W. J., Vyas, I. L., & Heikkila, R. E. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90146-8 · Cited by 1,266 · see citing works

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

Blum, D. L., Torch, S., Lambeng, N., Nissou, M.-F., Benabid, A., Sadoul, R., & Verna, J. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00003-x · Cited by 1,246 · see citing works

Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model

Björklund, L. M., Sánchez‐Pernaute, R., Chung, S., Andersson, T., CHEN, I. Y., McNaught, K. S. P., Brownell, A., Jenkins, B. G., Wahlestedt, C., Kim, K. S., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022438099 · Cited by 1,170 · see citing works

Oxidative Pathways for Catecholamines in the Genesis of Neuromelanin and Cytotoxic Quinones

GRAHAM, D. G. (1978) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13535-9 · Cited by 1,126 · see citing works

A Hydrophobic Stretch of 12 Amino Acid Residues in the Middle of α-Synuclein Is Essential for Filament Assembly

Giasson, B. I., Murray, I. V. J., Trojanowski, J. Q., & Lee, V. M.-Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008919200 · Cited by 1,080 · see citing works

Abnormalities of the electron transport chain in idiopathic parkinson's disease

Parker, W. D., Boyson, S. J., & Parks, J. K. (1989) · Annals of Neurology · doi:10.1002/ana.410260606 · Cited by 1,061 · see citing works

New stereological methods for counting neurons

West, M. J. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90112-o · Cited by 940 · see citing works

Biochemical pathophysiology of Parkinson's disease.

Hornykiewicz, O., & Kish, S. J. (1987) · PubMed · Cited by 850 · see citing works

Environmental Risk Factors and Parkinson's Disease: Selective Degeneration of Nigral Dopaminergic Neurons Caused by the Herbicide Paraquat

McCormack, A. L., Thiruchelvam, M. J., Manning-Bog, A., Thiffault, C., Langston, J. W., Cory‐Slechta, D. A., & Monte, D. A. D. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0507 · Cited by 838 · see citing works

Genetic Animal Models of Parkinson's Disease

Dawson, T. M., Ko, H. S., & Dawson, V. L. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.034 · Cited by 825 · see citing works

Functional engraftment of human ES cell–derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes

Roy, N. S., Cléren, C., Singh, S. K., Yang, L., Beal, M. F., & Goldman, S. A. (2006) · Nature Medicine · doi:10.1038/nm1495 · Cited by 822 · see citing works

BLOCKADE OF ENDOGENOUS NOREPINEPHRINE SYNTHESIS BY ALPHA-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE.

Spector, S., Sjoerdsma, A., & Udenfriend, S. (1965) · PubMed · Cited by 812 · see citing works

Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde tracing and immunocytochemical study in the rat

Sauer, H., & Oertel, W. H. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90605-x · Cited by 807 · see citing works

A highly reproducible rotenone model of Parkinson's disease

Cannon, J. R., Tapias, V., Na, H. M., Honick, A. S., Drolet, R. E., & Greenamyre, J. T. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.01.016 · Cited by 802 · see citing works

Fibrils Formed in Vitro from α-Synuclein and Two Mutant Forms Linked to Parkinson's Disease are Typical Amyloid

Conway, K. A., Harper, J. D., & Lansbury, P. T. (2000) · Biochemistry · doi:10.1021/bi991447r · Cited by 786 · see citing works

Microglial activation‐mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease

Gao, H., Jiang, J., Wilson, B. C., Zhang, W., Hong, J., & Liu, B. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00928.x · Cited by 690 · see citing works

THE OCCURRENCE, DISTRIBUTION AND PHYSIOLOGICAL ROLE OF CATECHOLAMINES IN THE NERVOUS SYSTEM

Carlsson, A. (1959) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)07428-9 · Cited by 690 · see citing works

Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport

Sulzer, D., Chen, T., Lau, Y., Kristensen, H., Rayport, S., & Ewing, A. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-05-04102.1995 · Cited by 688 · see citing works

The Herbicide Paraquat Causes Up-regulation and Aggregation of α-Synuclein in Mice

Manning-Bog, A., McCormack, A. L., Li, J., Uversky, V. N., Fink, A. L., & Monte, D. A. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100560200 · Cited by 684 · see citing works

Localization of monoamines in the lower brain stem

Dahlström, A. B., & Fuxé, K. (1964) · Cellular and Molecular Life Sciences · doi:10.1007/bf02147990 · Cited by 680 · see citing works

Tests to assess motor phenotype in mice: a user's guide

Brooks, S. P., & Dunnett, S. B. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2652 · Cited by 668 · see citing works

Environmental risk factors and Parkinson's disease

Liou, H., Tsai, M.-C., Chen, C., Jeng, J., Chang, Y. C., Chen, S. Y., & Chen, R.-T. (1997) · Neurology · doi:10.1212/wnl.48.6.1583 · Cited by 616 · see citing works

The connections of the dopaminergic system with the striatum in rats and primates: an analysis with respect to the functional and compartmental organization of the striatum

Joel, D., & Weiner, I. (2000) · Neuroscience · doi:10.1016/s0306-4522(99)00575-8 · Cited by 614 · see citing works

Methamphetamine toxicity and messengers of death

Krasnova, I. N., & Cadet, J. L. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.03.002 · Cited by 589 · see citing works

The parkinson's complex: Parkinsonism is just the tip of the iceberg

Langston, J. W. (2006) · Annals of Neurology · doi:10.1002/ana.20834 · Cited by 585 · see citing works

Complex I Is the Major Site of Mitochondrial Superoxide Production by Paraquat

Cochemé, H. M., & Murphy, M. P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m708597200 · Cited by 563 · see citing works

Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and α-synuclein

Fornai, F., Schlüter, O. M., Lenzi, P., Gesi, M., Ruffoli, R., Ferrucci, M., Lazzeri, G., Busceti, C. L., Pontarelli, F., Battaglia, G., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409713102 · Cited by 526 · see citing works

The parkinsonian toxin 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP): a technical review of its utility and safety

Przedborski, S., Jackson-Lewis, V. R., Naini, A., Jakowec, M. W., Petzinger, G. M., Miller, R., & Akram, M. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00183.x · Cited by 507 · see citing works

Partial lesions of the dopaminergic nigrostriatal system in rat brain: biochemical characterization

Hefti, F. F., Melamed, E., & Wurtman, R. J. (1980) · Brain Research · doi:10.1016/0006-8993(80)90871-9 · Cited by 502 · see citing works

D-β-Hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease

Tieu, K., Perier, C., Caspersen, C., Teismann, P., Wu, D.-C., Yan, S.-D., Naini, A., Vila, M., Jackson-Lewis, V., Ramasamy, R., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318797 · Cited by 497 · see citing works

Early and Progressive Sensorimotor Anomalies in Mice Overexpressing Wild-Type Human α-Synuclein

Fleming, S. M., Salcedo, J. D., Fernagut, P., Rockenstein, E. M., Masliah, E., Levine, M. S., & Chesselet, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3080-04.2004 · Cited by 477 · see citing works

The Nigrostriatal Dopaminergic System as a Preferential Target of Repeated Exposures to Combined Paraquat and Maneb: Implications for Parkinson's Disease

Thiruchelvam, M. J., Richfield, E. K., Baggs, R. B., Tank, A. W., & Cory‐Slechta, D. A. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09207.2000 · Cited by 471 · see citing works

Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by instrastriatal injection of 6-hydroxydopamine

Przedbroski, S., Leviver, M., Jiang, H., Ferreira, M., Jackson-Lewis, V. R., Donaldson, D. M., & Togasaki, D. M. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00066-r · Cited by 453 · see citing works

Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress

Cubells, J. F., Rayport, S., Rajendran, G., & Sulzer, D. L. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-04-02260.1994 · Cited by 448 · see citing works

An electron microscopic study of selective, acute degeneration of sympathetic nerve terminals after administration of 6-hydroxydopamine

Tranzer, J. P., & Thoenen, H. (1968) · Cellular and Molecular Life Sciences · doi:10.1007/bf02146956 · Cited by 444 · see citing works

Behavioral phenotyping of the MPTP mouse model of Parkinson's disease

Sedelis, M., Schwarting, R. K. W., & Huston, J. P. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00309-6 · Cited by 434 · see citing works

Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss

Brooks, A. I., Chadwick, C. A., Gelbard, H. A., Cory‐Slechta, D. A., & Federoff, H. J. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01192-5 · Cited by 425 · see citing works

The Single Intranigral Injection of LPS as a New Model for Studying the Selective Effects of Inflammatory Reactions on Dopaminergic System

Herrera, A. J., Castaño, A., Venero, J. L., Cano, J., & Machado, A. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0289 · Cited by 392 · see citing works

α‐Synuclein Up‐Regulation in Substantia Nigra Dopaminergic Neurons Following Administration of the Parkinsonian Toxin MPTP

Vila, M., Vukosavić, S., Jackson-Lewis, V. R., Neystat, M., Jakowec, M. W., & Przedborski, S. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740721.x · Cited by 388 · see citing works

Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice

Ferfoglia, R. I., Mohapel, P., Brundin, P., & Paul, G. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.02.023 · Cited by 380 · see citing works

Locus ceruleus lesions and eosinophilic inclusions in MPTP‐treated monkeys

Forno, L. S., Langston, J. W., DeLanney, L. E., Irwin, I., & Ricaurte, G. A. (1986) · Annals of Neurology · doi:10.1002/ana.410200403 · Cited by 351 · see citing works

Lysosomal Degradation of α-Synuclein in Vivo

Mak, S. K., McCormack, A. L., Manning-Bog, A., Cuervo, A. M., & Monte, D. A. D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.074617 · Cited by 349 · see citing works

Emotional, cognitive and neurochemical alterations in a premotor stage model of Parkinson's disease

Tadaiesky, M. T., Dombrowski, P. A., Figueiredo, C. P., Cargnin‐Ferreira, E., Cunha, C. D., & Takahashi, R. N. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.08.035 · Cited by 342 · see citing works

Pesticide Exposure and Self-reported Parkinson's Disease in the Agricultural Health Study

Kamel, F., Tanner, C. M., Umbach, D. M., Hoppin, J. A., Alavanja, M. C. R., Blair, A. E., Comyns, K., Goldman, S., Korell, M., Langston, J. W., et al. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwk024 · Cited by 339 · see citing works

A simple quantitative bradykinesia test in MPTP-treated mice.

Ogawa, N., Hirose, Y., Ohara, S., Ono, T., & Watanabe, Y. (1985) · PubMed · Cited by 334 · see citing works

Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats

Höglinger, G. U., Féger, J., Prigent, A., Michel, P. P., Parain, K., Champy, P., Ruberg, M., Oertel, W. H., & Hirsch, É. C. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01533.x · Cited by 331 · see citing works

Chemical Neurotoxins as Denervation Tools in Neurobiology

Jonsson, G. (1980) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.03.030180.001125 · Cited by 324 · see citing works

Potentiated and preferential effects of combined paraquat and maneb on nigrostriatal dopamine systems: environmental risk factors for Parkinson’s disease?

Thiruchelvam, M. J., Brockel, B. J., Richfield, E. K., Baggs, R. B., & Cory‐Slechta, D. A. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02496-3 · Cited by 324 · see citing works

Anatomy of the dopamine system in the basal ganglia

Smith, Y., & Kieval, J. Z. (2000) · Trends in Neurosciences · doi:10.1016/s1471-1931(00)00023-9 · Cited by 320 · see citing works

Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: Implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity

Heikkila, R. E., Nicklas, W. J., Vyas, I. L., & Duvoisin, R. C. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90580-4 · Cited by 302 · see citing works

Role of dopamine in the neurotoxic effects of methamphetamine.

Schmidt, C. J., Ritter, J. K., Sonsalla, P. K., Hanson, G. R., & Gibb, J. W. (1985) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22853-1 · Cited by 300 · see citing works

Degeneration of adrenergic nerves produced by 6-hydroxydopamine

Malmfors, T., & Sachs, C. (1968) · European Journal of Pharmacology · doi:10.1016/0014-2999(68)90056-3 · Cited by 295 · see citing works

Amphetamine and Other Weak Bases Act to Promote Reverse Transport of Dopamine in Ventral Midbrain Neurons

Sulzer, D. L., Maidment, N. T., & Rayport, S. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03181.x · Cited by 292 · see citing works

6-Hydroxydopamine Lesion of the Rat Substantia Nigra: Time Course and Morphology of Cell Death

Jeon, B. S., Jackson-Lewis, V. R., & Burke, R. E. (1995) · Neurodegeneration · doi:10.1006/neur.1995.0016 · Cited by 291 · see citing works

Parkinson's disease: A case‐control study of occupational and environmental risk factors

Hertzman, C., Wiens, M., Bowering, D. J., Snow, B. J., & Calne, D. B. (1990) · American Journal of Industrial Medicine · doi:10.1002/ajim.4700170307 · Cited by 290 · see citing works

The Toxicity of Paraquat

Clark, D. G., McElligott, T. F., & Hurst, E. W. (1966) · Occupational and Environmental Medicine · doi:10.1136/oem.23.2.126 · Cited by 282 · see citing works

Age‐related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype

Thiruchelvam, M. J., McCormack, A. L., Richfield, E. K., Baggs, R. B., Tank, A. W., Monte, D. A. D., & Cory‐Slechta, D. A. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02781.x · Cited by 280 · see citing works

Paraquat Neurotoxicity is Distinct from that of MPTP and Rotenone

Richardson, J. R., Quan, Y., Sherer, T., Greenamyre, J. T., & Miller, G. W. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi304 · Cited by 275 · see citing works

Role of Dopamine Transporter in Methamphetamine-Induced Neurotoxicity: Evidence from Mice Lacking the Transporter

Fumagalli, F., Gainetdinov, R. R., Valenzano, K. J., & Caron, M. G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-13-04861.1998 · Cited by 266 · see citing works

Carrier-mediated processes in blood–brain barrier penetration and neural uptake of paraquat

Shimizu, K., Ohtaki, K., Matsubara, K., Aoyama, K., Uezono, T., Saitô, O., Suno, M., Ogawa, K., Hayase, N., Kimura, K., et al. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02577-x · Cited by 264 · see citing works

The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease

Ilijić, E., Guzmán, J. N., & Surmeier, D. J. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.04.007 · Cited by 260 · see citing works

Methamphetamine-induced hyperthermia and dopaminergic neurotoxicity in mice: pharmacological profile of protective and nonprotective agents.

Albers, D. S., & Sonsalla, P. K. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12160-5 · Cited by 258 · see citing works

Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology

Drolet, R. E., Cannon, J. R., Montero, L. M., & Greenamyre, J. T. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.06.017 · Cited by 257 · see citing works

Biochemical Characterization of the Core Structure of α-Synuclein Filaments

Miake, H., Mizusawa, H., Iwatsubo, T., & Hasegawa, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110551200 · Cited by 255 · see citing works

The non-motor symptom complex of Parkinson’s disease: A comprehensive assessment is essential

Chaudhuri, К. R., Yates, L. R., & Martínez‐Martín, P. (2005) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-005-0072-6 · Cited by 244 · see citing works

Increased Methamphetamine Neurotoxicity in Heterozygous Vesicular Monoamine Transporter 2 Knock-Out Mice

Fumagalli, F., Gainetdinov, R. R., Wang, Y., Valenzano, K. J., Miller, G. W., & Caron, M. G. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02424.1999 · Cited by 241 · see citing works

Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease

ANDERSON, G., Noorian, A. R., Taylor, G. T., Anitha, M., BERNHARD, D., SRINIVASAN, S., & GREENE, J. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.05.010 · Cited by 238 · see citing works

EFFECT OF 6-HYDROXYDOPAMINE AND SOME OTHER COMPOUNDS ON THE CONCENTRATION OF NOREPINEPHRINE IN THE HEARTS OF MICE

Porter, C. C., Totaro, J. A., & Stone, C. A. (1963) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)26555-7 · Cited by 234 · see citing works

Parkinson's disease and megacolon

Kupsky, W. J., Grimes, M. M., Sweeting, J. C., Bertsch, R., & Cote, L. J. (1987) · Neurology · doi:10.1212/wnl.37.7.1253 · Cited by 232 · see citing works

Behavioral and immunohistochemical effects of chronic intravenous and subcutaneous infusions of varying doses of rotenone

Fleming, S. M. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.01.023 · Cited by 230 · see citing works

Isoquinoline neurotoxins in the brain and Parkinson's disease

Nagatsu, T. (1997) · Neuroscience Research · doi:10.1016/s0168-0102(97)00083-7 · Cited by 229 · see citing works

Astrocytes and Therapeutics for Parkinson's Disease

Rappold, P. M., & Tieu, K. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.07.001 · Cited by 228 · see citing works

Animal models of Parkinson’s disease progression

Meredith, G. E., Sonsalla, P. K., & Chesselet, M. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0350-x · Cited by 228 · see citing works

The determination of hydroxydopamines and other trace amines in the urine of Parkinsonian patients and normal controls

Andrew, R., Watson, D. G., Best, S. A., Midgley, J. M., Wenlong, H., & Petty, R. (1993) · Neurochemical Research · doi:10.1007/bf00978370 · Cited by 226 · see citing works

The overall rod performance test in the MPTP-treated-mouse model of Parkinsonism

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