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Metal–organic frameworks as potential drug carriers
Open accessAbstract
Summary of Recent Advances Nanoparticle-based therapeutics have received increasing attention, as these systems can alleviate many drawbacks of conventional therapy. Metal-organic frameworks (MOFs), a new class of hybrid materials composed of metal ions and organic bridging ligands, have emerged as a promising platform for drug delivery, owing to their high drug loadings, biodegradability, and versatile functionality. The bulk MOF materials can absorb and release large amounts of therapeutics including ibuprofen, procainamide, and nitric oxide. Scale-down of MOFs to the nano-regime yields nanoscale metal-organic frameworks (NMOFs) which are more applicable as delivery vehicles, such as selective delivery of cisplatin prodrugs. Although progress has been made in utilizing NMOFs for drug delivery, many improvements must occur before they can become viable nanotherapeutics.
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Cites
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NO-Releasing Zeolites and Their Antithrombotic Properties
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Cited by
Metal–Organic Frameworks for Separations
Li, J.-R., Sculley, J., & Zhou, H.-C. (2012) · Chemical Reviews · doi:10.1021/cr200190s · Cited by 6,323
Metal–Organic-Framework-Based Materials for Antimicrobial Applications
Li, R., Chen, T., & Pan, X. (2021) · ACS Nano · doi:10.1021/acsnano.0c09617 · Cited by 555
Beuerle, F., & Gole, B. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201710190 · Cited by 528
Technologies for Arsenic Removal from Water: Current Status and Future Perspectives
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Ionic metal-organic frameworks (iMOFs): Design principles and applications
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Metadata
- Authors
- Huxford, R. C., Della Rocca, J., & Lin, W.
- Venue
- Current Opinion in Chemical Biology
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 14
- Issue
- 2
- Pages
- 262-268
- ISSN
- 1367-5931 (ISSN-L)
- OpenAlex
- W2131762032
- Cited by
- 840
- References
- 5
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- green
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