NO-Releasing Zeolites and Their Antithrombotic Properties
Abstract
Transition metal-exchanged zeolite-A adsorbs and stores nitric oxide in relatively high capacity (up to 1 mmol of NO/g of zeolite). The stored NO is released on contact with an aqueous environment under biologically relevant conditions of temperature and pH. The release of the NO can be tuned by altering the chemical composition of the zeolite, by controlling the amount of water contacting the zeolite, and by blending the zeolite with different polymers. The high capacity of zeolite for NO makes it extremely attractive for use in biological and medical applications, and our experiments indicate that the NO released from Co-exchanged zeolite-A inhibits platelet aggregation and adhesion of human platelets in vitro.
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The t1⁄2 of NO release from zeolite polymer disks increased from 340 s for zeolite powder to 509 s for PTFE disk and 3076 s for PDMS disk.
“The t½ values of NO release from zeolite polymer disks was significantly increased (from 340 s for zeolite powder to 509 s for PTFE disk and 3076 s for PDMS disk).207”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [207]
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- Authors
- Wheatley, P. S., Butler, A. R., Crane, M. S., Fox, S., Xiao, B., Rossi, A. G., Megson, I. L., & Morris, R. E.
- Affiliations
- University of St Andrews (GB)
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-12-20
- Volume
- 128
- Issue
- 2
- Pages
- 502-509
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2077780753
- Cited by
- 235
- References
- 3
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 4 · 2023: 15 · 2022: 10 · 2021: 9 · 2020: 11 · 2019: 12 · 2018: 5 · 2017: 7 · 2016: 15 · 2015: 18 · 2014: 13 · 2013: 14 · 2012: 10
- FWCI
- 8.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Chemical Society (publishedVersion)
- PubMed (publishedVersion)
- Science and Technology Facilities Council (submittedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Topics
- Physical Sciences › Chemistry › Inorganic Chemistry › Zeolite Catalysis and Synthesis
- Physical Sciences › Materials Science › Biomaterials › Clay minerals and soil interactions
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- nitric oxide storage, zeolite A, cobalt-exchanged zeolite, nitric oxide release, antithrombotic activity, platelet aggregation inhibition, platelet adhesion, polymer blends, water contact, pH and temperature effects
- MeSH terms
- Fibrinolytic Agents, Humans, Platelet Aggregation, Structure-Activity Relationship, X-Ray Diffraction, Molecular Structure, Zeolites, Nitric Oxide Donors
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