Cited by 86Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Health and Disease PreventionCardiovascular Disease and Adiposity

Effects of IL-6, adiponectin, CRP and metabolic syndrome on subclinical atherosclerosis

Nishida, Makoto, Moriyama, Toshiki, Ishii, Kouki, Takashima, Seiji, Yoshizaki, Kazuyuki, Sugita, Yoshiro, Yamauchi-Takihara, Keiko·2007·Clinica Chimica Acta

Abstract

Background Inflammation has been implicated in the pathogenesis of cardiovascular disease. Since there have been few studies elucidating gender-specific effect of inflammation and metabolic syndrome (MetS) on subclinical atherosclerosis, we evaluated the relative contribution of these factors in healthy subjects.Methods MetS components, carotid intima-media thickness (IMT) and pulse wave velocity (PWV) were evaluated in apparently healthy 714 men and 364 women (40-59 y). Serum levels of high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6) and adiponectin were also examined.Results Increase in number of clustering MetS components was more clearly associated with worsening of IMT and PWV in women than in men. Serum IL-6 level was positively correlated with IMT and PWV, and adiponectin level was negatively correlated with IMT in men but not in women. The subjects either with a "high" IL-6 or hs-CRP, or a "low" adiponectin were associated with increase in IMT in the presence of MetS, though there was no significant effect of MetS in those with low inflammation.Conclusions While IL-6 and adiponectin are the important risk factors for early arterial alterations in men, components of MetS present profound effects on subclinical atherosclerosis in women rather than in men.

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Crossref · 10.1016/j.cca.2007.06.009

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Authors
Nishida, M., Moriyama, T., Ishii, K., Takashima, S., Yoshizaki, K., Sugita, Y., & Yamauchi-Takihara, K.
Affiliations
The University of Osaka (JP)
Venue
Clinica Chimica Acta
Publisher
Elsevier BV
Published
2007-09
Volume
384
Issue
1-2
Pages
99-104
ISSN
0009-8981 (ISSN-L)
OpenAlex
W2082403489
Cited by
86
References
29
Citations by year
2023: 3 · 2022: 1 · 2021: 10 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 5 · 2015: 7 · 2014: 8 · 2013: 7 · 2012: 10
FWCI
4.59
Type
journal article
Language
en
Open access
closed
Locations
  • Clinica Chimica Acta (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Japan Health Foundation
  • Japan Society for the Promotion of Science
  • Ministry of Education, Culture, Sports, Science and Technology
  • Kurozumi Medical Foundation
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
subclinical atherosclerosis, interleukin-6, adiponectin, C-reactive protein, metabolic syndrome, carotid intima-media thickness, pulse wave velocity, inflammation, sex differences, cardiovascular risk factors, healthy adults
MeSH terms
Adult, Arteriosclerosis, C-Reactive Protein, Female, Humans, Male, Middle Aged, Interleukin-6, Tunica Intima, Metabolic Syndrome, Adiponectin

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