Effects of IL-6, adiponectin, CRP and metabolic syndrome on subclinical atherosclerosis
Abstract
Background Inflammation has been implicated in the pathogenesis of cardiovascular disease. Since there have been few studies elucidating gender-specific effect of inflammation and metabolic syndrome (MetS) on subclinical atherosclerosis, we evaluated the relative contribution of these factors in healthy subjects.Methods MetS components, carotid intima-media thickness (IMT) and pulse wave velocity (PWV) were evaluated in apparently healthy 714 men and 364 women (40-59 y). Serum levels of high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6) and adiponectin were also examined.Results Increase in number of clustering MetS components was more clearly associated with worsening of IMT and PWV in women than in men. Serum IL-6 level was positively correlated with IMT and PWV, and adiponectin level was negatively correlated with IMT in men but not in women. The subjects either with a "high" IL-6 or hs-CRP, or a "low" adiponectin were associated with increase in IMT in the presence of MetS, though there was no significant effect of MetS in those with low inflammation.Conclusions While IL-6 and adiponectin are the important risk factors for early arterial alterations in men, components of MetS present profound effects on subclinical atherosclerosis in women rather than in men.
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Patients with metabolic disorders may get more benefits from the intervention, as obese and unhealthy subjects tend to have higher levels of inflammatory factors.
“As some studies suggested these patients with metabolic disorders may get more benefits from the intervention, for obese and unhealthy subjects tending to accompany with higher levels of inflammatory factors [82, 83]; for instance, CRP is an indicator of general low-grade inflammation [84, 85].”
From Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose-response meta-analysis of randomized controlled trials (2021) · cites this paper as [83]
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- Authors
- Nishida, M., Moriyama, T., Ishii, K., Takashima, S., Yoshizaki, K., Sugita, Y., & Yamauchi-Takihara, K.
- Affiliations
- The University of Osaka (JP)
- Venue
- Clinica Chimica Acta
- Publisher
- Elsevier BV
- Published
- 2007-09
- Volume
- 384
- Issue
- 1-2
- Pages
- 99-104
- ISSN
- 0009-8981 (ISSN-L)
- OpenAlex
- W2082403489
- Cited by
- 86
- References
- 29
- Citations by year
- 2023: 3 · 2022: 1 · 2021: 10 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 5 · 2015: 7 · 2014: 8 · 2013: 7 · 2012: 10
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinica Chimica Acta (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Health Foundation
- Japan Society for the Promotion of Science
- Ministry of Education, Culture, Sports, Science and Technology
- Kurozumi Medical Foundation
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- subclinical atherosclerosis, interleukin-6, adiponectin, C-reactive protein, metabolic syndrome, carotid intima-media thickness, pulse wave velocity, inflammation, sex differences, cardiovascular risk factors, healthy adults
- MeSH terms
- Adult, Arteriosclerosis, C-Reactive Protein, Female, Humans, Male, Middle Aged, Interleukin-6, Tunica Intima, Metabolic Syndrome, Adiponectin
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