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Cited by 1,263Diabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic DiseasesDiet, Metabolism, and Disease

Metabolic syndrome: A comprehensive perspective based on interactions between obesity, diabetes, and inflammation

Dandona, Paresh, Aljada, Ahmad, Chaudhuri, Ajay, Mohanty, Priya, Garg, Rajesh·2005·Circulation
DOI 10.1161/01.cir.0000158483.13093.9d
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Crossref · 10.1161/01.cir.0000158483.13093.9d

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77 of 77 references verified0 citation errors · 0 not checkable

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  • Increased intake of high energy food rich in animal-saturated fat leads to oxidative stress at the cellular level and inflammation by increasing the expression of NADPH oxidase in adipocytes.

    “An increased intake of high energy food rich in animal-saturated fat leads to oxidative stress at the cellular level and inflammation by increasing the expression of nicotinamide adenine dinucleuotide phosphate (NADPH) oxidase (NOX) in adipocytes.”

    From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [16]

  • Activation of the NF-κB pathway results in increased expression of proinflammatory mediators such as TNFα, interleukin 6, and leptin while decreasing secretion of the protective adipokine adiponectin.

    “Through the activation of the nuclear factor-kappa B (NF-κB) pathway, it results in an increased expression of the proinflammatory mediators such as tumor necrosis factor alpha (TNFα), interleukin 6 (IL6), leptin while decreasing the secretion of the protective adipokine, adiponectin [4,16].”

    From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [16]

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Research works printed but not linked: 2

  1. Aljada A, Ghanim H, Mohanty P, Tufail S, Bandyopadhyay A, Dandona P. Glucose intake induces an increase in AP-1 and Egr-1 binding activities and tissue factor and matrix metalloproteinase expressions in mononuclear cells and plasma tissue factor and matrix metalloproteinase concentrations. Am J Clin Nutr. 2004;80:51-57.
  2. Mohanty P, Daoud N, Ghanim H, Ravishankar S, Szudzik E, Aljada A, Dandona P. Absence of oxidative stress and inflammation following the intake of a 900 kcalorie meal rich in fruit and fiber. Diabetes. 2004;53:A405.

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Authors
Dandona, P., Aljada, A., Chaudhuri, A., Mohanty, P., & Garg, R.
Affiliations
Kaleida Health (US)
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2005-03-22
Volume
111
Issue
11
Pages
1448-1454
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.0000158483.13093.9d
OpenAlex
W1985882893
Cited by
1,263
References
77
Citations by year
2026: 10 · 2025: 13 · 2024: 33 · 2023: 29 · 2022: 39 · 2021: 44 · 2020: 49 · 2019: 48 · 2018: 48 · 2017: 52 · 2016: 72 · 2015: 70 · 2014: 68 · 2013: 97 · 2012: 84
FWCI
9.26
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
metabolic syndrome
MeSH terms
Animals, Arteriosclerosis, C-Reactive Protein, Diabetes Mellitus, Type 2, Food, Gene Expression Regulation, Humans, Hypercholesterolemia, Hyperinsulinism, Hypertension, Hypoglycemic Agents, Inflammation, Insulin, Insulin Resistance, Lipoproteins, HDL, Models, Biological, Obesity, Hypertriglyceridemia, Cytokines, NF-kappa B, Apoptosis, Plasminogen Activator Inhibitor 1, Oxidative Stress, Metabolic Syndrome, Rats

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