Standardization of collection requirements for fasting samples
Abstract
Standardized protocols for patient preparation for laboratory testing are currently lacking. Moreover, a great heterogeneity exists in the definitions of "fasting" currently being used among healthcare workers and in the literature. Marked metabolic and hormonal changes occur after food ingestion, mainly due to the absorption of fluids, lipids, proteins, carbohydrates and other food constituents. This postprandial response varies markedly in response to numerous factors, such as eating behavior, food composition, fasting duration, time of the day, chronic and acute smoking, coffee and alcohol consumption. It is therefore crucial to minimize the total variability by controlling as many of these modifying factors as possible. Control of the abovementioned effects on postprandial response can only be achieved by standardizing the way patients are prepared for laboratory testing, i.e. by defining the fasting duration, as well as what is and what is not allowed (e.g., coffee, tea, smoking, water) during the period of fasting prior to sample collection. The aim of this article is to describe the range of effects of different approaches to fasting on laboratory tests, and to provide a framework for the harmonization of definitions for fasting requirements for laboratory tests.
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Fasting blood samples were collected to reduce pre-analytical variability and minimize influence caused by food.
“Fasting blood samples were collected to reduce pre-analytical variability and to minimize influence caused by food. [4]”
From Comparison of sleep in hypothyroid patients with normal controls (2017) · cites this paper as [4]
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Nordestgaard, B. G., Langsted, A., Mora, S., Kolovou, G., Baum, H., Bruckert, E., Watts, G. F., Sypniewska, G., Wiklund, O., Borén, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw152 · Cited by 847 · see citing works
Joint EFLM-COLABIOCLI Recommendation for venous blood sampling
Simundic, A.-M., Bölenius, K., Cadamuro, J., Church, S., Cornes, M. P., van Dongen-Lases, E. C., Eker, P., Erdeljanovic, T., Grankvist, K., Guimaraes, J. T., et al. (2018) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2018-0602 · Cited by 240 · see citing works
Self-citationNordestgaard, B. G., Langlois, M. R., Langsted, A., Chapman, M. J., Aakre, K. M., Baum, H., Borén, J., Bruckert, E., Catapano, A., Cobbaert, C., et al. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.12.005 · Cited by 240 · see citing works
A Test in Context: Lipid Profile, Fasting Versus Nonfasting
Nordestgaard, B. G. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.08.006 · Cited by 223 · see citing works
Lima-Oliveira, G., Volanski, W., Lippi, G., Picheth, G., & Guidi, G. C. (2017) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2017.1295317 · Cited by 117 · see citing works
Self-citationLima-Oliveira, G., Lippi, G., Salvagno, G. L., Picheth, G., & Guidi, G. C. (2015) · Journal of Medical Biochemistry · doi:10.2478/jomb-2014-0043 · Cited by 102 · see citing works
Self-citationKolovou, G. D., Watts, G. F., Mikhailidis, D. P., Pérez-Martínez, P., Mora, S., Bilianou, H., Panotopoulos, G., Katsiki, N., Ooi, T. C., Lopez-Miranda, J., et al. (2019) · Current Vascular Pharmacology · doi:10.2174/1570161117666190507110519 · Cited by 61 · see citing works
Cornes, M. P., Church, S., van Dongen-Lases, E., Grankvist, K., Guimarães, J. T., Ibarz, M., Kovalevskaya, S., Kristensen, G. B., Lippi, G., Nybo, M., et al. (2016) · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine · doi:10.1177/0004563216643969 · Cited by 43 · see citing works
Self-citationCould light meal jeopardize laboratory coagulation tests?
Lima-Oliveira, G., Salvagno, G. L., Lippi, G., Danese, E., Gelati, M., Montagnana, M., Picheth, G., & Guidi, G. C. (2014) · Biochemia Medica · doi:10.11613/bm.2014.036 · Cited by 30 · see citing works
Self-citationComparison of sleep in hypothyroid patients with normal controls
Sivaprakasam, K., & Ramamoorthy, S. (2017) · National Journal of Physiology, Pharmacy and Pharmacology · doi:10.5455/njppp.2017.7.0203427062017 · Cited by 4 · see citing works
“Fasting blood samples were collected to reduce pre-analytical variability and to minimize influence caused by food.[4]”
Background
- Authors
- Simundic, A. M., Cornes, M., Grankvist, K., Lippi, G., & Nybo, M.
- Affiliations
- New Cross Hospital (GB)
- Umeå University (SE)
- Ospedale di Parma (IT)
- Odense University Hospital (DK)
- Venue
- Clinica Chimica Acta
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 432
- Pages
- 33-37
- ISSN
- 0009-8981 (ISSN-L)
- OpenAlex
- W1821762998
- Cited by
- 156
- References
- 1
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 18 · 2023: 12 · 2022: 12 · 2021: 11 · 2020: 12 · 2019: 13 · 2018: 14 · 2017: 19 · 2016: 12 · 2015: 8 · 2014: 8
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinica Chimica Acta (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Keywords
- fasting, fasting requirement, sample collection, standardization, postprandial response, patient preparation, laboratory testing, fasting duration, dietary intake, smoking, alcohol consumption, coffee and tea
- MeSH terms
- Blood Chemical Analysis, Blood Specimen Collection, Fasting, Humans, Patient Compliance, Reference Standards, Postprandial Period
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