Evaluation of the performance of a new OptiScanner™ 5000 system for an intermittent glucose monitoring
Abstract
Background Mid-infrared spectral technology has shown a high degree of promise in detecting glucose in plasma. OptiScan Biomedical has developed a glucose monitor based on mid-infrared spectroscopy that withdraws blood samples and measures plasma glucose. The objective of this study was to evaluate the accuracy and performance of the OptiScanner™ 5000 system on different pools of blood. Methods This study was performed to validate the blood glucose measurements obtained with the OptiScanner™ 5000 by comparing them to Central Laboratory glucose measurements (VITROS® 5600 Integrated System) as a comparative method across a broad range of glucose values over a three day period to obtain 80-90 paired measurements. Results A total of 81 paired measurements, distributed between 33 and 320mg/100mL of glucose, were performed. The aggregate data points were within International Organization for Standardization standards, with 100% of the glucose values within ±15%. Conclusions The current study suggests that a mid-IR fixed-wavelength system (OptiScanner) can measure glucose accurately across a wide range of glucose values in plasma of ICU patients.
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The accuracy reported here for the Contour Next Link 2.4 BGMS is similar to or higher than the other glucose monitoring systems.
“It is difficult to make direct comparisons due to differences in methods among these studies; however, the accuracy reported here for the Contour ® Next Link 2.4 BGMS is similar to or higher than the other glucose monitoring systems.”
From Accuracy and user performance evaluation of the Contour Next Link 2.4 blood glucose monitoring system (2015) · cites this paper as [24]
Cites
STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT
Martin Bland, J., & Altman, D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90837-8 · Cited by 47,965 · see citing works
Beckett, A. H., Rowland, M., & TURNER, P. (1965) · The Lancet · doi:10.1016/s0140-6736(65)91037-8 · Cited by 16,917 · see citing works
Intensive insulin therapy in critically ill patients.
Van den Berghe, G., Wouters, P., Weekers, F., Verwaest, C., Bruyninckx, F., Schetz, M., Vlasselaers, D., Ferdinande, P., Lauwers, P., & Bouillon, R. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011300 · Cited by 9,977 · see citing works
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock
Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J. E., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31827e83af · Cited by 9,694 · see citing works
Dellinger, R. P., Levy, M. M., Carlet, J. M., Bion, J., Parker, M. M., Jaeschke, R., Reinhart, K., Angus, D. C., Brun‐Buisson, C., Beale, R. J., et al. (2007) · Intensive Care Medicine · doi:10.1007/s00134-007-0934-2 · Cited by 6,722 · see citing works
Determination of Glucose in Blood Using Glucose Oxidase with an Alternative Oxygen Acceptor
Trinder, P. (1969) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456326900600108 · Cited by 4,629 · see citing works
Malmberg, K., Rydén, L., Efendic, S., Herlitz, J., Nicol, P., Waldenstrom, A., Wedel, H., & Welin, L. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00126-k · Cited by 1,560 · see citing works
Evaluating clinical accuracy of systems for self-monitoring of blood glucose
Clarke, W. L., Cox, D., Gonder-Frederick, L. A., Carter, W., & Pohl, S. L. (1987) · Diabetes Care · doi:10.2337/diacare.10.5.622 · Cited by 1,435 · see citing works
Chemotaxis of Polymorphonuclear Leukocytes from Patients with Diabetes Mellitus
Mowat, A. G., & Baum, J. (1971) · New England Journal of Medicine · doi:10.1056/nejm197103252841201 · Cited by 721 · see citing works
Latham, R. H., Lancaster, A. D., Covington, J. F., Pirolo, J. S., & Thomas, C. S. (2001) · Infection Control and Hospital Epidemiology · doi:10.1086/501830 · Cited by 550 · see citing works
Reliability of point-of-care testing for glucose measurement in critically ill adults*
Kanji, S., Buffie, J., Hutton, B., Bunting, P. S., Singh, A., McDonald, K. B., Fergusson, D. A., McIntyre, L., & Hébert, P. C. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000189939.10881.60 · Cited by 391 · see citing works
Bagdade, J. D., Stewart, M., & Walters, E. (1978) · Diabetes · doi:10.2337/diab.27.6.677 · Cited by 249 · see citing works
Consensus Statement on Self-Monitor ing of Blood Glucose
(1987) · Diabetes Care · doi:10.2337/diacare.10.1.95 · Cited by 247 · see citing works
Boyd, J. C., & Bruns, D. E. (2001) · Clinical Chemistry · doi:10.1093/clinchem/47.2.209 · Cited by 227 · see citing works
Insulin Resistance and Hyperglycemia in Critical Illness
Robinson, L. E., & van Soeren, M. H. (2004) · AACN Clinical Issues Advanced Practice in Acute & Critical Care · doi:10.1097/00044067-200401000-00004 · Cited by 170 · see citing works
Accuracy of bedside glucose measurement from three glucometers in critically ill patients*
Hoedemaekers, C., Gunnewiek, J. M. T. K., Prinsen, M. A., Willems, J. L., & van der Hoeven, J. G. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e318186ffe6 · Cited by 165 · see citing works
Tight glucose control in the intensive care unit: Are glucose meters up to the task?
Scott, M. G., Bruns, D. E., Boyd, J. C., & Sacks, D. B. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.117291 · Cited by 162 · see citing works
Agreement Between Bedside Blood and Plasma Glucose Measurement in the ICU Setting
Finkielman, J. D., Oyen, L. J., & Afessa, B. (2005) · CHEST Journal · doi:10.1378/chest.127.5.1749 · Cited by 112 · see citing works
Heise, H. M., Marbach, R., Koschinsky, T., & Gries, F. A. (1994) · Applied Spectroscopy · doi:10.1366/0003702944027598 · Cited by 105 · see citing works
Perioperative diabetic and hyperglycemic management issues
Coursin, D. B., Connery, L. E., & Ketzler, J. T. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000115623.52021.c0 · Cited by 101 · see citing works
Multilayer film elements for clinical analysis: general concepts.
Curme, H. G., Columbus, R. L., Dappen, G. M., Eder, T. W., Fellows, W. D., Figueras, J., Glover, C. P., Goffe, C. A., Hill, D. E., Lawton, W. H., et al. (1978) · Clinical Chemistry · doi:10.1093/clinchem/24.8.1335 · Cited by 99 · see citing works
Sell-Monitoring of Blood Glucose
(1996) · Diabetes Care · doi:10.2337/diacare.19.1.s62 · Cited by 89 · see citing works
Mitchell, I., Knight, E., Gissane, J., Tamhane, R., Kolli, R., Leditschke, I. A., Bellomo, R., & Finfer, S. R. (2006) · Critical Care and Resuscitation · doi:10.1016/s1441-2772(23)02060-4 · Cited by 53 · see citing works
The relationship between blood glucose level and QTc duration in the critically ill
Burkett, E., Keijzers, G., & Lind, J. (2009) · Critical Care and Resuscitation · doi:10.1016/s1441-2772(23)01839-2 · Cited by 21 · see citing works
Krinsley, J. S., Bochicchio, K. M., Calentine, C., & Bochicchio, G. V. (2012) · Journal of Diabetes Science and Technology · doi:10.1177/193229681200600212 · Cited by 13 · see citing works
Plasma-Generating Glucose Monitor Accuracy Demonstrated in an Animal Model
Magarian, P., & Sterling, B. (2009) · Journal of Diabetes Science and Technology · doi:10.1177/193229680900300622 · Cited by 13 · see citing works
ICU VALIDATION OF THE OPTISCANNER, A CONTINUOUS GLUCOSE MONITORING DEVICE.
Krinsley, J. S., Zheng, P., Hall, D., & Magarian, P. (2006) · Critical Care Medicine · doi:10.1097/00003246-200612002-00236 · Cited by 13 · see citing works
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Cited by
Sorted by citations
A review of optical methods for continuous glucose monitoring
Jernelv, I. L., Mileńko, K., Fuglerud, S. S., Hjelme, D. R., Ellingsen, R., & Aksnes, A. (2018) · Applied Spectroscopy Reviews · doi:10.1080/05704928.2018.1486324 · Cited by 136 · see citing works
Continuous glucose monitoring: The achievement of 100 years of innovation in diabetes technology
Galindo, R. J., & Aleppo, G. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108502 · Cited by 138 · see citing works
Accuracy and Potential Interferences of Continuous Glucose Monitoring Sensors in the Hospital
Bellido, V., Freckman, G., Pérez, A., & Galindo, R. J. (2023) · Endocrine Practice · doi:10.1016/j.eprac.2023.06.007 · Cited by 51 · see citing works
Glucose Management Technologies for the Critically Ill
Salinas, P. D., & Mendez, C. E. (2019) · Journal of Diabetes Science and Technology · doi:10.1177/1932296818822838 · Cited by 29 · see citing works
Manual versus Automated moNitoring Accuracy of GlucosE II (MANAGE II)
Shinotsuka, C. R., Brasseur, A., Fagnoul, D., So, T., Vincent, J., & Preiser, J. (2016) · Critical Care · doi:10.1186/s13054-016-1547-3 · Cited by 23 · see citing works
Bailey, T., Wallace, J. F., Greene, C., Pardo, S., Brown, D., Pflug, B., & Klaff, L. J. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.06.001 · Cited by 14 · see citing works
Espina, C., Jenkins, I., Taylor, L., Farah, R., Cho, E., Epworth, J., Coleman, K., Pinelli, J. M., Mentzer, S. J., Jarrett, L., et al. (2016) · Bone Marrow Transplantation · doi:10.1038/bmt.2016.78 · Cited by 8 · see citing works
Li, X., Wang, J., Jiang, X., Hu, N., & Chen, D. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1794432
- Authors
- Barassi, A., Umbrello, M., Ghilardi, F., Damele, C. A. L., Massaccesi, L., Iapichino, G., & Melzi d’Eril, G. V.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Barassi, Alessandra
- Venue
- Clinica Chimica Acta
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 438
- Pages
- 252-254
- ISSN
- 0009-8981 (ISSN-L)
- OpenAlex
- W2016738082
- Cited by
- 8
- References
- 28
- Citations by year
- 2026: 1 · 2023: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 2 · 2015: 1
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinica Chimica Acta (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Keywords
- mid-infrared spectroscopy, point-of-care glucose testing, method comparison, intensive care unit patients, blood glucose
- MeSH terms
- Blood Glucose, Humans, Monitoring, Physiologic, Spectrophotometry, Infrared, Reproducibility of Results
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