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Cited by 349

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells

Open access
Schonberg, David L., Miller, Tyler E., Wu, Qiulian, Flavahan, William A., Das, Nupur K., Hale, James S., Hubert, Christopher G., Mack, Stephen C., Jarrar, Awad M., Karl, Robert T., Rosager, Ann Mari, Nixon, Anne M., Tesar, Paul J., Hamerlik, Petra, Kristensen, Bjarne W., Horbinski, Craig, Connor, James R., Fox, Paul L., Lathia, Justin D., Rich, Jeremy N.·2015·Cancer Cell
DOI 10.1016/j.ccell.2015.09.002
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Abstract

Summary Glioblastomas display hierarchies with self-renewing cancer stem-like cells (CSCs). RNA sequencing and enhancer mapping revealed regulatory programs unique to CSCs causing upregulation of the iron transporter transferrin, the top differentially expressed gene compared to tissue-specific progenitors. Direct interrogation of iron uptake demonstrated CSCs potently extract iron from the microenvironment more effectively than other tumor cells. Systematic interrogation of iron flux determined that CSCs preferentially require transferrin receptor and ferritin - two core iron regulators - to propagate and form tumors in vivo. Depleting ferritin disrupted CSC mitotic progression, through the STAT3-FoxM1 regulatory axis, revealing an iron-regulated CSC pathway. Iron is a unique, primordial metal fundamental for earliest life forms, and on which CSCs have an epigenetically programmed, targetable dependence.

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Metadata

Authors
Schonberg, D. L., Miller, T. E., Wu, Q., Flavahan, W. A., Das, N. K., Hale, J. S., Hubert, C. G., Mack, S. C., Jarrar, A. M., Karl, R. T., Rosager, A. M., Nixon, A. M., Tesar, P. J., Hamerlik, P., Kristensen, B. W., Horbinski, C., Connor, J. R., Fox, P. L., Lathia, J. D., & Rich, J. N.
Venue
Cancer Cell
Publisher
Elsevier BV
Published
2015-10
Volume
28
Issue
4
Pages
441-455
ISSN
1535-6108 (ISSN-L)
DOI
10.1016/j.ccell.2015.09.002
OpenAlex
W1891848729
Cited by
349
References
55
FWCI
10.27
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells. https://app.cochat.ai/papers/10.1016/j.ccell.2015.09.002
The paper
Schonberg, D. L., Miller, T. E., Wu, Q., Flavahan, W. A., Das, N. K., Hale, J. S., Hubert, C. G., Mack, S. C., Jarrar, A. M., Karl, R. T., Rosager, A. M., Nixon, A. M., Tesar, P. J., Hamerlik, P., Kristensen, B. W., Horbinski, C., Connor, J. R., Fox, P. L., Lathia, J. D., & Rich, J. N. (2015). Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells. Cancer Cell. https://doi.org/10.1016/j.ccell.2015.09.002

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.