The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics
Open accessAbstract
Tumor-educated blood platelets (TEPs) are implicated as central players in the systemic and local responses to tumor growth, thereby altering their RNA profile. We determined the diagnostic potential of TEPs by mRNA sequencing of 283 platelet samples. We distinguished 228 patients with localized and metastasized tumors from 55 healthy individuals with 96% accuracy. Across six different tumor types, the location of the primary tumor was correctly identified with 71% accuracy. Also, MET or HER2-positive, and mutant KRAS, EGFR, or PIK3CA tumors were accurately distinguished using surrogate TEP mRNA profiles. Our results indicate that blood platelets provide a valuable platform for pan-cancer, multiclass cancer, and companion diagnostics, possibly enabling clinical advances in blood-based "liquid biopsies".
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Liquid biopsies come of age: Towards implementation of circulating tumour DNA
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Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells
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Metadata
- Authors
- Best, M. G., Sol, N., Kooi, I., Tannous, J., Westerman, B. A., Rustenburg, F., Schellen, P., Verschueren, H., Post, E., Koster, J., Ylstra, B., Ameziane, N., Dorsman, J., Smit, E. F., Verheul, H. M., Noske, D. P., Reijneveld, J. C., Nilsson, R. J. A., Tannous, B. A., Wesseling, P., & Wurdinger, T.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 28
- Issue
- 5
- Pages
- 666-676
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2157820287
- Cited by
- 916
- References
- 72
- FWCI
- 19.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics. https://app.cochat.ai/papers/10.1016/j.ccell.2015.09.018
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- Best, M. G., Sol, N., Kooi, I., Tannous, J., Westerman, B. A., Rustenburg, F., Schellen, P., Verschueren, H., Post, E., Koster, J., Ylstra, B., Ameziane, N., Dorsman, J., Smit, E. F., Verheul, H. M., Noske, D. P., Reijneveld, J. C., Nilsson, R. J. A., Tannous, B. A., . . . Wurdinger, T. (2015). RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics. Cancer Cell. https://doi.org/10.1016/j.ccell.2015.09.018
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
