The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer
Open accessAbstract
SUMMARY Based on studies in mouse tumor models, granulocytes appear to play a tumor-promoting role. However, there are limited data about the phenotype and function of tumor-associated neutrophils (TANs) in humans. Here, we identify a subset of TANs that exhibited characteristics of both neutrophils and antigen-presenting cells (APC) in early-stage human lung cancer. These APC-like “hybrid neutrophils”, which originate from CD11b+CD15hiCD10−CD16low immature progenitors, are able to cross-present antigens, as well as trigger and augment anti-tumor T cell responses. IFN-γ and GM-CSF are requisite factors in the tumor that working through the Ikaros transcription factor, synergistically exert their APC-promoting effects on the progenitors. Overall, these data demonstrate the existence of a specialized TAN subset with anti-tumor capabilities in human cancer.
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Self-citationNeutrophils in the activation and regulation of innate and adaptive immunity
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Metadata
- Authors
- Singhal, S., Bhojnagarwala, P. S., O'Brien, S., Moon, E. K., Garfall, A. L., Rao, A. S., Quatromoni, J. G., Stephen, T. L., Litzky, L., Deshpande, C., Feldman, M. D., Hancock, W. W., Conejo-Garcia, J. R., Albelda, S. M., & Eruslanov, E. B.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 30
- Issue
- 1
- Pages
- 120-135
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2474950788
- Cited by
- 478
- References
- 37
- FWCI
- 15.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Singhal, S., Bhojnagarwala, P. S., O'Brien, S., Moon, E. K., Garfall, A. L., Rao, A. S., Quatromoni, J. G., Stephen, T. L., Litzky, L., Deshpande, C., Feldman, M. D., Hancock, W. W., Conejo-Garcia, J. R., Albelda, S. M., & Eruslanov, E. B. (2016). Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer. Cancer Cell. https://doi.org/10.1016/j.ccell.2016.06.001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
