The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Mouse neutrophils are professional antigen-presenting cells programmed to instruct Th1 and Th17 T-cell differentiation
Open accessAbstract
Neutrophils play a major role in the innate immune system and are normally considered to be short-lived effector cells that exert anti-microbial activity and sometimes immunopathology. Here, we show that these cells possess an additional function as professional antigen-presenting cells capable of priming a T(h)1- and T(h)17-acquired immune response. Using flow cytometry, fluorescence microscopy and western blotting, we show that mouse neutrophils express MHC class II and co-stimulatory molecules CD80 and CD86 after T-cell co-incubation. Neutrophils pulsed with ovalbumin (OVA) process and present peptide antigen to OVA-specific T cells in an MHC class II-dependent manner. Importantly, we demonstrate that neutrophils can prime antigen-specific T(h)1 and T(h)17 immune responses even without the addition of exogenous cytokines to cell cultures.
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Fridlender, Z. G., Sun, J., Mishalian, I., Singhal, S., Cheng, G., Kapoor, V., Horng, W., Fridlender, G., Bayuh, R., Worthen, G. S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031524 · Cited by 311
Metadata
- Authors
- Abi Abdallah, D. S., Egan, C. E., Butcher, B. A., & Denkers, E. Y.
- Venue
- International Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-03-21
- Volume
- 23
- Issue
- 5
- Pages
- 317-326
- ISSN
- 0953-8178 (ISSN-L)
- 1460-2377
- OpenAlex
- W2147207093
- Cited by
- 264
- References
- 57
- FWCI
- 8.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Abi Abdallah, D. S., Egan, C. E., Butcher, B. A., & Denkers, E. Y. (2011). Mouse neutrophils are professional antigen-presenting cells programmed to instruct Th1 and Th17 T-cell differentiation. International Immunology. https://doi.org/10.1093/intimm/dxr007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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