The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1
Open accessAbstract
SUMMARY Protein glycosylation provides proteomic diversity in regulating protein localization, stability and activity; it remains largely unknown whether the sugar moiety contributes to immunosuppression. In the study of immune receptor glycosylation, we showed EGF induces PD-L1 and receptor programmed cell death protein-1 (PD-1) interaction, requiring β-1,3-N-acetylglucosaminyl transferase (B3GNT3) expression in triple-negative breast cancer. Downregulation of B3GNT3 enhances cytotoxic T cell-mediated anti-tumor immunity. A monoclonal antibody targeting glycosylated PD-L1 (gPD-L1) blocks PD-L1/PD-1 interaction and promotes PD-L1 internalization and degradation. In addition to immune reactivation, drug-conjugated gPD-L1 antibody induces potent cell-killing effect as well as bystander-killing effect on adjacent cancer cells lacking PD-L1 expression without any detectable toxicity. Our work suggests targeting protein glycosylation as a potential strategy to enhance immune checkpoint therapy.
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Cites
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BackgroundInhibitory B7-family molecules in the tumour microenvironment
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Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
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Loss of IFN-γ pathway genes in tumor cells as a mechanism of resistance to anti-CTLA-4 therapy
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Galectin–glycan lattices regulate cell-surface glycoprotein organization and signalling
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Cited by
Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape
Jiang, X., Wang, J., Deng, X., Xiong, F., Ge, J., Xiang, B., Wu, X., Ma, J., Zhou, M., Li, X., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-018-0928-4 · Cited by 1,457
Immune checkpoint signaling and cancer immunotherapy
He, X., & Xu, C. (2020) · Cell Research · doi:10.1038/s41422-020-0343-4 · Cited by 1,371
Mechanisms Controlling PD-L1 Expression in Cancer
Cha, J.-H., Chan, L.-C., Li, C.-W., Hsu, J. L., & Hung, M.-C. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.09.030 · Cited by 1,045
Self-citationAutophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy
Gao, W., Wang, X., Zhou, Y., Wang, X., & Yu, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01046-3 · Cited by 1,042
Regulatory mechanisms of PD-1/PD-L1 in cancers
Lin, X., Kang, K., Chen, P., Zeng, Z., Li, G., Xiong, W., Yi, M., & Xiang, B. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02023-w · Cited by 784
Metadata
- Authors
- Li, C.-W., Lim, S.-O., Chung, E. M., Kim, Y.-S., Park, A. H., Yao, J., Cha, J.-H., Xia, W., Chan, L.-C., Kim, T., Chang, S.-S., Lee, H.-H., Chou, C.-K., Liu, Y.-L., Yeh, H.-C., Perillo, E. P., Dunn, A. K., Kuo, C.-W., Khoo, K.-H., Hsu, J. L., Wu, Y., Hsu, J.-M., Yamaguchi, H., Huang, T.-H., Sahin, A. A., Hortobagyi, G. N., Yoo, S. S., & Hung, M.-C.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 33
- Issue
- 2
- Pages
- 187-201.e10
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2787095966
- Cited by
- 602
- References
- 9
- FWCI
- 18.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Li, C.-W., Lim, S.-O., Chung, E. M., Kim, Y.-S., Park, A. H., Yao, J., Cha, J.-H., Xia, W., Chan, L.-C., Kim, T., Chang, S.-S., Lee, H.-H., Chou, C.-K., Liu, Y.-L., Yeh, H.-C., Perillo, E. P., Dunn, A. K., Kuo, C.-W., Khoo, K.-H., . . . Hung, M.-C. (2018). Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1. Cancer Cell. https://doi.org/10.1016/j.ccell.2018.01.009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
