The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
The Immune Revolution: A Case for Priming, Not Checkpoint
Open accessAbstract
Most tumors are unresponsive to immune checkpoint blockade, especially if deep immunosuppression in the tumor develops prior to and prevents T cell immunosurveillance. Failed or frustrated T-cell priming often needs repair before successful sensitization to PD-1/PD-L1 blockade. CD40 activation plays a critical role in generating T cell immunity, by activating dendritic cells, and converting cold tumors to hot. In preclinical studies, agonistic CD40 antibodies demonstrate T cell-dependent anti-tumor activity, especially in combination with chemotherapy, checkpoint inhibitory antibodies, and other immune modulators. With the advent of multiple CD40 agonists with acceptable single-agent toxicity, clinical evaluation of CD40 combinations has accelerated.
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Cites
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“In humans, T cell exclusion in PDA – with marked surrounding desmoplasia – is also well-described; however, a subset of primary pancreatic tumors do exhibit moderate infiltration of CD8+ T cells and other immune cells (Bailey et al., 2016; Balachandran et al., 2017; Fukunaga et al., 2004; Ino et al., 2013b; Wormann et…”
BackgroundIFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity
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Cited by
Martinez, M., & Moon, E. K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00128 · Cited by 851
Clinical relevance of tumour-associated macrophages
Pittet, M. J., Michielin, O., & Migliorini, D. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00620-6 · Cited by 731
Challenges and Opportunities for Pancreatic Cancer Immunotherapy
Bear, A. S., Vonderheide, R. H., & O'Hara, M. H. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.08.004 · Cited by 674
Self-citationCAR T cells in solid tumors: challenges and opportunities
Marofi, F., Motavalli, R., Safonov, V. A., Thangavelu, L., Yumashev, A. V., Alexander, M., Shomali, N., Chartrand, M. S., Pathak, Y., Jarahian, M., et al. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02128-1 · Cited by 582
CD40 agonist antibodies in cancer immunotherapy
Vonderheide, R. H. (2020) · Annual Review of Medicine · doi:10.1146/annurev-med-062518-045435 · Cited by 544
Self-citation
Metadata
- Authors
- Vonderheide, R. H.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 33
- Issue
- 4
- Pages
- 563-569
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2796894486
- Cited by
- 293
- References
- 91
- FWCI
- 13.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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