The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories
Open accessAbstract
Summary Identifying the earliest somatic changes in prostate cancer can give important insights into tumor evolution and aids in stratifying high- from low-risk disease. We integrated whole-genome, transcriptome and methylome analysis of early-onset prostate cancers (diagnosis ≤ 55 years). Characterization across 292 prostate cancer genomes revealed age-related genomic alterations and a clock-like enzymatic-driven mutational process contributing to the earliest mutations in prostate cancer patients. Our integrative analysis identified four molecular subgroups, including a particularly aggressive subgroup with recurrent duplications associated with increased expression of ESRP1, which we validate in 12,000 tissue microarray tumors. Finally, we combined the patterns of molecular co-occurrence and risk-based subgroup information to deconvolve the molecular and clinical trajectories of prostate cancer from single patient samples.
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Metadata
- Authors
- Gerhauser, C., Favero, F., Risch, T., Simon, R., Feuerbach, L., Assenov, Y., Heckmann, D., Sidiropoulos, N., Waszak, S. M., Hübschmann, D., Urbanucci, A., Girma, E. G., Kuryshev, V., Klimczak, L. J., Saini, N., Stütz, A. M., Weichenhan, D., Böttcher, L.-M., Toth, R., Hendriksen, J. D., Koop, C., Lutsik, P., Matzk, S., Warnatz, H.-J., Amstislavskiy, V., Feuerstein, C., Raeder, B., Bogatyrova, O., Schmitz, E.-M., Hube-Magg, C., Kluth, M., Huland, H., Graefen, M., Lawerenz, C., Henry, G. H., Yamaguchi, T. N., Malewska, A., Meiners, J., Schilling, D., Reisinger, E., Eils, R., Schlesner, M., Strand, D. W., Bristow, R. G., Boutros, P. C., von Kalle, C., Gordenin, D., Sültmann, H., Brors, B., Sauter, G., Plass, C., Yaspo, M.-L., Korbel, J. O., Schlomm, T., & Weischenfeldt, J.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 34
- Issue
- 6
- Pages
- 996-1011.e8
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2904355372
- Cited by
- 293
- References
- 81
- FWCI
- 15.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gerhauser, C., Favero, F., Risch, T., Simon, R., Feuerbach, L., Assenov, Y., Heckmann, D., Sidiropoulos, N., Waszak, S. M., Hübschmann, D., Urbanucci, A., Girma, E. G., Kuryshev, V., Klimczak, L. J., Saini, N., Stütz, A. M., Weichenhan, D., Böttcher, L.-M., Toth, R., . . . Weischenfeldt, J. (2018). Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories. Cancer Cell. https://doi.org/10.1016/j.ccell.2018.10.016
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