The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging
Open accessAbstract
Breast tumors are inherently heterogeneous, but the evolving cellular organization through neoplastic progression is poorly understood. Here we report a rapid, large-scale single-cell resolution 3D imaging protocol based on a one-step clearing agent that allows visualization of normal tissue architecture and entire tumors at cellular resolution. Imaging of multicolor lineage-tracing models of breast cancer targeted to either basal or luminal progenitor cells revealed profound clonal restriction during progression. Expression profiling of clones arising in Pten/Trp53-deficient tumors identified distinct molecular signatures. Strikingly, most clones harbored cells that had undergone an epithelial-to-mesenchymal transition, indicating widespread, inherent plasticity. Hence, an integrative pipeline that combines lineage tracing, 3D imaging, and clonal RNA sequencing technologies offers a comprehensive path for studying mechanisms underlying heterogeneity in whole tumors.
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Self-citationThe genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
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New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
Dongre, A., & Weinberg, R. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0080-4 · Cited by 3,876
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
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Structural and molecular interrogation of intact biological systems
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Cited by
Emerging role of tumor cell plasticity in modifying therapeutic response
Qin, S., Jiang, J., Lu, Y., Nice, E. C., Huang, C., Zhang, J., & He, W. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00313-5 · Cited by 268
Stem Cells and the Differentiation Hierarchy in Mammary Gland Development
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Self-citationCODA: quantitative 3D reconstruction of large tissues at cellular resolution
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A guidebook for DISCO tissue clearing
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Metadata
- Authors
- Rios, A. C., Capaldo, B. D., Vaillant, F., Pal, B., van Ineveld, R., Dawson, C. A., Chen, Y., Nolan, E., Fu, N. Y., Jackling, F. C., Devi, S., Clouston, D., Whitehead, L., Smyth, G. K., Mueller, S. N., Lindeman, G. J., & Visvader, J. E.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 35
- Issue
- 4
- Pages
- 618-632.e6
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2927656553
- Cited by
- 168
- References
- 7
- FWCI
- 9.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Rios, A. C., Capaldo, B. D., Vaillant, F., Pal, B., van Ineveld, R., Dawson, C. A., Chen, Y., Nolan, E., Fu, N. Y., Jackling, F. C., Devi, S., Clouston, D., Whitehead, L., Smyth, G. K., Mueller, S. N., Lindeman, G. J., & Visvader, J. E. (2019). Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging. Cancer Cell. https://doi.org/10.1016/j.ccell.2019.02.010
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