The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis
Open accessAbstract
SUMMARY Brain metastasis is a major cause of cancer mortality, but its molecular mechanisms are severely understudied. In addition, little is known regarding the role of m6A reader YTHDF3 in human diseases. Here we show that YTHDF3 overexpression clinically correlates with brain metastases in breast cancer patients. YTHDF3 promotes cancer cell interactions with brain endothelial cells and astrocytes, blood-brain barrier extravasation, angiogenesis, and outgrow. Mechanistically, YTHDF3 enchances the translation of m6A-enriched transcripts for ST6GALNAC5, GJA1, and EGFR, all associated with brain metastasis. Further, overexpression YTHDF3 in brain metastases is attributed to increased gene copy number and the autoregulation of YTHDF3 cap-independent translation by binding to m6A residues within its own 5’-UTR. Our work uncovers an essential role of YTHDF3 in controlling the interaction between cancer cells and brain microenvironment, thereby inducing brain metastatic competence.
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Cited by
Reading the m6A-encoded epitranscriptomic information in development and diseases
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Metadata
- Authors
- Chang, G., Shi, L., Ye, Y., Shi, H., Zeng, L., Tiwary, S., Huse, J. T., Huo, L., Ma, L., Ma, Y., Zhang, S., Zhu, J., Xie, V., Li, P., Han, L., He, C., & Huang, S.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2020-12
- Volume
- 38
- Issue
- 6
- Pages
- 857-871.e7
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W3097514211
- Cited by
- 412
- References
- 51
- FWCI
- 17.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Chang, G., Shi, L., Ye, Y., Shi, H., Zeng, L., Tiwary, S., Huse, J. T., Huo, L., Ma, L., Ma, Y., Zhang, S., Zhu, J., Xie, V., Li, P., Han, L., He, C., & Huang, S. (2020). YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis. Cancer Cell. https://doi.org/10.1016/j.ccell.2020.10.004
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