The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis
Open accessAbstract
Cancer metastases are commonly found in the lymphatic system. Like tumor blood angiogenesis, stimulation of tumor lymphangiogenesis may require the interplay of several tumor-derived growth factors. Here we report that members of the PDGF family act as lymphangiogenic factors. In vitro, PDGF-BB stimulated MAP kinase activity and cell motility of isolated lymphatic endothelial cells. In vivo, PDGF-BB potently induced growth of lymphatic vessels. Expression of PDGF-BB in murine fibrosarcoma cells induced tumor lymphangiogenesis, leading to enhanced metastasis in lymph nodes. These data demonstrate that PDGF-BB is an important growth factor contributing to lymphatic metastasis. Thus, blockage of PDGF-induced lymphangiogenesis may provide a novel approach for prevention and treatment of lymphatic metastasis.
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Cites
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Self-citationLYVE-1, a New Homologue of the CD44 Glycoprotein, Is a Lymph-specific Receptor for Hyaluronan
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Perioperative events influence cancer recurrence risk after surgery
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Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling
Weissmueller, S., Manchado, E., Saborowski, M., Morris, J. P., Wagenblast, E., Davis, C. A., Moon, S.-H., Pfister, N. T., Tschaharganeh, D. F., Kitzing, T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.066 · Cited by 466
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Macrophages: An Inflammatory Link Between Angiogenesis and Lymphangiogenesis
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Metadata
- Authors
- Cao, R., Björndahl, M. A., Religa, P., Clasper, S., Garvin, S., Galter, D., Meister, B., Ikomi, F., Tritsaris, K., Dissing, S., Ohhashi, T., Jackson, D. G., & Cao, Y.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2004-10
- Volume
- 6
- Issue
- 4
- Pages
- 333-345
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2049184800
- Cited by
- 527
- References
- 46
- FWCI
- 11.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cao, R., Björndahl, M. A., Religa, P., Clasper, S., Garvin, S., Galter, D., Meister, B., Ikomi, F., Tritsaris, K., Dissing, S., Ohhashi, T., Jackson, D. G., & Cao, Y. (2004). PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis. Cancer Cell. https://doi.org/10.1016/j.ccr.2004.08.034
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