Macrophages: An Inflammatory Link Between Angiogenesis and Lymphangiogenesis
Open accessAbstract
Angiogenesis and lymphangiogenesis often occur in response to tissue injury or in the presence of pathology (e.g., cancer), and it is these types of environments in which macrophages are activated and increased in number. Moreover, the blood vascular microcirculation and the lymphatic circulation serve as the conduits for entry and exit for monocyte‐derived macrophages in nearly every tissue and organ. Macrophages both affect and are affected by the vessels through which they travel. Therefore, it is not surprising that examination of macrophage behaviors in both angiogenesis and lymphangiogenesis has yielded interesting observations that suggest macrophages may be key regulators of these complex growth and remodeling processes. In this review, we will take a closer look at macrophages through the lens of angiogenesis and lymphangiogenesis, examining how their dynamic behaviors may regulate vessel sprouting and function. We present macrophages as a cellular link that spatially and temporally connects angiogenesis with lymphangiogenesis, in both physiological growth and in pathological adaptations, such as tumorigenesis. As such, attempts to therapeutically target macrophages in order to affect these processes may be particularly effective, and studying macrophages in both settings will accelerate the field's understanding of this important cell type in health and disease.
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Angiogenesis is associated with the classical M2 polarization state of macrophages.
“Angiogenesis is associated with the classical M2 polarization state of macrophages (60).”
From Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells (2026) · cites this paper as [60]
The “Macrophage phenotypic diversity” section links M2 macrophages to cytokines that promote angiogenesis, supporting the association. But it identifies M1—not M2—as the classically activated phenotype; M2 is alternatively activated. The supplied passages do not specify page numbers. (LLM, conf=0.88)
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- Authors
- Corliss, B. A., Azimi, M. S., Munson, J. M., Peirce, S. M., & Murfee, W. L.
- Affiliations
- University of Virginia (US)
- Tulane University (US)
- Corresponding author
- Peirce, Shayn M.
- Venue
- Microcirculation
- Publisher
- Wiley
- Published
- 2016-02
- Volume
- 23
- Issue
- 2
- Pages
- 95-121
- ISSN
- 1073-9688 (ISSN-L)
- 1549-8719
- PMC
- PMC4744134
- OpenAlex
- W2176476431
- Cited by
- 356
- References
- 317
- Citations by year
- 2026: 21 · 2025: 36 · 2024: 37 · 2023: 39 · 2022: 55 · 2021: 45 · 2020: 51 · 2019: 24 · 2018: 24 · 2017: 10 · 2016: 13 · 2015: 1
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Microcirculation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5‐P20GM103629‐04, EY022063, HL082838, T32GM008715, IRG 81‐001‐26)
- Hartwell Foundation
- American Cancer Society
- Topics
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- macrophages, angiogenesis, lymphangiogenesis, inflammation, vessel sprouting, monocyte-derived macrophages, lymphatic circulation, carcinogenesis, macrophage-targeted therapy, tissue damage
- MeSH terms
- Animals, Humans, Inflammation, Macrophages, Microcirculation, Neovascularization, Physiologic, Lymphangiogenesis
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