Cited by 358Lymphatic System and DiseasesAngiogenesis and VEGF in CancerImmune cells in cancer

Macrophages: An Inflammatory Link Between Angiogenesis and Lymphangiogenesis

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Corliss, Bruce A., Azimi, Mohammad S., Munson, Jennifer M., Peirce, Shayn M., Murfee, Walter L.·2016·Microcirculation

Abstract

Angiogenesis and lymphangiogenesis often occur in response to tissue injury or in the presence of pathology (e.g., cancer), and it is these types of environments in which macrophages are activated and increased in number. Moreover, the blood vascular microcirculation and the lymphatic circulation serve as the conduits for entry and exit for monocyte‐derived macrophages in nearly every tissue and organ. Macrophages both affect and are affected by the vessels through which they travel. Therefore, it is not surprising that examination of macrophage behaviors in both angiogenesis and lymphangiogenesis has yielded interesting observations that suggest macrophages may be key regulators of these complex growth and remodeling processes. In this review, we will take a closer look at macrophages through the lens of angiogenesis and lymphangiogenesis, examining how their dynamic behaviors may regulate vessel sprouting and function. We present macrophages as a cellular link that spatially and temporally connects angiogenesis with lymphangiogenesis, in both physiological growth and in pathological adaptations, such as tumorigenesis. As such, attempts to therapeutically target macrophages in order to affect these processes may be particularly effective, and studying macrophages in both settings will accelerate the field's understanding of this important cell type in health and disease.

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Crossref · 10.1111/micc.12259

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  • Angiogenesis is associated with the classical M2 polarization state of macrophages.

    “Angiogenesis is associated with the classical M2 polarization state of macrophages (60).”

    From Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells (2026) · cites this paper as [60]

    The “Macrophage phenotypic diversity” section links M2 macrophages to cytokines that promote angiogenesis, supporting the association. But it identifies M1—not M2—as the classically activated phenotype; M2 is alternatively activated. The supplied passages do not specify page numbers. (LLM, conf=0.88)

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Research works printed but not linked: 2

  1. [58]Davies LC Jenkins SJ Allen JE Taylor PR Tissue-resident macrophages Nat Immunol 14 986 995 2013 24048120 PMC4045180
  2. [236]Rőszer T Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms Mediators of Inflammation 2015 816460 2015 26089604 PMC4452191

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Authors
Corliss, B. A., Azimi, M. S., Munson, J. M., Peirce, S. M., & Murfee, W. L.
Affiliations
  • University of Virginia (US)
  • Tulane University (US)
Corresponding author
Peirce, Shayn M.
Venue
Microcirculation
Publisher
Wiley
Published
2016-02
Volume
23
Issue
2
Pages
95-121
ISSN
  • 1073-9688 (ISSN-L)
  • 1549-8719
OpenAlex
W2176476431
Cited by
356
References
317
Citations by year
2026: 21 · 2025: 36 · 2024: 37 · 2023: 39 · 2022: 55 · 2021: 45 · 2020: 51 · 2019: 24 · 2018: 24 · 2017: 10 · 2016: 13 · 2015: 1
FWCI
1.72
Type
journal article
Language
en
Open access
Locations
  • Microcirculation (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5‐P20GM103629‐04, EY022063, HL082838, T32GM008715, IRG 81‐001‐26)
  • Hartwell Foundation
  • American Cancer Society
Topics
  • Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords
macrophages, angiogenesis, lymphangiogenesis, inflammation, vessel sprouting, monocyte-derived macrophages, lymphatic circulation, carcinogenesis, macrophage-targeted therapy, tissue damage
MeSH terms
Animals, Humans, Inflammation, Macrophages, Microcirculation, Neovascularization, Physiologic, Lymphangiogenesis

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