Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice
Open accessAbstract
Diffuse large B cell lymphomas (DLBCL) derive from germinal center (GC) B cells and display chromosomal alterations deregulating the expression of BCL6, a transcriptional repressor required for GC formation. To investigate the role of BCL6 in DLBCL pathogenesis, we have engineered mice that express BCL6 constitutively in B cells by mimicking a chromosomal translocation found in human DLBCL. These mice display increased GC formation and perturbed post-GC differentiation characterized by a decreased number of post-isotype switch plasma cells. Subsequently, these mice develop a lymphoproliferative syndrome that culminates with the development of lymphomas displaying features typical of human DLBCL. These results define the oncogenic role of BCL6 in the pathogenesis of DLBCL and provide a faithful mouse model of this common disease.
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Overexpression of BCL6 is sufficient to drive lymphoma development in genetically engineered mice.
“In genetically engineered mice, overexpression of BCL6 is sufficient to drive lymphoma development17.”
From Small-molecule-induced polymerization triggers degradation of BCL6 (2020) · cites this paper as [17]
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- Authors
- Cattoretti, G., Pasqualucci, L., Ballon, G., Tam, W., Nandula, S. V., Shen, Q., Mo, T., Murty, V. V., & Dalla-Favera, R.
- Affiliations
- Columbia University (US)
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 7
- Issue
- 5
- Pages
- 445-455
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2091213817
- Cited by
- 383
- References
- 48
- Citations by year
- 2026: 10 · 2025: 5 · 2024: 15 · 2023: 24 · 2022: 15 · 2021: 23 · 2020: 19 · 2019: 10 · 2018: 12 · 2017: 14 · 2016: 22 · 2015: 17 · 2014: 15 · 2013: 17 · 2012: 23
- FWCI
- 16.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Columbia Academic Commons (Columbia University)
- Funders
- National Cancer Institute (P01CA092625, CA092625)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Keywords
- BCL6, diffuse large B-cell lymphoma, germinal center, chromosomal translocation, class switch recombination, plasma cells, lymphoproliferative disorders, B-cell lymphomagenesis
- MeSH terms
- Animals, Cell Differentiation, Chromosome Aberrations, Disease Models, Animal, DNA-Binding Proteins, Genes, Immunoglobulin, Hemagglutinins, Humans, Lymphoma, Non-Hodgkin, Lymphoproliferative Disorders, Mice, Inbred C57BL, Mice, Inbred Strains, Mice, Transgenic, Plasma Cells, Promoter Regions, Genetic, Spleen, Splenomegaly, Time Factors, Gene Expression, Survival Analysis, Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse, Mice, Knockout, Germinal Center, Mice, Proto-Oncogene Proteins c-bcl-6
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