Metal based neurodegenerative diseases—From molecular mechanisms to therapeutic strategies

Protein aggregation and neurodegenerative disease

Ross, C. A., & Poirier, M. A. (2004) · Nature Medicine · doi:10.1038/nm1066 · Cited by 3,454

Copper, iron and zinc in Alzheimer's disease senile plaques

Lovell, M. A., Robertson, J. D., Teesdale, W. J., Campbell, J. L., & Markesbery, W. R. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00092-6 · Cited by 2,120

Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)

Gaggelli, E., Kozlowski, H., Valensin, D., & Valensin, G. (2006) · Chemical Reviews · doi:10.1021/cr040410w · Cited by 1,729

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

Smith, M. A., Harris, P. L. R., Sayre, L. M., & Perry, G. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9866 · Cited by 1,365

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

Smith, M. A., Richey Harris, P. L., Sayre, L. M., Beckman, J. S., & Perry, G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02653.1997 · Cited by 1,239

Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis

Wang, H., Liao, H., Ochani, M., Justiniani, M., Lin, X., Yang, L., Al-Abed, Y., Wang, H., Metz, C., Miller, E. J., et al. (2004) · Nature Medicine · doi:10.1038/nm1124 · Cited by 1,170

4-Hydroxy-2-nonenal: a product and mediator of oxidative stress

Uchida, K. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00014-6 · Cited by 1,164

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

Sian, J., Dexter, D. T., Lees, A. J., Daniel, S., Agid, Y., Javoy‐Agid, F., Jenner, P., & Marsden, C. D. (1994) · Annals of Neurology · doi:10.1002/ana.410360305 · Cited by 1,161

4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease

Sayre, L., Zelasko, D. A., Harris, P. L. R., Perry, G., Salomon, R. G., & Smith, M. A. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68052092.x · Cited by 1,032

Oxidative damage in Alzheimer's

Smith, M. A., Perry, G. L., Richey, P. L., Sayrec, L. M., Anderson, V. E., Beal, M. F., & Kowall, N. W. (1996) · Nature · doi:10.1038/382120b0 · Cited by 897

Multicenter Metal–Organic Framework‐Based Ratiometric Fluorescent Sensors

Wu, S., Min, H., Shi, W., & Cheng, P. (2019) · Advanced Materials · doi:10.1002/adma.201805871 · Cited by 715

Highly Sensitive and Selective Colorimetric and Off−On Fluorescent Chemosensor for Cu2+ in Aqueous Solution and Living Cells

Zhao, Y., Zhang, X., Han, Z., Qiao, L., Li, C., Jian, L., Shen, G., & Yu, R. (2009) · Analytical Chemistry · doi:10.1021/ac901127n · Cited by 456

8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications

Prachayasittikul, V., Prachayasittikul, V., Prachayasittikul, S., & Ruchirawat, S. (2013) · Drug Design Development and Therapy · doi:10.2147/dddt.s49763 · Cited by 461

Environmental-induced oxidative stress in neurodegenerative disorders and aging

Migliore, L., & Coppedè, F. (2008) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2008.09.013 · Cited by 397

Chemodosimeters: An approach for detection and estimation of biologically and medically relevant metal ions, anions and thiols

Kaur, K., Saini, R., Kumar, A., Luxami, V., Kaur, N., Singh, P., & Kumar, S. (2012) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2012.04.013 · Cited by 381

High-Efficiency in Vitro and in Vivo Detection of Zn2+ by Dye-Assembled Upconversion Nanoparticles

Peng, J., Wang, X., Teoh, C. L., Han, S., Kim, B., Samanta, A., Er, J. C., Wang, L., Yuan, L., Liu, X., et al. (2015) · Journal of the American Chemical Society · doi:10.1021/ja5115248 · Cited by 255

Brain iron metabolism and its perturbation in neurological diseases

Crichton, R. R., Dexter, D. T., & Ward, R. J. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0470-z · Cited by 247

NIR- and FRET-Based Sensing of Cu2+and S2-in Physiological Conditions and in Live Cells

Kar, C., Adhikari, M. D., Ramesh, A., & Das, G. C. (2013) · Inorganic Chemistry · doi:10.1021/ic301872q · Cited by 238

Three Rhodamine-Based “Off–On” Chemosensors with High Selectivity and Sensitivity for Fe3+ Imaging in Living Cells

Yang, Z., She, M., Yin, B. Z., Cui, J., Zhang, Y., Sun, W. L., Li, J., & Shi, Z. (2011) · The Journal of Organic Chemistry · doi:10.1021/jo202056t · Cited by 223

Visible–Near‐Infrared and Fluorescent Copper Sensors Based on Julolidine Conjugates: Selective Detection and Fluorescence Imaging in Living Cells

Maity, D., Manna, A. K., Karthigeyan, D., Kundu, T. K., Pati, S. K., & Govindaraju, T. (2011) · Chemistry - A European Journal · doi:10.1002/chem.201101906 · Cited by 184

Coordination of redox active metal ions to the amyloid precursor protein and to amyloid-β peptides involved in Alzheimer disease. Part 1: An overview

Hureau, C. (2012) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2012.03.037 · Cited by 183

A review of metal‐catalyzed molecular damage: protection by melatonin

Romero, A., Ramos, E., Rı́os, C. D. L., Egea, J., del Pino, J., & Reiter, R. J. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12132 · Cited by 176

Optical Chemosensor for Ag+, Fe3+, and Cysteine: Information Processing at Molecular Level

Kumar, M., Kumar, R., & Bhalla, V. (2010) · Organic Letters · doi:10.1021/ol102543e · Cited by 169

Insights of 8-hydroxyquinolines: A novel target in medicinal chemistry

Gupta, R., Luxami, V., & Paul, K. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.104633 · Cited by 159

Metal Ion Physiopathology in Neurodegenerative Disorders

Bolognin, S., Luigi Messori, A., & Zatta, P. F. (2009) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8102-1 · Cited by 159

Single sensor for two metal ions: Colorimetric recognition of Cu2+ and fluorescent recognition of Hg2+

Tang, L., Li, F., Liu, M., & Nandhakumar, R. (2010) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2010.12.072 · Cited by 157

Metallobiology and therapeutic chelation of biometals (copper, zinc and iron) in Alzheimer’s disease: Limitations, and current and future perspectives

Fasae, K. D., Abolaji, A. O., Faloye, T. R., Odunsi, A., Oyetayo, B. O., Enya, J. I., Rotimi, J. A., Akinyemi, R., Whitworth, A. J., & Aschner, M. (2021) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2021.126779 · Cited by 161

Minding metals: Tailoring multifunctional chelating agents for neurodegenerative disease

Perez, L. R., & Franz, K. J. (2010) · Dalton Trans. · doi:10.1039/b919237a · Cited by 156

An aggregation-induced emission (AIE) active probe for multiple targets: a fluorescent sensor for Zn 2+ and Al 3+ & a colorimetric sensor for Cu 2+ and F −

Samanta, S., Manna, U., Ray, T., & Das, G. C. (2015) · Dalton Transactions · doi:10.1039/c5dt03186a · Cited by 152

Structural Studies of Copper(I) Complexes of Amyloid‐β Peptide Fragments: Formation of Two‐Coordinate Bis(histidine) Complexes

Himes, R. A., Park, G. Y., Siluvai, G. S., Blackburn, N. J., & Karlin, K. D. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200803908 · Cited by 148

Coordination of redox active metal ions to the amyloid precursor protein and to amyloid-β peptides involved in Alzheimer disease. Part 2: Dependence of Cu(II) binding sites with Aβ sequences

Hureau, C., & Dorlet, P. (2012) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2012.03.034 · Cited by 148

Phenol Formaldehyde Resin Nanoparticles Loaded with CdTe Quantum Dots: A Fluorescence Resonance Energy Transfer Probe for Optical Visual Detection of Copper(II) Ions

Yang, P. H., Zhao, Y., Lü, Y., Xu, Q., Xu, X.-W., Dong, L., & Yu, S. (2011) · ACS Nano · doi:10.1021/nn103352b · Cited by 137

The effect of Cu2+ and Zn2+ on the Aβ42 peptide aggregation and cellular toxicity

Sharma, A. K., Pavlova, S. T., Kim, J., Kim, J., & Mirica, L. M. (2013) · Metallomics · doi:10.1039/c3mt00161j · Cited by 135

Metal chelating ability and antioxidant properties of Curcumin-metal complexes – A DFT approach

Mary, C. P. V., Vijayakumar, S., & Shankar, R. (2017) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2017.10.022 · Cited by 137

Hydroxypyridinones as “privileged” chelating structures for the design of medicinal drugs

Santos, M. A., Marques, S. M., & Chaves, S. (2011) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2011.08.008 · Cited by 131

Synthesis, characterization and biological relevance of some metal (II) complexes with oxygen, nitrogen and oxygen (ONO) donor Schiff base ligand derived from thiazole and 2-hydroxy-1-naphthaldehyde

Yernale, N. G., & Mruthyunjayaswamy, B. H. M. (2014) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2014.12.058 · Cited by 126

Highly Selective Visible and Near‐IR Sensing of Cu2+ Based on Thiourea–Salicylaldehyde Coordination in Aqueous Media

Maity, D., & Govindaraju, T. (2011) · Chemistry - A European Journal · doi:10.1002/chem.201002570 · Cited by 126

Solvent Dependent Fluorescent Properties of a 1,2,3-Triazole Linked 8-Hydroxyquinoline Chemosensor: Tunable Detection from Zinc(II) to Iron(III) in the CH3CN/H2O System

Hao, E., Meng, T., Zhang, M., Pang, W., Zhou, Y., & Jiao, L. (2011) · The Journal of Physical Chemistry A · doi:10.1021/jp202700s · Cited by 119

Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review

Sheykhansari, S., Kozielski, K., Bill, J., Sitti, M., Gemmati, D., Zamboni, P., & Singh, A. V. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0379-2 · Cited by 124

Copper handling by astrocytes: Insights into neurodegenerative diseases

Tiffany-Castiglioni, E., Hong, S. J., & Qian, Y. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2011.09.004 · Cited by 116

Effects of Cyclen and Cyclam on Zinc(II)- and Copper(II)-Induced Amyloid β-Peptide Aggregation and Neurotoxicity

Chen, T., Wang, X., He, Y., Zhang, C., Wu, Z., Liao, K., Wang, J., & Guo, Z. (2009) · Inorganic Chemistry · doi:10.1021/ic900025x · Cited by 110

A novel approach to the identification and quantitative elemental analysis of amyloid deposits—Insights into the pathology of Alzheimer’s disease

Rajendran, R., Minqin, R., Ynsa, M. D., Casadesús, G., Smith, M. A., Perry, G. L., Halliwell, B. B., & Watt, F. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.02.136 · Cited by 105

A ratiometric fluorescent probe for iron(III) and its application for detection of iron(III) in human blood serum

Long, L., Zhou, L., Wang, L., Meng, S., Gong, A., & Chi Zhang, A. (2014) · Analytica Chimica Acta · doi:10.1016/j.aca.2013.12.024 · Cited by 101

Rhodamine–Ferrocene Conjugate Chemosensor for Selectively Sensing Copper(II) with Multisignals: Chromaticity, Fluorescence, and Electrochemistry and Its Application in Living Cell Imaging

Yuan, F., Zhou, Y., Rui, Q.-Q., & Yao, C. (2015) · Organometallics · doi:10.1021/acs.organomet.5b00285 · Cited by 96

FRET-based rational strategy for ratiometric detection of Cu2+ and live cell imaging

Maity, D., Karthigeyan, D., Kundu, T. K., & Govindaraju, T. (2012) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2012.09.071 · Cited by 96

Role of iron in neurotoxicity: a cause for concern in the elderly?

Stankiewicz, J., & Brass, S. D. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32831ba07c · Cited by 94

8-Hydroxyquinoline Schiff-base compounds as antioxidants and modulators of copper-mediated Aβ peptide aggregation

Gomes, L. M., Vieira, R. P., Jones, M. R., Wang, M. C. P., Dyrager, C., de Souza-Fagundes, E. M., Silva, J. G. D., Storr, T., & Beraldo, H. D. O. (2014) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2014.04.011 · Cited by 94

Squaramide Hydroxamate-Based Chemidosimeter Responding to Iron(III) with a Fluorescence Intensity Increase

Lim, N. C., Pavlova, S. V., & Brückner, C. (2008) · Inorganic Chemistry · doi:10.1021/ic801322x · Cited by 90

Engineering of Metal–Organic Frameworks as Ratiometric Sensors

Patel, N., Shukla, P., Lama, P., Das, S., & Pal, T. K. (2022) · Crystal Growth & Design · doi:10.1021/acs.cgd.1c01268 · Cited by 88

Synthesis, structural characterization and biological activities of metal(II) complexes with Schiff bases derived from 5-bromosalicylaldehyde: Ru(II) complexes transfer hydrogenation

Buldurun, K., Turan, N., Savcı, A., & Çolak, N. (2018) · Journal of Saudi Chemical Society · doi:10.1016/j.jscs.2018.06.002 · Cited by 87

A new rhodamine derivative-based chemosensor for highly selective and sensitive determination of Cu2+

Puangploy, P., Smanmoo, S., & Surareungchai, W. (2013) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2013.12.037 · Cited by 86

Design and application of dual-emission metal–organic framework-based ratiometric fluorescence sensors

Zhang, S., Xiao, J., Zhong, G., Xu, T., & Zhang, X. (2024) · The Analyst · doi:10.1039/d3an02187d · Cited by 85

Visual and Portable Strategy for Copper(II) Detection Based on a Striplike Poly(Thymine)-Caged and Microwell-Printed Hydrogel

Qing, Z., Mao, Z., Qing, T., He, X., Zou, Z., He, D., Shi, H., Huang, J. L., Liu, J., & Wang, K. (2014) · Analytical Chemistry · doi:10.1021/ac502843t · Cited by 82

Thiacalix[4]arene based fluorescent probe for sensing and imaging of Fe3+ ions

Kumar, M., Kumar, R., Bhalla, V., Sharma, P. R., Kaur, T., & Qurishi, Y. (2011) · Dalton Transactions · doi:10.1039/c1dt11169h · Cited by 81

Synthesis, spectroscopic characterization, biological screening and in vitro cytotoxic studies of 4‐methyl‐3‐thiosemicarbazone derived Schiff bases and their Co (II), Ni (II), Cu (II) and Zn (II) complexes

Devi, J., Yadav, M., Jindal, D. K., Kumar, D., & Poornachandra, Y. (2019) · Applied Organometallic Chemistry · doi:10.1002/aoc.5154 · Cited by 79

Designing, spectroscopic characterization, biological screening and antioxidant activity of mononuclear transition metal complexes of bidentate Schiff base hydrazones

Yadav, M., Sharma, S. D., & Devi, J. (2021) · Journal of Chemical Sciences · doi:10.1007/s12039-020-01854-6 · Cited by 78

A Review on Bioactive Anthraquinone and Derivatives as the Regulators for ROS

Zhao, L., & Zheng, L. (2023) · Molecules · doi:10.3390/molecules28248139 · Cited by 85

Review on metal speciation analysis in cerebrospinal fluid—current methods and results: A review

Michalke, B., & Nischwitz, V. (2010) · Analytica Chimica Acta · doi:10.1016/j.aca.2010.09.054 · Cited by 76

A lysosome-targetable fluorescent probe for imaging trivalent cations Fe3+, Al3+ and Cr3+ in living cells

Ye, F., Wu, N. C., Li, P., Liu, Y., Li, S., & Fu, Y. (2019) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2019.117242 · Cited by 76

A simple chalcone-based fluorescent chemosensor for the detection and removal of Fe 3+ ions using a membrane separation method

Velmurugan, K., Prabhu, J., Tang, L., Thamaraiselvan, C., Noel, M., Radhakrishnan, S., & Nandhakumar, R. (2014) · Analytical Methods · doi:10.1039/c3ay42139b · Cited by 73

Recent Developments in Metal-Based Drugs and Chelating Agents for Neurodegenerative Diseases Treatments

Sales, T. A., Prandi, I. G., de Castro, A. A., Leal, D. H. S., da Cunha, E. F. F., Kuča, K., & Ramalho, T. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081829 · Cited by 73

A novel fluorescent and colorimetric dual-channel sensor for the fast, reversible and simultaneous detection of Fe3+ and Cu2+ based on terthiophene derivative with high sensitivity and selectivity

Wang, J., Wei, T., Ma, F., Li, T., & Niu, Q. (2019) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2019.111982 · Cited by 70

Colorimetric detection of Cu2+ in aqueous solution and on the test kit by 4-aminoantipyrine derivatives

Xiong, J., Huang, P., Zhang, C., & Wu, F. (2015) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2015.11.113 · Cited by 68

Combined use of spectrophotometer and smartphone for the optical detection of Fe3+ using a vitamin B6 cofactor conjugated pyrene derivative and its application in live cells imaging

Upadhyay, Y., Anand, T., Babu, L. T., Paira, P., Kumar, S. K. A., Kumar, R., & Sahoo, S. K. (2018) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2018.05.002 · Cited by 66

Advances in metal ion–mediated macromolecular drug delivery

Li, K., Yang, J., Peng, Y., Zheng, H., Fu, Z.-Z., Li, M., Zhou, W., & Yu, G. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126501 · Cited by 77

Insights into the Potential Role of Mercury in Alzheimer’s Disease

Bjørklund, G., Tinkov, A. A., Dadar, M., Rahman, M. M., Chirumbolo, S., Skalny, A. V., Геннадиевна, С. М., Haley, B. E., Ajsuvakova, O. P., & Aaseth, J. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01274-3 · Cited by 64

Solid sensory polymer substrates for the quantification of iron in blood, wine and water by a scalable RGB technique

Vallejos, S., Muñoz, A., Ibeas, S., Serna, F. J., García, F. C., & García, J. M. (2013) · Journal of Materials Chemistry A · doi:10.1039/c3ta12703f · Cited by 62

Encapsulation of Dual‐Emitting Fluorescent Magnetic Nanoprobe in Metal‐Organic Frameworks for Ultrasensitive Ratiometric Detection of Cu2+

Wang, J., Chen, H., Ru, F., Zhang, Z., Mao, X., Shan, D., Chen, J., & Lu, X. (2018) · Chemistry - A European Journal · doi:10.1002/chem.201704557 · Cited by 61

An N-Heterocyclic Amine Chelate Capable of Antioxidant Capacity and Amyloid Disaggregation

Lincoln, K. M., Richardson, T. E., Rutter, L., Gonzalez, P., Simpkins, J. W., & Green, K. N. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn300060v · Cited by 60

Ionic Homeostasis Maintenance in ALS: Focus on New Therapeutic Targets

Sirabella, R., Valsecchi, V., Anzilotti, S., Cuomo, O., Vinciguerra, A., Cepparulo, P., Brancaccio, P., Guida, N., Blondeau, N., Canzoniero, L. M. T., et al. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00510 · Cited by 59

A Rhodamine-Based Off–On Fluorescent Chemosensor for Selectively Sensing Cu(II) in Aqueous Solution

Tang, R., Lei, K., Chen, K., Zhao, H., & Chen, J. (2010) · Journal of Fluorescence · doi:10.1007/s10895-010-0698-x · Cited by 56

A novel functionalized nanoporous SBA-15 as a selective fluorescent sensor for the detection of multianalytes (Fe 3+ and Cr 2 O 7 2 − ) in water

Lashgari, N., Badiei, A., & Ziarani, G. M. (2016) · Journal of Physics and Chemistry of Solids · doi:10.1016/j.jpcs.2016.11.021 · Cited by 55

A novel graphene oxide-based fluorescent nanosensor for selective detection of Fe3+ with a wide linear concentration and its application in logic gate

He, L., Li, J., & Xin, J. H. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.01.075 · Cited by 52

Synthesis, characterization, biological and docking studies of ZrO(II), VO(II) and Zn(II) complexes of a halogenated tetra-dentate Schiff base

Abdel‐Rahman, L. H., Adam, M. S. S., Al‐Zaqri, N., Shehata, M. R., Ahmed, H., & Mohamed, S. K. (2022) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2022.103737 · Cited by 54

Anthracene coupled thiourea as a colorimetric sensor for F−/Cu2+ and fluorescent sensor for Hg2+/picric acid

Udhayakumari, D., Velmathi, S., Venkatesan, P., & Wu, S. (2015) · Journal of Luminescence · doi:10.1016/j.jlumin.2015.01.052 · Cited by 52

Highly selective visual detection of Fe3+ at ppm level

Faizi, M. S. H., Gupta, S., Vaisakh Mohan, K., Jain, V. K., & Sen, P. (2015) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2015.08.029 · Cited by 51

Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry

Hare, D. J., Grubman, A., Ryan, T. M., Lothian, A., Liddell, J. R., Grimm, R., Matsuda, T., Doble, P., Cherny, R. A., Bush, A. I., et al. (2013) · Metallomics · doi:10.1039/c3mt00227f · Cited by 51

Small Bifunctional Chelators That Do Not Disaggregate Amyloid β Fibrils Exhibit Reduced Cellular Toxicity

Sharma, A. K., Kim, J., Prior, J. T., Hawco, N. J., Rath, N. P., Kim, J., & Mirica, L. M. (2014) · Inorganic Chemistry · doi:10.1021/ic500926c · Cited by 48

Effect of metal oxidation state on FRET: a Cu( i ) silent but selectively Cu( ii ) responsive fluorescent reporter and its bioimaging applications

Pal, S., Sen, B., Lohar, S., Mukherjee, M., Banerjee, S., & Chattopadhyay, P. (2014) · Dalton Transactions · doi:10.1039/c4dt03381g · Cited by 48

Synthesis, structural characterization, antimicrobial and DNA binding studies of homoleptic zinc and copper complexes of NO Schiff bases derived from homoveratrylamine

Satheesh, C. E., Kumar, P. R., Shivakumar, N., Lingaraju, K., Krishna, P. M., Rajanaika, H., & Hosamani, A. (2019) · Inorganica Chimica Acta · doi:10.1016/j.ica.2019.05.028 · Cited by 48

A naked-eye visible and turn-on fluorescence probe for Fe3+ and its bioimaging application in living cells

Liu, Y., Zhang, J., Ru, J., Yao, X., Yang, Y., Li, X., Tang, X., Zhang, G., & Liu, W. (2016) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2016.06.123 · Cited by 46

Selective interactions of trivalent cations Fe3+, Al3+ and Cr3+ turn on fluorescence in a naphthalimide based single molecular probe

Janakipriya, S., Chereddy, N. R., Korrapati, P. S., Thennarasu, S., & Mandal, A. B. (2015) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2015.08.044 · Cited by 45

A CHEF-based biocompatible turn ON ratiometric sensor for sensitive and selective probing of Cu2+

Kar, C., Adhikari, M. D., Datta, B. K., Ramesh, A., & Das, G. C. (2013) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2013.08.005 · Cited by 45

An electrochemical sensor for highly sensitive detection of copper ions based on a new molecular probe Pi-A decorated on graphene

Yang, L., Huang, N., Huang, L., Liu, M., Li, H., Zhang, Y., & Yao, S. (2016) · Analytical Methods · doi:10.1039/c6ay03006h · Cited by 45

Amentoflavone: A Bifunctional Metal Chelator that Controls the Formation of Neurotoxic Soluble Aβ 42 Oligomers

Sun, L., Sharma, A. K., Han, B.-H., & Mirica, L. M. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00376 · Cited by 46

Enhancing the Therapeutic Effect in Alzheimer's Disease Drugs: The role of Polypharmacology and Cholinesterase inhibitors

Martins, M. M., Branco, P. S., & Ferreira, L. M. (2023) · ChemistrySelect · doi:10.1002/slct.202300461 · Cited by 50

Melatonin—A Powerful Antioxidant in Neurodegenerative Diseases

Kołodziejska, R., Woźniak, A., Bilski, R., Wesołowski, R., Kupczyk, D., Porzych, M., Wróblewska, W., & Pawluk, H. (2025) · Antioxidants · doi:10.3390/antiox14070819 · Cited by 48

Distribution of Iron, Copper, Zinc and Cadmium in Glia, Their Influence on Glial Cells and Relationship with Neurodegenerative Diseases

Górska, A., Markiewicz-Gospodarek, A., Markiewicz, R., Chilimoniuk, Z., Borowski, B., Trubalski, M., & Czarnek, K. (2023) · Brain Sciences · doi:10.3390/brainsci13060911 · Cited by 44

A reversible two-photon fluorescence probe for Cu(II) based on Schiff-base in HEPES buffer and in vivo imaging

Hu, L., Wang, H., Fang, B., Hu, Z., Zhang, Q., Tian, X., Zhou, H., Wu, J., & Tian, Y. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.05.140 · Cited by 43

A turn-on hydrazide oxidative decomposition-based fluorescence probe for highly selective detection of Cu2+ in tap water as well as cell imaging

Okamoto, Y., Kishikawa, N., Hagimori, M., El‐Maghrabey, M., Kawakami, S., & Kuroda, N. (2022) · Analytica Chimica Acta · doi:10.1016/j.aca.2022.340024 · Cited by 42

Recent advancements in coumarin based colorimetric and fluorescent chemosensors

Kaur, G., Singh, I., Tandon, R., & Tandon, N. (2023) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2023.111480 · Cited by 40

A highly selective rhodamine-based optical–electrochemical multichannel chemosensor for Fe3+

Han, O., Gao, Y., & Yuan, Y. (2013) · Tetrahedron Letters · doi:10.1016/j.tetlet.2013.03.112 · Cited by 41

The Chaperone Grp78 in Protein Folding Disorders of the Nervous System

Moreno, J. A., & Tiffany‐Castiglioni, E. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1405-0 · Cited by 41

Sensitive and selective rhodamine-derived probes for fluorometric sensing of pH and colorimetric sensing of Cu2+

Xu, L., Wei, S., Diao, Q., Ma, P., Liu, X. H., Sun, Y. X., Song, D., & Wang, X. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.02.093 · Cited by 40

Highly selective fluorescent chemosensor for Fe3+ detection based on diaza-18-crown-6 ether appended with dual coumarins

Li, H., Li, L., & Yin, B. (2014) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2014.01.008 · Cited by 39

A new Fe3+ fluorescent chemosensor based on aggregation-induced emission

Ye, J., Liu, J., Wang, Z., Bai, Y., Zhang, W., & He, W. (2014) · Tetrahedron Letters · doi:10.1016/j.tetlet.2014.05.008 · Cited by 39

Thiazolothiazole‐Based Fluorescence Probe towards Detection of Copper and Iron Ions through Formation of Radical Cations

Sathiyan, G., Chatterjee, S., Sen, P., Garg, A., Gupta, R. K., & Singh, A. (2019) · ChemistrySelect · doi:10.1002/slct.201902994 · Cited by 38

Penicillamine-protected Ag20 nanoclusters and fluorescence chemosensing for trace detection of copper ions.

Liu, X.-H., Ding, W., Wu, Y., Zeng, C.-H., Luo, Z., & Fu, H.-B. (2017) · Nanoscale · doi:10.1039/c6nr09818e · Cited by 35

A fluorometric and colorimetric dual-mode sensor based on nitrogen and iron co-doped graphene quantum dots for detection of ferric ions in biological fluids and cellular imaging

Gao, X., Zhou, X., Feng, Y. Q., Wang, C. P., & Chu, F. (2018) · New Journal of Chemistry · doi:10.1039/c8nj01805g · Cited by 37

Blood Trace Element Status in Multiple Sclerosis: a Systematic Review and Meta-analysis

Nirooei, E., Kashani, S. M. A., Owrangi, S., Malekpour, F., Niknam, M., Moazzen, F., Nowrouzi‐Sohrabi, P., Farzinmehr, S., & Akbari, H. (2021) · Biological Trace Element Research · doi:10.1007/s12011-021-02621-5 · Cited by 37

A new water-soluble Cu(II) chelator that retrieves Cu from Cu(amyloid-β) species, stops associated ROS production and prevents Cu(II)‐induced Aβ aggregation

Noël, S., Perez, F., Pedersen, J. T., Aliès, B., Mallet‐Ladeira, S., Sayen, S., Guillon, E., Gras, E., & Hureau, C. (2012) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2012.05.016 · Cited by 37

Vitamin B6s inhibit oxidative stress caused by Alzheimer’s disease-related CuII-β-amyloid complexes—cooperative action of phospho-moiety

Hashim, A., Wang, L., Juneja, K. S., Ye, Y., Zhao, Y., & Ming, L. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.08.123 · Cited by 37

A simple BODIPY–imidazole-based probe for the colorimetric and fluorescent sensing of Cu(II) and Hg(II)

Xie, R., Yi, Y., He, Y., Liu, X., & Liu, Z. (2013) · Tetrahedron · doi:10.1016/j.tet.2013.07.059 · Cited by 35

Thiosemicarbazides, 1,3,4 thiadiazole Schiff base derivatives of transition metal complexes as antimicrobial agents

Pervaiz, M. A., Quratulain, R., Ejaz, A., Shahin, M., Saeed, Z., Nasir, S., Khan, R. R. M., Ashraf, A., Ullah, S., & Younas, U. (2023) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2023.111856 · Cited by 36

“Reactive” response evaluation of primary human astrocytes after methylmercury exposure

Malfa, G., Tomasello, B., Sinatra, F., Villaggio, G., Amenta, F., Avola, R., & Renis, M. (2014) · Journal of Neuroscience Research · doi:10.1002/jnr.23290 · Cited by 31

Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress

Leed, M. G. D., Wolkow, N., Pham, D. M., Daniel, C. L., Dunaief, J. L., & Franz, K. J. (2011) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2011.05.023 · Cited by 34

Nanomolar colorimetric quantitative detection of Fe3+ and PPi with high selectivity

Li, Z., Li, H., Shi, C., Yu, M., Wei, L., & Ni, Z. (2016) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2016.02.001 · Cited by 34

Smart PET based organic scaffold exhibiting bright “Turn–On” green fluorescence to detect Fe3+ ion: Live cell imaging and logic implication

Dwivedi, S. K., Gupta, R., Ali, R., Razi, S. S., Hira, S., Manna, P., & Misra, A. (2018) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2018.03.011 · Cited by 28

Rhodamine based turn-on chemosensor for Fe 3+ in aqueous medium and interactions of its Fe 3+ complex with DNA

Bhowmick, R., Islam, A. S. M., Saha, U., Kumar, G. S., & Ali, M. (2018) · New Journal of Chemistry · doi:10.1039/c7nj04505k · Cited by 32

Sulforaphane rescues memory dysfunction and synaptic and mitochondrial alterations induced by brain iron accumulation

Lavich, I. C., de Freitas, B. S., Kist, L. W., Falavigna, L., Dargél, V. A., Köbe, L. M., Aguzzoli, C. S., Piffero, B., Florian, P. Z., Bogo, M. R., et al. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.06.025 · Cited by 32

The transition metals copper and iron in neurodegenerative diseases

Rivera-Mancía, S., Pérez‐Neri, I., Ríos, C., Tristán-López, L. A., Rivera-Espinosa, L., & Montes, S. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.04.010 · Cited by 247

Metal-based neurodegeneration. From molecular mechanisms to therapeutic strategies, 2nd Edition

Crichton, R. R., & Ward, R. J. (2013) · DIAL (Catholic University of Leuven) · doi:10.1002/9781118553480 · Cited by 1

ROLA METALI W ROZWOJU CHOROBY ALZHEIMERA I PARKINSONA

Żygowska, J., & Szymańska, A. (2022) · Wiadomości Chemiczne · doi:10.53584/wiadchem.2022.1.1

Redox active metals in neurodegenerative diseases

Acevedo, K. M., Masaldan, S., Opazo, C., & Bush, A. I. (2019) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-019-01731-9 · Cited by 102

The Relevance of Metals in the Pathophysiology of Neurodegeneration, Pathological Considerations

Jellinger, K. A. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-410502-7.00002-8 · Cited by 101